node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEB99886.1 | cbiD | Selsp_0922 | Selsp_0918 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.998 |
AEB99886.1 | cbiE | Selsp_0922 | Selsp_0919 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COGs: COG2241 Precorrin-6B methylase 1; InterPro IPR000878:IPR012818; KEGG: vpr:Vpar_1145 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Tetrapyrrole methylase; SPTR: Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; manually curated; IMG reference gene:2504586392; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), Cb [...] | 0.982 |
AEB99886.1 | cbiK | Selsp_0922 | Selsp_1415 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Sirohydrochlorin cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: vpr:Vpar_1135 anaerobic cobalt chelatase; PFAM: Anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Cobalt chelatase; IMG reference gene:2504586897; PFAM: Cobalt chelatase (CbiK). | 0.794 |
AEB99886.1 | cbiK-2 | Selsp_0922 | Selsp_1606 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Anaerobic cobalt chelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: ssm:Spirs_0173 sirohydrochlorin cobaltochelatase; PFAM: Anaerobic cobalt chelatase; SPTR: Putative cobalt chelatase; IMG reference gene:2504587091; PFAM: Cobalt chelatase (CbiK). | 0.913 |
AEB99886.1 | cbiK-3 | Selsp_0922 | Selsp_1668 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Sirohydrochlorin cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: vpr:Vpar_1135 anaerobic cobalt chelatase; PFAM: Anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Cobalt chelatase; IMG reference gene:2504587156; PFAM: Cobalt chelatase (CbiK). | 0.906 |
AEB99886.1 | cbiT | Selsp_0922 | Selsp_0920 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR003682:IPR014008; KEGG: has:Halsa_2200 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: rRNA small subunit methyltransferase G; SPTR: Precorrin-6y c5,15-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiT, precorrin-6Y methyltransferase-core; IMG reference gene:2504586393; PFAM: rRNA small subunit methyltransferase G; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit. | 0.973 |
AEB99886.1 | cobB | Selsp_0922 | Selsp_0926 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.963 |
AEB99886.1 | cobH | Selsp_0922 | Selsp_0925 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: vpr:Vpar_1139 precorrin-8X methylmutase CbiC/CobH; PFAM: Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core; PRIAM: Precorrin-8X methylmutase; SPTR: Precorrin-8X methylmutase; IMG reference gene:2504586398; PFAM: Precorrin-8X methylmutase. | 0.989 |
AEB99886.1 | cobI | Selsp_0922 | Selsp_0893 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR000878; KEGG: vpr:Vpar_1130 precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Precorrin-2 C(20)-methyltransferase; SPTR: Precorrin-2 C(20)-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobI/CbiL, precorrin-2 C20-methyltransferase, core; IMG reference gene:2504586366; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.985 |
AEB99886.1 | cobJ | Selsp_0922 | Selsp_0923 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: vpr:Vpar_1141 precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: Precorrin-3B C(17)-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; IMG reference gene:2504586396; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.999 |
AEB99886.1 | cobK | Selsp_0922 | Selsp_0924 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: vpr:Vpar_1140 precorrin-6x reductase; PFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase; SPTR: Precorrin-6x reductase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase; IMG reference gene:2504586397; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | 0.996 |
AEB99886.1 | cobM | Selsp_0922 | Selsp_0921 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878; KEGG: vpr:Vpar_1143 precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C(11)-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase, core; IMG reference gene:2504586394; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. | 0.999 |
cbiD | AEB99886.1 | Selsp_0918 | Selsp_0922 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR021744:IPR002750; KEGG: aar:Acear_0836 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G N-terminal; Cobalamin (vitamin B12) biosynthesis CbiG, core; SPTR: CbiG protein; IMG reference gene:2504586395; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.998 |
cbiD | cbiE | Selsp_0918 | Selsp_0919 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COGs: COG2241 Precorrin-6B methylase 1; InterPro IPR000878:IPR012818; KEGG: vpr:Vpar_1145 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Tetrapyrrole methylase; SPTR: Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; manually curated; IMG reference gene:2504586392; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), Cb [...] | 0.984 |
cbiD | cbiK | Selsp_0918 | Selsp_1415 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Sirohydrochlorin cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: vpr:Vpar_1135 anaerobic cobalt chelatase; PFAM: Anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Cobalt chelatase; IMG reference gene:2504586897; PFAM: Cobalt chelatase (CbiK). | 0.641 |
cbiD | cbiK-2 | Selsp_0918 | Selsp_1606 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Anaerobic cobalt chelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: ssm:Spirs_0173 sirohydrochlorin cobaltochelatase; PFAM: Anaerobic cobalt chelatase; SPTR: Putative cobalt chelatase; IMG reference gene:2504587091; PFAM: Cobalt chelatase (CbiK). | 0.804 |
cbiD | cbiK-3 | Selsp_0918 | Selsp_1668 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Sirohydrochlorin cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: vpr:Vpar_1135 anaerobic cobalt chelatase; PFAM: Anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Cobalt chelatase; IMG reference gene:2504587156; PFAM: Cobalt chelatase (CbiK). | 0.775 |
cbiD | cbiT | Selsp_0918 | Selsp_0920 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR003682:IPR014008; KEGG: has:Halsa_2200 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: rRNA small subunit methyltransferase G; SPTR: Precorrin-6y c5,15-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiT, precorrin-6Y methyltransferase-core; IMG reference gene:2504586393; PFAM: rRNA small subunit methyltransferase G; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit. | 0.985 |
cbiD | cobB | Selsp_0918 | Selsp_0926 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.958 |
cbiD | cobH | Selsp_0918 | Selsp_0925 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: vpr:Vpar_1139 precorrin-8X methylmutase CbiC/CobH; PFAM: Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core; PRIAM: Precorrin-8X methylmutase; SPTR: Precorrin-8X methylmutase; IMG reference gene:2504586398; PFAM: Precorrin-8X methylmutase. | 0.985 |