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aroE aroE Fbal_0057 Fbal_0057 Fbal_0091 Fbal_0091 selD selD argC argC argB argB Fbal_0312 Fbal_0312 argG argG argH argH aroK aroK aroB aroB aroQ aroQ Fbal_0550 Fbal_0550 asd asd mtnN mtnN Fbal_0657 Fbal_0657 Fbal_0663 Fbal_0663 Fbal_0667 Fbal_0667 Fbal_0688 Fbal_0688 Fbal_0743 Fbal_0743 Fbal_0744 Fbal_0744 Fbal_0753 Fbal_0753 Fbal_0766 Fbal_0766 thrB thrB Fbal_0768 Fbal_0768 Fbal_0805 Fbal_0805 glyA glyA Fbal_0858 Fbal_0858 Fbal_0880 Fbal_0880 proB proB proA proA Fbal_0939 Fbal_0939 dapD dapD metAS metAS Fbal_1017 Fbal_1017 Fbal_1136 Fbal_1136 Fbal_1137 Fbal_1137 Fbal_1219 Fbal_1219 Fbal_1244 Fbal_1244 dapA dapA Fbal_1443 Fbal_1443 hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG Fbal_1921 Fbal_1921 aroA aroA hisC-2 hisC-2 serC serC serS serS folD folD Fbal_2165 Fbal_2165 Fbal_2203 Fbal_2203 Fbal_2228 Fbal_2228 Fbal_2265 Fbal_2265 cysZ cysZ Fbal_2424 Fbal_2424 dapE dapE trpD trpD trpF trpF trpB trpB trpA trpA Fbal_2580 Fbal_2580 folD-2 folD-2 asd-2 asd-2 aroC aroC Fbal_2814 Fbal_2814 Fbal_2851 Fbal_2851 carB carB carA carA dapB dapB proC proC Fbal_3020 Fbal_3020 cysI cysI Fbal_3188 Fbal_3188 panD panD Fbal_3308 Fbal_3308 Fbal_3367 Fbal_3367 argR argR argD argD Fbal_3511 Fbal_3511 Fbal_3512 Fbal_3512 Fbal_3514 Fbal_3514 Fbal_3558 Fbal_3558 ilvD ilvD ilvE ilvE Fbal_3649 Fbal_3649 ilvC ilvC leuD leuD leuC leuC leuB leuB leuA leuA lysA lysA dapF dapF Fbal_3737 Fbal_3737 mtnC mtnC
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aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa)
Fbal_0057COGs: COG0069 Glutamate synthase domain 2; InterPro IPR018967: IPR002932: IPR006622; KEGG: vpa:VPA0765 putative glutamate synthetase; PFAM: ferredoxin-dependent glutamate synthase; Iron sulphur domain-containing, CDGSH-type; SMART: zinc finger CDGSH-type domain protein; SPTR: A3UQB8 Glutamate synthase domain protein; PFAM: Iron-binding zinc finger CDGSH type; Conserved region in glutamate synthase. (524 aa)
Fbal_0091COGs: COG0174 Glutamine synthetase; InterPro IPR008146: IPR008147: IPR001637: IPR004809; KEGG: vha:VIBHAR_00588 glutamine synthetase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: A0XX56 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (469 aa)
selDSelenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (344 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa)
Fbal_0312Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa)
argGCOGs: COG0137 Argininosuccinate synthase; InterPro IPR001518: IPR018223; KEGG: amc:MADE_00529 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: A0XXT0 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa)
argHN-acetylglutamate synthase; COGs: COG0165 Argininosuccinate lyase; InterPro IPR000362: IPR000182: IPR020557: IPR009049; KEGG: cps:CPS_0464 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; PFAM: fumarate lyase; GCN5-related N-acetyltransferase; SPTR: P59620 Bifunctional protein argH; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; Acetyltransferase (GNAT) family; TIGRFAM: argininosuccinate lyase; In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (643 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
Fbal_0550Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1058 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
mtnNMethylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
Fbal_0657Glutamate synthase (NADPH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002489: IPR002932: IPR006982: IPR000583; KEGG: slo:Shew_1032 glutamate synthase subunit alpha; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; PRIAM: Glutamate synthase (ferredoxin); SPTR: A2V2C5 Ferredoxin-dependent glutamate synthase; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1483 aa)
Fbal_0663COGs: COG0527 Aspartokinase; InterPro IPR001048: IPR018042: IPR005260: IPR001341; KEGG: sse:Ssed_0817 aspartate kinase III; PFAM: aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase; SPTR: P08660 Lysine-sensitive aspartokinase 3; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (460 aa)
Fbal_0667Aspartate-ammonia ligase; COGs: COG2502 Asparagine synthetase A; InterPro IPR004618: IPR006195; KEGG: sfv:SFV_3770 asparagine synthetase AsnA; PFAM: aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Q83PJ4 Aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type. (325 aa)
Fbal_0688COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR002912: IPR006140; KEGG: vpa:VP2593 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: A3ELN9 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (409 aa)
Fbal_07433-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
Fbal_0744Chorismate mutase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002701: IPR011277; KEGG: saz:Sama_0894 bifunctional chorismate mutase/prephenate dehydrogenase; PFAM: Chorismate mutase; Prephenate dehydrogenase; SPTR: A2UV38 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydrogenase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of T-protein. (378 aa)
Fbal_0753Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR006218: IPR002912: IPR002701: IPR 018528: IPR006268: IPR010952; KEGG: swd:Swoo_1263 chorismate mutase; PFAM: prephenate dehydratase; DAHP synthetase I/KDSA; amino acid-binding ACT domain protein; Chorismate mutase; SPTR: A2UV42 Chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase domain of p [...] (672 aa)
Fbal_0766COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR002912: IPR005106: IPR001048: IPR 019811: IPR018042: IPR001341; KEGG: saz:Sama_0905 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2V048 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase; [...] (818 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa)
Fbal_0768COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR000634: IPR004450; KEGG: shn:Shewana3_1141 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: A2V050 Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa)
Fbal_0805KEGG: ppg:PputGB1_3052 nonspecific acid phosphatase; SPTR: A3HUP4 Nonspecific acid phosphatase. (324 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
Fbal_0858COGs: COG0527 Aspartokinase; InterPro IPR001057: IPR002912: IPR001048: IPR018042: IPR 005260: IPR001341; KEGG: pin:Ping_3379 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: A0Z876 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (406 aa)
Fbal_08803-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa)
Fbal_0939KEGG: son:SO_1613 hypothetical protein; SPTR: A2UVK2 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2789). (76 aa)
dapDCOGs: COG2171 Tetrahydrodipicolinate N-succinyltransferase; InterPro IPR001451: IPR018357: IPR005664; KEGG: shl:Shal_2984 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; PRIAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; SPTR: B0TP86 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; TIGRFAM:2,3,4,5-tetrahydropyridine-2,6-dicarboxylat eN-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (311 aa)
Fbal_1017COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002932; KEGG: hch:HCH_00332 glutamate synthase domain-containing 2; PFAM: ferredoxin-dependent glutamate synthase; SPTR: A0YEB0 Glutamate synthase domain 2; PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (504 aa)
Fbal_1136Glutamate--putrescine ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: cps:CPS_4677 glutamine synthetase family protein; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A3LHA3 Putative uncharacterized protein; PFAM: Glutamine synthetase, catalytic domain. (459 aa)
Fbal_1137COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: asa:ASA_0172 glutamine synthetase; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A2VUT5 Glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain. (443 aa)
Fbal_1219COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426: IPR017535; KEGG: pla:Plav_0816 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: A0P460 Putative asparagine synthetase (Glutamine amidotransferase) protein; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrol [...] (588 aa)
Fbal_1244COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426; KEGG: sbn:Sbal195_1769 asparagine synthetase B; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: A2V529 Asparagine synthase (Glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (554 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
Fbal_1443COGs: COG1045 Serine acetyltransferase; InterPro IPR001451: IPR010493: IPR018357: IPR005881; KEGG: amc:MADE_00201 serine acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein; PRIAM: Serine O-acetyltransferase; SPTR: A0XYV3 Serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase. (267 aa)
hisICOGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR002496: IPR008179; KEGG: swp:swp_3009 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: A2V1X4 Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (202 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: kpu:KP1_3685 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase; PFAM: histidine biosynthesis protein; SPTR: B8CR53 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM [...] (245 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa)
hisBCOGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR013954: IPR020565: IPR006543: IPR 005954: IPR006549; KEGG: ppr:PBPRA1089 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; PRIAM: Histidinol-phosphatase; SPTR: P62455 Histidine biosynthesis bifunctional protein hisB; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase; Imidazoleglyce [...] (355 aa)
hisCCOGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR001917: IPR005861; KEGG: slo:Shew_2199 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q8EFB2 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (307 aa)
Fbal_1921Protein of unknown function DUF227; InterPro IPR002575: IPR004119: IPR015897; KEGG: pat:Patl_3439 hypothetical protein; PFAM: protein of unknown function DUF227; aminoglycoside phosphotransferase; SMART: CHK kinase-like; SPTR: A1ZY78 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF227). (320 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
hisC-2COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR001176: IPR004839: IPR001917: IPR005861; KEGG: pin:Ping_1116 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q5QZ49 Histidinol-phosphate aminotransferase 1; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa)
folD5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
Fbal_2165GCN5-related N-acetyltransferase; InterPro IPR020441: IPR000182; KEGG: mxa:MXAN_6424 acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Q08021 Uncharacterized N-acetyltransferase yjgM; PFAM: Acetyltransferase (GNAT) family. (164 aa)
Fbal_22033-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa)
Fbal_2228Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: sdn:Sden_2013 pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: A2PU42 Cysteine synthase/cystathionine beta-synthase family protein; PFAM: Pyridoxal-phosphate dependent enzyme. (354 aa)
Fbal_2265Transferase hexapeptide repeat containing protein; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: tgr:Tgr7_2377 transferase hexapeptide repeat containing protein; PFAM: transferase hexapeptide repeat containing protein; SPTR: Q46F84 Serine O-acetyltransferase. (196 aa)
cysZProtein of unknown function DUF540; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (256 aa)
Fbal_2424COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR001216: IPR005856: IPR005859; KEGG: yen:YE1208 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: P0A1E3 Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
dapESuccinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa)
trpFPhosphoribosylanthranilate isomerase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001240: IPR013798: IPR001468; KEGG: saz:Sama_2132 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase; SPTR: A2V450 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (458 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
Fbal_2580COGs: COG3186 Phenylalanine-4-hydroxylase; InterPro IPR019774: IPR018301: IPR005960; KEGG: ilo:IL0725 phenylalanine 4-monooxygenase; PFAM: Aromatic amino acid hydroxylase-like; SPTR: A3WM90 Phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: Biopterin-dependent aromatic amino acid hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase, monomeric form. (263 aa)
folD-25,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
asd-2Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
Fbal_2814COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR019818; KEGG: swp:swp_3606 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: A2UVF1 Isocitrate/isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (335 aa)
Fbal_2851COGs: COG0560 Phosphoserine phosphatase; InterPro IPR005834: IPR004469: IPR006383; KEGG: asa:ASA_3650 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Phosphoserine phosphatase; SPTR: A2UZE1 Phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (304 aa)
carBCOGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005483: IPR003135: IPR005479: IPR003806: IPR 011607: IPR005480: IPR005481: IPR011761: IPR006275; KEGG: slo:Shew_2838 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A2UYB9 Carbamoyl-phosphate synthase, larg [...] (1073 aa)
carACOGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006220: IPR011702: IPR001317: IPR002474: IPR 000991: IPR006274; KEGG: saz:Sama_2504 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q8EHS6 Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (382 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa)
Fbal_3020Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa)
cysISulfite reductase (NADPH) beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (579 aa)
Fbal_3188Sulfite reductase (NADPH) alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (598 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa)
Fbal_3308Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (358 aa)
Fbal_3367Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa)
argRTranscriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (156 aa)
argDCOGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814: IPR004636: IPR017652; KEGG: son:SO_0617 bifunctional N-succinyldiaminopimelate-aminotransferase/ acetylornithine transaminase protein; PFAM: aminotransferase class-III; PRIAM: Succinyldiaminopimelate transaminase; SPTR: P59320 Acetylornithine aminotransferase; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferases; Belongs to [...] (405 aa)
Fbal_3511COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171: IPR004620; KEGG: sse:Ssed_4039 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: A2UWK0 Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
Fbal_3512COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR005106: IPR001048: IPR019811: IPR 018042: IPR001341; KEGG: saz:Sama_3170 bifunctional aspartate kinase II/homoserine dehydrogenase II; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2UWJ9 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine deh [...] (786 aa)
Fbal_3514Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. (106 aa)
Fbal_3558Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR019546: IPR006311; KEGG: shl:Shal_3744 aminotransferase class I and II; PFAM: aminotransferase class I and II; Twin-arginine translocation pathway, signal sequence, subgroup; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; PFAM: TAT (twin-arginine translocation) pathway signal sequence; Aminotransferase class I and II; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; histidinol-phosphate aminotransferase. (380 aa)
ilvDCOGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR020558: IPR004404; KEGG: slo:Shew_0292 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: A3Q9L6 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (323 aa)
Fbal_3649COGs: COG3978 Acetolactate synthase (isozyme II) small (regulatory) subunit; KEGG: sdn:Sden_3413 acetolactate synthase 2 regulatory subunit; SPTR: A2UYR6 Amino acid-binding ACT. (87 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (269 aa)
Fbal_3737InterPro IPR000182; KEGG: swd:Swoo_0090 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: A3UP63 Putative uncharacterized protein; PFAM: Acetyltransferase (GNAT) family. (148 aa)
mtnCAcireductone synthase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (225 aa)
Your Current Organism:
Ferrimonas balearica
NCBI taxonomy Id: 550540
Other names: F. balearica DSM 9799, Ferrimonas balearica DSM 9799, Ferrimonas balearica PAT, Ferrimonas balearica str. DSM 9799, Ferrimonas balearica strain DSM 9799
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