Your Input: | |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa) |
| | Fbal_2395 | COGs: COG2423 ornithine cyclodeaminase mu-crystallin homolog; InterPro IPR006151: IPR003462; KEGG: rhi:NGR_c34200 ornithine cyclodeaminase/mu-crystallin family protein; PFAM: ornithine cyclodeaminase/mu-crystallin; Shikimate/quinate 5-dehydrogenase; PRIAM: Ornithine cyclodeaminase; SPTR: A0NQ11 Ornithine cyclodeaminase; PFAM: Ornithine cyclodeaminase/mu-crystallin family. (313 aa) |
| | Fbal_2400 | COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR002220: IPR005263; KEGG: saz:Sama_1531 dihydrodipicolinate synthetase family protein; PFAM: dihydrodipicolinate synthetase; SPTR: A3L5Z2 Putative uncharacterized protein; TIGRFAM: dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase; Belongs to the DapA family. (304 aa) |
| | Fbal_2517 | COGs: COG1760 L-serine deaminase; InterPro IPR005130: IPR005131: IPR004644; KEGG: swp:swp_1748 L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A2V1Y8 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (457 aa) |
| | Fbal_2536 | COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999: IPR006805: IPR015890: IPR005257; KEGG: slo:Shew_2251 anthranilate synthase component I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: A3H2Y5 Anthranilate synthase aminase component; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: anthranilate synthase component I, proteobacterial subset. (518 aa) |
| | Fbal_2537 | COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterPro IPR006220: IPR011702: IPR001317: IPR000991: IPR 006221; KEGG: sbp:Sbal223_1663 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: A2V452 Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (198 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001240: IPR013798: IPR001468; KEGG: saz:Sama_2132 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase; SPTR: A2V450 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (458 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | Fbal_2551 | Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa) |
| | Fbal_2579 | COGs: COG2154 Pterin-4a-carbinolamine dehydratase; InterPro IPR001533: IPR017937; KEGG: shl:Shal_1532 pterin-4-alpha-carbinolamine dehydratase; PFAM: transcriptional coactivator/pterin dehydratase; PRIAM: 4a-hydroxytetrahydrobiopterin dehydratase; SPTR: B0TNB2 Putative pterin-4-alpha-carbinolamine dehydratase; PFAM: Pterin 4 alpha carbinolamine dehydratase. (113 aa) |
| | Fbal_2581 | Methionine gamma-lyase; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: sfr:Sfri_1369 methionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Methionine gamma-lyase; SPTR: A2V4R7 Methionine gamma-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase; O-succinylhomoserine sulfhydrylase. (407 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (263 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | Fbal_2630 | 3-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (708 aa) |
| | mltF | Lytic transglycosylase catalytic; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (462 aa) |
| | Fbal_2784 | COGs: COG2224 Isocitrate lyase; InterPro IPR000918; KEGG: pap:PSPA7_2573 isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; SPTR: A0Z837 Isocitrate lyase; PFAM: Isocitrate lyase family; TIGRFAM: isocitrate lyase. (530 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (257 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (314 aa) |
| | Fbal_2913 | Pectate lyase; KEGG: pca:Pcar_1517 pectate lyase; SPTR: C1VZ34 Putative uncharacterized protein. (543 aa) |
| | Fbal_2935 | COGs: COG2008 Threonine aldolase; InterPro IPR001597: IPR000277; KEGG: son:SO_3338 L-allo-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Threonine aldolase; SPTR: A2V0A9 Aromatic amino acid beta-eliminating lyase/threonine aldolase; PFAM: Beta-eliminating lyase. (336 aa) |
| | Fbal_3001 | Adenosylmethionine decarboxylase; InterPro IPR001985: IPR018166; KEGG: saz:Sama_1962 adenosylmethionine decarboxylase; PFAM: S-adenosylmethionine decarboxylase; PRIAM: Adenosylmethionine decarboxylase; SPTR: A2V0H8 S-adenosylmethionine decarboxylase; PFAM: Adenosylmethionine decarboxylase; TIGRFAM: S-adenosylmethionine decarboxylase proenzyme, eukaryotic form. (309 aa) |
| | Fbal_3040 | Lytic transglycosylase catalytic; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (365 aa) |
| | Fbal_3078 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa) |
| | Fbal_3139 | COGs: COG2986 Histidine ammonia-lyase; InterPro IPR001106; KEGG: slo:Shew_2280 phenylalanine/histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase; SPTR: A1ZWV6 Phenylalanine and histidine ammonia-lyase; PFAM: Phenylalanine and histidine ammonia-lyase. (548 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | queE-2 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (224 aa) |
| | Fbal_3291 | COGs: COG1024 Enoyl-CoA hydratase/carnithine racemase; InterPro IPR001753; KEGG: she:Shewmr4_3240 enoyl-CoA hydratase; PFAM: Enoyl-CoA hydratase/isomerase; SPTR: A2V561 Enoyl-CoA hydratase/isomerase; PFAM: Enoyl-CoA hydratase/isomerase family. (247 aa) |
| | Fbal_3324 | COGs: COG1760 L-serine deaminase; InterPro IPR005130: IPR005131: IPR004644; KEGG: sse:Ssed_0859 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A3H312 L-serine dehydratase; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (454 aa) |
| | Fbal_3329 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (404 aa) |
| | Fbal_3408 | Glutamine amidotransferase of anthranilate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterPro IPR006220: IPR011702: IPR001317: IPR000991: IPR 006221; KEGG: aha:AHA_3181 para-aminobenzoate synthase glutamine amidotransferase component II; PFAM: glutamine amidotransferase class-I; SPTR: P06195 Para-aminobenzoate synthase glutamine amidotransferase component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (192 aa) |
| | Fbal_3410 | COGs: COG3957 Phosphoketolase; InterPro IPR018969: IPR018970: IPR005593: IPR019790: IPR 019789; KEGG: son:SO_3542 putative phosphoketolase; PFAM: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase-like; PRIAM: Phosphoketolase; SPTR: A2UZZ0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; PFAM: XFP N-terminal domain; D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; XFP C-terminal domain. (788 aa) |
| | Fbal_3513 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277: IPR011821; KEGG: slo:Shew_0520 O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-synthase; SPTR: A2UWJ8 O-succinylhomoserine (Thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. (381 aa) |
| | Fbal_3555 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: slo:Shew_3382 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: A2V4N4 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa) |
| | ubiD | 3-octaprenyl-4hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (492 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (328 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (508 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR020558: IPR004404; KEGG: slo:Shew_0292 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: A3Q9L6 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa) |
| | prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (290 aa) |
| | Aconitase | Aconitase; COGs: COG1048 Aconitase A; InterPro IPR001030: IPR000573: IPR012708; KEGG: avn:Avin_23230 2-methylisocitrate dehydratase, Fe/S-dependent; PFAM: aconitate hydratase domain protein; SPTR: A3JGL7 Aconitate hydratase; TIGRFAM: 2-methylisocitrate dehydratase, Fe/S-dependent; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: 2-methylisocitrate dehydratase, Fe/S-dependent; aconitate hydratase 1. (871 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | Fbal_3690 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (559 aa) |
| | hutH | COGs: COG2986 Histidine ammonia-lyase; InterPro IPR001106: IPR005921; KEGG: spl:Spea_4168 histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase; PRIAM: Histidine ammonia-lyase; SPTR: A8HA91 Histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: Phenylalanine and histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase. (512 aa) |
| | Fbal_3738 | ThiJ/PfpI domain protein; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (219 aa) |
| | moaC | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa) |
| | moaA-2 | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | Fbal_3266 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa) |
| | Fbal_3692 | COGs: COG3072 Adenylate cyclase; InterPro IPR000274; KEGG: shw:Sputw3181_3725 adenylate cyclase; PFAM: adenylate cyclase class-I; PRIAM: Adenylate cyclase; SPTR: A2UYN9 Adenylate cyclase, class-I; PFAM: Adenylate cyclase, class-I. (792 aa) |
| | fadB | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa) |
| | menC | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (311 aa) |
| | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carbox ylatesynthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (239 aa) |
| | menD | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (569 aa) |
| | Fbal_0131 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa) |
| | mutM | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (270 aa) |
| | ubiC | Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (177 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (509 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (879 aa) |
| | argH | N-acetylglutamate synthase; COGs: COG0165 Argininosuccinate lyase; InterPro IPR000362: IPR000182: IPR020557: IPR009049; KEGG: cps:CPS_0464 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; PFAM: fumarate lyase; GCN5-related N-acetyltransferase; SPTR: P59620 Bifunctional protein argH; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; Acetyltransferase (GNAT) family; TIGRFAM: argininosuccinate lyase; In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (643 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa) |
| | Fbal_0376 | Aconitase; COGs: COG1049 Aconitase B; InterPro IPR015929: IPR001030: IPR018136: IPR004406; KEGG: vpa:VP2495 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal; aconitate hydratase domain protein; SPTR: A3H377 Aconitate hydratase 2; TIGRFAM: aconitate hydratase 2; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (864 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | psuG | Indigoidine synthase A family protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (305 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (290 aa) |
| | nnrD | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (495 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (213 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (633 aa) |
| | Fbal_0611 | COGs: COG2721 Altronate dehydratase; InterPro IPR007392; KEGG: shl:Shal_0412 D-galactarate dehydratase/altronate hydrolase domain-containing protein; PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; PRIAM: Altronate dehydratase; SPTR: A8MAM0 Altronate dehydratase; PFAM: D-galactarate dehydratase / Altronate hydrolase, C terminus. (394 aa) |
| | menB | 1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (300 aa) |
| | Fbal_0768 | COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR000634: IPR004450; KEGG: shn:Shewana3_1141 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: A2V050 Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (264 aa) |
| | ribB | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (364 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | Fbal_0863 | Sodium ion-translocating decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa) |
| | luxS | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (169 aa) |
| | fabZ | 3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | Fbal_0990 | hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR000169; KEGG: slo:Shew_2574 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: A3WM37 Hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. (306 aa) |
| | Fbal_0992 | COGs: COG1024 Enoyl-CoA hydratase/carnithine racemase; InterPro IPR001753; KEGG: saz:Sama_1360 enoyl-CoA hydratase/isomerase; PFAM: Enoyl-CoA hydratase/isomerase; SPTR: A2V347 Enoyl-CoA hydratase/isomerase; PFAM: Enoyl-CoA hydratase/isomerase family. (261 aa) |
| | Fbal_1021 | COGs: COG1024 Enoyl-CoA hydratase/carnithine racemase; InterPro IPR001753: IPR018376; KEGG: slo:Shew_1670 enoyl-CoA hydratase; PFAM: Enoyl-CoA hydratase/isomerase; SPTR: A2V1P2 Enoyl-CoA hydratase/isomerase; PFAM: Enoyl-CoA hydratase/isomerase family; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | Fbal_1081 | dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR013120: IPR002225: IPR003869: IPR001509: IPR 002198: IPR005888; KEGG: ttu:TERTU_4328 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; SPTR: A0Z331 dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. d [...] (365 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (322 aa) |
| | Fbal_1198 | Urea amidolyase related protein; COGs: COG1984 Allophanate hydrolase subunit 2; InterPro IPR003778; KEGG: mca:MCA0477 allophanate hydrolase, subunit 2; PFAM: Allophanate hydrolase subunit 2; PRIAM: Urea carboxylase; SMART: Allophanate hydrolase subunit 2; SPTR: Q7WY77 KipI antagonist; TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; TIGRFAM: biotin-dependent carboxylase uncharacterized domain. (325 aa) |
| | Fbal_1242 | ybaK/ebsC protein; COGs: COG2606 conserved hypothetical protein; InterPro IPR007214: IPR004369; KEGG: hch:HCH_01964 hypothetical protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; SPTR: A3LE39 Putative uncharacterized protein; TIGRFAM: ybaK/ebsC protein; PFAM: YbaK / prolyl-tRNA synthetases associated domain; TIGRFAM: ybaK/ebsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (156 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | queE | Radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa) |
| | Fbal_1383 | preQ(0) biosynthesis protein QueD; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: dda:Dd703_0857 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: A3H311 Queuosine biosynthesis QueD PTPS-I; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (122 aa) |
| | Fbal_1407 | Lytic transglycosylase catalytic; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (502 aa) |
| | Fbal_1473 | Fumarate lyase; COGs: COG1027 Aspartate ammonia-lyase; InterPro IPR000362: IPR018951: IPR020557; KEGG: hch:HCH_01841 aspartate ammonia-lyase; PFAM: fumarate lyase; Fumarase C-like; SPTR: P07346 Aspartate ammonia-lyase; PFAM: Lyase; Fumarase C C-terminus; TIGRFAM: aspartate ammonia-lyase. (472 aa) |
| | Fbal_1478 | COGs: COG0415 Deoxyribodipyrimidine photolyase; InterPro IPR002081: IPR006050: IPR005101: IPR018394; KEGG: pap:PSPA7_5309 deoxyribodipyrimidine photolyase; PFAM: DNA photolyase FAD-binding; DNA photolyase domain protein; PRIAM: Deoxyribodipyrimidine photo-lyase; SPTR: A3LKA8 Deoxyribodipyrimidine photolyase; PFAM: FAD binding domain of DNA photolyase; DNA photolyase; TIGRFAM: cryptochrome, DASH family. (456 aa) |
| | Fbal_1480 | Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions. (161 aa) |
| | dsdA | COGs: COG3048 D-serine dehydratase; InterPro IPR001926: IPR000634: IPR011780; KEGG: eum:ECUMN_2695 D-serine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: D-serine ammonia-lyase; SPTR: B7N5W6 D-serine dehydratase; TIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (440 aa) |
| | Fbal_1564 | COGs: COG4257 Streptogramin lyase; KEGG: noc:Noc_0277 streptogramin lyase; SPTR: A0Z1G6 Possible streptogramin lyase, gluconolactonase family protein. (332 aa) |
| | Fbal_1577 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (217 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR013954: IPR020565: IPR006543: IPR 005954: IPR006549; KEGG: ppr:PBPRA1089 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; PRIAM: Histidinol-phosphatase; SPTR: P62455 Histidine biosynthesis bifunctional protein hisB; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase; Imidazoleglyce [...] (355 aa) |
| | Fbal_1767 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa) |
| | Fbal_1860 | Aminodeoxychorismate lyase; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544: IPR018300: IPR017824; KEGG: asa:ASA_2051 4-amino-4-deoxychorismate lyase; PFAM: aminotransferase class IV; SPTR: A2V2R9 Aminotransferase, class IV; TIGRFAM: aminodeoxychorismate lyase; PFAM: Aminotransferase class IV; TIGRFAM: aminodeoxychorismate lyase. (270 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (337 aa) |
| | fabA | 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (179 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | Fbal_1962 | COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR000887; KEGG: shn:Shewana3_2148 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; PFAM: KDPG and KHG aldolase; SPTR: A2V5D9 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (211 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (603 aa) |
| | Fbal_1996 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa) |
| | Fbal_2002 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (137 aa) |
| | Fbal_2023 | Deoxyribodipyrimidine photo-lyase (single-stranded DNA-specific); COGs: COG0415 Deoxyribodipyrimidine photolyase; InterPro IPR002081: IPR006050: IPR005101: IPR014133; KEGG: maq:Maqu_0320 DNA photolyase FAD-binding subunit; PFAM: DNA photolyase FAD-binding; DNA photolyase domain protein; PRIAM: Deoxyribodipyrimidine photo-lyase; SPTR: A3JAL3 Deoxyribodipyrimidine photolyase; TIGRFAM: cryptochrome, DASH family; PFAM: FAD binding domain of DNA photolyase; DNA photolyase; TIGRFAM: cryptochrome, DASH family. (435 aa) |
| | Fbal_2024 | Deoxyribodipyrimidine photo-lyase family protein (cryptochrome); COGs: COG0415 Deoxyribodipyrimidine photolyase; InterPro IPR002081: IPR005101: IPR018394; KEGG: vha:VIBHAR_06659 deoxyribodipyrimidine photolyase; PFAM: DNA photolyase FAD-binding; PRIAM: Deoxyribodipyrimidine photo-lyase; SPTR: A3JDX2 Deoxyribodipyrimidine photolyase, putative; PFAM: FAD binding domain of DNA photolyase; DNA photolyase. (484 aa) |
| | Fbal_2026 | COGs: COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase; InterPro IPR007357; KEGG: vha:VIBHAR_06692 hypothetical protein; PFAM: deoxyribodipyrimidine photolyase-related protein; SPTR: A0YCX4 Putative uncharacterized protein; PFAM: Deoxyribodipyrimidine photo-lyase-related protein. (512 aa) |
| | Fbal_2029 | Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722: IPR012726; KEGG: vpa:VP3022 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: A2PS83 Thiazole biosynthesis protein ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (370 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (646 aa) |
| | Fbal_2075 | COGs: COG0076 Glutamate decarboxylase and related PLP-dependent protein; InterPro IPR000192: IPR002129; KEGG: ppr:PBPRB0277 amino acid decarboxylase; PFAM: Pyridoxal-dependent decarboxylase; aminotransferase class V; SPTR: A2W199 Glutamate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase conserved domain. (482 aa) |
| | purE-2 | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (362 aa) |
