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tiaS tiaS nadE nadE gatB gatB gatA gatA gatC gatC carA carA purP purP Mmah_0216 Mmah_0216 purM purM Mmah_0225 Mmah_0225 guaAA guaAA purC purC purL purL cbiA cbiA Mmah_0515 Mmah_0515 Mmah_0519 Mmah_0519 purD purD Mmah_0623 Mmah_0623 pncB pncB Mmah_0924 Mmah_0924 gatE gatE carB carB argG argG rimK rimK purA purA guaAB guaAB Mmah_1321 Mmah_1321 purQ purQ purS purS gatD gatD Mmah_1404 Mmah_1404 cbiA-2 cbiA-2 queC queC Mmah_1581 Mmah_1581 pyrG pyrG Mmah_1788 Mmah_1788 Mmah_1908 Mmah_1908 Mmah_1913 Mmah_1913
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tiaStRNA(Ile2) 2-agmatinylcytidine synthetase; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (425 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (260 aa)
gatBaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (476 aa)
gatAaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (473 aa)
gatCaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (93 aa)
carACOGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR006220:IPR011702:IPR001317:IPR002474:IPR 000991:IPR006274; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q12XK5 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (365 aa)
purPIMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (355 aa)
Mmah_0216COGs: COG0174 Glutamine synthetase; InterPro IPR008146:IPR008147:IPR004809; KEGG: dat:HRM2_45740 GlnA2; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Q12UM2 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (442 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918:IPR000728:IPR004733; KEGG: phosphoribosylformylglycinamidine cyclo-ligase (phosphoribosyl-aminoimidazole synthetase) (AIR synthase); K01933 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Q46E56 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase rel [...] (332 aa)
Mmah_0225Coenzyme F420-0 gamma-glutamyl ligase; COGs: COG1478 conserved hypothetical protein; InterPro IPR002847:IPR000292:IPR008225; KEGG: eba:p2A347 hypothetical protein; PFAM: protein of unknown function DUF129; SPTR: Q8PX01 F420-0:gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase; PFAM: F420-0:Gamma-glutamyl ligase; TIGRFAM: F420-0:gamma-glutamyl ligase. (251 aa)
guaAAGMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (191 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636:IPR018236; KEGG: maq:Maqu_1689 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (243 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (714 aa)
cbiAHydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or amm [...] (438 aa)
Mmah_0515COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085:IPR003382:IPR005252; KEGG: gbm:Gbem_1667 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: Q466Q5 Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopan [...] (402 aa)
Mmah_0519Pantothenate synthetase; COGs: COG1701 conserved hypothetical protein; InterPro IPR002855; PFAM: Protein of unknown function DUF137; SPTR: Q12WR9 Pantothenate synthetase; PFAM: Protein of unknown function DUF137. (247 aa)
purDCOGs: COG0151 Phosphoribosylamine-glycine ligase; InterProIPR020560:IPR020562:IPR020561:IPR011761:IPR 020559:IPR000115; KEGG: sat:SYN_02439 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Q12X37 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; [...] (434 aa)
Mmah_0623COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR003142:IPR013196:IPR004143:IPR004408; KEGG: gur:Gura_2817 biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; Helix-turn-helix type 11 domain protein; biotin protein ligase domain protein; SPTR: Q8PVX6 Biotin--[acetyl-COA-carboxylase] synthetase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: HTH domain; Biotin protein ligase C terminal domain; Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region; BirA biotin operon repressor domain. (322 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (408 aa)
Mmah_0924ATP binding protein; COGs: COG2102 ATPase of PP-loop superfamily; InterPro IPR001962:IPR002761; KEGG: similar to GA13952-PA; PFAM: protein of unknown function DUF71 ATP-binding region; asparagine synthase; SPTR: Q12YM5 Putative uncharacterized protein; TIGRFAM: ATP binding protein; PFAM: Asparagine synthase; ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; conserved hypothetical protein TIGR00289; asparagine synthase (glutamine-hydrolyzing). (690 aa)
gatEglutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (633 aa)
carBCOGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005483:IPR003135:IPR005479:IPR003806:IPR 013651:IPR011607:IPR005480:IPR005481:IPR011761:IPR006275; KEGG: gur:Gura_1864 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; RimK domain protein ATP-grasp; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: Q12XK4 C [...] (1079 aa)
argGCOGs: COG0137 Argininosuccinate synthase; InterPro IPR001518:IPR018223; KEGG: hypothetical protein; K01940 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Q12XK3 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa)
rimKCOGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR003806:IPR013651:IPR011761:IPR004666; KEGG: avn:Avin_05140 ribosomal protein S6 modification enzyme RimK; PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; SPTR: Q12Y24 Ribosomal protein S6 modification protein; TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family. (301 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
guaABGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (304 aa)
Mmah_1321Protein of unknown function DUF1486; COGs: COG5485 ester cyclase; InterPro IPR009959; KEGG: ott:OTT_0545 hypothetical protein; PFAM: protein of unknown function DUF1486; SPTR: Q12Z70 Putative uncharacterized protein; PFAM: SnoaL-like polyketide cyclase. (147 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (230 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (83 aa)
gatDglutamyl-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (414 aa)
Mmah_1404IMP biosynthesis enzyme PurP domain protein; COGs: COG1759 ATP-utilizing protein of ATP-grasp superfamily (probably carboligase); InterPro IPR010672:IPR009720; PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; SPTR: Q12X62 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1297); Protein of unknown function (DUF1246). (385 aa)
cbiA-2Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or amm [...] (481 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (228 aa)
Mmah_1581COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR003806:IPR013651:IPR011761:IPR004666; KEGG: afw:Anae109_2113 alpha-L-glutamate ligase; PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; SPTR: Q8Q0M5 Tetrahydromethanopterin:alpha-L-glutamate ligase; TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family. (301 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (529 aa)
Mmah_1788COGs: COG0174 Glutamine synthetase; InterPro IPR008146:IPR008147:IPR004809; KEGG: dat:HRM2_45740 GlnA2; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Q8PY99 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (448 aa)
Mmah_1908Coenzyme F420-0 gamma-glutamyl ligase; COGs: COG1478 conserved hypothetical protein; InterPro IPR002847:IPR008225; KEGG: eba:p2A347 hypothetical protein; PFAM: protein of unknown function DUF129; SPTR: Q12UZ4 Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase; PFAM: F420-0:Gamma-glutamyl ligase; TIGRFAM: F420-0:gamma-glutamyl ligase. (265 aa)
Mmah_1913COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR006390; KEGG: psa:PST_3318 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Q12V25 Dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase. (411 aa)
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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