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| | glyS | COGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR002311: IPR008909: IPR002114: IPR006194: IPR 015944; KEGG: esa:ESA_04169 glycyl-tRNA synthetase subunit beta; PFAM: glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain protein; PRIAM: Glycine--tRNA ligase; SPTR: A7MKS3 Glycyl-tRNA synthetase beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit; PFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit. (697 aa) |
| | glyQ | COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; InterPro IPR002310: IPR006194; KEGG: vcj:VCD_001489 glycyl-tRNA synthetase alpha chain; PFAM: glycyl-tRNA synthetase alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: A3GYE7 Glycyl-tRNA synthetase, alpha chain; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit. (303 aa) |
| | Fbal_0041 | O-succinylbenzoate-CoA ligase; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020459: IPR000873: IPR010192; KEGG: slo:Shew_3602 O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2V3Q7 O-succinylbenzoate-CoA ligase; TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-binding enzyme; TIGRFAM: O-succinylbenzoate-CoA ligase. (455 aa) |
| | Fbal_0091 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146: IPR008147: IPR001637: IPR004809; KEGG: vha:VIBHAR_00588 glutamine synthetase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: A0XX56 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (469 aa) |
| | Fbal_0108 | AMP-dependent synthetase and ligase; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR020459: IPR000873; KEGG: shm:Shewmr7_0326 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2UYT5 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (548 aa) |
| | Fbal_0131 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa) |
| | birA | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (320 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518: IPR018223; KEGG: amc:MADE_00529 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: A0XXT0 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (335 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (487 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanylligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (455 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (433 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (486 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR003806: IPR020560: IPR020562: IPR020561: IPR 011761: IPR020559: IPR000115; KEGG: ppr:PBPRA3420 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; protein of unknown function DUF201; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Q87KS8 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phospho [...] (428 aa) |
| | Fbal_0468 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | Fbal_0493 | lysyl-tRNA synthetase-related protein GenX; COGs: COG2269 Truncated possibly inactive lysyl-tRNA synthetase (class II); InterPro IPR018149: IPR004364: IPR006195: IPR004525; KEGG: vpa:VP2838 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); SPTR: Q87KY6 Putative lysyl-tRNA synthetase; TIGRFAM: lysyl-tRNA synthetase-related protein GenX; PFAM: tRNA synthetases class II (D, K and N); TIGRFAM: lysyl-tRNA synthetase-related protein GenX. (323 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | glnE | (Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (947 aa) |
| | mpl | UDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (455 aa) |
| | gshB | COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR003806: IPR004218: IPR013651: IPR004215: IPR 011761: IPR006284; KEGG: saz:Sama_0574 glutathione synthetase; PFAM: glutathione synthetase ATP-binding; protein of unknown function DUF201; RimK domain protein ATP-grasp; glutathione synthetase domain protein; PRIAM: Glutathione synthase; SPTR: A2UUD6 Glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: Prokaryotic glutathione synthetase, N-terminal domain; Prokaryotic glutathione synthetase, ATP-grasp domain; TIGRFAM: [...] (314 aa) |
| | Fbal_0615 | DNA ligase (ATP); COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310; KEGG: abo:ABO_2702 DNA ligase; PFAM: ATP dependent DNA ligase; PRIAM: DNA ligase (ATP); SPTR: A3J8E6 DNA ligase; PFAM: ATP dependent DNA ligase domain. (280 aa) |
| | Fbal_0624 | COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: eic:NT01EI_3361 5-formyltetrahydrofolate cyclo-ligase, putative; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: A3UUX9 Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (198 aa) |
| | Fbal_0667 | Aspartate-ammonia ligase; COGs: COG2502 Asparagine synthetase A; InterPro IPR004618: IPR006195; KEGG: sfv:SFV_3770 asparagine synthetase AsnA; PFAM: aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Q83PJ4 Aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type. (325 aa) |
| | lysS | COGs: COG1190 Lysyl-tRNA synthetase (class II); InterPro IPR018149: IPR004364: IPR004365: IPR006195: IPR 002313; KEGG: vfm:VFMJ11_0452 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; SPTR: B5F9U5 Lysyl-tRNA synthetase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family. (493 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (940 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (539 aa) |
| | lipB | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (215 aa) |
| | leuS | COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR002302: IPR015413: IPR013155: IPR002300: IPR 001412; KEGG: vpa:VP0727 leucyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ia; tRNA synthetase class I (M); tRNA synthetase valyl/leucyl anticodon-binding; SPTR: Q87RQ0 Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family. (859 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (876 aa) |
| | gshA | Glutamate-cysteine ligase; COGs: COG2918 Gamma-glutamylcysteine synthetase; InterPro IPR007370: IPR006334; KEGG: slo:Shew_1227 glutamate--cysteine ligase; PFAM: glutamate--cysteine ligase; PRIAM: Glutamate--cysteine ligase; SPTR: Q8EBF9 Glutamate--cysteine ligase; TIGRFAM: glutamate/cysteine ligase; PFAM: Glutamate-cysteine ligase; TIGRFAM: glutamate--cysteine ligase; glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type. (515 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | tilS | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (446 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (570 aa) |
| | Fbal_0991 | COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005482: IPR005479: IPR020561: IPR000089: IPR 005481: IPR011761: IPR011764: IPR001882; KEGG: saz:Sama_1359 3-methylcrotonyl-CoA carboxylase alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A2V346 Carbamoyl-phosphate synthase L chain, ATP-binding; PFAM: Carbamoyl-phosphate synthase L c [...] (649 aa) |
| | Fbal_0993 | COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR000022: IPR011762: IPR011763; KEGG: shl:Shal_2903 propionyl-CoA carboxylase; PFAM: carboxyl transferase; PRIAM: Methylcrotonoyl-CoA carboxylase; SPTR: A2V348 Carboxyl transferase; PFAM: Carboxyl transferase domain. (535 aa) |
| | Fbal_0998 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020459: IPR000873; KEGG: swp:swp_3440 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2V351 AMP-dependent synthetase and ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. (635 aa) |
| | Fbal_1136 | Glutamate--putrescine ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: cps:CPS_4677 glutamine synthetase family protein; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A3LHA3 Putative uncharacterized protein; PFAM: Glutamine synthetase, catalytic domain. (459 aa) |
| | Fbal_1137 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: asa:ASA_0172 glutamine synthetase; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A2VUT5 Glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain. (443 aa) |
| | Fbal_1198 | Urea amidolyase related protein; COGs: COG1984 Allophanate hydrolase subunit 2; InterPro IPR003778; KEGG: mca:MCA0477 allophanate hydrolase, subunit 2; PFAM: Allophanate hydrolase subunit 2; PRIAM: Urea carboxylase; SMART: Allophanate hydrolase subunit 2; SPTR: Q7WY77 KipI antagonist; TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; TIGRFAM: biotin-dependent carboxylase uncharacterized domain. (325 aa) |
| | Fbal_1218 | GNAT-family acetyltransferase TIGR03103; COGs: COG1181 D-alanine-D-alanine ligase and related ATP-grasp protein; InterPro IPR000182: IPR013651: IPR011761: IPR017534; KEGG: pla:Plav_0815 glutathione synthase; PFAM: GCN5-related N-acetyltransferase; RimK domain protein ATP-grasp; PRIAM: Cyanophycin synthase (L-arginine-adding); SPTR: A3LDQ6 Putative uncharacterized protein; TIGRFAM: GNAT-family acetyltransferase TIGR03103; PFAM: RimK-like ATP-grasp domain; Acetyltransferase (GNAT) family; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type [...] (579 aa) |
| | Fbal_1219 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426: IPR017535; KEGG: pla:Plav_0816 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: A0P460 Putative asparagine synthetase (Glutamine amidotransferase) protein; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrol [...] (588 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918: IPR000728: IPR004733; KEGG: sbp:Sbal223_2549 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: A9KY38 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: pho [...] (345 aa) |
| | rimK | COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR003806: IPR013651: IPR011761: IPR004666; KEGG: cja:CJA_1251 ribosomal protein S6 modification protein; PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; SPTR: B3PCD4 Ribosomal protein S6 modification protein; TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family; Belongs to the RimK family. (303 aa) |
| | Fbal_1347 | COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020459: IPR000873; KEGG: swd:Swoo_3995 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2UX84 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (523 aa) |
| | fhs | Formate-tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559; KEGG: ppr:PBPRA2764 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Q6LNJ0 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. (580 aa) |
| | glnS | COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase; InterPro IPR020060: IPR020059: IPR020058: IPR001412: IPR 004514; KEGG: vpa:VP0832 glutaminyl-tRNA synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; PRIAM: Glutamine--tRNA ligase; SPTR: Q87RG4 Glutaminyl-tRNA synthetase; TIGRFAM: glutaminyl-tRNA synthetase; PFAM: tRNA synthetases class I (E and Q), catalytic domain; tRNA synthetases class I (E and Q), anti-codon binding domain; TIGRFAM: glutaminyl-tRNA synthetase. (556 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa) |
| | Fbal_1405 | alpha-L-glutamate ligase, RimK family; COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR003806: IPR013651: IPR011761: IPR004666; KEGG: son:SO_2200 ribosomal protein S6 modification protein, putative; PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; SPTR: A2V4S7 Alpha-L-glutamate ligases, RimK family; TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family; Belongs to the RimK family. (302 aa) |
| | Fbal_1444 | Glutamate--cysteine ligase GCS2; InterPro IPR006336; KEGG: hch:HCH_00352 hypothetical protein; PFAM: glutamate--cysteine ligase GCS2; SPTR: A0YFA7 Putative uncharacterized protein; PFAM: Glutamate-cysteine ligase family 2(GCS2). (490 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa) |
| | pheS | COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterPro IPR004188: IPR002319: IPR006195: IPR004529; KEGG: aha:AHA_2323 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; PRIAM: Phenylalanine--tRNA ligase; SPTR: A0KKP5 Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the cla [...] (327 aa) |
| | pheT | COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterPro IPR002547: IPR005121: IPR005147: IPR005146: IPR 004532; KEGG: shl:Shal_1813 phenylalanyl-tRNA synthetase subunit beta; PFAM: B3/4 domain protein; ferredoxin-fold anticodon-binding; t-RNA-binding domain protein; tRNA synthetase B5; SPTR: A2V125 Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete [...] (795 aa) |
| | Fbal_1719 | COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020459: IPR000873; KEGG: she:Shewmr4_2177 long-chain-fatty-acid--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2V4U7 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (557 aa) |
| | Fbal_1722 | COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020459: IPR000873; KEGG: aha:AHA_2204 long-chain-fatty-acid--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: P69451 Long-chain-fatty-acid--CoA ligase; PFAM: AMP-binding enzyme. (555 aa) |
| | asnS | COGs: COG0017 Aspartyl/asparaginyl-tRNA synthetase; InterPro IPR002312: IPR004364: IPR004365: IPR006195: IPR 004522; KEGG: sdn:Sden_1958 asparaginyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; SPTR: Q12MT5 Asparaginyl-tRNA synthetase; TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: asparaginyl-tRNA synthetase. (466 aa) |
| | thrS | Ser-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (644 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (685 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (588 aa) |
| | Fbal_2015 | alpha-L-glutamate ligase-like protein; InterPro IPR011758; KEGG: saz:Sama_1849 alpha-L-glutamate ligase-related protein; SPTR: A3UU38 Putative uncharacterized protein; TIGRFAM: alpha-L-glutamate ligase-like protein; TIGRFAM: alpha-L-glutamate ligase-related protein. (318 aa) |
| | Fbal_2048 | Glutathione synthase; InterPro IPR005615; KEGG: vfm:VFMJ11_1030 glutathione synthetase; PFAM: glutathione synthase ATP-binding; PRIAM: Glutathione synthase; SPTR: A3XSR1 Glutathione synthetase; PFAM: Eukaryotic glutathione synthase; Eukaryotic glutathione synthase, ATP binding domain; TIGRFAM: glutathione synthetase, eukaryotic. (485 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (362 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (233 aa) |
| | Fbal_2253 | Trypanothione synthase; COGs: COG0754 Glutathionylspermidine synthase; InterPro IPR005494; KEGG: pat:Patl_1219 glutathionylspermidine synthase; PFAM: glutathionylspermidine synthase; PRIAM: Trypanothione synthase; SPTR: P0ADT5 Uncharacterized protein ygiC; PFAM: Glutathionylspermidine synthase. (388 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (685 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (470 aa) |
| | cysS | COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803: IPR015413: IPR015273: IPR002308; KEGG: pha:PSHAa2065 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); PRIAM: Cysteine--tRNA ligase; SPTR: Q3IF51 Cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | Fbal_2609 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR004101: IPR013221: IPR018109: IPR001645; KEGG: swp:swp_3115 folylpolyglutamate synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; PRIAM: Dihydrofolate synthase; SPTR: A2V423 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (416 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1297 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (524 aa) |
| | hisS | COGs: COG0124 Histidyl-tRNA synthetase; InterPro IPR002314: IPR004154: IPR006195: IPR015807; KEGG: sdn:Sden_1257 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Q12PT3 Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase. (425 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005483: IPR003135: IPR005479: IPR003806: IPR 011607: IPR005480: IPR005481: IPR011761: IPR006275; KEGG: slo:Shew_2838 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A2UYB9 Carbamoyl-phosphate synthase, larg [...] (1073 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006220: IPR011702: IPR001317: IPR002474: IPR 000991: IPR006274; KEGG: saz:Sama_2504 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q8EHS6 Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (382 aa) |
| | Fbal_3021 | phenylacetate-CoA ligase, putative; COGs: COG1541 Coenzyme F390 synthetase; KEGG: swp:swp_3485 phenylacetate-CoA ligase, putative; SPTR: A0XYN7 Putative phenylacetate-coenzyme A ligase; PFAM: AMP-binding enzyme. (409 aa) |
| | Fbal_3026 | AMP-dependent synthetase and ligase; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: swp:swp_3490 branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding, putative; PFAM: AMP-dependent synthetase and ligase; SPTR: A0XYP2 Putative branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding protein; PFAM: AMP-binding enzyme. (653 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (395 aa) |
| | Fbal_3207 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (185 aa) |
| | gluQ | Glutamate--tRNA ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (292 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa) |
| | queC-2 | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (220 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (948 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636: IPR014106; KEGG: ppr:PBPRA1469 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q480B3 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type. (367 aa) |
| | Fbal_3320 | alpha-L-glutamate ligase, RimK family; COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR003806: IPR013651: IPR011761: IPR004666; KEGG: shm:Shewmr7_2272 alpha-L-glutamate ligase; PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; SPTR: A2V4S7 Alpha-L-glutamate ligases, RimK family; TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family; Belongs to the RimK family. (311 aa) |
| | argS | COGs: COG0018 Arginyl-tRNA synthetase; InterPro IPR015945: IPR005148: IPR008909: IPR001278; KEGG: tau:Tola_0472 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; SPTR: Q6D474 Arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase. (582 aa) |
| | Fbal_3576 | YbaK/prolyl-tRNA synthetase associated region; COGs: COG2606 conserved hypothetical protein; InterPro IPR007214; KEGG: swd:Swoo_1361 YbaK/prolyl-tRNA synthetase associated region; PFAM: YbaK/prolyl-tRNA synthetase associated region; SPTR: A3RU42 Putative uncharacterized protein; PFAM: YbaK / prolyl-tRNA synthetases associated domain. (171 aa) |
| | Fbal_3779 | AMP-dependent synthetase and ligase; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR020459: IPR000873; KEGG: shm:Shewmr7_0076 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2UY18 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (611 aa) |
