node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fbal_1996 | folD | Fbal_1996 | Fbal_2061 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.873 |
Fbal_1996 | folD-2 | Fbal_1996 | Fbal_2600 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.873 |
Fbal_1996 | guaA | Fbal_1996 | Fbal_2738 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.860 |
Fbal_1996 | guaB | Fbal_1996 | Fbal_2739 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.810 |
Fbal_1996 | purA | Fbal_1996 | Fbal_0521 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.993 |
Fbal_1996 | purC | Fbal_1996 | Fbal_3297 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636: IPR014106; KEGG: ppr:PBPRA1469 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q480B3 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type. | 0.994 |
Fbal_1996 | purD | Fbal_1996 | Fbal_0412 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR003806: IPR020560: IPR020562: IPR020561: IPR 011761: IPR020559: IPR000115; KEGG: ppr:PBPRA3420 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; protein of unknown function DUF201; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Q87KS8 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phospho [...] | 0.943 |
Fbal_1996 | purE | Fbal_1996 | Fbal_0029 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.891 |
Fbal_1996 | purE-2 | Fbal_1996 | Fbal_2084 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.891 |
Fbal_1996 | purF | Fbal_1996 | Fbal_2606 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.944 |
Fbal_1996 | purH | Fbal_1996 | Fbal_0414 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607: IPR013982: IPR002695; KEGG: vfm:VFMJ11_2512 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: B5FC70 Bifunctional purine biosynthesis protein purH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMP [...] | 0.993 |
Fbal_1996 | purK | Fbal_1996 | Fbal_2085 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.925 |
Fbal_1996 | purL | Fbal_1996 | Fbal_2699 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.969 |
Fbal_1996 | purM | Fbal_1996 | Fbal_1254 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918: IPR000728: IPR004733; KEGG: sbp:Sbal223_2549 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: A9KY38 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: pho [...] | 0.931 |
Fbal_1996 | purN | Fbal_1996 | Fbal_1253 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.936 |
folD | Fbal_1996 | Fbal_2061 | Fbal_1996 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.873 |
folD | folD-2 | Fbal_2061 | Fbal_2600 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.904 |
folD | guaA | Fbal_2061 | Fbal_2738 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.491 |
folD | purA | Fbal_2061 | Fbal_0521 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.769 |
folD | purC | Fbal_2061 | Fbal_3297 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636: IPR014106; KEGG: ppr:PBPRA1469 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q480B3 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type. | 0.492 |