STRINGSTRING
TOP1 TOP1 YCG1_0 YCG1_0 H1_0 H1_0 H1_1 H1_1 SMC2_0 SMC2_0 YCS4_0 YCS4_0 HMO1_1 HMO1_1 HMO1_0 HMO1_0 RPD3_1 RPD3_1 YCG1_1 YCG1_1 BRN1 BRN1 YCS4_1 YCS4_1 SMC2_1 SMC2_1 SMC4 SMC4 RPD3_0 RPD3_0
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (796 aa)
YCG1_0Condensin complex subunit 3. (1182 aa)
H1_0Histone H1. (182 aa)
H1_1Histone H1. (179 aa)
SMC2_0Structural maintenance of chromosomes protein. (1171 aa)
YCS4_0Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1165 aa)
HMO1_1Transcriptional regulator HMO1. (224 aa)
HMO1_0Transcriptional regulator HMO1. (224 aa)
RPD3_1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (544 aa)
YCG1_1Condensin complex subunit 3. (1181 aa)
BRN1Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (765 aa)
YCS4_1Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1159 aa)
SMC2_1Structural maintenance of chromosomes protein. (1171 aa)
SMC4Structural maintenance of chromosomes protein. (1339 aa)
RPD3_0Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (545 aa)
Your Current Organism:
Candida viswanathii
NCBI taxonomy Id: 5486
Other names: ATCC 22981, C. viswanathii, CBS 4024, CCRC 21330, CCRC:21330, Candida lodderae, Candida viswanathii Viswanathan & H.S. Randhawa ex R.S. Sandhu & H.S. Randhawa, 2015, DBVPG 6189, IFO 10321, JCM 9567, NRRL Y-6660
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