STRINGSTRING
folE folE folP folP folB folB folK folK AEB99209.1 AEB99209.1 AEC00054.1 AEC00054.1 mutM mutM AEC00057.1 AEC00057.1 miaB miaB AEC00062.1 AEC00062.1 def def fmt fmt AEC00066.1 AEC00066.1 sun sun rlmN rlmN AEC00069.1 AEC00069.1 AEC00070.1 AEC00070.1 AEC00071.1 AEC00071.1 AEC00072.1 AEC00072.1 AEC00073.1 AEC00073.1 AEC00074.1 AEC00074.1 rsgA rsgA queC queC folE2 folE2 queE queE queD queD AEC00234.1 AEC00234.1 adk adk AEC00455.1 AEC00455.1 AEC00456.1 AEC00456.1 ribH ribH AEC00458.1 AEC00458.1 ribB ribB ribE ribE ribD ribD queF queF folB-2 folB-2 AEC00701.1 AEC00701.1 nrdG nrdG nrdD nrdD AEC01192.1 AEC01192.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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folECOGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602; KEGG: vpr:Vpar_0493 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; IMG reference gene:2504585685; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (189 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: sga:GALLO_1229 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inediphosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; IMG reference gene:2504585688; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphok [...] (197 aa)
AEB99209.1KEGG: vcj:VCD_000991 hypothetical protein; SPTR: Procyclic form-specific polypeptide A-beta; IMG reference gene:2504585690. (289 aa)
AEC00054.1ErfK/YbiS/YcfS/YnhG family protein; COGs: COG1376 conserved hypothetical protein; InterPro IPR005490; KEGG: ttm:Tthe_1098 ErfK/YbiS/YcfS/YnhG family protein; PFAM: YkuD domain; SPTR: ErfK/YbiS/YcfS/YnhG family protein; IMG reference gene:2504586574; PFAM: L,D-transpeptidase catalytic domain. (409 aa)
mutMformamidopyrimidine-DNA glycosylase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the FPG family. (477 aa)
AEC00057.1COGs: COG0741 Soluble lytic murein transglycosylase and related regulatory protein (some contain LysM/invasin domains); InterPro IPR008258; KEGG: dhd:Dhaf_2473 lytic transglycosylase catalytic; PFAM: Lytic transglycosylase-like, catalytic; SPTR: Soluble lytic murein transglycosylase; IMG reference gene:2504586577; PFAM: Transglycosylase SLT domain. (209 aa)
miaBRNA modification enzyme, MiaB family; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (444 aa)
AEC00062.1Protein of unknown function DUF548; InterPro IPR007536; KEGG: dau:Daud_0555 hypothetical protein; PFAM: Protein of unknown function DUF548; SPTR: Putative uncharacterized protein; IMG reference gene:2504586582; PFAM: Protein of unknown function (DUF548). (263 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (155 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (313 aa)
AEC00066.1Protein of unknown function DUF116; COGs: COG1852 conserved hypothetical protein; InterPro IPR002829; KEGG: afn:Acfer_0312 protein of unknown function DUF116; PFAM: Protein of unknown function DUF116; SPTR: Putative nucleotide-binding protein; IMG reference gene:2504586586; PFAM: Protein of unknown function DUF116. (276 aa)
sunSun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (443 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (350 aa)
AEC00069.1COGs: COG1716 FOG: FHA domain; InterPro IPR000253:IPR022128; KEGG: tjr:TherJR_1792 FHA domain containing protein; PFAM: Protein of unknown function DUF3662; Forkhead-associated (FHA) domain; SMART: Forkhead-associated (FHA) domain; SPTR: FHA domain containing protein; IMG reference gene:2504586589; PFAM: Protein of unknown function (DUF2662); FHA domain. (250 aa)
AEC00070.1COGs: COG1716 FOG: FHA domain; InterPro IPR000253; KEGG: dae:Dtox_2308 FHA domain-containing protein; PFAM: Forkhead-associated (FHA) domain; SMART: Forkhead-associated (FHA) domain; SPTR: FHA domain containing protein; IMG reference gene:2504586590; PFAM: FHA domain. (150 aa)
AEC00071.1COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR014045:IPR001932; KEGG: cth:Cthe_0573 protein serine/threonine phosphatases; PFAM: Protein phosphatase 2C, N-terminal; SMART: Protein phosphatase 2C-like; SPTR: Protein phosphatase 1; IMG reference gene:2504586591; PFAM: Protein phosphatase 2C. (236 aa)
AEC00072.1Cell cycle protein; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182; KEGG: dae:Dtox_2306 cell cycle protein; PFAM: Cell cycle protein; SPTR: Cell division protein FtsW; IMG reference gene:2504586592; PFAM: Cell cycle protein; Belongs to the SEDS family. (417 aa)
AEC00073.1Peptidoglycan glycosyltransferase; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR001460; KEGG: toc:Toce_0254 peptidoglycan glycosyltransferase; PFAM: Penicillin-binding protein, transpeptidase; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Peptidoglycan glycosyltransferase; IMG reference gene:2504586593; PFAM: Penicillin binding protein transpeptidase domain. (464 aa)
AEC00074.1COGs: COG0515 Serine/threonine protein kinase; InterPro IPR005543:IPR017442:IPR002290; KEGG: vpr:Vpar_0853 serine/threonine protein kinase with PASTA sensor(s); PFAM: Serine/threonine-protein kinase-like domain; PASTA; PRIAM: Non-specific protein-tyrosine kinase; SMART: Serine/threonine-protein kinase domain; PASTA; SPTR: Serine/threonine-protein kinase PrkC; IMG reference gene:2504586594; PFAM: Protein kinase domain; PASTA domain. (593 aa)
rsgARibosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (293 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (224 aa)
folE2GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. (273 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (241 aa)
queDQueuosine biosynthesis protein QueD; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: drm:Dred_1754 putative 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase-related; SPTR: Queuosine biosynthesis protein QueD; TIGRFAM: queuosine biosynthesis protein QueD; IMG reference gene:2504586623; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (125 aa)
AEC00234.1COGs: COG1564 Thiamine pyrophosphokinase; InterPro IPR006282:IPR007371; KEGG: aco:Amico_0854 thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic domain; SPTR: Thiamine diphosphokinase; TIGRFAM: Thiamin pyrophosphokinase; IMG reference gene:2504586755; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain; TIGRFAM: thiamine pyrophosphokinase. (233 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
AEC00455.1Protein of unknown function DUF2276; InterPro IPR019267; KEGG: vpr:Vpar_1811 hypothetical protein; PFAM: Protein of unknown function DUF2276; SPTR: Putative CRISPR-associated protein; IMG reference gene:2504586980; PFAM: Uncharacterized conserved protein (DUF2276); TIGRFAM: CRISPR-associated endoribonuclease Cas6. (267 aa)
AEC00456.1Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: tpd:Teth39_1576 phosphodiesterase; PFAM: Metallo-dependent phosphatase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: Phosphodiesterase MJ0936; IMG reference gene:2504586981; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. (185 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa)
AEC00458.1ThiJ/PfpI domain-containing protein; InterPro IPR002818; KEGG: bfr:BF3075 hypothetical protein; PFAM: ThiJ/PfpI; SPTR: DJ-1/PfpI family protein; manually curated; IMG reference gene:2504586983; PFAM: DJ-1/PfpI family. (204 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (404 aa)
ribECOGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: cth:Cthe_0105 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; IMG reference gene:2504586985; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (217 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
queFNADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (165 aa)
folB-2Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
AEC00701.1KEGG: adg:Adeg_1883 dihydropteroate synthase; SPTR: Dihydropteroate synthase; IMG reference gene:2504587235. (121 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (167 aa)
nrdDCOGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: elm:ELI_3633 anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; IMG reference gene:2504587655; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase. (777 aa)
AEC01192.1Adenylate cyclase; COGs: COG2954 conserved hypothetical protein; InterPro IPR008172; KEGG: hha:Hhal_1263 adenylate cyclase; PFAM: Adenylate cyclase; SPTR: Adenylate cyclase; IMG reference gene:2504587764; PFAM: CYTH domain. (155 aa)
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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