node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGG14464.1 | AGG14733.1 | HydHO_0127 | HydHO_0398 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Peptidase family protein; IMG reference gene:2506377291; PFAM: Peptidase family M20/M25/M40; SPTR: Putative uncharacterized protein; KEGG: pth:PTH_2466 hypothetical protein. | 0.450 |
AGG14464.1 | AGG15105.1 | HydHO_0127 | HydHO_0784 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Aspartate kinase; IMG reference gene:2506377688; PFAM: ACT domain; Amino acid kinase family; Family description; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Aspartokinase; KEGG: aae:aq_1152 aspartokinase; COGs: COG0527 Aspartokinase; InterProIPR005260:IPR001341:IPR018042:IPR001048:IPR 002912; Belongs to the aspartokinase family. | 0.650 |
AGG14464.1 | AGG15520.1 | HydHO_0127 | HydHO_1206 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Glutamate synthase (ferredoxin); IMG reference gene:2506378122; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; PRIAM: Glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; SPTR: Glutamate synthase (Ferredoxin); KEGG: hth:HTH_0871 ferredoxin-dependent glutamate synthase; COGs: COG0069 Glutamate synthase domain 2; InterProIPR017932:IPR000583:IPR006982:IPR002932:IPR 002489. | 0.583 |
AGG14464.1 | aroA | HydHO_0127 | HydHO_0977 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.945 |
AGG14464.1 | aroC | HydHO_0127 | HydHO_0222 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.988 |
AGG14464.1 | aroD | HydHO_0127 | HydHO_0221 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.581 |
AGG14464.1 | aroE | HydHO_0127 | HydHO_1184 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.690 |
AGG14464.1 | aroK | HydHO_0127 | HydHO_1034 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.688 |
AGG14464.1 | asd | HydHO_0127 | HydHO_0391 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.579 |
AGG14464.1 | dapA | HydHO_0127 | HydHO_0340 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.916 |
AGG14464.1 | dapB | HydHO_0127 | HydHO_0070 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.630 |
AGG14464.1 | dapF | HydHO_0127 | HydHO_1160 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.566 |
AGG14464.1 | dapL | HydHO_0127 | HydHO_0476 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | LL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. | 0.434 |
AGG14464.1 | lysA | HydHO_0127 | HydHO_0511 | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.577 |
AGG14733.1 | AGG14464.1 | HydHO_0398 | HydHO_0127 | Peptidase family protein; IMG reference gene:2506377291; PFAM: Peptidase family M20/M25/M40; SPTR: Putative uncharacterized protein; KEGG: pth:PTH_2466 hypothetical protein. | Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242. | 0.450 |
AGG14733.1 | dapB | HydHO_0398 | HydHO_0070 | Peptidase family protein; IMG reference gene:2506377291; PFAM: Peptidase family M20/M25/M40; SPTR: Putative uncharacterized protein; KEGG: pth:PTH_2466 hypothetical protein. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.499 |
AGG14733.1 | dapF | HydHO_0398 | HydHO_1160 | Peptidase family protein; IMG reference gene:2506377291; PFAM: Peptidase family M20/M25/M40; SPTR: Putative uncharacterized protein; KEGG: pth:PTH_2466 hypothetical protein. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.409 |
AGG14867.1 | AGG15876.1 | HydHO_0536 | HydHO_1571 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; IMG reference gene:2506377431; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; KEGG: aae:aq_162 folate biosynthesis 7,8-dihydro-6-hydroxymet [...] | FolC bifunctional protein; IMG reference gene:2506378502; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; SPTR: FolC bifunctional protein; KEGG: aae:aq_2045 folylpolyglutamate synthetase; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645:IPR013221:IPR004101:IPR018109. | 0.646 |
AGG14915.1 | AGG15105.1 | HydHO_0585 | HydHO_0784 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | Aspartate kinase; IMG reference gene:2506377688; PFAM: ACT domain; Amino acid kinase family; Family description; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Aspartokinase; KEGG: aae:aq_1152 aspartokinase; COGs: COG0527 Aspartokinase; InterProIPR005260:IPR001341:IPR018042:IPR001048:IPR 002912; Belongs to the aspartokinase family. | 0.807 |
AGG14915.1 | AGG15360.1 | HydHO_0585 | HydHO_1045 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | Nicotinate-nucleotide pyrophosphorylase (carboxylating); IMG reference gene:2506377959; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase; SPTR: Nicotinate-nucleotide pyrophosphorylase; KEGG: aae:aq_869 quinolinate phosphoribosyl transferase; COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR0 [...] | 0.995 |