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ERO1_1 ERO1_1 HEM14_1 HEM14_1 LPD1_1 LPD1_1 ERO1_0 ERO1_0 NCP1-2 NCP1-2 ERV1_1 ERV1_1 DAO1_1 DAO1_1 HEM14_0 HEM14_0 COQ6_1 COQ6_1 ERV1_0 ERV1_0 SDH1_2 SDH1_2 ARH1 ARH1 NCP1 NCP1 GLR1_1 GLR1_1 MET13_1 MET13_1 MCR1 MCR1 COQ6_0 COQ6_0 POX2_1 POX2_1 DAO1_0 DAO1_0 CBR1 CBR1 SDH1_0 SDH1_0 TAH18_1 TAH18_1 SDH1_1 SDH1_1 FRD1_1 FRD1_1 BNA4_1 BNA4_1 MET12_1 MET12_1 BNA4_0 BNA4_0 FRD1_0 FRD1_0 TAH18_0 TAH18_0 MET12_0 MET12_0 PGA3 PGA3 PUT1 PUT1 ACAD11 ACAD11 GLR1_0 GLR1_0 MET13_0 MET13_0 ERV2 ERV2 TRR1 TRR1 dao1 dao1 CIR2 CIR2 POX2_0 POX2_0
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ERO1_1Endoplasmic reticulum oxidoreductin-1. (590 aa)
HEM14_1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (531 aa)
LPD1_1Dihydrolipoyl dehydrogenase. (491 aa)
ERO1_0Endoplasmic reticulum oxidoreductin-1. (594 aa)
NCP1-2NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (679 aa)
ERV1_1Sulfhydryl oxidase. (186 aa)
DAO1_1D-amino-acid oxidase. (361 aa)
HEM14_0Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (531 aa)
COQ6_1Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (481 aa)
ERV1_0Sulfhydryl oxidase. (185 aa)
SDH1_2Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa)
ARH1NADPH:adrenodoxin oxidoreductase, mitochondrial. (486 aa)
NCP1NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (679 aa)
GLR1_1Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (488 aa)
MET13_1Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (609 aa)
MCR1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (211 aa)
COQ6_0Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (481 aa)
POX2_1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (724 aa)
DAO1_0D-amino-acid oxidase. (361 aa)
CBR1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (304 aa)
SDH1_0Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa)
TAH18_1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (582 aa)
SDH1_1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa)
FRD1_1Fumarate reductase; Irreversibly catalyzes the reduction of fumarate to succinate. (489 aa)
BNA4_1Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (455 aa)
MET12_1Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (630 aa)
BNA4_0Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (455 aa)
FRD1_0Fumarate reductase; Irreversibly catalyzes the reduction of fumarate to succinate. (489 aa)
TAH18_0NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (582 aa)
MET12_0Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (630 aa)
PGA3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (285 aa)
PUT1Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (490 aa)
ACAD11Acyl-CoA dehydrogenase family member 11. (440 aa)
GLR1_0Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (488 aa)
MET13_0Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (609 aa)
ERV2Sulfhydryl oxidase. (233 aa)
TRR1Thioredoxin reductase. (320 aa)
dao1D-amino-acid oxidase. (346 aa)
CIR2Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (626 aa)
POX2_0Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (724 aa)
Your Current Organism:
Candida viswanathii
NCBI taxonomy Id: 5486
Other names: ATCC 22981, C. viswanathii, CBS 4024, CCRC 21330, CCRC:21330, Candida lodderae, Candida viswanathii Viswanathan & H.S. Randhawa ex R.S. Sandhu & H.S. Randhawa, 2015, DBVPG 6189, IFO 10321, JCM 9567, NRRL Y-6660
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