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| | Fbal_1860 | Aminodeoxychorismate lyase; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544: IPR018300: IPR017824; KEGG: asa:ASA_2051 4-amino-4-deoxychorismate lyase; PFAM: aminotransferase class IV; SPTR: A2V2R9 Aminotransferase, class IV; TIGRFAM: aminodeoxychorismate lyase; PFAM: Aminotransferase class IV; TIGRFAM: aminodeoxychorismate lyase. (270 aa) |
| | fabA | 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (179 aa) |
| | Fbal_1921 | Protein of unknown function DUF227; InterPro IPR002575: IPR004119: IPR015897; KEGG: pat:Patl_3439 hypothetical protein; PFAM: protein of unknown function DUF227; aminoglycoside phosphotransferase; SMART: CHK kinase-like; SPTR: A1ZY78 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF227). (320 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | hisC-2 | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR001176: IPR004839: IPR001917: IPR005861; KEGG: pin:Ping_1116 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q5QZ49 Histidinol-phosphate aminotransferase 1; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | Fbal_2050 | Iron-only hydrogenase maturation protein HydE; COGs: COG0502 Biotin synthase; InterPro IPR007197: IPR006638; KEGG: shl:Shal_1413 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: A1HRP0 Radical SAM domain protein; PFAM: Radical SAM superfamily. (342 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | Fbal_2157 | COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960: IPR011921; KEGG: sbp:Sbal223_2416 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; PFAM: lipid A biosynthesis acyltransferase; SPTR: A2V127 Lipid A biosynthesis (KDO)2-(Lauroyl)-lipid IVA acyltransferase; TIGRFAM: lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase; TIGRFAM: lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase. (310 aa) |
| | lpxM | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | Fbal_2165 | GCN5-related N-acetyltransferase; InterPro IPR020441: IPR000182; KEGG: mxa:MXAN_6424 acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Q08021 Uncharacterized N-acetyltransferase yjgM; PFAM: Acetyltransferase (GNAT) family. (164 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisI | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR002496: IPR008179; KEGG: swp:swp_3009 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: A2V1X4 Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (202 aa) |
| | Fbal_1681 | Periplasmic copper-binding protein; COGs: COG3420 Nitrous oxidase accessory protein; InterPro IPR007742: IPR006626: IPR006633; KEGG: swp:swp_4649 periplasmic copper-binding; PFAM: periplasmic copper-binding; SMART: Carbohydrate-binding and sugar hydrolysis; Parallel beta-helix repeat; SPTR: A2UUX7 Periplasmic copper-binding; PFAM: Periplasmic copper-binding protein (NosD); Protein of unknown function (DUF1565). (432 aa) |
| | Fbal_1521 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR013154: IPR013149; KEGG: vha:VIBHAR_05254 oxidoreductase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: A1DS54 DTDP-glucose 4,6-dehydratase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (327 aa) |
| | Fbal_1443 | COGs: COG1045 Serine acetyltransferase; InterPro IPR001451: IPR010493: IPR018357: IPR005881; KEGG: amc:MADE_00201 serine acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein; PRIAM: Serine O-acetyltransferase; SPTR: A0XYV3 Serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase. (267 aa) |
| | Fbal_1399 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | Fbal_1396 | COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043: IPR004410; KEGG: son:SO_2777 acyl carrier protein S-malonyltransferase; PFAM: Acyl transferase; SPTR: P0AAI9 Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; malonate decarboxylase, epsilon subunit. (309 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (322 aa) |
| | plsX | Phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (341 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa) |
| | Fbal_1376 | Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216: IPR013217; KEGG: psa:PST_3863 biotin synthesis protein BioC; PFAM: Methyltransferase type 11; Methyltransferase type 12; SPTR: A3LHV6 Putative uncharacterized protein; PFAM: Methyltransferase domain; TIGRFAM: biotin biosynthesis protein BioC. (243 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (341 aa) |
| | Fbal_1373 | COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814: IPR005815; KEGG: spe:Spro_1310 adenosylmethionine--8-amino-7-oxononanoate transaminase; PFAM: aminotransferase class-III; SPTR: Q5LEY1 Biotin synthase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | Fbal_1244 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426; KEGG: sbn:Sbal195_1769 asparagine synthetase B; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: A2V529 Asparagine synthase (Glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (554 aa) |
| | Fbal_1219 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426: IPR017535; KEGG: pla:Plav_0816 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: A0P460 Putative asparagine synthetase (Glutamine amidotransferase) protein; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrol [...] (588 aa) |
| | Fbal_1148 | Aminotransferase class-III; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: aha:AHA_0245 beta alanine--pyruvate transaminase; PFAM: aminotransferase class-III; SPTR: A0P1C1 Beta alanine-pyruvate transaminase; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa) |
| | Fbal_1138 | Aminotransferase class-III; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: asa:ASA_0173 putative aminotransferase; PFAM: aminotransferase class-III; SPTR: A3LHA6 Putrescine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (466 aa) |
| | Fbal_1137 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: asa:ASA_0172 glutamine synthetase; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A2VUT5 Glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain. (443 aa) |
| | Fbal_1136 | Glutamate--putrescine ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: cps:CPS_4677 glutamine synthetase family protein; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A3LHA3 Putative uncharacterized protein; PFAM: Glutamine synthetase, catalytic domain. (459 aa) |
| | Fbal_1087 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR011128: IPR014027: IPR014026: IPR001732: IPR 017476; KEGG: vha:VIBHAR_00706 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: A3EK13 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-g [...] (388 aa) |
| | Fbal_1017 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002932; KEGG: hch:HCH_00332 glutamate synthase domain-containing 2; PFAM: ferredoxin-dependent glutamate synthase; SPTR: A0YEB0 Glutamate synthase domain 2; PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (504 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (311 aa) |
| | Fbal_0993 | COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR000022: IPR011762: IPR011763; KEGG: shl:Shal_2903 propionyl-CoA carboxylase; PFAM: carboxyl transferase; PRIAM: Methylcrotonoyl-CoA carboxylase; SPTR: A2V348 Carboxyl transferase; PFAM: Carboxyl transferase domain. (535 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | fabZ | 3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | dapD | COGs: COG2171 Tetrahydrodipicolinate N-succinyltransferase; InterPro IPR001451: IPR018357: IPR005664; KEGG: shl:Shal_2984 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; PRIAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; SPTR: B0TP86 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; TIGRFAM:2,3,4,5-tetrahydropyridine-2,6-dicarboxylat eN-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | Fbal_0939 | KEGG: son:SO_1613 hypothetical protein; SPTR: A2UVK2 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2789). (76 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | Fbal_0881 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (291 aa) |
| | Fbal_0880 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa) |
| | Fbal_0858 | COGs: COG0527 Aspartokinase; InterPro IPR001057: IPR002912: IPR001048: IPR018042: IPR 005260: IPR001341; KEGG: pin:Ping_3379 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: A0Z876 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (406 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | Fbal_0805 | KEGG: ppg:PputGB1_3052 nonspecific acid phosphatase; SPTR: A3HUP4 Nonspecific acid phosphatase. (324 aa) |
| | Fbal_0768 | COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR000634: IPR004450; KEGG: shn:Shewana3_1141 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: A2V050 Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | Fbal_0766 | COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR002912: IPR005106: IPR001048: IPR 019811: IPR018042: IPR001341; KEGG: saz:Sama_0905 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2V048 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase; [...] (818 aa) |
| | Fbal_0753 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR006218: IPR002912: IPR002701: IPR 018528: IPR006268: IPR010952; KEGG: swd:Swoo_1263 chorismate mutase; PFAM: prephenate dehydratase; DAHP synthetase I/KDSA; amino acid-binding ACT domain protein; Chorismate mutase; SPTR: A2UV42 Chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase domain of p [...] (672 aa) |
| | Fbal_0744 | Chorismate mutase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002701: IPR011277; KEGG: saz:Sama_0894 bifunctional chorismate mutase/prephenate dehydrogenase; PFAM: Chorismate mutase; Prephenate dehydrogenase; SPTR: A2UV38 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydrogenase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of T-protein. (378 aa) |
| | Fbal_0743 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa) |
| | Fbal_0688 | COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR002912: IPR006140; KEGG: vpa:VP2593 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: A3ELN9 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (409 aa) |
| | Fbal_0667 | Aspartate-ammonia ligase; COGs: COG2502 Asparagine synthetase A; InterPro IPR004618: IPR006195; KEGG: sfv:SFV_3770 asparagine synthetase AsnA; PFAM: aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Q83PJ4 Aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type. (325 aa) |
| | Fbal_0663 | COGs: COG0527 Aspartokinase; InterPro IPR001048: IPR018042: IPR005260: IPR001341; KEGG: sse:Ssed_0817 aspartate kinase III; PFAM: aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase; SPTR: P08660 Lysine-sensitive aspartokinase 3; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (460 aa) |
| | Fbal_0657 | Glutamate synthase (NADPH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002489: IPR002932: IPR006982: IPR000583; KEGG: slo:Shew_1032 glutamate synthase subunit alpha; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; PRIAM: Glutamate synthase (ferredoxin); SPTR: A2V2C5 Ferredoxin-dependent glutamate synthase; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1483 aa) |
| | mtnN | Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | lpxL | Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | Fbal_0550 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1058 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | Fbal_0469 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (150 aa) |
| | Fbal_0468 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | Fbal_0443 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR011128: IPR014027: IPR014026: IPR001732: IPR 017476; KEGG: tau:Tola_2842 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: A3EK13 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-gluc [...] (388 aa) |
| | Fbal_0386 | MaoC domain protein dehydratase; COGs: COG2030 Acyl dehydratase; InterPro IPR003965: IPR002539; KEGG: spl:Spea_1753 dehydratase; PFAM: MaoC domain protein dehydratase; SPTR: A9UWL2 Predicted protein; PFAM: MaoC like domain. (130 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (233 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | argH | N-acetylglutamate synthase; COGs: COG0165 Argininosuccinate lyase; InterPro IPR000362: IPR000182: IPR020557: IPR009049; KEGG: cps:CPS_0464 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; PFAM: fumarate lyase; GCN5-related N-acetyltransferase; SPTR: P59620 Bifunctional protein argH; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; Acetyltransferase (GNAT) family; TIGRFAM: argininosuccinate lyase; In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (643 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518: IPR018223; KEGG: amc:MADE_00529 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: A0XXT0 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | Fbal_0312 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa) |
| | Fbal_0233 | Transcriptional regulator, TetR family; InterPro IPR001647; KEGG: shl:Shal_4155 DNA-binding transcriptional repressor FabR; PFAM: regulatory protein TetR; SPTR: A2V2R1 Transcriptional regulator, TetR family; PFAM: Bacterial regulatory proteins, tetR family. (197 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (344 aa) |
| | bioH | Carboxylesterase BioH (pimeloyl-CoA synthesis); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (264 aa) |
| | ubiC | Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (177 aa) |
| | Fbal_0147 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR014027: IPR014026: IPR001732: IPR017476; KEGG: avn:Avin_27790 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: A3JJ75 Predicted UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP [...] (446 aa) |
| | Fbal_0091 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146: IPR008147: IPR001637: IPR004809; KEGG: vha:VIBHAR_00588 glutamine synthetase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: A0XX56 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (469 aa) |
| | Fbal_0057 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR018967: IPR002932: IPR006622; KEGG: vpa:VPA0765 putative glutamate synthetase; PFAM: ferredoxin-dependent glutamate synthase; Iron sulphur domain-containing, CDGSH-type; SMART: zinc finger CDGSH-type domain protein; SPTR: A3UQB8 Glutamate synthase domain protein; PFAM: Iron-binding zinc finger CDGSH type; Conserved region in glutamate synthase. (524 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa) |
| | Fbal_2197 | InterPro IPR002539; KEGG: mxa:MXAN_1481 MaoC domain-containing protein; PFAM: MaoC domain protein dehydratase; SPTR: A3TKR7 Putative dehydratase; PFAM: MaoC like domain. (277 aa) |
| | Fbal_2203 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | Fbal_2228 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: sdn:Sden_2013 pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: A2PU42 Cysteine synthase/cystathionine beta-synthase family protein; PFAM: Pyridoxal-phosphate dependent enzyme. (354 aa) |
| | Fbal_2265 | Transferase hexapeptide repeat containing protein; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: tgr:Tgr7_2377 transferase hexapeptide repeat containing protein; PFAM: transferase hexapeptide repeat containing protein; SPTR: Q46F84 Serine O-acetyltransferase. (196 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (354 aa) |
| | fabH-2 | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (359 aa) |
| | cysZ | Protein of unknown function DUF540; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (256 aa) |
| | Fbal_2424 | COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR001216: IPR005856: IPR005859; KEGG: yen:YE1208 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: P0A1E3 Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001240: IPR013798: IPR001468; KEGG: saz:Sama_2132 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase; SPTR: A2V450 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (458 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | Fbal_2580 | COGs: COG3186 Phenylalanine-4-hydroxylase; InterPro IPR019774: IPR018301: IPR005960; KEGG: ilo:IL0725 phenylalanine 4-monooxygenase; PFAM: Aromatic amino acid hydroxylase-like; SPTR: A3WM90 Phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: Biopterin-dependent aromatic amino acid hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase, monomeric form. (263 aa) |
| | fabV | Trans-2-enoyl-CoA reductase (NAD(+)); Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (402 aa) |
| | folD-2 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | Fbal_2609 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR004101: IPR013221: IPR018109: IPR001645; KEGG: swp:swp_3115 folylpolyglutamate synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; PRIAM: Dihydrofolate synthase; SPTR: A2V423 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (416 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa) |
| | asd-2 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | Fbal_2615 | COGs: COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; InterPro IPR014031: IPR014030: IPR018201; KEGG: vfm:VFMJ11_1826 3-oxoacyl-(acyl-carrier-protein) synthase 1; PFAM: Beta-ketoacyl synthase; SPTR: A3ELX7 3-oxoacyl-(Acyl-carrier-protein) synthase I; PFAM: Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (407 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | Fbal_2780 | Protein of unknown function DUF479; COGs: COG3124 conserved hypothetical protein; InterPro IPR007431; KEGG: slo:Shew_2339 hypothetical protein; PFAM: protein of unknown function DUF479; SPTR: A3L4P4 Putative uncharacterized protein; PFAM: Protein of unknown function, DUF479. (204 aa) |
| | Fbal_2814 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR019818; KEGG: swp:swp_3606 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: A2UVF1 Isocitrate/isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (335 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006218: IPR006269; KEGG: ttu:TERTU_2850 3-deoxy-8-phosphooctulonate synthase; PFAM: DAHP synthetase I/KDSA; SPTR: A0YEN9 2-dehydro-3-deoxyphosphooctonate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase. (283 aa) |
| | Fbal_2851 | COGs: COG0560 Phosphoserine phosphatase; InterPro IPR005834: IPR004469: IPR006383; KEGG: asa:ASA_3650 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Phosphoserine phosphatase; SPTR: A2UZE1 Phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (304 aa) |
| | Fbal_2879 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (278 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005483: IPR003135: IPR005479: IPR003806: IPR 011607: IPR005480: IPR005481: IPR011761: IPR006275; KEGG: slo:Shew_2838 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A2UYB9 Carbamoyl-phosphate synthase, larg [...] (1073 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006220: IPR011702: IPR001317: IPR002474: IPR 000991: IPR006274; KEGG: saz:Sama_2504 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q8EHS6 Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (382 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | Fbal_2894 | Short-chain dehydrogenase/reductase SDR; COGs: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; InterPro IPR002347: IPR002198: IPR013968: IPR001509; KEGG: ppr:PBPRA0143 oxidoreductase; PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; SPTR: A2PSZ2 Oxidoreductase, short-chain dehydrogenase/reductase family; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (240 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | Fbal_3020 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa) |
| | cysI | Sulfite reductase (NADPH) beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (579 aa) |
| | Fbal_3188 | Sulfite reductase (NADPH) alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (598 aa) |
| | Fbal_3214 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: tau:Tola_2301 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: A3LK30 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphok [...] (158 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | Fbal_3265 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: sbn:Sbal195_1228 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; SPTR: A2V2A0 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi [...] (164 aa) |
| | Fbal_3266 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa) |
| | Fbal_3308 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (358 aa) |
| | Fbal_3367 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (156 aa) |
| | Fbal_3397 | COGs: COG0429 hydrolase of the alpha/beta-hydrolase fold; InterPro IPR000073: IPR000952; KEGG: spc:Sputcn32_3122 alpha/beta hydrolase fold; PFAM: alpha/beta hydrolase fold; SPTR: A2V4B8 Alpha/beta hydrolase fold; PFAM: alpha/beta hydrolase fold. (321 aa) |
| | argD | COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814: IPR004636: IPR017652; KEGG: son:SO_0617 bifunctional N-succinyldiaminopimelate-aminotransferase/ acetylornithine transaminase protein; PFAM: aminotransferase class-III; PRIAM: Succinyldiaminopimelate transaminase; SPTR: P59320 Acetylornithine aminotransferase; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferases; Belongs to [...] (405 aa) |
| | Fbal_3511 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171: IPR004620; KEGG: sse:Ssed_4039 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: A2UWK0 Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. (297 aa) |
| | Fbal_3512 | COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR005106: IPR001048: IPR019811: IPR 018042: IPR001341; KEGG: saz:Sama_3170 bifunctional aspartate kinase II/homoserine dehydrogenase II; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2UWJ9 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine deh [...] (786 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: kpu:KP1_3685 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase; PFAM: histidine biosynthesis protein; SPTR: B8CR53 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM [...] (245 aa) |
| | Fbal_3514 | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. (106 aa) |
| | Fbal_3558 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR019546: IPR006311; KEGG: shl:Shal_3744 aminotransferase class I and II; PFAM: aminotransferase class I and II; Twin-arginine translocation pathway, signal sequence, subgroup; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; PFAM: TAT (twin-arginine translocation) pathway signal sequence; Aminotransferase class I and II; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; histidinol-phosphate aminotransferase. (380 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR020558: IPR004404; KEGG: slo:Shew_0292 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: A3Q9L6 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (323 aa) |
| | Fbal_3649 | COGs: COG3978 Acetolactate synthase (isozyme II) small (regulatory) subunit; KEGG: sdn:Sden_3413 acetolactate synthase 2 regulatory subunit; SPTR: A2UYR6 Amino acid-binding ACT. (87 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa) |
| | Fbal_3690 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (269 aa) |
| | Fbal_3737 | InterPro IPR000182; KEGG: swd:Swoo_0090 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: A3UP63 Putative uncharacterized protein; PFAM: Acetyltransferase (GNAT) family. (148 aa) |
| | mtnC | Acireductone synthase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (225 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR013954: IPR020565: IPR006543: IPR 005954: IPR006549; KEGG: ppr:PBPRA1089 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; PRIAM: Histidinol-phosphatase; SPTR: P62455 Histidine biosynthesis bifunctional protein hisB; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase; Imidazoleglyce [...] (355 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR001917: IPR005861; KEGG: slo:Shew_2199 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q8EFB2 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (307 aa) |
| | Fbal_1799 | COGs: COG0656 Aldo/keto reductase related to diketogulonate reductase; InterPro IPR020471: IPR001395: IPR018170; KEGG: ttu:TERTU_2150 2,5-didehydrogluconate reductase; PFAM: aldo/keto reductase; SPTR: A0XYC6 2,5-diketo-D-gluconate reductase B; PFAM: Aldo/keto reductase family. (268 aa) |
