STRINGSTRING
AEC01132.1 AEC01132.1 pflB pflB AEB99086.1 AEB99086.1 bioF bioF AEB99178.1 AEB99178.1 metA metA AEB99507.1 AEB99507.1 yeaZ yeaZ rimI rimI tsaD tsaD AEB99552.1 AEB99552.1 AEB99715.1 AEB99715.1 AEB99867.1 AEB99867.1 AEB99954.1 AEB99954.1 AEC00195.1 AEC00195.1 mprF mprF plsY plsY AEC00205.1 AEC00205.1 AEC00213.1 AEC00213.1 AEC00214.1 AEC00214.1 leuA leuA argJ argJ glmU glmU fabF fabF fabD fabD plsX plsX AEC00752.1 AEC00752.1 lpxD lpxD AEC00766.1 AEC00766.1 AEC00850.1 AEC00850.1 lpxA lpxA fabZ fabZ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEC01132.1COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: csh:Closa_2133 citrate synthase; PFAM: Citrate synthase-like; SPTR: 2-methylcitrate synthase; IMG reference gene:2504587703; PFAM: Citrate synthase; Belongs to the citrate synthase family. (446 aa)
pflBCOGs: COG1882 Pyruvate-formate lyase; InterPro IPR004184:IPR005949:IPR001150; KEGG: eel:EUBELI_20055 formate C-acetyltransferase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Formate acetyltransferase; TIGRFAM: Formate acetyltransferase; IMG reference gene:2504587754; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1. (750 aa)
AEB99086.1GCN5-related N-acetyltransferase; COGs: COG1670 Acetyltransferase including N-acetylase of ribosomal protein; InterPro IPR000182; KEGG: cst:CLOST_0135 gcn5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Putative spermidine N1-acetyltransferase; IMG reference gene:2504585559; PFAM: Acetyltransferase (GNAT) family. (177 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (638 aa)
AEB99178.1COGs: COG1835 acyltransferase; InterPro IPR002656; KEGG: efa:EF0783 acyltransferase, putative; PFAM: Acyltransferase 3; SPTR: Acyltransferase 3; IMG reference gene:2504585655; PFAM: Acyltransferase family. (610 aa)
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (311 aa)
AEB99507.1Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: glo:Glov_0787 pyruvate carboxyltransferase; PFAM: Pyruvate carboxyltransferase; SPTR: Putative uncharacterized protein; IMG reference gene:2504585994; PFAM: HMGL-like. (538 aa)
yeaZUniversal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR022496:IPR000905; KEGG: afn:Acfer_1580 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: Conserved hypothetical protein CHP03725, YeaZ; IMG reference gene:2504586009; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. (241 aa)
rimICOGs: COG0456 Acetyltransferase; InterPro IPR006464:IPR000182; KEGG: eat:EAT1b_2086 ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Ribosomal-protein-alanine acetyltransferase; TIGRFAM: Ribosomal-protein-alanine acetyltransferase; IMG reference gene:2504586010; PFAM: Acetyltransferase (GNAT) family; TIGRFAM: ribosomal-protein-alanine acetyltransferase. (165 aa)
tsaDMetalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (343 aa)
AEB99552.1Acetyltransferase; KEGG: ols:Olsu_0417 acetyltransferase; SPTR: Acetyltransferase, GNAT family; IMG reference gene:2504586040. (91 aa)
AEB99715.1KEGG: afn:Acfer_1042 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504586213. (552 aa)
AEB99867.1Acyltransferase 3; InterPro IPR002656; KEGG: vpr:Vpar_0420 hypothetical protein; PFAM: Acyltransferase 3; SPTR: Putative membrane protein; IMG reference gene:2504586376; PFAM: Acyltransferase family. (371 aa)
AEB99954.1GCN5-related N-acetyltransferase; COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182; KEGG: sth:STH2891 acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Acetyltransferase, GNAT family; IMG reference gene:2504586472; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (157 aa)
AEC00195.1COGs: COG0663 Carbonic anhydrase/acetyltransferase isoleucine patch superfamily; InterPro IPR001451; KEGG: tmt:Tmath_1072 carbonic anhydrase; SPTR: Transferase hexapeptide repeat family protein; IMG reference gene:2504586716. (179 aa)
mprFLysylphosphatidylglycerol synthetase/UPF0104; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. (333 aa)
plsYProtein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (196 aa)
AEC00205.1COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: afn:Acfer_1240 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase; SPTR: 1-acyl-sn-glycerol-3-phosphate acyltransferase; IMG reference gene:2504586726; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases. (201 aa)
AEC00213.1COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: ere:EUBREC_1577 serine acetyltransferase, plasmid; PRIAM: Serine O-acetyltransferase; SPTR: Serine acetyltransferase; IMG reference gene:2504586734; TIGRFAM: serine O-acetyltransferase. (317 aa)
AEC00214.1Esterase; COGs: COG4947 conserved hypothetical protein; InterPro IPR000801; KEGG: lba:Lebu_1199 putative esterase; PFAM: Putative esterase; SPTR: Putative esterase; IMG reference gene:2504586735; PFAM: Putative esterase. (246 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (403 aa)
glmUBifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (462 aa)
fabF3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa)
fabDCOGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043:IPR004410:IPR020801; KEGG: vpr:Vpar_0698 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; SMART: Polyketide synthase, acyl transferase domain; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; IMG reference gene:2504587218; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase. (314 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (356 aa)
AEC00752.1COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: vpr:Vpar_0532 lipid A biosynthesis acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase; SPTR: Putative lipid A biosynthesis acyltransferase; IMG reference gene:2504587288; PFAM: Bacterial lipid A biosynthesis acyltransferase. (288 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (342 aa)
AEC00766.1KEGG: vpr:Vpar_0521 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504587302; PFAM: SpoIVB peptidase S55. (797 aa)
AEC00850.1COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: afn:Acfer_1679 lipid A biosynthesis acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase; SPTR: Lipid A biosynthesis acyltransferase; IMG reference gene:2504587391; PFAM: Bacterial lipid A biosynthesis acyltransferase. (305 aa)
lpxAAcyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (286 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (147 aa)
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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