(74 nodes) Glycine, serine and threonine metabolism network (Candida viswanathii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	TDA10	Putative ATP-dependent kinase TDA10. (280 aa)
	dad4_0	DASH complex subunit dad4. (80 aa)
	THR4	Threonine synthase. (503 aa)
	Cantr_10847	AMP_N domain-containing protein. (472 aa)
	dao1	D-amino-acid oxidase. (346 aa)
	SHM2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (470 aa)
	CHO1_1	CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (274 aa)
	CHA1_0	Catabolic L-serine/threonine dehydratase. (329 aa)
	GLY1_5	Low-specificity L-threonine aldolase. (373 aa)
	ICP55_0	Intermediate cleaving peptidase 55. (490 aa)
	GCV3_1	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (181 aa)
	GLY1_4	Low-specificity L-threonine aldolase. (373 aa)
	SER3_1	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (463 aa)
	GLY1_2	Low-specificity L-threonine aldolase. (373 aa)
	CYS3_1	Cystathionine gamma-lyase. (399 aa)
	GCV3_0	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (181 aa)
	SER3_0	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (463 aa)
	LPD1_1	Dihydrolipoyl dehydrogenase. (491 aa)
	GLY1_3	Low-specificity L-threonine aldolase. (373 aa)
	HEM1_1	5-aminolevulinate synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (558 aa)
	GCV2_1	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1000 aa)
	AMPP_1	Putative Xaa-Pro aminopeptidase P. (725 aa)
	GLY1_1	Low-specificity L-threonine aldolase. (368 aa)
	DAO1_1	D-amino-acid oxidase. (361 aa)
	GPM1_3	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (261 aa)
	CYS4_1	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (496 aa)
	GCV2_0	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1000 aa)
	HOM6_1	Homoserine dehydrogenase. (357 aa)
	Cantr_08742	Uncharacterized protein. (222 aa)
	FRA1_1	Putative Xaa-Pro aminopeptidase FRA1; Belongs to the peptidase M24B family. (695 aa)
	AMO_1	Amine oxidase. (707 aa)
	CHA1_2	Catabolic L-serine/threonine dehydratase. (360 aa)
	trp2	Tryptophan synthase. (557 aa)
	SER2_1	Phosphoserine phosphatase. (302 aa)
	ILV1_1	Threonine dehydratase. (570 aa)
	CHO1_0	CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (274 aa)
	HOM6_0	Homoserine dehydrogenase. (357 aa)
	CYS4_0	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (496 aa)
	DAO1_0	D-amino-acid oxidase. (361 aa)
	GLY1_0	Low-specificity L-threonine aldolase. (368 aa)
	GPM1_2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (261 aa)
	HOM3	Aspartokinase. (541 aa)
	Cantr_04897	Uncharacterized protein. (222 aa)
	GCV1	Aminomethyltransferase, mitochondrial. (366 aa)
	ICP55_1	Intermediate cleaving peptidase 55. (490 aa)
	CHA1_3	Catabolic L-serine/threonine dehydratase. (329 aa)
	AGX1	Alanine--glyoxylate aminotransferase 1. (386 aa)
	dad4_1	DASH complex subunit dad4. (80 aa)
	yeaW	Putative dioxygenase subunit alpha YeaW. (434 aa)
	AMPP_0	Putative Xaa-Pro aminopeptidase P. (725 aa)
	HEM1_0	5-aminolevulinate synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (566 aa)
	YMR226C	NADP-dependent 3-hydroxy acid dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (269 aa)
	GPM1_1	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
	AO-I_1	Amine oxidase. (661 aa)
	SHB17_1	Sedoheptulose 1,7-bisphosphatase. (253 aa)
	SER1_1	Phosphoserine aminotransferase. (392 aa)
	HOM2_1	Aspartate-semialdehyde dehydrogenase. (365 aa)
	SHM1_0	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (491 aa)
	Cantr_01082	D-serine dehydratase. (418 aa)
	THR1	Homoserine kinase. (350 aa)
	AMO_0	Amine oxidase. (707 aa)
	SHM1_1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (491 aa)
	SER1_0	Phosphoserine aminotransferase. (392 aa)
	ILV1_0	Threonine dehydratase. (570 aa)
	SER2_0	Phosphoserine phosphatase. (302 aa)
	HOM2_0	Aspartate-semialdehyde dehydrogenase. (365 aa)
	SHB17_0	Sedoheptulose 1,7-bisphosphatase. (253 aa)
	GPM1_0	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
	AO-I_0	Amine oxidase. (661 aa)
	FRA1_0	Putative Xaa-Pro aminopeptidase FRA1; Belongs to the peptidase M24B family. (695 aa)
	CHA1_1	Catabolic L-serine/threonine dehydratase. (360 aa)
	Cantr_02113	D-serine dehydratase. (418 aa)
	CYS3_0	Cystathionine gamma-lyase. (399 aa)
	RMT2	Arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. (425 aa)

Your Current Organism:

Candida viswanathii

NCBI taxonomy Id: 5486
Other names: ATCC 22981, C. viswanathii, CBS 4024, CCRC 21330, CCRC:21330, Candida lodderae, Candida viswanathii Viswanathan & H.S. Randhawa ex R.S. Sandhu & H.S. Randhawa, 2015, DBVPG 6189, IFO 10321, JCM 9567, NRRL Y-6660

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGX1	CHA1_0	A0A367XWI0	A0A367YFB2	Alanine--glyoxylate aminotransferase 1.	Catabolic L-serine/threonine dehydratase.	0.943
AGX1	CHA1_1	A0A367XWI0	A0A367YLM0	Alanine--glyoxylate aminotransferase 1.	Catabolic L-serine/threonine dehydratase.	0.943
AGX1	CHA1_2	A0A367XWI0	A0A367XPR3	Alanine--glyoxylate aminotransferase 1.	Catabolic L-serine/threonine dehydratase.	0.943
AGX1	CHA1_3	A0A367XWI0	A0A367XVN6	Alanine--glyoxylate aminotransferase 1.	Catabolic L-serine/threonine dehydratase.	0.943
AGX1	CHO1_0	A0A367XWI0	A0A367XQZ1	Alanine--glyoxylate aminotransferase 1.	CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.929
AGX1	CHO1_1	A0A367XWI0	A0A367YFI2	Alanine--glyoxylate aminotransferase 1.	CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.929
AGX1	CYS3_0	A0A367XWI0	A0A367YKI5	Alanine--glyoxylate aminotransferase 1.	Cystathionine gamma-lyase.	0.542
AGX1	CYS3_1	A0A367XWI0	A0A367YCR3	Alanine--glyoxylate aminotransferase 1.	Cystathionine gamma-lyase.	0.542
AGX1	CYS4_0	A0A367XWI0	A0A367XSN0	Alanine--glyoxylate aminotransferase 1.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.935
AGX1	CYS4_1	A0A367XWI0	A0A367Y467	Alanine--glyoxylate aminotransferase 1.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.935
AGX1	DAO1_0	A0A367XWI0	A0A367XT05	Alanine--glyoxylate aminotransferase 1.	D-amino-acid oxidase.	0.952
AGX1	DAO1_1	A0A367XWI0	A0A367Y6A8	Alanine--glyoxylate aminotransferase 1.	D-amino-acid oxidase.	0.952
AGX1	GCV1	A0A367XWI0	A0A367XV46	Alanine--glyoxylate aminotransferase 1.	Aminomethyltransferase, mitochondrial.	0.964
AGX1	GCV2_0	A0A367XWI0	A0A367Y462	Alanine--glyoxylate aminotransferase 1.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.950
AGX1	GCV2_1	A0A367XWI0	A0A367YBZ2	Alanine--glyoxylate aminotransferase 1.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.950
AGX1	GCV3_0	A0A367XWI0	A0A367YCP2	Alanine--glyoxylate aminotransferase 1.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.949
AGX1	GCV3_1	A0A367XWI0	A0A367YE97	Alanine--glyoxylate aminotransferase 1.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.949
AGX1	GLY1_0	A0A367XWI0	A0A367Y2D9	Alanine--glyoxylate aminotransferase 1.	Low-specificity L-threonine aldolase.	0.941
AGX1	GLY1_1	A0A367XWI0	A0A367YA16	Alanine--glyoxylate aminotransferase 1.	Low-specificity L-threonine aldolase.	0.941
AGX1	GLY1_2	A0A367XWI0	A0A367YCV4	Alanine--glyoxylate aminotransferase 1.	Low-specificity L-threonine aldolase.	0.929

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