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| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | AEB99081.1 | KEGG: bbe:BBR47_58710 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504585554. (338 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (638 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa) |
| | bioA | COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814:IPR005815; KEGG: afn:Acfer_0058 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Adenosylmethionine--8-amino-7-oxononanoate transaminase; SPTR: Adenosylmethionine-8-amino-7-oxononanoate transaminase; TIGRFAM: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; IMG reference gene:2504585649; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-de [...] (448 aa) |
| | AEB99175.1 | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (326 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: sga:GALLO_1229 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inediphosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; IMG reference gene:2504585688; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphok [...] (197 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839:IPR005861; KEGG: eel:EUBELI_00629 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: Histidinol-phosphate aminotransferase; IMG reference gene:2504585758; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransfer [...] (350 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa) |
| | AEB99348.1 | Transcriptional repressor, CtsR; COGs: COG4463 Transcriptional repressor of class III stress genes; InterPro IPR008463; KEGG: ppm:PPSC2_c4814 transcriptional repressor; PFAM: Firmicute transcriptional repressor of class III stress genes; SPTR: Transcriptional regulator CtsR; IMG reference gene:2504585835; PFAM: Firmicute transcriptional repressor of class III stress genes (CtsR). (194 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (286 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (311 aa) |
| | hydE | Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR007197:IPR010722:IPR006638; KEGG: thx:Thet_0618 radical SAM domain-containing protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; Biotin/thiamin synthesis-associated protein; SPTR: Radical SAM domain protein; IMG reference gene:2504585901; PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE. (346 aa) |
| | ilvN | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR004789:IPR019455; KEGG: dhd:Dhaf_3616 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504585904; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (167 aa) |
| | cysK | COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR001926:IPR005859; KEGG: elm:ELI_3635 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase K/M; Cysteine synthase A; IMG reference gene:2504585945; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | AEB99463.1 | COGs: COG0077 Prephenate dehydratase; InterPro IPR001086:IPR002912; KEGG: dau:Daud_1904 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT; PRIAM: Prephenate dehydratase; SPTR: Chorismate mutase/prephenate dehydratase; IMG reference gene:2504585950; PFAM: Prephenate dehydratase; ACT domain. (296 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218:IPR006268; KEGG: tmt:Tmath_1028 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: 3-deoxy-7-phosphoheptulonate synthase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; IMG reference gene:2504585951; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (343 aa) |
| | AEB99503.1 | COGs: COG1216 glycosyltransferase; InterPro IPR001173; KEGG: cbb:CLD_1847 glycosyltransferase; PFAM: Glycosyl transferase, family 2; SPTR: Glycosyltransferase; IMG reference gene:2504585990; PFAM: Glycosyl transferase family 2. (990 aa) |
| | aroF-2 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218:IPR006268; KEGG: tmt:Tmath_1028 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: 3-deoxy-7-phosphoheptulonate synthase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; IMG reference gene:2504586473; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa) |
| | AEC01231.1 | COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR006158:IPR003759:IPR003726:IPR000489; KEGG: hmo:HM1_2499 methionine synthase, putative; PFAM: Homocysteine S-methyltransferase; Cobalamin (vitamin B12)-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Pterin-binding; PRIAM: Methionine synthase; SPTR: Vitamin B12-dependent methionine synthase family protein; IMG reference gene:2504587804; PFAM: Pterin binding enzyme; B12 binding domain; Homocysteine S-methyltransferase; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain; 5-methyltetrahyd [...] (790 aa) |
| | AEC01230.1 | InterPro IPR004223; KEGG: vpr:Vpar_1849 vitamin B12 dependent methionine synthase activation region; PFAM: Vitamin B12-dependent methionine synthase, activation domain; SPTR: Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; IMG reference gene:2504587803; PFAM: Vitamin B12 dependent methionine synthase, activation domain. (230 aa) |
| | ilvA | COGs: COG1171 Threonine dehydratase; InterPro IPR001926:IPR005789; KEGG: clj:CLJU_c15090 threonine dehydratase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; SPTR: Threonine ammonia-lyase; TIGRFAM: Threonine dehydratase II; IMG reference gene:2504587795; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine ammonia-lyase, biosynthetic, long form; threonine dehydratase, medium form. (415 aa) |
| | AEC01214.1 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: afn:Acfer_0167 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Vitamin-B12 independent methionine synthase family protein; IMG reference gene:2504587787; PFAM: Cobalamin-independent synthase, Catalytic domain. (372 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (372 aa) |
| | AEC01133.1 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: amt:Amet_1319 isocitrate dehydrogenase (NAD(+)); PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: Isocitrate dehydrogenase; IMG reference gene:2504587704; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases. (333 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (362 aa) |
| | serA | COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006236:IPR006139:IPR006140:IPR002912; KEGG: pth:PTH_0012 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT; PRIAM: Phosphoglycerate dehydrogenase; SPTR: Phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; IMG reference gene:2504587536; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hy [...] (527 aa) |
| | glyA-2 | COGs: COG0112 Glycine/serine hydroxymethyltransferase; InterPro IPR001085; KEGG: cni:Calni_0592 serine hydroxymethyltransferase; PFAM: Serine hydroxymethyltransferase; PRIAM: Glycine hydroxymethyltransferase; SPTR: Glycine hydroxymethyltransferase; IMG reference gene:2504587420; PFAM: Serine hydroxymethyltransferase. (444 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (147 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; HAMAP: 3-deoxy-8-phosphooctulonate synthase; InterPro IPR006269:IPR006218; KEGG: vpr:Vpar_0543 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-8-phosphooctulonate synthase; SPTR: 2-dehydro-3-deoxyphosphooctonate aldolase; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; IMG reference gene:2504587393; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase. (276 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (296 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (384 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (365 aa) |
| | AEC00767.1 | Hypothetical protein; SPTR: Putative Acetyl-CoA carboxylase alpha chain; IMG reference gene:2504587303. (99 aa) |
| | AEC00733.1 | Biotin carboxylase; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005482:IPR005479:IPR005481; KEGG: tjr:TherJR_1719 acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Biotin carboxylase, C-terminal; Carbamoyl-phosphate synthase, large subunit, N-terminal; PRIAM: Biotin carboxylase; SMART: Biotin carboxylase, C-terminal; SPTR: Acetyl-CoA carboxylase, biotin carboxylase subunit; IMG reference gene:2504587268; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal [...] (468 aa) |
| | AEC00732.1 | COGs: COG0498 Threonine synthase; InterPro IPR001926; KEGG: mpd:MCP_0979 putative threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; IMG reference gene:2504587267; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (331 aa) |
| | AEC00722.1 | PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013; KEGG: str:Sterm_1709 histidinol phosphate phosphatase HisJ family; PFAM: PHP, C-terminal; SPTR: Histidinol-phosphatase; IMG reference gene:2504587256; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (282 aa) |
| | trpF | COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: gem:GM21_2257 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; IMG reference gene:2504587242; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (206 aa) |
| | trpC | COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798; KEGG: gme:Gmet_2494 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol phosphate synthase; IMG reference gene:2504587241; PFAM: Indole-3-glycerol phosphate synthase. (266 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | AEC00701.1 | KEGG: adg:Adeg_1883 dihydropteroate synthase; SPTR: Dihydropteroate synthase; IMG reference gene:2504587235. (121 aa) |
| | folB-2 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (356 aa) |
| | fabD | COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043:IPR004410:IPR020801; KEGG: vpr:Vpar_0698 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; SMART: Polyketide synthase, acyl transferase domain; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; IMG reference gene:2504587218; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase. (314 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | fabF | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (149 aa) |
| | AEC00525.1 | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR001327; KEGG: cpy:Cphy_3412 putative oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, homotetrameric; IMG reference gene:2504587054; PFAM: Pyridine nucleotide-disulphide oxidoreductase. (409 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa) |
| | AEC00458.1 | ThiJ/PfpI domain-containing protein; InterPro IPR002818; KEGG: bfr:BF3075 hypothetical protein; PFAM: ThiJ/PfpI; SPTR: DJ-1/PfpI family protein; manually curated; IMG reference gene:2504586983; PFAM: DJ-1/PfpI family. (204 aa) |
| | ilvE | COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544:IPR005786; KEGG: eel:EUBELI_01912 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; PRIAM: Branched-chain-amino-acid transaminase; SPTR: Branched-chain-amino-acid transaminase; TIGRFAM: Branched-chain amino acid aminotransferase II; IMG reference gene:2504586939; PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II. (341 aa) |
| | AEC00375.1 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR002933:IPR010168; KEGG: clj:CLJU_c06270 putative amidohydrolase; PFAM: Peptidase M20; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Peptidase, M20D family; TIGRFAM: Peptidase M20D, amidohydrolase; IMG reference gene:2504586899; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (383 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa) |
| | AEC00213.1 | COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: ere:EUBREC_1577 serine acetyltransferase, plasmid; PRIAM: Serine O-acetyltransferase; SPTR: Serine acetyltransferase; IMG reference gene:2504586734; TIGRFAM: serine O-acetyltransferase. (317 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (436 aa) |
| | AEC00198.1 | COGs: COG0460 Homoserine dehydrogenase; InterPro IPR001342:IPR005106:IPR002912; KEGG: drm:Dred_1165 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase; IMG reference gene:2504586719; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (440 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | ilvN-2 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR004789:IPR019455; KEGG: ate:Athe_0503 acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504586712; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (176 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | AEC00179.1 | HAD-superfamily hydrolase, subfamily IB (PSPase-like); COGs: COG0560 Phosphoserine phosphatase; InterPro IPR006383:IPR005834; KEGG: dds:Ddes_1017 HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Phosphoserine phosphatase; TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like; IMG reference gene:2504586699; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; ATPase, P-type (transporting), HAD superfamily, subfamily IC. (199 aa) |
| | AEC00176.1 | C_GCAxxG_C_C family protein; InterPro IPR010181; KEGG: eel:EUBELI_20402 hypothetical protein; PFAM: CGCAxxGCC motif; SPTR: Redox family protein; IMG reference gene:2504586696; PFAM: Putative redox-active protein (C_GCAxxG_C_C). (131 aa) |
| | AEC00174.1 | Radical SAM domain protein; InterPro IPR007197:IPR006638; KEGG: dae:Dtox_0061 radical SAM domain protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; IMG reference gene:2504586694; PFAM: Radical SAM superfamily. (412 aa) |
| | AEC00150.1 | InterPro IPR011733; KEGG: tde:TDE0907 hypothetical protein; PFAM: Conserved hypothetical CHP02185, integral membrane; SPTR: Putative membrane protein; TIGRFAM: Conserved hypothetical CHP02185, integral membrane; IMG reference gene:2504586670; PFAM: Hypothetical bacterial integral membrane protein (Trep_Strep); TIGRFAM: conserved hypothetical integral membrane protein TIGR02185. (192 aa) |
| | AEC00145.1 | COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048:IPR002912:IPR005260; KEGG: vpr:Vpar_1126 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; IMG reference gene:2504586665; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (409 aa) |
| | pdxB | COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR006139; KEGG: cbe:Cbei_4594 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; PRIAM: Phosphoglycerate dehydrogenase; SPTR: Glycerate dehydrogenase; IMG reference gene:2504586661; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (313 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: afn:Acfer_1425 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; IMG reference gene:2504586638; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa) |
| | AEC00107.1 | Glycosyl transferase, WecB/TagA/CpsF family; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (251 aa) |
| | hisE | phosphoribosyl-ATP diphosphatase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179:IPR002496:IPR021130; KEGG: ipo:Ilyop_2707 phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; PRIAM: Phosphoribosyl-AMP cyclohydrolase., Phosphoribosyl-ATP diphosphatase; SPTR: Histidine biosynthesis protein HisIE; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504586616; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFA [...] (235 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062:IPR006063; KEGG: dae:Dtox_0756 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; IMG referen [...] (243 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; IMG reference gene:2504586612; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (449 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (222 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (394 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (151 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (263 aa) |
| | AEC00004.1 | Purine or other phosphorylase family 1; COGs: COG0775 Nucleoside phosphorylase; InterPro IPR000845; KEGG: aci:ACIAD0773 putative MTA/SAH nucleosidase; PFAM: Nucleoside phosphorylase domain; SPTR: Putative MTA/SAH nucleosidase; IMG reference gene:2504586523; PFAM: Phosphorylase superfamily. (264 aa) |
| | argH | COGs: COG0165 Argininosuccinate lyase; InterPro IPR022761:IPR009049; KEGG: vpr:Vpar_1567 argininosuccinate lyase; PFAM: Lyase 1, N-terminal; PRIAM: Argininosuccinate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase; IMG reference gene:2504586514; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (475 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518; KEGG: hmo:HM1_1436 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; IMG reference gene:2504586513; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argD | COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR004636:IPR005814; KEGG: afn:Acfer_0596 acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine transaminase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; IMG reference gene:2504586511; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotra [...] (401 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (294 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (403 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | AEB99956.1 | COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: gur:Gura_1463 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; PRIAM: Prephenate dehydrogenase; SPTR: Prephenate dehydrogenase; IMG reference gene:2504586474; PFAM: Prephenate dehydrogenase. (293 aa) |
| | AEB99507.1 | Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: glo:Glov_0787 pyruvate carboxyltransferase; PFAM: Pyruvate carboxyltransferase; SPTR: Putative uncharacterized protein; IMG reference gene:2504585994; PFAM: HMGL-like. (538 aa) |
| | AEB99511.1 | COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR002658; KEGG: glo:Glov_0789 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase AroB; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase; IMG reference gene:2504585998; PFAM: 3-dehydroquinate synthase. (357 aa) |
| | AEB99583.1 | 2-dehydropantoate 2-reductase; COGs: COG1893 Ketopantoate reductase; InterPro IPR003710:IPR013332:IPR013752; KEGG: swo:Swol_1181 putative oxidoreductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal; Ketopantoate reductase ApbA/PanE, C-terminal; SPTR: 2-dehydropantoate 2-reductase; TIGRFAM: Ketopantoate reductase ApbA/PanE; IMG reference gene:2504586072; PFAM: Ketopantoate reductase PanE/ApbA; Ketopantoate reductase PanE/ApbA C terminal; TIGRFAM: 2-dehydropantoate 2-reductase. (308 aa) |
| | AEB99647.1 | Hypothetical protein; COGs: COG0253 Diaminopimelate epimerase; KEGG: ami:Amir_3920 hypothetical protein; SPTR: Putative diaminopimelate epimerase; IMG reference gene:2504586140. (265 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | aroH | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (121 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | AEB99803.1 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: hmo:HM1_1450 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; IMG reference gene:2504586312; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (248 aa) |
| | gltA | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR013027:IPR001327; KEGG: ckr:CKR_0405 putative oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, homotetrameric; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2504586314; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (468 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa) |
| | AEB99846.1 | Monogalactosyldiacylglycerol synthase; COGs: COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; InterPro IPR009695:IPR007235; KEGG: vpr:Vpar_1358 monogalactosyldiacylglycerol synthase; PFAM: Monogalactosyldiacylglycerol synthase; Glycosyl transferase, family 28, C-terminal; SPTR: Putative UDP-glucuronosyltransferase; IMG reference gene:2504586355; PFAM: Glycosyltransferase family 28 C-terminal domain; Monogalactosyldiacylglycerol (MGDG) synthase. (376 aa) |
| | glnA | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: vpr:Vpar_0890 glutamine synthetase catalytic region; PFAM: Glutamine synthetase, catalytic domain; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504586385; PFAM: Glutamine synthetase, catalytic domain. (628 aa) |
| | AEB99895.1 | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839; KEGG: tjr:TherJR_1312 L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase, class I/classII; SPTR: Threonine-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; manually curated; IMG reference gene:2504586404; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. (357 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR002474:IPR000991:IPR006274; KEGG: vpr:Vpar_0565 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; IMG reference gene:2504586428; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phos [...] (357 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR006275:IPR011607:IPR005480:IPR005479:IPR 005481; KEGG: afn:Acfer_1315 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Carbamoyl-phosphate synthase, large subunit, N-terminal; PRIAM: Carbamoyl-phosphate synthase (ammonia); SMART: Methylglyoxal synthase-like domain; SPTR: Carbamoyl-phosphate synthase large chain; TIGRFAM: Carbamoyl-phosphate [...] (1076 aa) |
| | AEB99954.1 | GCN5-related N-acetyltransferase; COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182; KEGG: sth:STH2891 acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Acetyltransferase, GNAT family; IMG reference gene:2504586472; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (157 aa) |
