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ilvB ilvB ilvN ilvN AEB99509.1 AEB99509.1 AEB99954.1 AEB99954.1 argC argC argJ argJ argB argB argD argD asd asd ilvD ilvD AEC00145.1 AEC00145.1 ilvB-2 ilvB-2 leuB leuB leuD leuD leuC leuC ilvC ilvC ilvN-2 ilvN-2 AEC00258.1 AEC00258.1 leuA leuA ilvE ilvE AEC01131.1 AEC01131.1 AEC01132.1 AEC01132.1 AEC01133.1 AEC01133.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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textmining
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Your Input:
ilvBAcetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: dhd:Dhaf_3617 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:2504585902; PFAM: Thiamine pyrophosphate en [...] (562 aa)
ilvNCOGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR004789:IPR019455; KEGG: dhd:Dhaf_3616 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504585904; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (167 aa)
AEB99509.1Acetolactate synthase; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR011766:IPR012001:IPR012000; KEGG: csh:Closa_0571 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central domain; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase; IMG reference gene:2504585996; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine p [...] (604 aa)
AEB99954.1GCN5-related N-acetyltransferase; COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182; KEGG: sth:STH2891 acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: Acetyltransferase, GNAT family; IMG reference gene:2504586472; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (157 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (403 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (294 aa)
argDCOGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR004636:IPR005814; KEGG: afn:Acfer_0596 acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine transaminase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; IMG reference gene:2504586511; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotra [...] (401 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
ilvDCOGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: afn:Acfer_1425 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; IMG reference gene:2504586638; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa)
AEC00145.1COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048:IPR002912:IPR005260; KEGG: vpr:Vpar_1126 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; IMG reference gene:2504586665; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (409 aa)
ilvB-2Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR011766:IPR012001:IPR012000; KEGG: thx:Thet_0020 acetolactate synthase large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central domain; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase, large subunit; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:2504586707; PFAM: Thiamine py [...] (553 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
leuCHomoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
ilvN-2COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR004789:IPR019455; KEGG: ate:Athe_0503 acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504586712; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (176 aa)
AEC00258.1COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: afn:Acfer_0715 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Aspartate transaminase; SPTR: Aspartate aminotransferase; IMG reference gene:2504586779; PFAM: Aminotransferase class I and II. (394 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
ilvECOGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544:IPR005786; KEGG: eel:EUBELI_01912 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; PRIAM: Branched-chain-amino-acid transaminase; SPTR: Branched-chain-amino-acid transaminase; TIGRFAM: Branched-chain amino acid aminotransferase II; IMG reference gene:2504586939; PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II. (341 aa)
AEC01131.1Aconitate hydratase; COGs: COG1048 Aconitase A; InterPro IPR006250:IPR001030:IPR000573; KEGG: tjr:TherJR_2355 aconitate hydratase; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Putative aconitate hydratase; TIGRFAM: Aconitase, putative; IMG reference gene:2504587702; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, putative, Aquifex type. (644 aa)
AEC01132.1COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: csh:Closa_2133 citrate synthase; PFAM: Citrate synthase-like; SPTR: 2-methylcitrate synthase; IMG reference gene:2504587703; PFAM: Citrate synthase; Belongs to the citrate synthase family. (446 aa)
AEC01133.1COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: amt:Amet_1319 isocitrate dehydrogenase (NAD(+)); PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: Isocitrate dehydrogenase; IMG reference gene:2504587704; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases. (333 aa)
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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