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| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | Fbal_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | Fbal_0016 | Protoporphyrinogen oxidase; COGs: COG4635 Flavodoxin; InterPro IPR008254; KEGG: saz:Sama_0036 protoporphyrinogen oxidase; PRIAM: Protoporphyrinogen oxidase; SPTR: A2V477 Protoporphyrinogen oxidase. (174 aa) |
| | Fbal_0018 | Protoporphyrinogen oxidase; COGs: COG4635 Flavodoxin; InterPro IPR001226: IPR008254; KEGG: sse:Ssed_0029 protoporphyrinogen oxidase; PRIAM: Protoporphyrinogen oxidase; SPTR: A2V475 Protoporphyrinogen oxidase. (178 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa) |
| | hemF | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (304 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa) |
| | Fbal_0062 | GCN5-related N-acetyltransferase; InterPro IPR000182; KEGG: cja:CJA_2433 acetyltransferase, GNAT family; PFAM: GCN5-related N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family. (141 aa) |
| | Fbal_0068 | COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR006076: IPR003953: IPR019546: IPR002345: IPR 006311: IPR010960; KEGG: sse:Ssed_4184 flavocytochrome c; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; Twin-arginine translocation pathway, signal sequence, subgroup; SPTR: A2UXH7 Flavocytochrome c; TIGRFAM: flavocytochrome c; PFAM: FAD binding domain; TIGRFAM: flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (500 aa) |
| | Fbal_0105 | Thioesterase domain protein; InterPro IPR012660; KEGG: amc:MADE_03531 fused GNAT family acetyltransferase/PaaI-related uncharacterized conserved domain; PFAM: Thioesterase putative; SPTR: A3WKL8 Acetyltransferase, GNAT family fused to PaaI related uncharacterized conserved domain; TIGRFAM: thioesterase domain protein; PFAM: Putative thioesterase (yiiD_Cterm); TIGRFAM: thioesterase domain, putative. (146 aa) |
| | Fbal_0110 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (92 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | Fbal_0131 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | Fbal_0146 | NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR008089: IPR013120: IPR002225: IPR003869: IPR 002198: IPR005913: IPR001509; KEGG: kpn:KPN_02492 uridine diphosphate galacturonate 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; polysaccharide biosynthesis protein CapD; short-chain dehydrogenase/reductase SDR; dTDP-4-dehydrorhamnose reductase; SPTR: A0ZBU2 Capsular polysaccharide biosynthesis protein I; PFAM: NAD dependent epimerase/dehydratase family. (333 aa) |
| | Fbal_0147 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR014027: IPR014026: IPR001732: IPR017476; KEGG: avn:Avin_27790 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: A3JJ75 Predicted UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP [...] (446 aa) |
| | Fbal_0192 | Cytochrome oxidase assembly; COGs: COG1612 Uncharacterized protein required for cytochrome oxidase assembly; InterPro IPR003780; KEGG: swp:swp_4835 cytochrome oxidase assembly; PFAM: cytochrome oxidase assembly; SPTR: A2V2H4 Cytochrome oxidase assembly; PFAM: Cytochrome oxidase assembly protein. (318 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (301 aa) |
| | coaA | COGs: COG1072 Panthothenate kinase; InterPro IPR004566; KEGG: slo:Shew_0143 pantothenate kinase; SPTR: A3Q967 Pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: pantothenate kinase, bacterial type. (312 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (181 aa) |
| | atpH | ATP synthase F1 subcomplex delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1341 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1402 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa) |
| | Fbal_0307 | Competence/damage-inducible protein cinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR001453: IPR008136: IPR008135; KEGG: swd:Swoo_0325 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: B1KNC9 CinA-like protein; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum [...] (429 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | Fbal_0365 | COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638: IPR004393; KEGG: shn:Shewana3_0422 nicotinate-nucleotide pyrophosphorylase [carboxylating]; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: A2UYJ7 Nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (285 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR003806: IPR020560: IPR020562: IPR020561: IPR 011761: IPR020559: IPR000115; KEGG: ppr:PBPRA3420 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; protein of unknown function DUF201; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Q87KS8 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phospho [...] (428 aa) |
| | purH | IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607: IPR013982: IPR002695; KEGG: vfm:VFMJ11_2512 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: B5FC70 Bifunctional purine biosynthesis protein purH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMP [...] (530 aa) |
| | Fbal_0439 | Hypothetical protein. (195 aa) |
| | Fbal_0443 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR011128: IPR014027: IPR014026: IPR001732: IPR 017476; KEGG: tau:Tola_2842 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: A3EK13 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-gluc [...] (388 aa) |
| | Fbal_0468 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | priB | Restart primosome assembly protein PriB; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (103 aa) |
| | Fbal_0543 | COGs: COG2820 Uridine phosphorylase; InterPro IPR000845; KEGG: vvy:VVA0211 uridine phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: A2P4Y7 Uridine phosphorylase; PFAM: Phosphorylase superfamily. (242 aa) |
| | hldE | D-alpha,beta-D-heptose 7-phosphate 1-kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa) |
| | Fbal_0570 | COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR003043: IPR006366; KEGG: slo:Shew_0672 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A2UZS2 Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (279 aa) |
| | Fbal_0584 | COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR002375: IPR005904; KEGG: sdn:Sden_0654 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: A2UWU6 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa) |
| | Fbal_0624 | COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: eic:NT01EI_3361 5-formyltetrahydrofolate cyclo-ligase, putative; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: A3UUX9 Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (198 aa) |
| | Fbal_0649 | COGs: COG1270 Cobalamin biosynthesis protein CobD/CbiB; InterPro IPR004485; KEGG: sbn:Sbal195_1252 cobalamin biosynthesis protein CbiB; PFAM: cobalamin biosynthesis protein CbiB; SPTR: A2PT85 Cobalamin biosynthesis protein CbiB, putative; PFAM: CobD/Cbib protein. (320 aa) |
| | folE2 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. (315 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (379 aa) |
| | Fbal_0708 | RNA polymerase, sigma-24 subunit, RpoE; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR013249: IPR007627: IPR014284; KEGG: sbp:Sbal223_3552 RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: A2V5H4 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (175 aa) |
| | Fbal_0710 | Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; InterPro IPR006674: IPR003607; KEGG: hch:HCH_03679 hypothetical protein; PFAM: metal-dependent phosphohydrolase HD sub domain; PRIAM: 5'-nucleotidase; SMART: metal-dependent phosphohydrolase HD region; SPTR: Q87R72 UPF0207 protein VP0926; PFAM: HD domain. (204 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | Fbal_0723 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (536 aa) |
| | Fbal_0724 | RNA polymerase, sigma-24 subunit, RpoE; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR013249: IPR007627: IPR007630: IPR014286: IPR 014284; KEGG: shm:Shewmr7_2936 RNA polymerase sigma factor RpoE; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; SPTR: A2V2E3 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor RpoE; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 fa [...] (192 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (244 aa) |
| | Fbal_0743 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa) |
| | Fbal_0744 | Chorismate mutase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002701: IPR011277; KEGG: saz:Sama_0894 bifunctional chorismate mutase/prephenate dehydrogenase; PFAM: Chorismate mutase; Prephenate dehydrogenase; SPTR: A2UV38 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydrogenase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of T-protein. (378 aa) |
| | Fbal_0753 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR006218: IPR002912: IPR002701: IPR 018528: IPR006268: IPR010952; KEGG: swd:Swoo_1263 chorismate mutase; PFAM: prephenate dehydratase; DAHP synthetase I/KDSA; amino acid-binding ACT domain protein; Chorismate mutase; SPTR: A2UV42 Chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase domain of p [...] (672 aa) |
| | Fbal_0782 | FMN adenylyltransferase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR002606; KEGG: slo:Shew_1098 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; SPTR: A2UZZ7 Riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (315 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (539 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (222 aa) |
| | Fbal_0823 | COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372: IPR005790; KEGG: sdn:Sden_0795 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; PRIAM: DNA-directed DNA polymerase; SPTR: A2UY86 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. (344 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (136 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (273 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa) |
| | rpoS | RNA polymerase, sigma 38 subunit, RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (328 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | thiI | (ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (484 aa) |
| | Fbal_0880 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa) |
| | Fbal_0891 | Transcriptional regulator, BolA protein family; COGs: COG0271 Stress-induced morphogen (activity unknown); InterPro IPR002634; KEGG: asa:ASA_3200 cell division protein BolA; PFAM: BolA family protein; SPTR: A3UUC8 Cell division protein BolA; PFAM: BolA-like protein; Belongs to the BolA/IbaG family. (98 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (356 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (285 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa) |
| | Fbal_0967 | COGs: COG0587 DNA polymerase III alpha subunit; InterPro IPR011708: IPR004013: IPR004365: IPR003141: IPR 004805; KEGG: slo:Shew_2620 DNA polymerase III subunit alpha; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein; SPTR: A2V1K3 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc). (1165 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | tdk | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: sfr:Sfri_2745 thymidine kinase; PFAM: thymidine kinase; PRIAM: Thymidine kinase; SPTR: Q8ECK0 Thymidine kinase; PFAM: Thymidine kinase. (192 aa) |
| | Fbal_0997 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197: IPR006638; KEGG: vsa:VSAL_I1750 coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; PRIAM: Coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; SPTR: A3UL94 Coproporphyrinogen III oxidase; PFAM: Radical SAM superfamily. (449 aa) |
| | Fbal_0998 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020459: IPR000873; KEGG: swp:swp_3440 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2V351 AMP-dependent synthetase and ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. (635 aa) |
| | Fbal_1038 | Flagellar protein export ATPase FliI; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR000194: IPR003593: IPR020003: IPR020005: IPR 005714; KEGG: saz:Sama_2294 flagellum-specific ATP synthase; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; PRIAM: H(+)-transporting two-sector ATPase; SMART: AAA ATPase; SPTR: A2UYY1 Flagellar protein export ATPase FliI; TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family; PFAM: ATP synthase alpha/beta family, nucleotide-binding domain; TIGRFAM: ATPase FliI/YscN family; flag [...] (446 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (237 aa) |
| | Fbal_1079 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | Fbal_1080 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (303 aa) |
| | Fbal_1087 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR011128: IPR014027: IPR014026: IPR001732: IPR 017476; KEGG: vha:VIBHAR_00706 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: A3EK13 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-g [...] (388 aa) |
| | Fbal_1157 | InterPro IPR018106; KEGG: sfr:Sfri_2632 primosomal replication protein N'', putative; SPTR: A2V4S1 Primosomal replication protein N'', putative; PFAM: Primosomal replication protein priB and priC. (213 aa) |
| | Fbal_1160 | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. (771 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | Fbal_1181 | COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR001270: IPR003959: IPR003593: IPR012763; KEGG: swd:Swoo_1793 DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase central domain protein; PRIAM: DNA-directed DNA polymerase; SMART: AAA ATPase; SPTR: A2V5J5 DNA polymerase III, subunits gamma and tau; TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: ATPase family associated with various cellular activities (AAA); DNA polymerase III tau subunit V interacting with alpha; DNA polymerase III subunits gamma and tau domain III; TIGRFAM: DNA polymerase III, subun [...] (830 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (322 aa) |
| | Fbal_1233 | COGs: COG3721 Putative heme iron utilization protein; InterPro IPR010413; KEGG: shn:Shewana3_3234 heme utilization protein HuvX; PFAM: protein of unknown function DUF1008; SPTR: A3UL93 Putative uncharacterized protein; PFAM: ChuX-like family. (171 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918: IPR000728: IPR004733; KEGG: sbp:Sbal223_2549 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: A9KY38 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: pho [...] (345 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | queE | Radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa) |
| | Fbal_1383 | preQ(0) biosynthesis protein QueD; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: dda:Dd703_0857 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: A3H311 Queuosine biosynthesis QueD PTPS-I; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (122 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (240 aa) |
| | Fbal_1477 | Protein of unknown function DUF1486; InterPro IPR009959; KEGG: maq:Maqu_1483 hypothetical protein; PFAM: protein of unknown function DUF1486; SPTR: A3EJK8 Transcriptional regulator, putative; PFAM: SnoaL-like polyketide cyclase. (146 aa) |
| | folE | COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602: IPR018234: IPR001474; KEGG: vsp:VS_1750 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: A3URH9 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (211 aa) |
| | Fbal_1550 | COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR013027: IPR006076: IPR003953: IPR006311: IPR 010960; KEGG: sse:Ssed_4178 flavocytochrome c flavin subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD dependent oxidoreductase; SPTR: A2UXH7 Flavocytochrome c; TIGRFAM: flavocytochrome c; PFAM: FAD binding domain; TIGRFAM: flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (500 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa) |
| | Fbal_1599 | Aminoglycoside phosphotransferase; COGs: COG0510 choline kinase involved in LPS biosynthesis; InterPro IPR002575: IPR002573; KEGG: rlt:Rleg2_4020 choline/ethanolamine kinase; PFAM: aminoglycoside phosphotransferase; Choline/ethanolamine kinase; SPTR: A0Y817 Cholinephosphate cytidylyltransferase/choline kinase; PFAM: Phosphotransferase enzyme family. (271 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa) |
| | Fbal_1661 | COGs: COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; InterPro IPR013749: IPR004625; KEGG: bxe:Bxe_A2936 pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: Q1J237 Pyridoxamine kinase; TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: pyridoxal kinase; Belongs to the pyridoxine kinase family. (284 aa) |
| | Fbal_1684 | Protoporphyrinogen oxidase; COGs: COG4635 Flavodoxin; KEGG: sfr:Sfri_0813 protoporphyrinogen oxidase; PRIAM: Protoporphyrinogen oxidase; SPTR: A2V477 Protoporphyrinogen oxidase; PFAM: Flavodoxin. (176 aa) |
| | Fbal_1752 | Aminodeoxychorismate synthase, subunit I; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999: IPR006805: IPR015890: IPR005802; KEGG: aha:AHA_2435 para-aminobenzoate synthase, component I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Aminodeoxychorismate synthase; SPTR: A2PV21 Para-aminobenzoate synthase, component I; TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacte [...] (483 aa) |
| | Fbal_1821 | Ribonucleoside-triphosphate reductase class III activase subunit; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (155 aa) |
| | Fbal_1831 | RNA polymerase, sigma-24 subunit, ECF subfamily; InterPro IPR014284: IPR011517; KEGG: scl:sce4890 hypothetical protein; SPTR: A3I0X2 DNA-directed RNA polymerase specialized sigma subunit sigma24-like protein; TIGRFAM: RNA polymerase sigma factor; RNA polymerase sigma factor, sigma-70 family; PFAM: ECF sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma factor, TIGR02999 family. (174 aa) |
| | udk | COGs: COG0572 Uridine kinase; InterPro IPR000764: IPR006083; KEGG: saz:Sama_2047 uridine kinase; PFAM: phosphoribulokinase/uridine kinase; PRIAM: Uridine kinase; SPTR: A1S796 Uridine kinase; TIGRFAM: uridine kinase; PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: uridine kinase. (214 aa) |
| | dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (194 aa) |
| | Fbal_1860 | Aminodeoxychorismate lyase; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544: IPR018300: IPR017824; KEGG: asa:ASA_2051 4-amino-4-deoxychorismate lyase; PFAM: aminotransferase class IV; SPTR: A2V2R9 Aminotransferase, class IV; TIGRFAM: aminodeoxychorismate lyase; PFAM: Aminotransferase class IV; TIGRFAM: aminodeoxychorismate lyase. (270 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa) |
| | Fbal_1863 | COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR004622; KEGG: slo:Shew_1580 DNA polymerase III, delta prime subunit; PRIAM: DNA-directed DNA polymerase; SPTR: A2V2S2 DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit. (301 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (341 aa) |
| | Fbal_1918 | Protein of unknown function DUF2006; COGs: COG5621 secreted hydrolase; InterPro IPR018549; KEGG: cps:CPS_2642 putative lipoprotein; PFAM: Protein of unknown function DUF2006; SPTR: A0Y0K9 Putative lipoprotein; PFAM: Hydroxyneurosporene synthase (CrtC). (349 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | cmk | COGs: COG0283 Cytidylate kinase; InterPro IPR011994: IPR003136; KEGG: sse:Ssed_2299 cytidylate kinase; PFAM: cytidylate kinase region; SPTR: A8FVN5 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase. (228 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa) |
| | Fbal_1947 | COGs: COG0208 Ribonucleotide reductase beta subunit; InterPro IPR000358; KEGG: prw:PsycPRwf_1578 ribonucleotide-diphosphate reductase subunit beta; PFAM: ribonucleotide reductase; SPTR: P43755 Ribonucleoside-diphosphate reductase subunit beta; PFAM: Ribonucleotide reductase, small chain. (378 aa) |
| | Fbal_1949 | Glyoxalase/bleomycin resistance protein/dioxygenase; COGs: COG2764 conserved hypothetical protein; InterPro IPR004360; KEGG: cbd:CBUD_0821 PhnB; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: A3RPV0 PhnB protein; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (160 aa) |
| | Fbal_1958 | COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: slo:Shew_2002 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UZF9 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phospha [...] (338 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | Fbal_1996 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa) |
| | Fbal_2029 | Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722: IPR012726; KEGG: vpa:VP3022 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: A2PS83 Thiazole biosynthesis protein ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (370 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (253 aa) |
| | Fbal_2031 | COGs: COG2104 Sulfur transfer protein involved in thiamine biosynthesis; InterPro IPR003749: IPR010035; KEGG: seh:SeHA_C4491 sulfur carrier protein ThiS; PFAM: thiamineS protein; SPTR: A3EJT1 Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (66 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (528 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (646 aa) |
| | Fbal_2047 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: hypothetical protein; PFAM: deoxynucleoside kinase; SPTR: A7S258 Predicted protein (Fragment); PFAM: Deoxynucleoside kinase. (209 aa) |
| | Fbal_2052 | Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722; KEGG: she:Shewmr4_3253 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Q6PSL4 Fe-hydrogenase assembly protein; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (477 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | Fbal_2067 | KEGG: amc:MADE_01799 hypothetical protein; SPTR: A0Y4X0 Putative orphan protein. (223 aa) |
| | purE-2 | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (362 aa) |
| | add | COGs: COG1816 Adenosine deaminase; InterPro IPR001365: IPR006330; KEGG: aha:AHA_0273 adenosine deaminase; PFAM: adenosine/AMP deaminase; PRIAM: Adenosine deaminase; SPTR: Q320Y0 Adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (332 aa) |
| | Fbal_2203 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | Fbal_2227 | COGs: COG3530 conserved hypothetical protein; KEGG: gbm:Gbem_0992 hypothetical protein; SPTR: A2V0B4 Putative uncharacterized protein. (71 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (233 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1021 aa) |
| | Fbal_2297 | RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; InterPro IPR000943: IPR007624: IPR013249: IPR007627: IPR 007630: IPR014284: IPR012845; KEGG: sse:Ssed_0051 flagellar biosynthesis sigma factor; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 3 domain protein; SPTR: A3FIL5 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma- [...] (242 aa) |
| | Fbal_2322 | Flagellar protein export ATPase FliI; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR000194: IPR004100: IPR003593: IPR020003: IPR 020005: IPR005714; KEGG: sse:Ssed_0074 FliI/YscN family ATPase; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; PRIAM: H(+)-transporting two-sector ATPase; SMART: AAA ATPase; SPTR: A3J9N8 Flagellum-specific ATP synthase; TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family; PFAM: ATP synthase alpha/beta family, [...] (440 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (354 aa) |
| | Fbal_2374 | Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; InterPro IPR006674: IPR003607; KEGG: cps:CPS_3233 hypothetical protein; PFAM: metal-dependent phosphohydrolase HD sub domain; PRIAM: 5'-nucleotidase; SMART: metal-dependent phosphohydrolase HD region; SPTR: A3GZX2 Putative uncharacterized protein. (200 aa) |
| | Fbal_2448 | KEGG: spl:Spea_0906 hypothetical protein; SPTR: Q53216 Uncharacterized protein y4vH. (178 aa) |
| | Fbal_2536 | COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999: IPR006805: IPR015890: IPR005257; KEGG: slo:Shew_2251 anthranilate synthase component I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: A3H2Y5 Anthranilate synthase aminase component; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: anthranilate synthase component I, proteobacterial subset. (518 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001240: IPR013798: IPR001468; KEGG: saz:Sama_2132 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase; SPTR: A2V450 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (458 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | Fbal_2555 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (711 aa) |
| | Fbal_2579 | COGs: COG2154 Pterin-4a-carbinolamine dehydratase; InterPro IPR001533: IPR017937; KEGG: shl:Shal_1532 pterin-4-alpha-carbinolamine dehydratase; PFAM: transcriptional coactivator/pterin dehydratase; PRIAM: 4a-hydroxytetrahydrobiopterin dehydratase; SPTR: B0TNB2 Putative pterin-4-alpha-carbinolamine dehydratase; PFAM: Pterin 4 alpha carbinolamine dehydratase. (113 aa) |
| | Fbal_2580 | COGs: COG3186 Phenylalanine-4-hydroxylase; InterPro IPR019774: IPR018301: IPR005960; KEGG: ilo:IL0725 phenylalanine 4-monooxygenase; PFAM: Aromatic amino acid hydroxylase-like; SPTR: A3WM90 Phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: Biopterin-dependent aromatic amino acid hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase, monomeric form. (263 aa) |
| | folD-2 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa) |
| | Fbal_2609 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR004101: IPR013221: IPR018109: IPR001645; KEGG: swp:swp_3115 folylpolyglutamate synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; PRIAM: Dihydrofolate synthase; SPTR: A2V423 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (416 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa) |
| | pdxB | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (379 aa) |
| | Fbal_2618 | ATP-NAD/AcoX kinase; COGs: COG3199 conserved hypothetical protein; InterPro IPR002504; KEGG: saz:Sama_2157 hypothetical protein; PFAM: ATP-NAD/AcoX kinase; SPTR: A2V1C0 ATP-NAD/AcoX kinase; PFAM: ATP-NAD kinase. (376 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | Fbal_2636 | InterPro IPR002035; KEGG: swp:swp_3145 Von Willebrand factor type A domain protein; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A; SPTR: A2V1A5 Von Willebrand factor, type A; PFAM: von Willebrand factor type A domain. (322 aa) |
| | Fbal_2639 | RNA polymerase, sigma-24 subunit, RpoE; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR013249: IPR007627: IPR000838: IPR014284; KEGG: saz:Sama_2175 RNA polymerase sigma factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: A2V1A2 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa) |
| | Fbal_2640 | KEGG: saz:Sama_2176 hypothetical protein; SPTR: A2V1A1 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3379). (233 aa) |
| | Fbal_2641 | GCN5-related N-acetyltransferase; COGs: COG2153 acyltransferase; InterPro IPR000182; KEGG: xca:xccb100_0706 hypothetical protein; PFAM: GCN5-related N-acetyltransferase; SPTR: A2VRM9 Putative uncharacterized protein; PFAM: Acetyltransferase (GNAT) family. (155 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1297 aa) |
| | Fbal_2728 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (188 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (524 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | Fbal_2772 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: sdn:Sden_1407 siroheme synthase; PRIAM: Precorrin-2 dehydrogenase; SPTR: A2V188 Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. (307 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (72 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (374 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase-iso merase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (352 aa) |
| | Fbal_2794 | COGs: COG0248 Exopolyphosphatase; InterPro IPR003695; KEGG: amc:MADE_03154 putative exopolyphosphatase; PFAM: Ppx/GppA phosphatase; PRIAM: Guanosine-5'-triphosphate,3'-diphosphate diphosphatase; SPTR: A3GPM3 Exopolyphosphatase; PFAM: Ppx/GppA phosphatase family; Belongs to the GppA/Ppx family. (495 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | Fbal_2845 | CBS domain containing protein; COGs: COG4535 Putative Mg2+ and Co2+ transporter CorC; InterPro IPR000644: IPR005170; KEGG: slo:Shew_2926 CBS domain-containing protein; PFAM: CBS domain containing protein; transporter-associated region; SMART: CBS domain containing protein; SPTR: A2UY78 CBS domain containing protein; PFAM: CBS domain; Transporter associated domain. (304 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (500 aa) |
| | Fbal_2879 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (278 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005483: IPR003135: IPR005479: IPR003806: IPR 011607: IPR005480: IPR005481: IPR011761: IPR006275; KEGG: slo:Shew_2838 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A2UYB9 Carbamoyl-phosphate synthase, larg [...] (1073 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006220: IPR011702: IPR001317: IPR002474: IPR 000991: IPR006274; KEGG: saz:Sama_2504 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q8EHS6 Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (382 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (309 aa) |
| | Fbal_2930 | Protein of unknown function DUF179; COGs: COG1678 Putative transcriptional regulator protein; InterPro IPR003774; KEGG: sse:Ssed_1237 hypothetical protein; PFAM: protein of unknown function DUF179; SPTR: A8FSM5 UPF0301 protein Ssed_1237; PFAM: Uncharacterized ACR, COG1678. (187 aa) |
| | Fbal_2949 | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (379 aa) |
| | Fbal_2983 | RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR013249: IPR007627: IPR007630: IPR014284; KEGG: ilo:IL1391 RNA polymerase sigma factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; SPTR: A3WL47 RNA polymerase sigma-70 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa) |
| | Fbal_3005 | Cobalamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR017858: IPR002779; KEGG: AGAP012864-PA; PFAM: cobalamin adenosyltransferase; SPTR: A0NAI0 AGAP012864-PA; PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase. (180 aa) |
| | Fbal_3012 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (199 aa) |
| | Fbal_3080 | Erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (341 aa) |
| | pyrB | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006130: IPR002082: IPR002292: IPR006132: IPR 006131; KEGG: vsp:VS_2740 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: A3UTH1 Aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: as [...] (309 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa) |
| | hemL | COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: saz:Sama_0839 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: A1S3U0 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (429 aa) |
| | Fbal_3126 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (336 aa) |
| | Fbal_3138 | COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR006076: IPR003953: IPR006311: IPR010960; KEGG: sse:Ssed_0344 flavocytochrome c flavin subunit, putative; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; SPTR: A2UXH7 Flavocytochrome c; TIGRFAM: flavocytochrome c; PFAM: FAD binding domain; TIGRFAM: flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (519 aa) |
| | Fbal_3214 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: tau:Tola_2301 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: A3LK30 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphok [...] (158 aa) |
| | Fbal_3235 | Queuine/other tRNA-ribosyltransferase; InterPro IPR002616; KEGG: cps:CPS_2935 hypothetical protein; PFAM: Queuine/other tRNA-ribosyltransferase; SPTR: A3IZM8 Putative uncharacterized protein; PFAM: Queuine tRNA-ribosyltransferase; TIGRFAM: tRNA-guanine transglycosylases, various specificities. (419 aa) |
| | queC-2 | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (220 aa) |
| | Fbal_3246 | KEGG: slo:Shew_1473 hypothetical protein; SPTR: A3WP97 Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase. (293 aa) |
| | queE-2 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (224 aa) |
| | Fbal_3253 | Glyoxalase/bleomycin resistance protein/dioxygenase; COGs: COG2764 conserved hypothetical protein; InterPro IPR004360; KEGG: bgl:bglu_1g05330 glyoxalase family protein; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: A2WCR3 Putative uncharacterized protein; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (141 aa) |
| | Fbal_3257 | COGs: COG2927 DNA polymerase III chi subunit; InterPro IPR007459; KEGG: saz:Sama_0791 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit HolC; PRIAM: DNA-directed DNA polymerase; SPTR: A2UZ59 DNA polymerase III chi subunit, HolC; PFAM: DNA polymerase III chi subunit, HolC. (153 aa) |
| | Fbal_3265 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: sbn:Sbal195_1228 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; SPTR: A2V2A0 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi [...] (164 aa) |
| | Fbal_3266 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (595 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (610 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636: IPR014106; KEGG: ppr:PBPRA1469 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q480B3 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type. (367 aa) |
| | Fbal_3309 | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | Fbal_3313 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (252 aa) |
| | Fbal_3339 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR010723: IPR007197: IPR010413: IPR006638; KEGG: ppr:PBPRA2102 coproporphyrinogen III oxidase; PFAM: protein of unknown function DUF1008; Radical SAM domain protein; HemN domain protein; PRIAM: Coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; SPTR: A3H2W4 Radical SAM family protein HutW similar to coproporphyrinogen III oxidase oxygen-independent associated with heme uptake; PFAM: Radical SAM superfamily; ChuX-like family; HemN C-terminal region. (681 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (328 aa) |
| | Fbal_3363 | ApaG domain protein; COGs: COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport; InterPro IPR007474; KEGG: swp:swp_4088 ApaG protein; PFAM: ApaG domain protein; SPTR: B8CSX6 Protein apaG; PFAM: Protein of unknown function (DUF525). (124 aa) |
| | Fbal_3367 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa) |
| | Fbal_3442 | RNA polymerase, sigma 54 subunit, RpoN/SigL; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (485 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (728 aa) |
| | Fbal_3533 | COGs: COG2068 Uncharacterized MobA-related protein; InterPro IPR001228; KEGG: sfr:Sfri_1413 hypothetical protein; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; SPTR: Q4JA99 Universally conserved protein; PFAM: Uncharacterized protein family UPF0007. (208 aa) |
| | Fbal_3555 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: slo:Shew_3382 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: A2V4N4 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (421 aa) |
| | Fbal_3672 | KEGG: vha:VIBHAR_05694 hypothetical protein; SPTR: A3UWU7 Putative uncharacterized protein; PFAM: Nitrous oxide-stimulated promoter. (130 aa) |
| | Fbal_3688 | HemY domain protein; COGs: COG3071 Uncharacterized protein of heme biosynthesis; InterPro IPR010817: IPR013026; KEGG: shn:Shewana3_0383 HemY domain-containing protein; PFAM: HemY domain protein; SPTR: A2UYP3 HemY-like; PFAM: HemY protein N-terminus; TIGRFAM: hemY protein. (387 aa) |
| | Fbal_3690 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | Fbal_3692 | COGs: COG3072 Adenylate cyclase; InterPro IPR000274; KEGG: shw:Sputw3181_3725 adenylate cyclase; PFAM: adenylate cyclase class-I; PRIAM: Adenylate cyclase; SPTR: A2UYN9 Adenylate cyclase, class-I; PFAM: Adenylate cyclase, class-I. (792 aa) |
| | Fbal_3716 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR010723: IPR007197: IPR006638: IPR017441; KEGG: son:SO_4520 coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; PRIAM: Coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; SPTR: A2V621 Radical SAM; PFAM: Radical SAM superfamily; HemN C-terminal region. (444 aa) |
| | Fbal_3735 | Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (220 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (922 aa) |
| | Fbal_3746 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR010723: IPR007197: IPR006638: IPR004558; KEGG: son:SO_4730 coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; PRIAM: Coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; SPTR: A2V5C7 Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyri [...] (456 aa) |
| | Fbal_3747 | COGs: COG1816 Adenosine deaminase; InterPro IPR001365: IPR006330; KEGG: aha:AHA_0273 adenosine deaminase; PFAM: adenosine/AMP deaminase; PRIAM: Adenosine deaminase; SPTR: A2PCL5 Adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase. (335 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (286 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (450 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (141 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa) |
