STRINGSTRING
Mmah_0226 Mmah_0226 Mmah_0318 Mmah_0318 Mmah_0319 Mmah_0319 Mmah_0320 Mmah_0320 thiL thiL Mmah_0322 Mmah_0322 thyA thyA dut dut pyrG pyrG Mmah_1586 Mmah_1586 Mmah_1587 Mmah_1587 Mmah_1588 Mmah_1588 Mmah_1832 Mmah_1832 tmk tmk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mmah_0226CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125:IPR016192; KEGG: gem:GM21_1224 dCMP deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Q12UL2 CMP/dCMP deaminase, zinc-binding; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (156 aa)
Mmah_0318Glutaredoxin; InterPro IPR002109; KEGG: ech:ECH_1062 glutaredoxin 3; PFAM: glutaredoxin; SPTR: Q12U79 Glutaredoxin-like protein; PFAM: Glutaredoxin. (84 aa)
Mmah_0319COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: sat:SYN_01979 anaerobic ribonucleoside-triphosphate reductase; SPTR: Q12U78 Ribonucleoside-triphosphate reductase, anaerobic; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase. (793 aa)
Mmah_0320Anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197:IPR012840; KEGG: pca:Pcar_2732 pyruvate-formate lyase-activating enzyme; PFAM: Radical SAM domain protein; SPTR: Q12U77 Ribonucleoside-triphosphate reductase, anaerobic-like protein; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein. (272 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (294 aa)
Mmah_0322S-layer-related duplication domain protein; InterPro IPR006457:IPR003961; KEGG: pub:SAR11_0932 hypothetical protein; PFAM: S-layer-related duplication domain; SMART: Fibronectin type III domain protein; SPTR: Q12U74 S-layer-related duplication domain; PFAM: Protein of unknown function (DUF1608); TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; S-layer-related duplication domain. (1266 aa)
thyAThymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (217 aa)
dutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (172 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (529 aa)
Mmah_1586Hypothetical protein; SPTR: Q12WH4 Putative uncharacterized protein. (218 aa)
Mmah_1587Protein of unknown function DUF343; InterPro IPR005651; KEGG: cvi:CV_3952 hypothetical protein; PFAM: protein of unknown function DUF343; SPTR: Q12WH3 Putative uncharacterized protein; PFAM: Trm112p-like protein. (60 aa)
Mmah_1588Nucleoside recognition domain protein; COGs: COG3366 conserved hypothetical protein; InterPro IPR011642:IPR010916; KEGG: dal:Dalk_3536 nucleoside recognition domain protein; PFAM: nucleoside recognition domain protein; SPTR: Q12WH2 Nucleoside recognition. (312 aa)
Mmah_1832Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (596 aa)
tmkCOGs: COG0125 Thymidylate kinase; InterPro IPR000062:IPR018094; KEGG: mmb:Mmol_1138 thymidylate kinase; PFAM: thymidylate kinase; PRIAM: dTMP kinase; SPTR: Q12VF9 Probable thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (199 aa)
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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