STRINGSTRING
RAD27_1 RAD27_1 LYS12_1 LYS12_1 LSC2_1 LSC2_1 Cantr_09367 Cantr_09367 ARO10_1 ARO10_1 IDP2_1 IDP2_1 DNF2_1 DNF2_1 LYS5 LYS5 ISN1_1 ISN1_1 NEO1_1 NEO1_1 panB_1 panB_1 lpa-14 lpa-14 DNF2_0 DNF2_0 Cantr_07848 Cantr_07848 IDP2_0 IDP2_0 PDC11_3 PDC11_3 FAS2_0 FAS2_0 DNF1 DNF1 Cantr_00446 Cantr_00446 THG1 THG1 PAPA PAPA LYS12_0 LYS12_0 LEU2 LEU2 HIS1 HIS1 IDH2_2 IDH2_2 IDP1_0 IDP1_0 IPP1_0 IPP1_0 ENO1_0 ENO1_0 RNASEH1_0 RNASEH1_0 UTR4_0 UTR4_0 CDC19_0 CDC19_0 IDH2_0 IDH2_0 PRS5_0 PRS5_0 SER2_0 SER2_0 rnh1_0 rnh1_0 PRS1_1 PRS1_1 pgmA_0 pgmA_0 DNF3_0 DNF3_0 FRS1_0 FRS1_0 PRS4_0 PRS4_0 ARO10_0 ARO10_0 Cantr_07540 Cantr_07540 RAD27_0 RAD27_0 LSC2_0 LSC2_0 FAS2_1 FAS2_1 DRS2_1 DRS2_1 Cantr_06046 Cantr_06046 PRM15_1 PRM15_1 PDC11_2 PDC11_2 ILV2_1 ILV2_1 NEO1_0 NEO1_0 panB_0 panB_0 ISN1_0 ISN1_0 PDC11_1 PDC11_1 SER2_1 SER2_1 PRS1_2 PRS1_2 PRS5_1 PRS5_1 IPP1_1 IPP1_1 CDC19_1 CDC19_1 RNASEH1_1 RNASEH1_1 rnh1_1 rnh1_1 IDH2_1 IDH2_1 UTR4_1 UTR4_1 IDP1_1 IDP1_1 PRS1_0 PRS1_0 PRM15_0 PRM15_0 AGM1_1 AGM1_1 Cantr_10510 Cantr_10510 ILV2_0 ILV2_0 DRS2_0 DRS2_0 PDC11_0 PDC11_0 IDH1_1 IDH1_1 PPA2_1 PPA2_1 AGM1_0 AGM1_0 ENO1_1 ENO1_1 acpS_1 acpS_1 PPA2_0 PPA2_0 pgmA_1 pgmA_1 FRS1_1 FRS1_1 DNF3_1 DNF3_1 acpS_0 acpS_0 Cantr_09897 Cantr_09897 IDH1_0 IDH1_0 Cantr_09066 Cantr_09066
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD27_1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (377 aa)
LYS12_1Homoisocitrate dehydrogenase, mitochondrial. (377 aa)
LSC2_1Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (415 aa)
Cantr_09367Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family. (334 aa)
ARO10_1Transaminated amino acid decarboxylase. (620 aa)
IDP2_1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (411 aa)
DNF2_1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1450 aa)
LYS5L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (306 aa)
ISN1_1IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. (446 aa)
NEO1_1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1162 aa)
panB_13-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. (309 aa)
lpa-144'-phosphopantetheinyl transferase. (289 aa)
DNF2_0Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1447 aa)
Cantr_07848Uncharacterized protein. (192 aa)
IDP2_0Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (411 aa)
PDC11_3Pyruvate decarboxylase. (316 aa)
FAS2_03-oxoacyl-[acyl-carrier-protein] reductase. (1886 aa)
DNF1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1571 aa)
Cantr_00446Uncharacterized protein. (89 aa)
THG1tRNA(His) guanylyltransferase. (218 aa)
PAPAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (558 aa)
LYS12_0Homoisocitrate dehydrogenase, mitochondrial. (377 aa)
LEU23-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (374 aa)
HIS1ATP phosphoribosyltransferase. (298 aa)
IDH2_2Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial. (348 aa)
IDP1_0Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (430 aa)
IPP1_0Inorganic pyrophosphatase. (288 aa)
ENO1_0Enolase 1. (440 aa)
RNASEH1_0Ribonuclease H1. (243 aa)
UTR4_0Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (235 aa)
CDC19_0Pyruvate kinase; Belongs to the pyruvate kinase family. (508 aa)
IDH2_0Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (369 aa)
PRS5_0Ribose-phosphate pyrophosphokinase 5. (444 aa)
SER2_0Phosphoserine phosphatase. (302 aa)
rnh1_0Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (282 aa)
PRS1_1Ribose-phosphate pyrophosphokinase 1. (320 aa)
pgmA_0Phosphoglucomutase; Belongs to the phosphohexose mutase family. (560 aa)
DNF3_0Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1761 aa)
FRS1_0Phenylalanine--tRNA ligase beta subunit. (593 aa)
PRS4_0Ribose-phosphate pyrophosphokinase 4. (319 aa)
ARO10_0Transaminated amino acid decarboxylase. (620 aa)
Cantr_07540Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family. (334 aa)
RAD27_0Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (377 aa)
LSC2_0Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (415 aa)
FAS2_13-oxoacyl-[acyl-carrier-protein] reductase. (1878 aa)
DRS2_1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1293 aa)
Cantr_06046Uncharacterized protein. (96 aa)
PRM15_1Phosphoribomutase. (615 aa)
PDC11_2Pyruvate decarboxylase. (575 aa)
ILV2_1Acetolactate synthase. (679 aa)
NEO1_0Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1162 aa)
panB_03-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. (309 aa)
ISN1_0IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. (446 aa)
PDC11_1Pyruvate decarboxylase. (567 aa)
SER2_1Phosphoserine phosphatase. (302 aa)
PRS1_2Ribose-phosphate pyrophosphokinase 1. (320 aa)
PRS5_1Ribose-phosphate pyrophosphokinase 5. (440 aa)
IPP1_1Inorganic pyrophosphatase. (288 aa)
CDC19_1Pyruvate kinase; Belongs to the pyruvate kinase family. (508 aa)
RNASEH1_1Ribonuclease H1. (222 aa)
rnh1_1Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (272 aa)
IDH2_1Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (369 aa)
UTR4_1Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (235 aa)
IDP1_1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (430 aa)
PRS1_0Ribose-phosphate pyrophosphokinase 1. (407 aa)
PRM15_0Phosphoribomutase. (615 aa)
AGM1_1Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. Belongs to the phosphohexose mutase family. (533 aa)
Cantr_10510Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (428 aa)
ILV2_0Acetolactate synthase. (679 aa)
DRS2_0Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1293 aa)
PDC11_0Pyruvate decarboxylase. (575 aa)
IDH1_1Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (364 aa)
PPA2_1Inorganic pyrophosphatase, mitochondrial. (329 aa)
AGM1_0Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. Belongs to the phosphohexose mutase family. (533 aa)
ENO1_1Enolase 1. (440 aa)
acpS_1Holo-[acyl-carrier-protein] synthase. (136 aa)
PPA2_0Inorganic pyrophosphatase, mitochondrial. (327 aa)
pgmA_1Phosphoglucomutase; Belongs to the phosphohexose mutase family. (560 aa)
FRS1_1Phenylalanine--tRNA ligase beta subunit. (593 aa)
DNF3_1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1783 aa)
acpS_0Holo-[acyl-carrier-protein] synthase. (136 aa)
Cantr_09897Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (428 aa)
IDH1_0Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (364 aa)
Cantr_09066Uncharacterized protein. (192 aa)
Your Current Organism:
Candida viswanathii
NCBI taxonomy Id: 5486
Other names: ATCC 22981, C. viswanathii, CBS 4024, CCRC 21330, CCRC:21330, Candida lodderae, Candida viswanathii Viswanathan & H.S. Randhawa ex R.S. Sandhu & H.S. Randhawa, 2015, DBVPG 6189, IFO 10321, JCM 9567, NRRL Y-6660
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.