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upp upp glyA glyA deoC deoC deoB deoB purF purF guaA guaA glmS glmS AEB99692.1 AEB99692.1 AEB99717.1 AEB99717.1 thyX thyX deoD deoD folD folD fhs fhs AEB99804.1 AEB99804.1 gltA gltA pyrR pyrR glnA glnA pyrB pyrB pyrC pyrC carA carA carB carB pyrF pyrF pyrE pyrE AEB99948.1 AEB99948.1 AEB99963.1 AEB99963.1 pyrD pyrD purE purE purC purC purM purM purN purN AEB99978.1 AEB99978.1 purD purD surE surE AEC00515.1 AEC00515.1 AEC00525.1 AEC00525.1 AEC00548.1 AEC00548.1 glyA-2 glyA-2 cdd cdd pyn pyn purB purB purA purA AEC01233.1 AEC01233.1
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uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (214 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (397 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa)
glmSGlucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
AEB99692.1COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644:IPR001093; KEGG: cbe:Cbei_2114 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: Inosine-5'-monophosphate dehydrogenase; IMG reference gene:2504586187; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. (500 aa)
AEB99717.1COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR004843; KEGG: afn:Acfer_0834 5'-nucleotidase domain protein; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase family protein; IMG reference gene:2504586215; PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase; Belongs to the 5'-nucleotidase family. (533 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (215 aa)
deoDCOGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845:IPR004402; KEGG: lsa:LSA0797 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase deoD-type; TIGRFAM: Purine nucleoside phosphorylase; IMG reference gene:2504586300; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). (237 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
fhsFormate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559; KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; IMG reference gene:2504586309; PFAM: Formate--tetrahydrofolate ligase. (555 aa)
AEB99804.1Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR008333:IPR001433:IPR019480; KEGG: dhd:Dhaf_3502 ferredoxin-NADP(+) reductase subunit alpha; PFAM: Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Oxidoreductase, NAD-binding; IMG reference gene:2504586313; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidor [...] (280 aa)
gltACOGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR013027:IPR001327; KEGG: ckr:CKR_0405 putative oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, homotetrameric; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2504586314; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (468 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (184 aa)
glnACOGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: vpr:Vpar_0890 glutamine synthetase catalytic region; PFAM: Glutamine synthetase, catalytic domain; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504586385; PFAM: Glutamine synthetase, catalytic domain. (628 aa)
pyrBCOGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase, eukaryotic; InterPro IPR002082:IPR006132:IPR006131; KEGG: vpr:Vpar_0563 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Aspartate carbamoyltransferase; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; IMG reference gene:2504586426; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornit [...] (319 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa)
carACOGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR002474:IPR000991:IPR006274; KEGG: vpr:Vpar_0565 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; IMG reference gene:2504586428; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phos [...] (357 aa)
carBCOGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR006275:IPR011607:IPR005480:IPR005479:IPR 005481; KEGG: afn:Acfer_1315 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Carbamoyl-phosphate synthase, large subunit, N-terminal; PRIAM: Carbamoyl-phosphate synthase (ammonia); SMART: Methylglyoxal synthase-like domain; SPTR: Carbamoyl-phosphate synthase large chain; TIGRFAM: Carbamoyl-phosphate [...] (1076 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (239 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (191 aa)
AEB99948.1COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: tte:TTE1778 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; SPTR: Phosphoribulokinase family protein; IMG reference gene:2504586466; PFAM: Phosphoribulokinase / Uridine kinase family. (548 aa)
AEB99963.1Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR008333:IPR001433:IPR019480; KEGG: vpr:Vpar_0567 oxidoreductase FAD/NAD(P)-binding domain protein; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; SPTR: Dihydroorotate dehydrogenase, electron transfer subunit; IMG reference gene:2504586481; PFAM: Oxidoreductase FAD-binding [...] (254 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (304 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636; KEGG: tle:Tlet_1916 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase; IMG reference gene:2504586494; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (237 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR004733:IPR010918:IPR000728; KEGG: afn:Acfer_1279 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2504586495; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal dom [...] (350 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa)
AEB99978.1Phosphoribosylaminoimidazolecarboxamide formyltransferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982; KEGG: afn:Acfer_1277 IMP cyclohydrolase; PFAM: Methylglyoxal synthase-like domain; AICARFT/IMPCHase bienzyme, transformylase domain; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: Methylglyoxal synthase-like domain; SPTR: Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; IMG reference gene:2504586497; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain. (197 aa)
purDCOGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR000115:IPR020561:IPR020562:IPR020560; KEGG: afn:Acfer_1276 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; IMG reference gene:2504586500; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) do [...] (425 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa)
AEC00515.1COGs: COG2233 Xanthine/uracil permease; InterPro IPR006042:IPR006043; KEGG: drm:Dred_1317 uracil transporter; PFAM: Xanthine/uracil/vitamin C permease; SPTR: Uracil permease; TIGRFAM: Xanthine/uracil permease; IMG reference gene:2504587043; PFAM: Permease family; TIGRFAM: uracil-xanthine permease. (419 aa)
AEC00525.1COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR001327; KEGG: cpy:Cphy_3412 putative oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, homotetrameric; IMG reference gene:2504587054; PFAM: Pyridine nucleotide-disulphide oxidoreductase. (409 aa)
AEC00548.1COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR010918:IPR010141; KEGG: tjr:TherJR_0822 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; IMG reference gene:2504587077; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synthase, clade II. (1261 aa)
glyA-2COGs: COG0112 Glycine/serine hydroxymethyltransferase; InterPro IPR001085; KEGG: cni:Calni_0592 serine hydroxymethyltransferase; PFAM: Serine hydroxymethyltransferase; PRIAM: Glycine hydroxymethyltransferase; SPTR: Glycine hydroxymethyltransferase; IMG reference gene:2504587420; PFAM: Serine hydroxymethyltransferase. (444 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (129 aa)
pynCOGs: COG0213 Thymidine phosphorylase; InterPro IPR018090:IPR013102:IPR000312:IPR017459; KEGG: clo:HMPREF0868_0655 pyrimidine-nucleoside phosphorylase; PFAM: Glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal; Glycosyl transferase, family 3, N-terminal; PRIAM: Pyrimidine-nucleoside phosphorylase; SMART: Pyrimidine nucleoside phosphorylase, C-terminal; SPTR: Pyrimidine-nucleoside phosphorylase; TIGRFAM: Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic; IMG reference gene:2504587716; PFAM: Glycosyl transferase family, a/b domain; Pyrimidine nucleosid [...] (477 aa)
purBCOGs: COG0015 Adenylosuccinate lyase; InterPro IPR022761:IPR004769:IPR019468; KEGG: bhy:BHWA1_00426 adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal metazoa/fungi; SPTR: Adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; IMG reference gene:2504587766; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
AEC01233.1Phosphoribosylaminoimidazolecarboxamide formyltransferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR013982; KEGG: cbe:Cbei_3561 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; SPTR: Purine biosynthesis protein PURH; IMG reference gene:2504587806; PFAM: AICARFT/IMPCHase bienzyme. (390 aa)
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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