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Mmah_1976 Mmah_1976 truA truA Mmah_0032 Mmah_0032 Mmah_0054 Mmah_0054 Mmah_0172 Mmah_0172 apgM apgM tpiA tpiA Mmah_0282 Mmah_0282 Mmah_0304 Mmah_0304 Mmah_0307 Mmah_0307 groL groL Mmah_0407 Mmah_0407 Mmah_0431 Mmah_0431 Mmah_0477 Mmah_0477 top6B top6B top6A top6A Mmah_0722 Mmah_0722 Mmah_0833 Mmah_0833 rpiA rpiA gyrB gyrB gyrA gyrA Mmah_0969 Mmah_0969 Mmah_1022 Mmah_1022 Mmah_1023 Mmah_1023 pus10 pus10 topA topA Mmah_1248 Mmah_1248 truB truB hemL hemL Mmah_1492 Mmah_1492 trpF trpF Mmah_1524 Mmah_1524 fni fni truD truD hisA hisA Mmah_1806 Mmah_1806 Mmah_1816 Mmah_1816 gpmI gpmI Mmah_1855 Mmah_1855 Mmah_1869 Mmah_1869 nnrD nnrD
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Mmah_1976Histidine biosynthesis protein; COGs: COG1411 Uncharacterized protein related to proFAR isomerase (HisA); InterPro IPR006062; KEGG: noc:Noc_0258 histidine biosynthesis; PFAM: histidine biosynthesis protein; SPTR: Q12VF7 Histidine biosynthesis; PFAM: Histidine biosynthesis protein; TIGRFAM: hisA/hisF family protein. (235 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (273 aa)
Mmah_0032Hypothetical protein; KEGG: gem:GM21_2435 cycloartenol synthase-like protein; SPTR: Q6LZX2 Putative uncharacterized protein. (502 aa)
Mmah_0054COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005846:IPR005843:IPR 005845:IPR016066; KEGG: cla:Cla_1567 phosphoglucomutase/phosphomannomutase family protein; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; PRIAM: Phosphoglucosamine mutase; SPTR: Q46AY7 Probable phosphoglucosamine mutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomuta [...] (431 aa)
Mmah_0172Ribose 1,5-bisphosphate isomerase; COGs: COG1184 Translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559:IPR005250; KEGG: gur:Gura_4322 aIF-2BI family translation initiation factor; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Q12UQ7 Ribose 1,5-bisphosphate isomerase; TIGRFAM: translation initiation factor, aIF-2BII family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; ribos [...] (308 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (394 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa)
Mmah_0282COGs: COG0502 Biotin synthase; InterPro IPR007197:IPR006638; KEGG: dat:HRM2_15240 BioB2; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Q12UB7 Biotin synthase; PFAM: Radical SAM superfamily. (346 aa)
Mmah_0304COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005846:IPR005843:IPR 005845:IPR016066; KEGG: Phosphoglucomutase/phosphomannomutase, C-terminal domain containing protein; K01840 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; PRIAM: Phosphoglucosamine mutase; SPTR: Q12U88 Phosphoglucosamine mutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha [...] (448 aa)
Mmah_0307Translation initiation factor 2B subunit I family (IF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (339 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (536 aa)
Mmah_0407COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179; KEGG: predicted protein; PFAM: peptidylprolyl isomerase FKBP-type; SPTR: Q12TV9 Peptidylprolyl isomerase, FKBP-type; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (176 aa)
Mmah_0431COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179; KEGG: dde:Dde_2668 peptidyl-prolyl cis-trans isomerase, FKBP-type; PFAM: peptidylprolyl isomerase FKBP-type; SPTR: Q46B63 Peptidyl-prolyl cis-trans isomerase; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (207 aa)
Mmah_0477COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179; KEGG: dol:Dole_0174 peptidylprolyl isomerase FKBP-type; PFAM: peptidylprolyl isomerase FKBP-type; SPTR: A0P3R1 Peptidyl-prolyl cis-trans isomerase; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (143 aa)
top6BDNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (617 aa)
top6ADNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (367 aa)
Mmah_0722Protein of unknown function DUF2088; COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: geo:Geob_0833 hypothetical protein; PFAM: Protein of unknown function DUF2088; SPTR: Q8TR70 Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2088). (411 aa)
Mmah_0833COGs: COG0550 Topoisomerase IA; InterProIPR000380:IPR013497:IPR006171:IPR013498:IPR 003601:IPR006154:IPR003602:IPR000572:IPR000209; KEGG: TOP3B; topoisomerase (DNA) III beta (EC:5.99.1.2); K03165 DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein; SPTR: Q8TPW5 DNA topoisomerase; PFAM: Toprim domain; Topoisomerase DNA binding C4 zinc finger; DNA topoisomerase; TI [...] (776 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (230 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (634 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (824 aa)
Mmah_0969Metalloenzyme domain protein; COGs: COG0696 Phosphoglyceromutase; InterPro IPR000917:IPR006124; KEGG: hypothetical protein; K01834 phosphoglycerate mutase; PFAM: metalloenzyme domain protein; sulfatase; SPTR: Q12XR3 Metalloenzyme; PFAM: Metalloenzyme superfamily. (459 aa)
Mmah_1022Phosphoribosylaminoimidazole carboxylase; COGs: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; InterPro IPR000031; KEGG: nis:NIS_1514 phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PRIAM: Phosphoribosylaminoimidazole carboxylase; SPTR: Q12XK0 Phosphoribosylaminoimidazole carboxylase; PFAM: AIR carboxylase; TIGRFAM: phosphoribosylaminoimidazole carboxylase, PurE protein. (130 aa)
Mmah_1023COGs: COG1605 Chorismate mutase; InterPro IPR002701:IPR010950; KEGG: mxa:MXAN_3221 chorismate mutase/prephenate dehydratase; PFAM: Chorismate mutase; SPTR: Q12XK1 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase type II; TIGRFAM: chorismate mutase, archaeal type. (94 aa)
pus10THUMP domain protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (430 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (737 aa)
Mmah_1248COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179:IPR019793; KEGG: dat:HRM2_10530 FKBP-type peptidyl-prolyl cis-trans isomerase; PFAM: peptidylprolyl isomerase FKBP-type; SPTR: Q12Z11 Peptidylprolyl isomerase, FKBP-type; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (241 aa)
truBtRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (342 aa)
hemLCOGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814:IPR004639; KEGG: gur:Gura_4245 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: Q12WM7 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (429 aa)
Mmah_1492precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: scl:sce0238 hypothetical protein; PFAM: Precorrin-8X methylmutase CbiC/CobH; SPTR: Q12TL7 Precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase. (237 aa)
trpFCOGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: sat:SYN_02592 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: Q12TL0 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (220 aa)
Mmah_1524COGs: COG1260 Myo-inositol-1-phosphate synthase; InterPro IPR002587:IPR013021; KEGG: noc:Noc_2981 myo-inositol-1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; SPTR: Q12TJ3 Myo-inositol-1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase. (367 aa)
fniIsopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (363 aa)
truDtRNA pseudouridine synthase D TruD; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (438 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062:IPR006063; KEGG: geo:Geob_0692 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; SPTR: Q12WC6 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis pro [...] (250 aa)
Mmah_1806COGs: COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzyme; InterPro IPR010551; KEGG: stm:STM2757 putative cytoplasmic protein; PFAM: glucose-6-phosphate isomerase; SPTR: Q12VW6 Glucose-6-phosphate isomerase; PFAM: Glucose-6-phosphate isomerase (GPI). (243 aa)
Mmah_1816COGs: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; InterPro IPR002130; KEGG: cco:CCC13826_1513 peptidyl-prolyl cis-trans isomerase B (PPIase B; rotamase B); PFAM: peptidyl-prolyl cis-trans isomerase cyclophilin type; SPTR: Q12VY4 Peptidylprolyl isomerase; PFAM: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. (141 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (514 aa)
Mmah_1855Methanogenesis marker protein 3; COGs: COG4070 peptidyl-prolyl cis-trans isomerase (rotamase) cyclophilin family; InterPro IPR016466; SPTR: Q12UU1 Putative uncharacterized protein; TIGRFAM: methanogenesis marker protein 3; TIGRFAM: putative methanogenesis marker protein 3; Belongs to the UPF0288 family. (520 aa)
Mmah_1869COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR001347:IPR017552; KEGG: mca:MCA3050 SIS domain-containing protein; PFAM: sugar isomerase (SIS); SPTR: Q12UV4 Hexulose-6-phosphate isomerase; TIGRFAM: 6-phospho 3-hexuloisomerase; PFAM: SIS domain; TIGRFAM: 6-phospho 3-hexuloisomerase. (200 aa)
nnrDCarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (488 aa)
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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