STRINGSTRING
IMH3_0 IMH3_0 TMP1_1 TMP1_1 ADE8_1 ADE8_1 Cantr_04569 Cantr_04569 Cantr_04345 Cantr_04345 IMH3_1 IMH3_1 GPP1_1 GPP1_1 RNR2_3 RNR2_3 ADE1_1 ADE1_1 RNR2_2 RNR2_2 AMD1_1 AMD1_1 ADE4 ADE4 HBR1_0 HBR1_0 AAH1_1 AAH1_1 ADE1_2 ADE1_2 Cantr_03618 Cantr_03618 DAS2_0 DAS2_0 YND1 YND1 RNR1_1 RNR1_1 URA3_2 URA3_2 CDA CDA URA6_0 URA6_0 URA3_3 URA3_3 URA3_4 URA3_4 URK1_1 URK1_1 DOG2 DOG2 YSA1_1 YSA1_1 GRX7_1 GRX7_1 GLR1_1 GLR1_1 ADK1 ADK1 ADE2_1 ADE2_1 PNP1_1 PNP1_1 GDA1_1 GDA1_1 ADE6_0 ADE6_0 ADE13_0 ADE13_0 ADE17_0 ADE17_0 RNR1_2 RNR1_2 GRX2_1 GRX2_1 URA6_1 URA6_1 HAM1_0 HAM1_0 URA2_0 URA2_0 HBR1_1 HBR1_1 DAS2_1 DAS2_1 GUK1_0 GUK1_0 ADE13_1 ADE13_1 ADE17_1 ADE17_1 rnr-1 rnr-1 ADE6_1 ADE6_1 URA5 URA5 Cantr_09897 Cantr_09897 URA9_0 URA9_0 CDC8_0 CDC8_0 HAM1_1 HAM1_1 GUK1_1 GUK1_1 URA2_1 URA2_1 Cantr_10834 Cantr_10834 CDC8_1 CDC8_1 URA9_1 URA9_1 GUA1_0 GUA1_0 Cantr_09566 Cantr_09566 ADE2_0 ADE2_0 YSA1_0 YSA1_0 Cantr_10510 Cantr_10510 GUA1_1 GUA1_1 URK1_0 URK1_0 NDK1 NDK1 URA3_0 URA3_0 GDA1_0 GDA1_0 ADO1 ADO1 TRX2_0 TRX2_0 ADK2 ADK2 GRX7_0 GRX7_0 FUR1_0 FUR1_0 GRXC6 GRXC6 GLR1_0 GLR1_0 PNP1_0 PNP1_0 URA7 URA7 GLRX GLRX TRX2_1 TRX2_1 GUD1 GUD1 ade5 ade5 RNR1_0 RNR1_0 AAH1_0 AAH1_0 TMP1_0 TMP1_0 ADE8_0 ADE8_0 APT1_0 APT1_0 Cantr_02736 Cantr_02736 RNR2_1 RNR2_1 AMD1_0 AMD1_0 Cantr_02512 Cantr_02512 URA3_1 URA3_1 ADE1_0 ADE1_0 GPP1_0 GPP1_0 RNR2_0 RNR2_0 Cantr_03470 Cantr_03470
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IMH3_0Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (521 aa)
TMP1_1Thymidylate synthase. (303 aa)
ADE8_1Phosphoribosylglycinamide formyltransferase. (223 aa)
Cantr_04569Metallophos domain-containing protein. (573 aa)
Cantr_04345Glutaredoxin domain-containing protein. (300 aa)
IMH3_1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (521 aa)
GPP1_1Glycerol-1-phosphate phosphohydrolase 1. (254 aa)
RNR2_3Ribonucleoside-diphosphate reductase small chain 1. (395 aa)
ADE1_1Phosphoribosylaminoimidazole-succinocarboxamide synthase. (294 aa)
RNR2_2Ribonucleoside-diphosphate reductase small chain 1. (415 aa)
AMD1_1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (791 aa)
ADE4Amidophosphoribosyltransferase. (484 aa)
HBR1_0Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (243 aa)
AAH1_1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (355 aa)
ADE1_2Bifunctional purine biosynthetic protein ADE1. (626 aa)
Cantr_03618Uncharacterized protein. (988 aa)
DAS2_0Putative uridine kinase DAS2. (256 aa)
YND1Golgi apyrase; Belongs to the GDA1/CD39 NTPase family. (600 aa)
RNR1_1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (865 aa)
URA3_2Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (267 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (149 aa)
URA6_0Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (294 aa)
URA3_3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (267 aa)
URA3_4Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (267 aa)
URK1_1Uridine kinase; Belongs to the uridine kinase family. (545 aa)
DOG22-deoxyglucose-6-phosphate phosphatase 2. (233 aa)
YSA1_1ADP-ribose pyrophosphatase. (210 aa)
GRX7_1Monothiol glutaredoxin-7. (233 aa)
GLR1_1Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (488 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (248 aa)
ADE2_1Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (568 aa)
PNP1_1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (307 aa)
GDA1_1Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. (582 aa)
ADE6_0Phosphoribosylformylglycinamidine synthase. (1339 aa)
ADE13_0Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
ADE17_0Bifunctional purine biosynthesis protein ADE17. (588 aa)
RNR1_2Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (817 aa)
GRX2_1Glutaredoxin-2, mitochondrial. (119 aa)
URA6_1Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (297 aa)
HAM1_0Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
URA2_0Protein URA2. (2210 aa)
HBR1_1Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (241 aa)
DAS2_1Putative uridine kinase DAS2. (256 aa)
GUK1_0Guanylate kinase. (191 aa)
ADE13_1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
ADE17_1Bifunctional purine biosynthesis protein ADE17. (588 aa)
rnr-1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (817 aa)
ADE6_1Phosphoribosylformylglycinamidine synthase. (1339 aa)
URA5Orotate phosphoribosyltransferase. (197 aa)
Cantr_09897Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (428 aa)
URA9_0Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (440 aa)
CDC8_0Thymidylate kinase. (222 aa)
HAM1_1Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
GUK1_1Guanylate kinase. (191 aa)
URA2_1Protein URA2. (2210 aa)
Cantr_10834Deoxycytidylate deaminase. (335 aa)
CDC8_1Thymidylate kinase. (222 aa)
URA9_1Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (440 aa)
GUA1_0GMP synthase [glutamine-hydrolyzing]. (530 aa)
Cantr_09566Deoxycytidylate deaminase. (338 aa)
ADE2_0Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (568 aa)
YSA1_0ADP-ribose pyrophosphatase. (222 aa)
Cantr_10510Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (428 aa)
GUA1_1GMP synthase [glutamine-hydrolyzing]. (530 aa)
URK1_0Uridine kinase; Belongs to the uridine kinase family. (545 aa)
NDK1Nucleoside diphosphate kinase. (151 aa)
URA3_0Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (174 aa)
GDA1_0Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. (582 aa)
ADO1Adenosine kinase. (347 aa)
TRX2_0Thioredoxin-2. (135 aa)
ADK2GTP:AMP phosphotransferase, mitochondrial; Belongs to the adenylate kinase family. (166 aa)
GRX7_0Monothiol glutaredoxin-7. (233 aa)
FUR1_0Uracil phosphoribosyltransferase. (218 aa)
GRXC6Glutaredoxin-C6. (113 aa)
GLR1_0Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (488 aa)
PNP1_0Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (307 aa)
URA7CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (575 aa)
GLRXGlutaredoxin. (116 aa)
TRX2_1Thioredoxin; Belongs to the thioredoxin family. (105 aa)
GUD1Putative guanine deaminase. (527 aa)
ade5Phosphoribosylglycinamide formyltransferase. (157 aa)
RNR1_0Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (865 aa)
AAH1_0Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (355 aa)
TMP1_0Thymidylate synthase. (303 aa)
ADE8_0Phosphoribosylglycinamide formyltransferase. (223 aa)
APT1_0Adenine phosphoribosyltransferase. (188 aa)
Cantr_02736Glutaredoxin domain-containing protein. (298 aa)
RNR2_1Ribonucleoside-diphosphate reductase small chain 1. (419 aa)
AMD1_0AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (790 aa)
Cantr_02512Metallophos domain-containing protein. (573 aa)
URA3_1Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (243 aa)
ADE1_0Phosphoribosylaminoimidazole-succinocarboxamide synthase. (294 aa)
GPP1_0Glycerol-1-phosphate phosphohydrolase 1. (254 aa)
RNR2_0Ribonucleoside-diphosphate reductase small chain 1. (395 aa)
Cantr_03470Uncharacterized protein. (988 aa)
Your Current Organism:
Candida viswanathii
NCBI taxonomy Id: 5486
Other names: ATCC 22981, C. viswanathii, CBS 4024, CCRC 21330, CCRC:21330, Candida lodderae, Candida viswanathii Viswanathan & H.S. Randhawa ex R.S. Sandhu & H.S. Randhawa, 2015, DBVPG 6189, IFO 10321, JCM 9567, NRRL Y-6660
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.