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| | gatC | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (96 aa) |
| | AEB99023.1 | O-antigen polymerase; InterPro IPR007016; KEGG: cno:NT01CX_1531 hypothetical protein; PFAM: O-antigen ligase-related; SPTR: O-antigen polymerase family protein; IMG reference gene:2504585491; PFAM: O-Antigen ligase. (463 aa) |
| | AEB99081.1 | KEGG: bbe:BBR47_58710 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504585554. (338 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (486 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa) |
| | AEB99250.1 | o-succinylbenzoate--CoA ligase; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: afn:Acfer_0829 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: o-succinylbenzoate--CoA ligase; SPTR: CoA ligase; IMG reference gene:2504585732; PFAM: AMP-binding enzyme; TIGRFAM: O-succinylbenzoate-CoA ligase. (492 aa) |
| | thrS | COGs: COG0441 Threonyl-tRNA synthetase; InterPro IPR012947:IPR002320:IPR002314:IPR004154; KEGG: tro:trd_1067 threonyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; SMART: Threonyl/alanyl tRNA synthetase, SAD; SPTR: Threonyl-tRNA synthetase; TIGRFAM: Threonyl-tRNA synthetase, class IIa; IMG reference gene:2504585815; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRN [...] (593 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (286 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (886 aa) |
| | folC | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR001645:IPR004101; KEGG: afn:Acfer_0398 FolC bifunctional protein; PFAM: Mur ligase, central; Mur ligase, C-terminal; PRIAM: Tetrahydrofolate synthase; SPTR: Tetrahydrofolate synthase; TIGRFAM: Folylpolyglutamate synthetase; IMG reference gene:2504585958; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (431 aa) |
| | AEB99472.1 | COGs: COG3307 Lipid A core - O-antigen ligase; InterPro IPR007016; KEGG: vpr:Vpar_1250 O-antigen polymerase; PFAM: O-antigen ligase-related; SPTR: Putative O-antigen polymerase; IMG reference gene:2504585959; PFAM: O-Antigen ligase. (448 aa) |
| | mmdA | COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR000022; KEGG: vpr:Vpar_1244 carboxyl transferase; PFAM: Carboxyl transferase; PRIAM: Propionyl-CoA carboxylase; SPTR: Propionyl-CoA carboxylase, beta subunit; IMG reference gene:2504585965; PFAM: Carboxyl transferase domain; TIGRFAM: methylmalonyl-CoA decarboxylase alpha subunit. (509 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (655 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | AEB99722.1 | COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: toc:Toce_0352 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; IMG reference gene:2504586220; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (195 aa) |
| | hisS | COGs: COG0124 Histidyl-tRNA synthetase; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; InterPro IPR002314:IPR004154:IPR015807; KEGG: afn:Acfer_1513 histidyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; IMG reference gene:2504586230; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase. (420 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (599 aa) |
| | cysS | COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803:IPR015273; KEGG: vpr:Vpar_1015 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; PRIAM: Cysteine--tRNA ligase; SMART: Cysteinyl-tRNA synthetase, class Ia, DALR; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; IMG reference gene:2504586247; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (629 aa) |
| | fhs | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559; KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; IMG reference gene:2504586309; PFAM: Formate--tetrahydrofolate ligase. (555 aa) |
| | tilS | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (513 aa) |
| | glnS | COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase; HAMAP: Glutaminyl-tRNA synthetase, bacterial; InterPro IPR020058:IPR020059:IPR004514:IPR022861; KEGG: slp:Slip_2326 glutaminyl-tRNA synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; PRIAM: Glutamine--tRNA ligase; SPTR: Glutaminyl-tRNA synthetase; TIGRFAM: Glutaminyl-tRNA synthetase, class Ic; IMG reference gene:2504586347; PFAM: tRNA synthetases class I (E and Q), catalytic domain; tRNA synthetases class I (E and Q), anti-cod [...] (554 aa) |
| | leuS | COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR002300:IPR013155:IPR002302; KEGG: afn:Acfer_0634 leucyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ia; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; PRIAM: Leucine--tRNA ligase; SPTR: Leucyl-tRNA synthetase; TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; IMG reference gene:2504586350; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family. (824 aa) |
| | hypF | (NiFe) hydrogenase maturation protein HypF; COGs: COG0068 Hydrogenase maturation factor; InterPro IPR006070:IPR001792:IPR004421:IPR011125; KEGG: clj:CLJU_c23090 putative hydrogenase maturation protein HypF; PFAM: Sua5/YciO/YrdC, N-terminal; Acylphosphatase-like; Zinc finger, HypF-type; SPTR: [NiFe] hydrogenase maturation protein HypF; TIGRFAM: Carbamoyltransferase, HypF-type; IMG reference gene:2504586384; PFAM: HypF finger; yrdC domain; Acylphosphatase; TIGRFAM: [NiFe] hydrogenase maturation protein HypF. (787 aa) |
| | glnA | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: vpr:Vpar_0890 glutamine synthetase catalytic region; PFAM: Glutamine synthetase, catalytic domain; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504586385; PFAM: Glutamine synthetase, catalytic domain. (628 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (468 aa) |
| | tmcAL | Protein of unknown function DUF795; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (419 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR002474:IPR000991:IPR006274; KEGG: vpr:Vpar_0565 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; IMG reference gene:2504586428; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phos [...] (357 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR006275:IPR011607:IPR005480:IPR005479:IPR 005481; KEGG: afn:Acfer_1315 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Carbamoyl-phosphate synthase, large subunit, N-terminal; PRIAM: Carbamoyl-phosphate synthase (ammonia); SMART: Methylglyoxal synthase-like domain; SPTR: Carbamoyl-phosphate synthase large chain; TIGRFAM: Carbamoyl-phosphate [...] (1076 aa) |
| | AEB99948.1 | COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: tte:TTE1778 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; SPTR: Phosphoribulokinase family protein; IMG reference gene:2504586466; PFAM: Phosphoribulokinase / Uridine kinase family. (548 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636; KEGG: tle:Tlet_1916 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase; IMG reference gene:2504586494; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (237 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR004733:IPR010918:IPR000728; KEGG: afn:Acfer_1279 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2504586495; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal dom [...] (350 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR000115:IPR020561:IPR020562:IPR020560; KEGG: afn:Acfer_1276 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; IMG reference gene:2504586500; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) do [...] (425 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518; KEGG: hmo:HM1_1436 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; IMG reference gene:2504586513; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (406 aa) |
| | AEC00066.1 | Protein of unknown function DUF116; COGs: COG1852 conserved hypothetical protein; InterPro IPR002829; KEGG: afn:Acfer_0312 protein of unknown function DUF116; PFAM: Protein of unknown function DUF116; SPTR: Putative nucleotide-binding protein; IMG reference gene:2504586586; PFAM: Protein of unknown function DUF116. (276 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (224 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (394 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (669 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (874 aa) |
| | AEC00157.1 | phenylacetate-CoA ligase; COGs: COG1541 Coenzyme F390 synthetase; KEGG: sfu:Sfum_4074 phenylacetate-CoA ligase; SPTR: Putative phenylacetate-coenzyme A ligase; IMG reference gene:2504586677. (322 aa) |
| | AEC00166.1 | Cobaltochelatase; COGs: COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatase; InterPro IPR003672; KEGG: vpr:Vpar_0072 CobN/magnesium chelatase; PFAM: CobN/magnesium chelatase; PRIAM: Cobaltochelatase; SPTR: Cobaltochelatase, CobN subunit; IMG reference gene:2504586686; PFAM: CobN/Magnesium Chelatase; TIGRFAM: magnesium chelatase, H subunit; cobaltochelatase, CobN subunit. (1230 aa) |
| | AEC00169.1 | COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR003593; KEGG: aoe:Clos_2327 magnesium chelatase; PRIAM: Magnesium chelatase; SMART: ATPase, AAA+ type, core; SPTR: Magnesium chelatase, ATPase subunit I; IMG reference gene:2504586689; PFAM: Magnesium chelatase, subunit ChlI. (339 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (479 aa) |
| | gatA | Glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (490 aa) |
| | pheT | COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR005121:IPR005147:IPR005146:IPR004532:IPR 002547; KEGG: vpr:Vpar_1067 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/B4 tRNA-binding domain; tRNA synthetase, B5; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding; tRNA-binding domain; SMART: B3/B4 tRNA-binding domain; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding; tRNA synthetase, B5; SPTR: Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial [...] (810 aa) |
| | pheS | COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterPro IPR004529:IPR004188:IPR002319; KEGG: vpr:Vpar_1068 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; Phenylalanyl-tRNA synthetase, class II, N-terminal; SPTR: Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; IMG reference gene:2504586762; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA [...] (342 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1039 aa) |
| | trpS | COGs: COG0180 Tryptophanyl-tRNA synthetase; InterPro IPR002306:IPR002305; KEGG: bvu:BVU_0408 tryptophanyl-tRNA synthetase II; PFAM: Aminoacyl-tRNA synthetase, class Ib; PRIAM: Tryptophan--tRNA ligase; SPTR: Tryptophan--tRNA ligase; TIGRFAM: Tryptophanyl-tRNA synthetase, class Ib; IMG reference gene:2504586855; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase. (363 aa) |
| | AEC00334.1 | UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR007901:IPR000594; KEGG: ere:EUBREC_0899 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: Thiazole biosynthesis adenylyltransferase ThiF; IMG reference gene:2504586856; PFAM: MoeZ/MoeB domain; ThiF family. (261 aa) |
| | birA | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (326 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | argS | COGs: COG0018 Arginyl-tRNA synthetase; HAMAP: Arginyl-tRNA synthetase, class Ic; InterPro IPR001278:IPR005148:IPR015945:IPR008909; KEGG: vpr:Vpar_1585 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; Arginyl tRNA synthetase, class Ic, N-terminal; DALR anticodon binding; PRIAM: Arginine--tRNA ligase; SMART: DALR anticodon binding; SPTR: Arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; IMG reference gene:2504586910; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA [...] (551 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (568 aa) |
| | AEC00408.1 | COGs: COG1190 Lysyl-tRNA synthetase (class II); HAMAP: Lysyl-tRNA synthetase, class II; InterPro IPR002313:IPR004365:IPR004364; KEGG: bmd:BMD_0098 lysyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: Lysine--tRNA ligase; SPTR: Lysyl-tRNA synthetase; TIGRFAM: Lysyl-tRNA synthetase, class II; IMG reference gene:2504586932; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl- [...] (511 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa) |
| | sucC | Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa) |
| | AEC00543.1 | UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR000594; KEGG: thx:Thet_1429 UBA/ThiF-type NAD/FAD-binding protein; PFAM: UBA/THIF-type NAD/FAD binding fold; SPTR: Hydrogenase accessory protein HypB; IMG reference gene:2504587072; PFAM: ThiF family. (246 aa) |
| | AEC00548.1 | COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR010918:IPR010141; KEGG: tjr:TherJR_0822 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; IMG reference gene:2504587077; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synthase, clade II. (1261 aa) |
| | glyS | COGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR015944:IPR008909:IPR002311; KEGG: afn:Acfer_1779 glycyl-tRNA synthetase, beta subunit; PFAM: Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal; DALR anticodon binding; PRIAM: Glycine--tRNA ligase; SMART: DALR anticodon binding; SPTR: Glycyl-tRNA synthetase beta subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, beta subunit; IMG reference gene:2504587082; PFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit. (688 aa) |
| | glyQ | COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; HAMAP: Glycyl-tRNA synthetase, class IIc, alpha subunit; InterPro IPR002310; KEGG: afn:Acfer_1780 glycyl-tRNA synthetase, alpha subunit; PFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; IMG reference gene:2504587083; PFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit. (293 aa) |
| | AEC00590.1 | InterPro IPR002847; KEGG: afn:Acfer_0690 protein of unknown function DUF129; PFAM: F420-0 gamma-glutamyl ligase-related; SPTR: Putative uncharacterized protein; IMG reference gene:2504587122; PFAM: F420-0:Gamma-glutamyl ligase. (218 aa) |
| | fliI | ATPase, FliI/YscN family; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterProIPR003593:IPR004100:IPR000194:IPR005714:IPR 022425; KEGG: tjr:TherJR_1539 flagellar protein export ATPase FliI; PFAM: ATPase, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; PRIAM: H(+)-transporting two-sector ATPase; SMART: ATPase, AAA+ type, core; SPTR: Flagellar protein export ATPase FliI; TIGRFAM: ATPase, type III secretion system, FliI/YscN; Flagellar export ATPase, FliI, clade 2; IMG reference gene:2504587189; PFAM: ATP [...] (475 aa) |
| | AEC00733.1 | Biotin carboxylase; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005482:IPR005479:IPR005481; KEGG: tjr:TherJR_1719 acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Biotin carboxylase, C-terminal; Carbamoyl-phosphate synthase, large subunit, N-terminal; PRIAM: Biotin carboxylase; SMART: Biotin carboxylase, C-terminal; SPTR: Acetyl-CoA carboxylase, biotin carboxylase subunit; IMG reference gene:2504587268; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal [...] (468 aa) |
| | AEC00767.1 | Hypothetical protein; SPTR: Putative Acetyl-CoA carboxylase alpha chain; IMG reference gene:2504587303. (99 aa) |
| | ddl | D-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (312 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (457 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa) |
| | murE | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (966 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (141 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (470 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (283 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (506 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (167 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (84 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (224 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa) |
| | AEC01073.1 | Protein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: cbe:Cbei_3556 hypothetical protein; PFAM: Uncharacterised protein family UPF0027; SPTR: Putative uncharacterized protein; IMG reference gene:2504587641; PFAM: Uncharacterized protein family UPF0027. (413 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
