STRINGSTRING
AEB99012.1 AEB99012.1 deoB deoB AEB99323.1 AEB99323.1 purF purF AEB99588.1 AEB99588.1 guaA guaA AEB99692.1 AEB99692.1 AEB99717.1 AEB99717.1 AEB99728.1 AEB99728.1 deoD deoD hpt hpt purE purE purC purC purM purM purN purN purD purD AEC00037.1 AEC00037.1 surE surE ndk ndk adk adk AEC00467.1 AEC00467.1 AEC00530.1 AEC00530.1 AEC00548.1 AEC00548.1 gmk gmk rdgB rdgB prs prs AEC00731.1 AEC00731.1 AEC01016.1 AEC01016.1 nrdD nrdD pyk pyk AEC01192.1 AEC01192.1 purB purB purA purA AEC01233.1 AEC01233.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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AEB99012.1COGs: COG0248 Exopolyphosphatase; InterPro IPR003695:IPR006674; KEGG: vpr:Vpar_0618 Ppx/GppA phosphatase; PFAM: Ppx/GppA phosphatase; Metal-dependent phosphohydrolase, HD subdomain; PRIAM: Guanosine-5'-triphosphate,3'-diphosphate diphosphatase; SPTR: Exopolyphosphatase; IMG reference gene:2504585479; PFAM: HD domain; Ppx/GppA phosphatase family; TIGRFAM: exopolyphosphatase. (510 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (397 aa)
AEB99323.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (749 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa)
AEB99588.1COGs: COG0248 Exopolyphosphatase; InterPro IPR003695; KEGG: mla:Mlab_0394 hypothetical protein; PFAM: Ppx/GppA phosphatase; SPTR: Putative exopolyphosphatase; IMG reference gene:2504586078; PFAM: Ppx/GppA phosphatase family. (308 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa)
AEB99692.1COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644:IPR001093; KEGG: cbe:Cbei_2114 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: Inosine-5'-monophosphate dehydrogenase; IMG reference gene:2504586187; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. (500 aa)
AEB99717.1COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR004843; KEGG: afn:Acfer_0834 5'-nucleotidase domain protein; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase family protein; IMG reference gene:2504586215; PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase; Belongs to the 5'-nucleotidase family. (533 aa)
AEB99728.1(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (740 aa)
deoDCOGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845:IPR004402; KEGG: lsa:LSA0797 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase deoD-type; TIGRFAM: Purine nucleoside phosphorylase; IMG reference gene:2504586300; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). (237 aa)
hptCOGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR005904:IPR000836; KEGG: chy:CHY_1067 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Hypoxanthine phosphoribosyltransferase; TIGRFAM: Hypoxanthine phosphoribosyl transferase; IMG reference gene:2504586335; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636; KEGG: tle:Tlet_1916 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase; IMG reference gene:2504586494; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (237 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR004733:IPR010918:IPR000728; KEGG: afn:Acfer_1279 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2504586495; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal dom [...] (350 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa)
purDCOGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR000115:IPR020561:IPR020562:IPR020560; KEGG: afn:Acfer_1276 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; IMG reference gene:2504586500; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) do [...] (425 aa)
AEC00037.1NUDIX hydrolase; InterPro IPR000086; KEGG: rmr:Rmar_1927 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: ADP-ribose pyrophosphatase(Adenosine diphosphoribose pyrophosphatase); IMG reference gene:2504586557; PFAM: NUDIX domain. (182 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
AEC00467.1COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR003607:IPR006261:IPR006674; KEGG: dhd:Dhaf_4219 deoxyguanosinetriphosphate triphosphohydrolase-like protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Putative deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; IMG reference gene:2504586993; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (335 aa)
AEC00530.1RelA/SpoT domain protein; COGs: COG2357 conserved hypothetical protein; InterPro IPR007685; KEGG: smc:SmuNN2025_1101 hypothetical protein; PFAM: RelA/SpoT; SMART: RelA/SpoT; SPTR: RelA/SpoT domain protein; IMG reference gene:2504587059; PFAM: Region found in RelA / SpoT proteins. (211 aa)
AEC00548.1COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR010918:IPR010141; KEGG: tjr:TherJR_0822 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; IMG reference gene:2504587077; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synthase, clade II. (1261 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)
rdgBNon-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
AEC00731.1COGs: COG0194 Guanylate kinase; InterPro IPR008144:IPR008145; KEGG: saf:SULAZ_0277 guanylate kinase; PFAM: Guanylate kinase; SMART: Guanylate kinase/L-type calcium channel; SPTR: Putative guanylate kinase; IMG reference gene:2504587266; PFAM: Guanylate kinase. (194 aa)
AEC01016.1COGs: COG0248 Exopolyphosphatase; InterPro IPR003695:IPR003607; KEGG: vpr:Vpar_0619 exopolyphosphatase-like protein; PFAM: Ppx/GppA phosphatase; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Putative uncharacterized protein; IMG reference gene:2504587584; PFAM: Ppx/GppA phosphatase family. (512 aa)
nrdDCOGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: elm:ELI_3633 anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; IMG reference gene:2504587655; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase. (777 aa)
pykCOGs: COG0469 Pyruvate kinase; InterPro IPR015795:IPR001697:IPR015793; KEGG: vpr:Vpar_1405 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; IMG reference gene:2504587705; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
AEC01192.1Adenylate cyclase; COGs: COG2954 conserved hypothetical protein; InterPro IPR008172; KEGG: hha:Hhal_1263 adenylate cyclase; PFAM: Adenylate cyclase; SPTR: Adenylate cyclase; IMG reference gene:2504587764; PFAM: CYTH domain. (155 aa)
purBCOGs: COG0015 Adenylosuccinate lyase; InterPro IPR022761:IPR004769:IPR019468; KEGG: bhy:BHWA1_00426 adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal metazoa/fungi; SPTR: Adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; IMG reference gene:2504587766; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
AEC01233.1Phosphoribosylaminoimidazolecarboxamide formyltransferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR013982; KEGG: cbe:Cbei_3561 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; SPTR: Purine biosynthesis protein PURH; IMG reference gene:2504587806; PFAM: AICARFT/IMPCHase bienzyme. (390 aa)
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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