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| | ribK | CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (220 aa) |
| | polB | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (486 aa) |
| | Mmah_0008 | Methyltransferase MtaA/CmuA family; COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257:IPR006360; KEGG: geo:Geob_2543 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q8TSE3 Methylcobamide:CoM methyltransferase isozyme M; TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (342 aa) |
| | Mmah_0020 | COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257; KEGG: ppd:Ppro_1430 uroporphyrinogen decarboxylase; PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q12XC7 Uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (346 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (439 aa) |
| | purP | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (355 aa) |
| | Mmah_0049 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG1600 Uncharacterized Fe-S protein; InterPro IPR001450:IPR017900; KEGG: dal:Dalk_1124 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q8TIA6 Putative uncharacterized protein. (230 aa) |
| | Mmah_0052 | Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR001451:IPR005835; KEGG: similar to mannose-1-phosphate guanylyltransferase; PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; SPTR: Q12TM8 Nucleotidyl transferase; PFAM: Nucleotidyl transferase; TIGRFAM: glucose-1-phosphate thymidylylransferase, long form. (406 aa) |
| | Mmah_0055 | Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR001451:IPR005835; KEGG: tgr:Tgr7_3303 UDP-N-acetylglucosamine pyrophosphorylase / diamine N-acetyltransferase; PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; SPTR: Q46AY8 Glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase; Bacterial transferase hexapeptide (three repeats); TIGRFAM: glucose-1-phosphate thymi [...] (396 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa) |
| | Mmah_0139 | Rhodanese domain protein; COGs: COG0607 Rhodanese-related sulfurtransferase; InterPro IPR001763; KEGG: gem:GM21_3931 rhodanese domain protein; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: Q12VR2 Rhodanese-like protein; PFAM: Rhodanese-like domain. (139 aa) |
| | Mmah_0142 | IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982:IPR002695; KEGG: gsu:GSU0609 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: Q12UR7 Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycloh [...] (538 aa) |
| | Mmah_0167 | Adenylyl cyclase CyaB; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008172:IPR008173; KEGG: vpa:VP1760 putative adenylate cyclase; PFAM: adenylate cyclase; SPTR: Q12UR0 Adenylate cyclase; TIGRFAM: adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative. (171 aa) |
| | Mmah_0185 | Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR000385; KEGG: scl:sce6686 hypothetical protein; PFAM: Radical SAM domain protein; SPTR: Q12UP4 Fe-S protein, radical SAM family; PFAM: Radical SAM superfamily. (324 aa) |
| | Mmah_0189 | Beta-lactamase domain protein; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; InterPro IPR001279; KEGG: gem:GM21_0314 beta-lactamase domain protein; PFAM: beta-lactamase domain protein; SPTR: Q12UP1 Beta-lactamase-like protein; PFAM: Metallo-beta-lactamase superfamily. (248 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918:IPR000728:IPR004733; KEGG: phosphoribosylformylglycinamidine cyclo-ligase (phosphoribosyl-aminoimidazole synthetase) (AIR synthase); K01933 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Q46E56 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase rel [...] (332 aa) |
| | fae-hps | 3-hexulose-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (392 aa) |
| | guaAA | GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (191 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636:IPR018236; KEGG: maq:Maqu_1689 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (243 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (714 aa) |
| | Mmah_0272 | Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; InterPro IPR001279; KEGG: dal:Dalk_4089 beta-lactamase domain protein; PFAM: beta-lactamase domain protein; SPTR: Q12UC6 Beta-lactamase-like protein; PFAM: Metallo-beta-lactamase superfamily. (218 aa) |
| | Mmah_0279 | Methylamine-specific methylcobalamin:coenzyme M methyltransferase; COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257:IPR006360; KEGG: geo:Geob_2543 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q12UC0 Methylamine-specific methylcobalamin:coenzyme M methyltransferase; TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (342 aa) |
| | Mmah_0280 | Hypothetical protein; KEGG: rme:Rmet_1835 6-phosphogluconate dehydrogenase, NAD-binding; SPTR: Q12UB9 Putative uncharacterized protein; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. (259 aa) |
| | Mmah_0281 | Protein of unknown function DUF201; COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR003806:IPR020561:IPR011761; KEGG: bpr:GBP346_A2048 argininosuccinate lyase 2 (arginosuccinase 2) (asal 2); PFAM: protein of unknown function DUF201; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; SPTR: Q12UB8 Putative uncharacterized protein; PFAM: ATP-grasp domain. (360 aa) |
| | Mmah_0282 | COGs: COG0502 Biotin synthase; InterPro IPR007197:IPR006638; KEGG: dat:HRM2_15240 BioB2; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Q12UB7 Biotin synthase; PFAM: Radical SAM superfamily. (346 aa) |
| | thi4 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (258 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (334 aa) |
| | cobS | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (275 aa) |
| | Mmah_0314 | COGs: COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase; KEGG: swp:swp_4982 molybdopterin-guanine dinucleotide biosynthesis protein; SPTR: Q12UA9 Putative nucleotidyltransferase; PFAM: Uncharacterized protein family UPF0007; TIGRFAM: conserved hypothetical protein TIGR00454. (205 aa) |
| | Mmah_0320 | Anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197:IPR012840; KEGG: pca:Pcar_2732 pyruvate-formate lyase-activating enzyme; PFAM: Radical SAM domain protein; SPTR: Q12U77 Ribonucleoside-triphosphate reductase, anaerobic-like protein; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein. (272 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (327 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (294 aa) |
| | Mmah_0351 | Pyruvate ferredoxin oxidoreductase, gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR011894; KEGG: lch:Lcho_2149 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: Q12U51 Pyruvate ferredoxin oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family. (181 aa) |
| | Mmah_0352 | Pyruvate ferredoxin oxidoreductase, delta subunit; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR001080:IPR001450:IPR017900:IPR011898; KEGG: ppd:Ppro_0323 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q2Y4G5 Pyruvate synthase, delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (86 aa) |
| | Mmah_0353 | Pyruvate ferredoxin oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR005476:IPR002880; KEGG: lch:Lcho_2150 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; SPTR: Q2Y4G6 Pyruvate synthase, alpha subunit; PFAM: domain; Transketolase, C-terminal domain. (404 aa) |
| | Mmah_0354 | Pyruvate ferredoxin oxidoreductase, beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: sat:SYN_00154 pyruvate:ferredoxin oxidoreductase beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Q2Y4G7 Pyruvate synthase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (292 aa) |
| | dbh | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (363 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (470 aa) |
| | Mmah_0375 | Hypothetical protein; SPTR: Q46D83 Putative uncharacterized protein. (49 aa) |
| | moaA | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (306 aa) |
| | cbiA | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or amm [...] (438 aa) |
| | priL | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (351 aa) |
| | Mmah_0389 | COGs: COG1594 DNA-directed RNA polymerase subunit M/Transcription elongation factor TFIIS; InterPro IPR001529:IPR001222:IPR019761:IPR006288; KEGG: hypothetical protein; K03019 DNA-directed RNA polymerase III subunit C11; PFAM: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; SMART: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; SPTR: Q12U17 DNA-directed RNA polymerase, subunit M; TIGRFAM: transcription factor S; PFAM: RNA polymerases M/15 Kd subunit; Transcription factor S-II (TFIIS); TIGRFAM: transcription factor S, archaeal. (104 aa) |
| | mptD | Protein of unknown function DUF381; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (120 aa) |
| | Mmah_0468 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG1600 Uncharacterized Fe-S protein; InterPro IPR001450:IPR017900; KEGG: dal:Dalk_4692 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q12X35 4Fe-4S ferredoxin, iron-sulfur binding; TIGRFAM: iron-sulfur cluster binding protein, putative. (231 aa) |
| | Mmah_0490 | COGs: COG1095 DNA-directed RNA polymerase subunit E'; InterPro IPR003029:IPR005576:IPR004519; KEGG: hypothetical protein; K03015 DNA-directed RNA polymerase II subunit G; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein; PRIAM: DNA-directed RNA polymerase; SPTR: Q12TT6 DNA-directed RNA polymerase, subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: S1 RNA binding domain; RNA polymerase Rpb7-like, N-terminal domain; TIGRFAM: DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form. (187 aa) |
| | Mmah_0492 | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (196 aa) |
| | Mmah_0515 | COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085:IPR003382:IPR005252; KEGG: gbm:Gbem_1667 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: Q466Q5 Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopan [...] (402 aa) |
| | Mmah_0516 | COGs: COG1829 kinase (sugar kinase superfamily); InterPro IPR006204; PFAM: GHMP kinase; SPTR: Q8PUQ0 Conserved protein; PFAM: GHMP kinases N terminal domain. (291 aa) |
| | Mmah_0518 | Methyltransferase MtaA/CmuA family; COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257:IPR006360; KEGG: geo:Geob_2543 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q12X82 Methyltransferase MtaA/CmuA; TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (346 aa) |
| | Mmah_0519 | Pantothenate synthetase; COGs: COG1701 conserved hypothetical protein; InterPro IPR002855; PFAM: Protein of unknown function DUF137; SPTR: Q12WR9 Pantothenate synthetase; PFAM: Protein of unknown function DUF137. (247 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (78 aa) |
| | Mmah_0529 | COGs: COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit; InterPro IPR007642:IPR007645:IPR007644; KEGG: NRPB2; NRPB2 (EMBRYO DEFECTIVE 1989); DNA binding; K03010 DNA-directed RNA polymerase II subunit B; PFAM: RNA polymerase beta subunit; RNA polymerase Rpb2 domain 3; RNA polymerase Rpb2 domain 2; SPTR: Q12WS4 DNA-directed RNA polymerase, subunit B'; PFAM: RNA polymerase Rpb2, domain 3; RNA polymerase Rpb2, domain 2; RNA polymerase beta subunit; Belongs to the RNA polymerase beta chain family. (545 aa) |
| | Mmah_0530 | DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (604 aa) |
| | Mmah_0531 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (886 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (385 aa) |
| | nusA | NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family. (141 aa) |
| | Mmah_0541 | Hypothetical protein. (48 aa) |
| | Mmah_0549 | Indolepyruvate ferredoxin oxidoreductase, subunit iorB; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR017719; KEGG: gem:GM21_2860 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate/ketoisovalerate oxidoreductase; PRIAM: Indolepyruvate ferredoxin oxidoreductase; SPTR: Q12WW9 Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: indolepyruvate ferredoxin oxidoreductase, beta subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: indolepyruvate ferredoxin oxidoreductase, be [...] (197 aa) |
| | Mmah_0557 | Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR006638; KEGG: dol:Dole_1225 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Q46BK8 Metallo cofactor biosynthesis protein; PFAM: Radical SAM superfamily. (397 aa) |
| | Mmah_0558 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: dal:Dalk_4009 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrinogen III synthase HEM4; SPTR: Q12WZ2 Uroporphyrinogen-III synthase; PFAM: Uroporphyrinogen-III synthase HemD. (262 aa) |
| | Mmah_0559 | COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR003043:IPR006366; KEGG: sfu:Sfum_3201 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Q8Q031 Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (254 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | lig | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (561 aa) |
| | thyA | Thymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (217 aa) |
| | Mmah_0591 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR020557:IPR004769; KEGG: nam:NAMH_1763 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: Q8TJ18 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (447 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterProIPR020560:IPR020562:IPR020561:IPR011761:IPR 020559:IPR000115; KEGG: sat:SYN_02439 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Q12X37 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; [...] (434 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (180 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (378 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (447 aa) |
| | polC | DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1135 aa) |
| | tfb | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (337 aa) |
| | Mmah_0657 | COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257; KEGG: geo:Geob_2498 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q8TSF1 Methyltransferase; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (358 aa) |
| | Mmah_0671 | Hypothetical protein. (48 aa) |
| | Mmah_0688 | Sjogrens syndrome scleroderma autoantigen 1; COGs: COG1645 Uncharacterized Zn-finger containing protein; InterPro IPR009563; KEGG: hypothetical protein; PFAM: Sjogrens syndrome scleroderma autoantigen 1; SPTR: Q8PX36 Putative uncharacterized protein; PFAM: Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27). (163 aa) |
| | dut | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (172 aa) |
| | Mmah_0707 | MoaD family protein; COGs: COG1977 Molybdopterin converting factor small subunit; InterPro IPR003749:IPR010038; KEGG: scl:sce5755 hypothetical protein; PFAM: thiamineS protein; SPTR: A3ERN4 Molybdopterin converting factor, small subunit; TIGRFAM: MoaD family protein; PFAM: ThiS family; TIGRFAM: MoaD family protein, archaeal. (91 aa) |
| | Mmah_0721 | Molybdopterin-guanine dinucleotide biosynthesis protein B; COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR004435:IPR003448; KEGG: similar to molybdopterin synthase small subunit MOCS2A; PFAM: molybdopterin biosynthesis MoaE protein; molybdopterin-guanine dinucleotide biosynthesis MobB region; SPTR: Q12YV0 Molybdopterin-guanine dinucleotide biosynthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: Molybdopterin guanine dinucleotide synthesis protein B; MoaE protein; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis [...] (274 aa) |
| | Mmah_0746 | DNA ligase D, 3'-phosphoesterase domain protein; InterPro IPR014144; KEGG: cbc:CbuK_0042 ATP-dependent DNA ligase; SPTR: Q8Q0C8 Putative uncharacterized protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain. (152 aa) |
| | Mmah_0779 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. (256 aa) |
| | mptE | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (208 aa) |
| | Mmah_0788 | COGs: COG2038 NaMN:DMB phosphoribosyltransferase; InterPro IPR003200:IPR002805; KEGG: abu:Abu_2184 hypothetical protein; PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; SPTR: Q12ZC5 Putative uncharacterized protein; PFAM: Phosphoribosyltransferase; TIGRFAM: conserved hypothetical protein TIGR00303; Belongs to the UPF0284 family. (351 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (45 aa) |
| | Mmah_0804 | 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: afw:Anae109_4459 hypothetical protein; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: Q12TU9 Phosphoribosylaminoimidazole carboxylase related protein; PFAM: AIR carboxylase. (271 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (408 aa) |
| | Mmah_0829 | Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; InterPro IPR001279; KEGG: kpe:KPK_0638 metallo-beta-lactamase family protein; PFAM: beta-lactamase domain protein; SPTR: Q8TPF1 Metallo-beta-lactamase superfamily protein; PFAM: Metallo-beta-lactamase superfamily. (279 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (426 aa) |
| | dbh-2 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (376 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (286 aa) |
| | Mmah_0845 | COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836; KEGG: sat:SYN_03353 xanthine-guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: Q8THD6 Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (232 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (199 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (149 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (455 aa) |
| | Mmah_0901 | Methyltransferase MtaA/CmuA family; COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257:IPR006360; KEGG: geo:Geob_2498 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q8TNW5 Methylcobamide:CoM methyltransferase isozyme M; TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (338 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (263 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (220 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR006220:IPR011702:IPR001317:IPR002474:IPR 000991:IPR006274; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q12XK5 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (365 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005483:IPR003135:IPR005479:IPR003806:IPR 013651:IPR011607:IPR005480:IPR005481:IPR011761:IPR006275; KEGG: gur:Gura_1864 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; RimK domain protein ATP-grasp; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: Q12XK4 C [...] (1079 aa) |
| | Mmah_0970 | Methanol-specific methylcobalamin: coenzyme M methyltransferase; COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257:IPR001969:IPR006360; KEGG: geo:Geob_2543 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q12XR2 Methanol-specific methylcobalamin: coenzyme M methyltransferase; TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (339 aa) |
| | Mmah_0987 | COGs: COG3830 ACT domain-containing protein; InterPro IPR002912; KEGG: pca:Pcar_2118 hypothetical protein; PFAM: amino acid-binding ACT domain protein; SPTR: Q466X6 Phosphoserine phosphatase; PFAM: ACT domain; Belongs to the UPF0237 family. (92 aa) |
| | Mmah_1004 | COGs: COG0379 Quinolinate synthase; InterPro IPR003473; KEGG: gur:Gura_0199 quinolinate synthetase; PFAM: Quinolinate synthetase A; SPTR: Q12Y91 Quinolinate synthetase A; TIGRFAM: quinolinate synthetase complex, A subunit; PFAM: Quinolinate synthetase A protein; TIGRFAM: quinolinate synthetase complex, A subunit. (302 aa) |
| | Mmah_1009 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020459:IPR000873; KEGG: pca:Pcar_1242 acetyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: Q12Y97 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (490 aa) |
| | Mmah_1014 | Hypothetical protein; KEGG: bpt:Bpet2709 acetyltransferase; SPTR: Q8PSS1 Acetyltransferase. (88 aa) |
| | Mmah_1022 | Phosphoribosylaminoimidazole carboxylase; COGs: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; InterPro IPR000031; KEGG: nis:NIS_1514 phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PRIAM: Phosphoribosylaminoimidazole carboxylase; SPTR: Q12XK0 Phosphoribosylaminoimidazole carboxylase; PFAM: AIR carboxylase; TIGRFAM: phosphoribosylaminoimidazole carboxylase, PurE protein. (130 aa) |
| | Mmah_1030 | DNA-directed RNA polymerase, subunit F; COGs: COG1460 conserved hypothetical protein; InterPro IPR005574; KEGG: bpt:Bpet3134 transcription elongation factor NusA; PFAM: RNA polymerase Rpb4; SPTR: Q12XH5 DNA-directed RNA polymerase, subunit F; PFAM: RNA polymerase Rpb4. (117 aa) |
| | Mmah_1073 | Beta-lactamase domain protein; COGs: COG0607 Rhodanese-related sulfurtransferase; InterPro IPR001279:IPR001763; KEGG: sat:SYN_01287 hydroxyacylglutathione hydrolase; PFAM: beta-lactamase domain protein; Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: Q8TNG7 Metallo-beta-lactamase; PFAM: Metallo-beta-lactamase superfamily; Rhodanese-like domain. (456 aa) |
| | Mmah_1087 | KEGG: dal:Dalk_1616 hypothetical protein; PFAM: Flavodoxin. (170 aa) |
| | Mmah_1090 | PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR002008:IPR004013:IPR002054:IPR003141:IPR 003583; KEGG: cbc:CbuK_1370 DNA polymerase X family; PFAM: PHP domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding class 1; SPTR: Q46C05 DNA polymerase X family / putative histidinol phosphatase; PFAM: PHP domain. (570 aa) |
| | lig-2 | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (569 aa) |
| | ribL | Glycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (142 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (134 aa) |
| | Mmah_1124 | COGs: COG1731 riboflavin synthase; InterPro IPR002180:IPR006399; KEGG: bgl:bglu_1g07930 6,7-dimethyl-8-ribityllumazine synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase; PRIAM: Riboflavin synthase; SPTR: Q12YH9 Riboflavin synthase alpha chain; TIGRFAM: riboflavin synthase; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; TIGRFAM: riboflavin synthase. (154 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa) |
| | tfe | Transcription factor IIE (TFIIE), alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...] (164 aa) |
| | mobA | Formate dehydrogenase family accessory protein FdhD; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (219 aa) |
| | Mmah_1203 | COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798:IPR001468; KEGG: abu:Abu_0850 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Q12ZK1 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase. (266 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (390 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (257 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (157 aa) |
| | pyrB | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterProIPR006130:IPR002082:IPR002292:IPR006132:IPR 006131; KEGG: ngo:NGO1877 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Aspartate carbamoyltransferase; SPTR: Q12ZP0 Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding dom [...] (308 aa) |
| | guaAB | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (304 aa) |
| | mptA | GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (317 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (266 aa) |
| | Mmah_1260 | Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197; KEGG: sat:SYN_01224 metallo cofactor biosynthesis protein; PFAM: Radical SAM domain protein; SPTR: Q8PU73 Metallo cofactor biosynthesis protein; PFAM: Radical SAM superfamily. (199 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (279 aa) |
| | Mmah_1274 | Nicotinate-nucleotide diphosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (263 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (230 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (83 aa) |
| | cmk | COGs: COG1102 Cytidylate kinase; InterPro IPR011892; KEGG: wbm:Wbm0321 adenylate kinase; PRIAM: Cytidylate kinase; SPTR: Q12ZS5 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; Adenylate kinase; TIGRFAM: cytidylate kinase, putative. (179 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (215 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (646 aa) |
| | Mmah_1404 | IMP biosynthesis enzyme PurP domain protein; COGs: COG1759 ATP-utilizing protein of ATP-grasp superfamily (probably carboligase); InterPro IPR010672:IPR009720; PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; SPTR: Q12X62 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1297); Protein of unknown function (DUF1246). (385 aa) |
| | cbiX | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (131 aa) |
| | cbiA-2 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or amm [...] (481 aa) |
| | Mmah_1424 | Rhodanese domain protein; COGs: COG0607 Rhodanese-related sulfurtransferase; InterPro IPR001763; KEGG: geo:Geob_0482 rhodanese domain protein; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: Q8PVQ8 Putative uncharacterized protein; PFAM: Rhodanese-like domain. (89 aa) |
| | atpD | V-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (205 aa) |
| | atpB | ATP synthase, B subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (460 aa) |
| | atpA | ATP synthase, A subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (576 aa) |
| | atpF | Vacuolar H+transporting two-sector ATPase F subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (100 aa) |
| | atpC | ATP synthase A1, C subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (357 aa) |
| | atpE | H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (183 aa) |
| | Mmah_1457 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: prw:PsycPRwf_1107 uroporphyrin-III C-methyltransferase; PRIAM: Sirohydrochlorin ferrochelatase; SPTR: Q46CH4 Precorrin-2 oxidase / ferrochelatase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. (238 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (423 aa) |
| | Mmah_1459 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: dps:DP2824 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Q12WM6 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (325 aa) |
| | hemL | COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814:IPR004639; KEGG: gur:Gura_4245 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: Q12WM7 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (429 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (308 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (299 aa) |
| | pyrK | Dihydroorotate oxidase B, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily. (502 aa) |
| | Mmah_1476 | COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257; KEGG: geo:Geob_2542 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q8TI03 Methylcobamide:CoM methyltransferase isozyme M; PFAM: Uroporphyrinogen decarboxylase (URO-D). (361 aa) |
| | Mmah_1478 | Methyltransferase MtaA/CmuA family; COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257:IPR006360; KEGG: geo:Geob_2543 uroporphyrinogen decarboxylase (URO-D); PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q8THF8 Methylcobamide:CoM methyltransferase isozyme M; TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family. (289 aa) |
| | Mmah_1481 | Methyltransferase cognate corrinoid protein; COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759:IPR000257:IPR012741; KEGG: geo:Geob_2541 cobalamin B12-binding domain protein; PFAM: Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; Uroporphyrinogen decarboxylase (URO-D); SPTR: Q8TSD9 Putative uncharacterized protein; TIGRFAM: methyltransferase cognate corrinoid protein; PFAM: Uroporphyrinogen decarboxylase (URO-D); B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family; methylmalo [...] (634 aa) |
| | Mmah_1489 | 2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR002734:IPR011549:IPR006401; KEGG: pca:Pcar_1445 riboflavin biosynthesis protein RibD; PFAM: bifunctional deaminase-reductase domain protein; PRIAM: 5-amino-6-(5-phosphoribosylamino)uracil reductase; SPTR: Q12TM0 2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; TIGRFAM:2,5-diamino-6-hydroxy-4-(5-phosphoribosylam ino)pyrimidine1-reductase; PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain; 2,5 [...] (226 aa) |
| | Mmah_1492 | precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: scl:sce0238 hypothetical protein; PFAM: Precorrin-8X methylmutase CbiC/CobH; SPTR: Q12TL7 Precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase. (237 aa) |
| | Mmah_1493 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878:IPR017871:IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: Q12TL6 Precorrin-3 methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. (265 aa) |
| | Mmah_1494 | KEGG: gem:GM21_3606 cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Q8PY68 Cobalamin biosynthesis protein G; PFAM: Cobalamin synthesis G C-terminus. (117 aa) |
| | Mmah_1495 | COGs: COG2073 Cobalamin biosynthesis protein CbiG; KEGG: ppd:Ppro_3230 cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Q8PY67 Cobalamin biosynthesis protein G; PFAM: Cobalamin synthesis G N-terminal. (163 aa) |
| | Mmah_1496 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878; KEGG: gem:GM21_3607 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Q8PY66 Precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. (242 aa) |
| | Mmah_1497 | Cobalt-factor II C20-methyltransferase; COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878:IPR003043; KEGG: dde:Dde_3107 cobalt-factor II C20-methyltransferase. (205 aa) |
| | cbiT | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (191 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (490 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (353 aa) |
| | trpF | COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: sat:SYN_02592 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: Q12TL0 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (220 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (521 aa) |
| | Mmah_1509 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (179 aa) |
| | Mmah_1511 | COGs: COG1056 Nicotinamide mononucleotide adenylyltransferase; InterPro IPR004820:IPR004821:IPR006418; KEGG: vei:Veis_4845 cytidyltransferase-like protein; PFAM: cytidylyltransferase; PRIAM: Nicotinamide-nucleotide adenylyltransferase; SPTR: Q12TK4 Nicotinamide-nucleotide adenylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain protein; PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. (173 aa) |
| | Mmah_1522 | Archaeoflavoprotein AfpA; COGs: COG1036 flavoprotein; InterPro IPR003382:IPR014072; KEGG: mfa:Mfla_1582 flavoprotein; PFAM: flavoprotein; SPTR: Q12TJ4 Flavoprotein; TIGRFAM: archaeoflavoprotein AfpA; PFAM: Flavoprotein; TIGRFAM: archaeoflavoprotein AfpA. (183 aa) |
| | rpoN | DNA-directed RNA polymerase, subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (62 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (60 aa) |
| | Mmah_1566 | Radical SAM domain protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197; KEGG: pca:Pcar_2732 pyruvate-formate lyase-activating enzyme; PFAM: Radical SAM domain protein; SPTR: Q12WJ0 Fe-S protein, radical SAM family; PFAM: Radical SAM superfamily. (232 aa) |
| | Mmah_1568 | COGs: COG2144 Selenophosphate synthetase-related protein; InterPro IPR010918:IPR000728:IPR017668; KEGG: scl:sce8999 hypothetical protein; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; SPTR: Q12WI8 AIR synthase related protein; TIGRFAM: methanogenesis marker protein 2; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: putative methanogenesis marker protein 2. (325 aa) |
| | Mmah_1570 | COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: acp:A2cp1_1997 queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: Q12WI6 Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (116 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (239 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (228 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (529 aa) |
| | cofG | FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (327 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (391 aa) |
| | Mmah_1626 | InterPro IPR006154; SMART: Toprim sub domain protein; SPTR: Q12WD6 Toprim subdomain; Belongs to the UPF0292 family. (135 aa) |
| | Mmah_1634 | Sulfide dehydrogenase (flavoprotein) subunit SudB; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001433:IPR019480; KEGG: sat:SYN_00607 ferredoxin-NADP(+) reductase subunit alpha; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Q12WC9 Sulfide dehydrogenase (Flavoprotein) subunit SudB; PFAM: Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain. (283 aa) |
| | Mmah_1653 | DRTGG domain protein; COGs: COG0857 BioD-like N-terminal domain of phosphotransacetylase; InterPro IPR010766; KEGG: dvl:Dvul_1641 DRTGG domain-containing protein; PFAM: DRTGG domain protein; SPTR: Q12WB2 Cobyrinic acid ac-diamide synthase; PFAM: DRTGG domain; CobQ/CobB/MinD/ParA nucleotide binding domain. (355 aa) |
| | Mmah_1686 | COGs: COG2036 Histones H3 and H4; InterPro IPR007125:IPR003958; PFAM: Transcription factor CBF/NF-Y/histone domain protein; Histone core domain protein; SPTR: Q12W85 Archaeal histone; PFAM: Histone-like transcription factor (CBF/NF-Y) and archaeal histone. (73 aa) |
| | priS | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (408 aa) |
| | Mmah_1725 | Ubiquitin-like small archaeal modifier protein (SAMP); COGs: COG1977 Molybdopterin converting factor small subunit; InterPro IPR003749:IPR010038; KEGG: mxa:MXAN_4067 ThiS family protein; PFAM: thiamineS protein; SPTR: Q12W49 Molybdopterin converting factor small subunit MoaD; TIGRFAM: MoaD family protein; PFAM: ThiS family; TIGRFAM: MoaD family protein, archaeal. (91 aa) |
| | Mmah_1731 | Molybdenum cofactor synthesis domain protein; COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453:IPR008284; KEGG: mxa:MXAN_2759 molybdenum cofactor biosynthesis protein B; PFAM: molybdopterin binding domain; SPTR: Q12W44 Molybdopterin binding protein; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (178 aa) |
| | hpt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (91 aa) |
| | tbp | TATA binding protein of transcription factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (183 aa) |
| | thiC-2 | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (427 aa) |
| | Mmah_1839 | Molybdenum cofactor synthesis domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterPro IPR005111:IPR005110:IPR001453; KEGG: gur:Gura_3393 molybdenum cofactor synthesis domain-containing protein; PFAM: MoeA domain protein domain I and II; MoeA domain protein domain IV; molybdopterin binding domain; SPTR: Q12VS8 Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofactor synthesis domain. (398 aa) |
| | moaC | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (155 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (282 aa) |
| | Mmah_1909 | COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: glo:Glov_2764 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: Q8TU14 Thiamine biosynthesis protein; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC. (414 aa) |
| | Mmah_1913 | COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR006390; KEGG: psa:PST_3318 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Q12V25 Dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase. (411 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | Mmah_1916 | COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376:IPR001555:IPR004607; KEGG: gme:Gmet_1845 phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; SPTR: Q12V28 Phosphoribosylglycinamide formyltransferase; TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. (202 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (260 aa) |
| | Mmah_1922 | COGs: COG0856 Orotate phosphoribosyltransferase homologs; InterPro IPR000836:IPR002375; KEGG: GG14926 gene product from transcript GG14926-RA; PFAM: phosphoribosyltransferase; SPTR: Q12V34 PyrE-like protein; PFAM: Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (203 aa) |
| | Mmah_1926 | AIR synthase related protein domain protein; COGs: COG1973 Hydrogenase maturation factor; InterPro IPR010918:IPR000728; KEGG: avi:Avi_7579 selenophosphate synthetase-related protein; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; SPTR: Q12V38 AIR synthase related protein; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain. (439 aa) |
| | Mmah_1928 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterProIPR011128:IPR014027:IPR014026:IPR001732:IPR 017476; KEGG: bja:bll8129 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: Q12V42 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-ma [...] (430 aa) |
| | tmk | COGs: COG0125 Thymidylate kinase; InterPro IPR000062:IPR018094; KEGG: mmb:Mmol_1138 thymidylate kinase; PFAM: thymidylate kinase; PRIAM: dTMP kinase; SPTR: Q12VF9 Probable thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (199 aa) |
| | mfnB | Protein of unknown function DUF556; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (233 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa) |
| | nadX | Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (271 aa) |
| | Mmah_1982 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (278 aa) |
| | Mmah_1995 | COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR017966:IPR006134:IPR006133:IPR006172:IPR 017964:IPR004578; KEGG: CaJ7_0319; hypothetical protein; K02327 DNA polymerase delta subunit 1; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: Q12VE4 DNA polymerase; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; TIGRFAM: DNA polymerase (pol2). (918 aa) |
| | cbiN | Cobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (97 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (231 aa) |
| | Mmah_2016 | precorrin-6Y C5,15-methyltransferase (decarboxylating); COGs: COG2241 Precorrin-6B methylase 1; InterPro IPR000878:IPR012818; KEGG: ara:Arad_9591 precorrin-6Y C5; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Q8PWB0 Precorrin-6Y C5,15-methyltransferase (Decarboxylating); TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. (193 aa) |
| | cbiD | Cobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (339 aa) |
| | Mmah_2023 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (242 aa) |
