STRINGSTRING
fadA fadA fadB fadB Fbal_0016 Fbal_0016 Fbal_0018 Fbal_0018 purE purE hemF hemF aroE aroE Fbal_0041 Fbal_0041 menC menC menH menH menD menD menF menF glpE glpE ubiC ubiC plsB plsB Fbal_0192 Fbal_0192 cyoE cyoE pckA pckA argC argC argB argB Fbal_0312 Fbal_0312 argG argG argH argH aroK aroK aroB aroB Fbal_0328 Fbal_0328 gph gph Fbal_0370 Fbal_0370 Fbal_0371 Fbal_0371 Fbal_0372 Fbal_0372 Fbal_0376 Fbal_0376 hemE hemE Fbal_0390 Fbal_0390 Fbal_0394 Fbal_0394 purD purD purH purH Fbal_0441 Fbal_0441 Fbal_0456 Fbal_0456 Fbal_0457 Fbal_0457 Fbal_0458 Fbal_0458 Fbal_0468 Fbal_0468 Fbal_0469 Fbal_0469 aroQ aroQ psd psd miaA miaA Fbal_0531 Fbal_0531 Fbal_0550 Fbal_0550 Fbal_0570 Fbal_0570 fbp fbp ubiX ubiX Fbal_0584 Fbal_0584 asd asd metK metK Fbal_0616 Fbal_0616 Fbal_0621 Fbal_0621 Fbal_0628 Fbal_0628 Fbal_0629 Fbal_0629 gcvT gcvT gcvH gcvH gcvP gcvP Fbal_0644 Fbal_0644 Fbal_0656 Fbal_0656 Fbal_0657 Fbal_0657 Fbal_0663 Fbal_0663 Fbal_0667 Fbal_0667 Fbal_0688 Fbal_0688 rpiA rpiA menB menB Fbal_0743 Fbal_0743 Fbal_0744 Fbal_0744 Fbal_0753 Fbal_0753 Fbal_0766 Fbal_0766 thrB thrB Fbal_0768 Fbal_0768 pgi pgi tal tal Fbal_0782 Fbal_0782 ispH ispH glyA glyA Fbal_0831 Fbal_0831 Fbal_0832 Fbal_0832 ribB ribB ribH ribH eno eno ispD ispD ispF ispF surE surE Fbal_0858 Fbal_0858 dxs dxs Fbal_0875 Fbal_0875 Fbal_0880 Fbal_0880 Fbal_0881 Fbal_0881 proB proB proA proA Fbal_0934 Fbal_0934 uppS uppS Fbal_0957 Fbal_0957 dxr dxr accA accA Fbal_0990 Fbal_0990 menA menA metAS metAS Fbal_1018 Fbal_1018 Fbal_1024 Fbal_1024 Fbal_1078 Fbal_1078 Fbal_1079 Fbal_1079 Fbal_1080 Fbal_1080 Fbal_1081 Fbal_1081 Fbal_1086 Fbal_1086 Fbal_1095 Fbal_1095 Fbal_1097 Fbal_1097 glk glk cysD cysD cysN cysN Fbal_1113 Fbal_1113 Fbal_1118 Fbal_1118 Fbal_1144 Fbal_1144 adk adk hemH hemH Fbal_1219 Fbal_1219 Fbal_1222 Fbal_1222 Fbal_1244 Fbal_1244 purN purN purM purM dapA dapA Fbal_1309 Fbal_1309 Fbal_1354 Fbal_1354 Fbal_1389 Fbal_1389 plsX plsX Fbal_1396 Fbal_1396 Fbal_1397 Fbal_1397 acpP acpP Fbal_1441 Fbal_1441 Fbal_1443 Fbal_1443 katG katG Fbal_1490 Fbal_1490 Fbal_1622 Fbal_1622 acsA acsA Fbal_1684 Fbal_1684 katG-2 katG-2 hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG Fbal_1758 Fbal_1758 Fbal_1767 Fbal_1767 Fbal_1806 Fbal_1806 Fbal_1842 Fbal_1842 Fbal_1917 Fbal_1917 Fbal_1926 Fbal_1926 aroA aroA hisC-2 hisC-2 serC serC ubiG ubiG Fbal_1952 Fbal_1952 Fbal_1956 Fbal_1956 Fbal_1958 Fbal_1958 pgl pgl zwf zwf Fbal_1967 Fbal_1967 Fbal_1990 Fbal_1990 Fbal_1991 Fbal_1991 Fbal_1996 Fbal_1996 Fbal_2000 Fbal_2000 Fbal_2057 Fbal_2057 purE-2 purE-2 purK purK deoD deoD Fbal_2117 Fbal_2117 Fbal_2187 Fbal_2187 Fbal_2201 Fbal_2201 Fbal_2203 Fbal_2203 Fbal_2228 Fbal_2228 Fbal_2260 Fbal_2260 Fbal_2265 Fbal_2265 Fbal_2356 Fbal_2356 Fbal_2357 Fbal_2357 Fbal_2358 Fbal_2358 Fbal_2366 Fbal_2366 Fbal_2373 Fbal_2373 Fbal_2397 Fbal_2397 Fbal_2424 Fbal_2424 Fbal_2458 Fbal_2458 Fbal_2460 Fbal_2460 sucD sucD sucC sucC Fbal_2486 Fbal_2486 Fbal_2487 Fbal_2487 Fbal_2488 Fbal_2488 Fbal_2489 Fbal_2489 Fbal_2490 Fbal_2490 Fbal_2491 Fbal_2491 Fbal_2492 Fbal_2492 Fbal_2496 Fbal_2496 Fbal_2517 Fbal_2517 Fbal_2535 Fbal_2535 Fbal_2536 Fbal_2536 Fbal_2537 Fbal_2537 trpD trpD trpF trpF trpB trpB trpA trpA gltX gltX fabV fabV purF purF accD accD asd-2 asd-2 aroC aroC Fbal_2630 Fbal_2630 fadI fadI purL purL Fbal_2728 Fbal_2728 guaB guaB ispG ispG ndk ndk Fbal_2763 Fbal_2763 Fbal_2772 Fbal_2772 Fbal_2784 Fbal_2784 Fbal_2785 Fbal_2785 Fbal_2814 Fbal_2814 hemA hemA ispE ispE prs prs Fbal_2840 Fbal_2840 Fbal_2851 Fbal_2851 deoD-2 deoD-2 tpiA tpiA dapB dapB Fbal_2905 Fbal_2905 Fbal_2925 Fbal_2925 Fbal_2935 Fbal_2935 proC proC Fbal_3020 Fbal_3020 Fbal_3078 Fbal_3078 pgk pgk hemL hemL Fbal_3127 Fbal_3127 Fbal_3171 Fbal_3171 panB panB panC panC panD panD Fbal_3231 Fbal_3231 plsY plsY Fbal_3278 Fbal_3278 purC purC Fbal_3324 Fbal_3324 Fbal_3352 Fbal_3352 Fbal_3373 Fbal_3373 mdh mdh argD argD Fbal_3512 Fbal_3512 Fbal_3513 Fbal_3513 ubiE ubiE Fbal_3555 Fbal_3555 Fbal_3558 Fbal_3558 ubiD ubiD ubiA ubiA Fbal_3643 Fbal_3643 ilvA ilvA ilvD ilvD ilvE ilvE Fbal_3649 Fbal_3649 Fbal_3650 Fbal_3650 ilvC ilvC leuD leuD leuC leuC leuB leuB leuA leuA Fbal_3689 Fbal_3689 Fbal_3690 Fbal_3690 hemC hemC lysA lysA dapF dapF Fbal_3713 Fbal_3713 Fbal_3746 Fbal_3746 gpsA gpsA gpmI gpmI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa)
fadBFatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa)
Fbal_0016Protoporphyrinogen oxidase; COGs: COG4635 Flavodoxin; InterPro IPR008254; KEGG: saz:Sama_0036 protoporphyrinogen oxidase; PRIAM: Protoporphyrinogen oxidase; SPTR: A2V477 Protoporphyrinogen oxidase. (174 aa)
Fbal_0018Protoporphyrinogen oxidase; COGs: COG4635 Flavodoxin; InterPro IPR001226: IPR008254; KEGG: sse:Ssed_0029 protoporphyrinogen oxidase; PRIAM: Protoporphyrinogen oxidase; SPTR: A2V475 Protoporphyrinogen oxidase. (178 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
hemFCoproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (304 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa)
Fbal_0041O-succinylbenzoate-CoA ligase; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020459: IPR000873: IPR010192; KEGG: slo:Shew_3602 O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A2V3Q7 O-succinylbenzoate-CoA ligase; TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-binding enzyme; TIGRFAM: O-succinylbenzoate-CoA ligase. (455 aa)
menCO-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (311 aa)
menH2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carbox ylatesynthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (239 aa)
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (569 aa)
menFIsochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. (436 aa)
glpEThiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (105 aa)
ubiCChorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (177 aa)
plsBCOGs: COG2937 Glycerol-3-phosphate O-acyltransferase; InterPro IPR002123; KEGG: slo:Shew_3530 glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase; PRIAM: Glycerol-3-phosphate O-acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: A3QIU8 Glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase; Belongs to the GPAT/DAPAT family. (803 aa)
Fbal_0192Cytochrome oxidase assembly; COGs: COG1612 Uncharacterized protein required for cytochrome oxidase assembly; InterPro IPR003780; KEGG: swp:swp_4835 cytochrome oxidase assembly; PFAM: cytochrome oxidase assembly; SPTR: A2V2H4 Cytochrome oxidase assembly; PFAM: Cytochrome oxidase assembly protein. (318 aa)
cyoEProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (301 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (509 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa)
Fbal_0312Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa)
argGCOGs: COG0137 Argininosuccinate synthase; InterPro IPR001518: IPR018223; KEGG: amc:MADE_00529 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: A0XXT0 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa)
argHN-acetylglutamate synthase; COGs: COG0165 Argininosuccinate lyase; InterPro IPR000362: IPR000182: IPR020557: IPR009049; KEGG: cps:CPS_0464 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; PFAM: fumarate lyase; GCN5-related N-acetyltransferase; SPTR: P59620 Bifunctional protein argH; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; Acetyltransferase (GNAT) family; TIGRFAM: argininosuccinate lyase; In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (643 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa)
Fbal_0328COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: shm:Shewmr7_0253 ribulose-5-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: A2V3E8 Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (224 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (233 aa)
Fbal_03702-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa)
Fbal_0371Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (632 aa)
Fbal_0372COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR000759: IPR013027: IPR000103: IPR000815: IPR 001327: IPR004099: IPR002218: IPR012999: IPR006258; KEGG: shm:Shewmr7_3597 dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; SPTR: A2UYJ1 Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-dis [...] (475 aa)
Fbal_0376Aconitase; COGs: COG1049 Aconitase B; InterPro IPR015929: IPR001030: IPR018136: IPR004406; KEGG: vpa:VP2495 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal; aconitate hydratase domain protein; SPTR: A3H377 Aconitate hydratase 2; TIGRFAM: aconitate hydratase 2; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (864 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
Fbal_0390COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: shw:Sputw3181_2923 glyceraldehyde-3-phosphate dehydrogenase; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UV92 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate [...] (335 aa)
Fbal_0394Haloacid dehalogenase domain protein hydrolase; COGs: COG0546 phosphatase; InterPro IPR005834; KEGG: pct:PC1_3478 haloacid dehalogenase domain protein hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: A0YA55 Probable phosphoglycolate phosphatase; PFAM: haloacid dehalogenase-like hydrolase. (223 aa)
purDCOGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR003806: IPR020560: IPR020562: IPR020561: IPR 011761: IPR020559: IPR000115; KEGG: ppr:PBPRA3420 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; protein of unknown function DUF201; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Q87KS8 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phospho [...] (428 aa)
purHIMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607: IPR013982: IPR002695; KEGG: vfm:VFMJ11_2512 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: B5FC70 Bifunctional purine biosynthesis protein purH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMP [...] (530 aa)
Fbal_0441COGs: COG1210 UDP-glucose pyrophosphorylase; InterPro IPR005835: IPR005771; KEGG: cps:CPS_2107 UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; SPTR: A0Y112 Glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase. (304 aa)
Fbal_0456InterPro IPR018956; KEGG: shn:Shewana3_0401 fumarate reductase cytochrome b-556 subunit; PFAM: Fumarate reductase respiratory complex; SPTR: A2UYL7 Fumarate reductase respiratory complex, transmembrane subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (234 aa)
Fbal_0457COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR004112: IPR006076: IPR003953: IPR003952: IPR 014006; KEGG: shn:Shewana3_0403 fumarate reductase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; PRIAM: Succinate dehydrogenase; SPTR: A2UYL5 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase or fumarate redu [...] (653 aa)
Fbal_0458COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterPro IPR001041: IPR006058: IPR004489; KEGG: lhk:LHK_02342 succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; PRIAM: Succinate dehydrogenase; SPTR: A2UYL4 Succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (244 aa)
Fbal_0468Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
Fbal_0469Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (150 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (290 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (315 aa)
Fbal_0531Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa)
Fbal_0550Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1058 aa)
Fbal_0570COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR003043: IPR006366; KEGG: slo:Shew_0672 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A2UZS2 Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (279 aa)
fbpD-fructose 1,6-bisphosphatase; COGs: COG0158 Fructose-1 6-bisphosphatase; InterPro IPR000146: IPR018087; KEGG: slo:Shew_0773 fructose-1,6-bisphosphatase; PFAM: Inositol phosphatase/fructose-16-bisphosphatase; SPTR: A3QAZ7 Fructose-1,6-bisphosphatase class 1; PFAM: Fructose-1-6-bisphosphatase. (320 aa)
ubiX3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (213 aa)
Fbal_0584COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR002375: IPR005904; KEGG: sdn:Sden_0654 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: A2UWU6 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa)
Fbal_0616Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa)
Fbal_0621Thioesterase superfamily protein; COGs: COG2050 Uncharacterized protein possibly involved in aromatic compounds catabolism; InterPro IPR006683: IPR003736; KEGG: ppr:PBPRB0662 hypothetical protein; PFAM: thioesterase superfamily protein; SPTR: A3UVZ2 Putative uncharacterized protein; PFAM: Thioesterase superfamily; TIGRFAM: uncharacterized domain 1. (143 aa)
Fbal_0628COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR003042: IPR002938: IPR006076: IPR018168: IPR 010971: IPR011295; KEGG: eck:EC55989_3195 2-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding; PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; SPTR: P25534 2-octaprenyl-6-methoxyphenol hydroxylase; TIGRFAM: 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: FAD binding domain; TIGRFAM: 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Ubiquinone biosynth [...] (401 aa)
Fbal_0629COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR003042: IPR002938: IPR006076: IPR018168: IPR 010971; KEGG: spl:Spea_3304 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase; PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; SPTR: A2UUI7 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: FAD binding domain; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. (400 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa)
Fbal_0644Catalase; COGs: COG0753 Catalase; InterPro IPR002226: IPR018028: IPR010582; KEGG: saz:Sama_2941 catalase; PFAM: Catalase related subgroup; Catalase domain protein; PRIAM: Catalase; SPTR: Q27710 Catalase; PFAM: Catalase; Catalase-related immune-responsive; Belongs to the catalase family. (485 aa)
Fbal_0656Glutamate synthase (NADPH) small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR000759: IPR013027: IPR000103: IPR001327: IPR 006006; KEGG: saz:Sama_0856 glutamate synthase subunit beta; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: A2V2C4 Glutamate synthase, small subunit; TIGRFAM: glutamate synthase, small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase small subunit family protein, proteobacterial. (472 aa)
Fbal_0657Glutamate synthase (NADPH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002489: IPR002932: IPR006982: IPR000583; KEGG: slo:Shew_1032 glutamate synthase subunit alpha; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; PRIAM: Glutamate synthase (ferredoxin); SPTR: A2V2C5 Ferredoxin-dependent glutamate synthase; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1483 aa)
Fbal_0663COGs: COG0527 Aspartokinase; InterPro IPR001048: IPR018042: IPR005260: IPR001341; KEGG: sse:Ssed_0817 aspartate kinase III; PFAM: aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase; SPTR: P08660 Lysine-sensitive aspartokinase 3; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (460 aa)
Fbal_0667Aspartate-ammonia ligase; COGs: COG2502 Asparagine synthetase A; InterPro IPR004618: IPR006195; KEGG: sfv:SFV_3770 asparagine synthetase AsnA; PFAM: aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Q83PJ4 Aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type. (325 aa)
Fbal_0688COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR002912: IPR006140; KEGG: vpa:VP2593 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: A3ELN9 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (409 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa)
menB1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (300 aa)
Fbal_07433-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
Fbal_0744Chorismate mutase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002701: IPR011277; KEGG: saz:Sama_0894 bifunctional chorismate mutase/prephenate dehydrogenase; PFAM: Chorismate mutase; Prephenate dehydrogenase; SPTR: A2UV38 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydrogenase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of T-protein. (378 aa)
Fbal_0753Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR006218: IPR002912: IPR002701: IPR 018528: IPR006268: IPR010952; KEGG: swd:Swoo_1263 chorismate mutase; PFAM: prephenate dehydratase; DAHP synthetase I/KDSA; amino acid-binding ACT domain protein; Chorismate mutase; SPTR: A2UV42 Chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase domain of p [...] (672 aa)
Fbal_0766COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR002912: IPR005106: IPR001048: IPR 019811: IPR018042: IPR001341; KEGG: saz:Sama_0905 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2V048 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase; [...] (818 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa)
Fbal_0768COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR000634: IPR004450; KEGG: shn:Shewana3_1141 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: A2V050 Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa)
pgiCOGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR001672: IPR018189; KEGG: shl:Shal_1121 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); PRIAM: Glucose-6-phosphate isomerase; SPTR: B0TJ99 Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family. (548 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa)
Fbal_0782FMN adenylyltransferase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR002606; KEGG: slo:Shew_1098 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; SPTR: A2UZZ7 Riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (315 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (309 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
Fbal_0831Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (373 aa)
Fbal_0832COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sbn:Sbal195_3302 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: A2UZ97 Riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (217 aa)
ribBGTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (364 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (155 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (232 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa)
surE5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (248 aa)
Fbal_0858COGs: COG0527 Aspartokinase; InterPro IPR001057: IPR002912: IPR001048: IPR018042: IPR 005260: IPR001341; KEGG: pin:Ping_3379 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: A0Z876 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (406 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa)
Fbal_0875COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: tau:Tola_2504 polyprenyl synthetase; PFAM: Polyprenyl synthetase; SPTR: A3H3G8 Octaprenyl-diphosphate synthase/dimethylallyltransferase/geranyltranstransferas e/ geranylgeranyl pyrophosphate synthetase; PFAM: Polyprenyl synthetase. (294 aa)
Fbal_08803-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa)
Fbal_08812-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (291 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa)
Fbal_0934COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: vvu:VV2_0869 NAD-dependent aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; PRIAM: Aldehyde dehydrogenase (NAD(+)); SPTR: A3XRZ9 NAD-dependent aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (506 aa)
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (250 aa)
Fbal_0957Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: shn:Shewana3_2810 phosphatidate cytidylyltransferase; PFAM: phosphatidate cytidylyltransferase; SPTR: A2V1J3 Phosphatidate cytidylyltransferase; PFAM: Cytidylyltransferase family; Belongs to the CDS family. (284 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (396 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
Fbal_0990hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR000169; KEGG: slo:Shew_2574 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: A3WM37 Hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. (306 aa)
menA1,4-dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (289 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (311 aa)
Fbal_1018COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR002155; KEGG: spc:Sputcn32_1397 acetyl-CoA acetyltransferase; PFAM: Thiolase; PRIAM: Acetyl-CoA C-acetyltransferase; SPTR: A2V1N9 Acetyl-CoA acetyltransferases; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
Fbal_1024Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002424: IPR002198: IPR013968; KEGG: swp:swp_3381 3-ketoacyl-(acyl-carrier-protein) reductase; PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; SPTR: A2V1P5 Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase. (253 aa)
Fbal_1078Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (292 aa)
Fbal_1079dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa)
Fbal_1080dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (303 aa)
Fbal_1081dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR013120: IPR002225: IPR003869: IPR001509: IPR 002198: IPR005888; KEGG: ttu:TERTU_4328 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; SPTR: A0Z331 dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. d [...] (365 aa)
Fbal_1086COGs: COG1210 UDP-glucose pyrophosphorylase; InterPro IPR005835: IPR005771; KEGG: ppr:PBPRA2674 putative UTP-glucose-1-phosphateuridylyltransferase, GalU; PFAM: Nucleotidyl transferase; SPTR: P0AEP6 UTP--glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase. (295 aa)
Fbal_1095Alpha amylase catalytic region; COGs: COG0366 Glycosidase; InterPro IPR006047: IPR006589; KEGG: sml:Smlt1174 putative alpha-glucosidase agla (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidase) (acid maltase); PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; SPTR: A0XZI6 Alpha-glucosidase; PFAM: Alpha amylase, catalytic domain. (540 aa)
Fbal_1097Tryptophan halogenase; InterPro IPR006905: IPR006076; KEGG: sdn:Sden_2030 tryptophan halogenase; PFAM: tryptophan halogenase; FAD dependent oxidoreductase; SPTR: A0XZI4 Putative uncharacterized protein; PFAM: Tryptophan halogenase. (499 aa)
glkGlucokinase; COGs: COG0837 Glucokinase; InterPro IPR003836; KEGG: pha:PSHAa1364 glucokinase; PFAM: Glucokinase; PRIAM: Glucokinase; SPTR: A0Y6J1 Putative glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; TIGRFAM: glucokinase, proteobacterial type; Belongs to the bacterial glucokinase family. (324 aa)
cysDSulfate adenylyltransferase subunit 2; COGs: COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase; InterPro IPR002500: IPR011784; KEGG: pin:Ping_0796 sulfate adenylyltransferase subunit 2; PFAM: phosphoadenosine phosphosulfate reductase; SPTR: A1ST25 Sulfate adenylyltransferase subunit 2; TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: Phosphoadenosine phosphosulfate reductase family; TIGRFAM: sulfate adenylyltransferase, small subunit. (302 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa)
Fbal_1113COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: swp:swp_1640 fructokinase; PFAM: ROK family protein; SPTR: A2V1L1 ROK domain containing protein; PFAM: ROK family. (306 aa)
Fbal_1118COGs: COG1210 UDP-glucose pyrophosphorylase; InterPro IPR005835: IPR005771; KEGG: tau:Tola_0934 UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; SPTR: A2V1M7 UTP-glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase. (298 aa)
Fbal_1144COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR006090: IPR006092: IPR006091: IPR013107: IPR 006089; KEGG: smd:Smed_4671 acyl-CoA dehydrogenase domain-containing protein; PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase type 2 domain; SPTR: A0Z5K1 Glutaryl-CoA dehydrogenase; PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain. (389 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (322 aa)
Fbal_1219COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426: IPR017535; KEGG: pla:Plav_0816 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: A0P460 Putative asparagine synthetase (Glutamine amidotransferase) protein; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrol [...] (588 aa)
Fbal_1222Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (278 aa)
Fbal_1244COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426; KEGG: sbn:Sbal195_1769 asparagine synthetase B; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: A2V529 Asparagine synthase (Glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (554 aa)
purNFormyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918: IPR000728: IPR004733; KEGG: sbp:Sbal223_2549 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: A9KY38 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: pho [...] (345 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
Fbal_1309HAD-superfamily hydrolase, subfamily IA, variant 1; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005833: IPR005834: IPR019758: IPR006402: IPR 006439; KEGG: she:Shewmr4_3606 nucleotidase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: A2UYS3 HAD-superfamily hydrolase, subfamily IA, variant 1; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid dehaloge [...] (223 aa)
Fbal_1354COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: vfm:VFMJ11_2265 glycerate kinase; PFAM: glycerate kinase; PRIAM: Glycerate kinase; SPTR: A1HTZ8 Glycerate kinase; TIGRFAM: glycerate kinase; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. (377 aa)
Fbal_1389HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0546 phosphatase; InterPro IPR005834: IPR006402: IPR006439; KEGG: slo:Shew_1595 HAD family hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: A2V325 HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid dehalogenase superfamily, subfamily IA, va [...] (215 aa)
plsXPhosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (341 aa)
Fbal_1396COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043: IPR004410; KEGG: son:SO_2777 acyl carrier protein S-malonyltransferase; PFAM: Acyl transferase; SPTR: P0AAI9 Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; malonate decarboxylase, epsilon subunit. (309 aa)
Fbal_13973-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)
Fbal_1441COGs: COG1446 Asparaginase; InterPro IPR000246; KEGG: sfr:Sfri_1445 peptidase T2, asparaginase 2; PFAM: peptidase T2 asparaginase 2; SPTR: A0Y027 L-asparaginase; PFAM: Asparaginase. (341 aa)
Fbal_1443COGs: COG1045 Serine acetyltransferase; InterPro IPR001451: IPR010493: IPR018357: IPR005881; KEGG: amc:MADE_00201 serine acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein; PRIAM: Serine O-acetyltransferase; SPTR: A0XYV3 Serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase. (267 aa)
katGCatalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (752 aa)
Fbal_1490COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670: IPR015590: IPR018211; KEGG: swd:Swoo_2241 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; SPTR: A2V102 Iron-containing alcohol dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (868 aa)
Fbal_1622Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: azo:azo3380 putative transaminase; PFAM: aminotransferase class I and II; SPTR: A3J880 Aminotransferase, class I and II; PFAM: Aminotransferase class I and II. (379 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
Fbal_1684Protoporphyrinogen oxidase; COGs: COG4635 Flavodoxin; KEGG: sfr:Sfri_0813 protoporphyrinogen oxidase; PRIAM: Protoporphyrinogen oxidase; SPTR: A2V477 Protoporphyrinogen oxidase; PFAM: Flavodoxin. (176 aa)
katG-2Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (727 aa)
hisICOGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR002496: IPR008179; KEGG: swp:swp_3009 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: A2V1X4 Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (202 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: kpu:KP1_3685 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase; PFAM: histidine biosynthesis protein; SPTR: B8CR53 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM [...] (245 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa)
hisBCOGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR013954: IPR020565: IPR006543: IPR 005954: IPR006549; KEGG: ppr:PBPRA1089 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; PRIAM: Histidinol-phosphatase; SPTR: P62455 Histidine biosynthesis bifunctional protein hisB; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase; Imidazoleglyce [...] (355 aa)
hisCCOGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR001917: IPR005861; KEGG: slo:Shew_2199 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q8EFB2 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (307 aa)
Fbal_1758COGs: COG0247 Fe-S oxidoreductase; KEGG: tgr:Tgr7_0836 protein of unknown function DUF224 cysteine-rich region domain protein; SPTR: A0Z1Q5 Putative ferredoxin. (446 aa)
Fbal_1767Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa)
Fbal_1806COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR013027: IPR006076: IPR004792: IPR003953: IPR 011031: IPR010960; KEGG: sse:Ssed_3877 succinate dehydrogenase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein; SPTR: Q07WU7 Fumarate reductase flavoprotein subunit; TIGRFAM: flavocytochrome c; PFAM: FAD binding domain; TIGRFAM: flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH su [...] (594 aa)
Fbal_1842COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: slo:Shew_2036 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: A2V5Z7 Riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (203 aa)
Fbal_1917COGs: COG1448 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR000796: IPR004839: IPR004838; KEGG: esa:ESA_02414 aromatic amino acid aminotransferase; PFAM: aminotransferase class I and II; PRIAM: Aspartate transaminase; SPTR: P00509 Aspartate aminotransferase; PFAM: Aminotransferase class I and II. (396 aa)
Fbal_1926Phospholipase D/Transphosphatidylase; COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: tau:Tola_3003 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; SPTR: A3H3Y0 CDP-diacylglycerol--serine O-phosphatidyltransferase. (448 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
hisC-2COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR001176: IPR004839: IPR001917: IPR005861; KEGG: pin:Ping_1116 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q5QZ49 Histidinol-phosphate aminotransferase 1; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (237 aa)
Fbal_1952Asparaginase; COGs: COG0252 L-asparaginase/ Glu-tRNAGln amidotransferase subunit D; InterPro IPR006034: IPR006033; KEGG: asa:ASA_0944 cytoplasmic asparaginase I; PFAM: Asparaginase/glutaminase; PRIAM: 1-alkyl-2-acetylglycerophosphocholine esterase; SPTR: A2V0R5 L-asparaginases, type I; TIGRFAM: L-asparaginase, type I; PFAM: Asparaginase; TIGRFAM: L-asparaginases, type I. (336 aa)
Fbal_1956COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: saz:Sama_1806 glyceraldehyde-3-phosphate dehydrogenase; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UZG1 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehyd [...] (474 aa)
Fbal_1958COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: slo:Shew_2002 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UZF9 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phospha [...] (338 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (235 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (488 aa)
Fbal_1967COGs: COG0469 Pyruvate kinase; InterPro IPR015793: IPR015794: IPR001697; KEGG: sbm:Shew185_2128 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: A2V5D4 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
Fbal_1990Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804: IPR019818: IPR004439; KEGG: pmr:PMI0891 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: P08200 Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (417 aa)
Fbal_1991Isocitrate dehydrogenase, NADP-dependent; COGs: COG2838 Monomeric isocitrate dehydrogenase; InterPro IPR004436; KEGG: pin:Ping_0983 isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: A0Y1L4 Isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Monomeric isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (752 aa)
Fbal_1996COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR013539: IPR020557: IPR004769; KEGG: she:Shewmr4_1601 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; SPTR: A2V1D7 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
Fbal_2000COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097: IPR006096: IPR006095; KEGG: saz:Sama_2067 leucine dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; SPTR: A2V1E0 Glu/Leu/Phe/Val dehydrogenase, dimerisation region; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain. (344 aa)
Fbal_2057COGs: COG1062 Zn-dependent alcohol dehydrogenase class III; InterPro IPR013154: IPR013149: IPR002328: IPR014183; KEGG: shl:Shal_3111 S-(hydroxymethyl)glutathione dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: A2V1Y5 Alcohol dehydrogenase GroES-like; TIGRFAM: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Belongs to the zinc-co [...] (377 aa)
purE-25-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (362 aa)
deoDCOGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845: IPR018016: IPR004402; KEGG: swd:Swoo_3884 purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: B8F672 Purine nucleoside phosphorylase deoD-type; TIGRFAM: purine nucleoside phosphorylase; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). (236 aa)
Fbal_2117COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR006076: IPR003953: IPR006311; KEGG: sfr:Sfri_3694 twin-arginine translocation pathway signal; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; SPTR: A2UV06 Twin-arginine translocation pathway signal; PFAM: FAD binding domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence. (559 aa)
Fbal_2187NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR013120: IPR002225: IPR001509; KEGG: mlo:mll1262 NDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; SPTR: P55579 Uncharacterized protein y4nG; PFAM: NAD dependent epimerase/dehydratase family. (334 aa)
Fbal_2201Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (791 aa)
Fbal_22033-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa)
Fbal_2228Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: sdn:Sden_2013 pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: A2PU42 Cysteine synthase/cystathionine beta-synthase family protein; PFAM: Pyridoxal-phosphate dependent enzyme. (354 aa)
Fbal_2260COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR013027: IPR002218: IPR006076: IPR004792: IPR 003953: IPR011031: IPR010960; KEGG: sfr:Sfri_2586 flavocytochrome c; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; FAD dependent oxidoreductase; HI0933 family protein; SPTR: Q9Z4P0 Fumarate reductase flavoprotein subunit; TIGRFAM: flavocytochrome c; PFAM: FAD binding domain; TIGRFAM: flavocytochrome c; Belongs to the FAD-de [...] (588 aa)
Fbal_2265Transferase hexapeptide repeat containing protein; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: tgr:Tgr7_2377 transferase hexapeptide repeat containing protein; PFAM: transferase hexapeptide repeat containing protein; SPTR: Q46F84 Serine O-acetyltransferase. (196 aa)
Fbal_2356Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR004167: IPR000089: IPR001078; KEGG: saz:Sama_1711 dihydrolipoamide acetyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: A2UZF7 Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Bi [...] (515 aa)
Fbal_2357Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005476: IPR005475; KEGG: hch:HCH_03686 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component subunit beta; PFAM: Transketolase central region; Transketolase domain protein; SPTR: A3JES1 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (325 aa)
Fbal_23583-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COGs: COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type alpha subunit; InterPro IPR001017; KEGG: saz:Sama_1709 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); PFAM: dehydrogenase E1 component; PRIAM: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); SPTR: A2UZF5 Dehydrogenase, E1 component; PFAM: Dehydrogenase E1 component. (394 aa)
Fbal_2366Phosphoglucomutase, alpha-D-glucose phosphate-specific; COGs: COG0033 Phosphoglucomutase; InterPro IPR005844: IPR005846: IPR005843: IPR005845: IPR 016066: IPR005852; KEGG: saz:Sama_1706 phosphoglucomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; SPTR: P36938 Phosphoglucomutase; TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: Phosphoglucomutase/phosphomannomutase, [...] (545 aa)
Fbal_2373Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176: IPR004839: IPR001412; KEGG: sfr:Sfri_1907 aminotransferase AlaT; PFAM: aminotransferase class I and II; SPTR: A2V5E2 Aminotransferase, class I and II; PFAM: Aminotransferase class I and II. (404 aa)
Fbal_2397Aldose 1-epimerase; COGs: COG0676 protein related to aldose 1-epimerase; InterPro IPR008183; KEGG: dar:Daro_2733 aldose 1-epimerase; PFAM: Aldose 1-epimerase; SPTR: C3ZP58 Putative uncharacterized protein; PFAM: Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (266 aa)
Fbal_2424COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR001216: IPR005856: IPR005859; KEGG: yen:YE1208 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: P0A1E3 Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
Fbal_2458FAD dependent oxidoreductase; COGs: COG0578 Glycerol-3-phosphate dehydrogenase; InterPro IPR000447: IPR006076; KEGG: sse:Ssed_0595 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: A3JDP0 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. (495 aa)
Fbal_2460Phospholipase A(2); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. (312 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
Fbal_24862-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (398 aa)
Fbal_2487COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR001017: IPR005475: IPR011603; KEGG: slo:Shew_1655 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component; SPTR: A2V1H2 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component. (935 aa)
Fbal_2488COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterPro IPR001041: IPR017900: IPR004489; KEGG: saz:Sama_1426 succinate dehydrogenase iron-sulfur subunit; PRIAM: Succinate dehydrogenase; SPTR: A2V1H3 Succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (235 aa)
Fbal_2489COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR013027: IPR004112: IPR003953: IPR003952: IPR 014006: IPR011281; KEGG: asa:ASA_2359 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: A3WKB9 Succinate dehydrogenase; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; succinate dehydrogenase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; succinate [...] (586 aa)
Fbal_2490Succinate dehydrogenase subunit D; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
Fbal_2491COGs: COG2009 Succinate dehydrogenase/fumarate reductase cytochrome b subunit; InterPro IPR000701: IPR018495: IPR014314; KEGG: spe:Spro_1263 succinate dehydrogenase cytochrome b556 large membrane subunit; PFAM: succinate dehydrogenase cytochrome b subunit; SPTR: P63725 Succinate dehydrogenase cytochrome b556 subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit. (125 aa)
Fbal_2492COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR019810: IPR010953; KEGG: shl:Shal_2494 type II citrate synthase; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: A2V1H7 Citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family. (428 aa)
Fbal_2496Beta-lactamase domain protein; COGs: COG0491 Zn-dependent hydrolase including glyoxylase; InterPro IPR001279; KEGG: swp:swp_2280 beta-lactamase-like protein; PFAM: beta-lactamase domain protein; SPTR: A2TU75 Zn-dependent hydrolase, glyoxylase family protein; PFAM: Metallo-beta-lactamase superfamily. (285 aa)
Fbal_2517COGs: COG1760 L-serine deaminase; InterPro IPR005130: IPR005131: IPR004644; KEGG: swp:swp_1748 L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A2V1Y8 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (457 aa)
Fbal_2535COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218: IPR006268; KEGG: ppr:PBPRA2485 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Q9WYH8 Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa)
Fbal_2536COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999: IPR006805: IPR015890: IPR005257; KEGG: slo:Shew_2251 anthranilate synthase component I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: A3H2Y5 Anthranilate synthase aminase component; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: anthranilate synthase component I, proteobacterial subset. (518 aa)
Fbal_2537COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterPro IPR006220: IPR011702: IPR001317: IPR000991: IPR 006221; KEGG: sbp:Sbal223_1663 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: A2V452 Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (198 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa)
trpFPhosphoribosylanthranilate isomerase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001240: IPR013798: IPR001468; KEGG: saz:Sama_2132 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase; SPTR: A2V450 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (458 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (470 aa)
fabVTrans-2-enoyl-CoA reductase (NAD(+)); Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (402 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa)
accDacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
asd-2Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
Fbal_26303-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (708 aa)
fadI3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1297 aa)
Fbal_2728Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (188 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (371 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
Fbal_2763Inositol monophosphatase; COGs: COG0483 fructose-1 6-bisphosphatase of inositol monophosphatase family; InterPro IPR000760: IPR020583: IPR020550; KEGG: dze:Dd1591_1101 inositol monophosphatase; PFAM: inositol monophosphatase; SPTR: P0ADG4 Inositol-1-monophosphatase; PFAM: Inositol monophosphatase family. (267 aa)
Fbal_2772COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: sdn:Sden_1407 siroheme synthase; PRIAM: Precorrin-2 dehydrogenase; SPTR: A2V188 Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. (307 aa)
Fbal_2784COGs: COG2224 Isocitrate lyase; InterPro IPR000918; KEGG: pap:PSPA7_2573 isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; SPTR: A0Z837 Isocitrate lyase; PFAM: Isocitrate lyase family; TIGRFAM: isocitrate lyase. (530 aa)
Fbal_2785COGs: COG2225 Malate synthase; InterPro IPR011076: IPR019830: IPR006252; KEGG: saz:Sama_2381 malate synthase; PFAM: Malate synthase family protein; PRIAM: Malate synthase; SPTR: A2UVA6 Malate synthase; TIGRFAM: malate synthase A; PFAM: Malate synthase; TIGRFAM: malate synthase A; Belongs to the malate synthase family. (545 aa)
Fbal_2814COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR019818; KEGG: swp:swp_3606 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: A2UVF1 Isocitrate/isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (335 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
Fbal_2840COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR003042: IPR013027: IPR002938: IPR006076: IPR 010971; KEGG: asa:ASA_1075 2-polyprenyl-6-methoxyphenol hydroxylase; PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; SPTR: A2UY74 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: FAD binding domain; TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. (388 aa)
Fbal_2851COGs: COG0560 Phosphoserine phosphatase; InterPro IPR005834: IPR004469: IPR006383; KEGG: asa:ASA_3650 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Phosphoserine phosphatase; SPTR: A2UZE1 Phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (304 aa)
deoD-2COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845: IPR018016: IPR004402; KEGG: sfr:Sfri_1005 purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: Q086F7 Purine nucleoside phosphorylase deoD-type; TIGRFAM: purine nucleoside phosphorylase; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). (234 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa)
Fbal_2905COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670: IPR018211; KEGG: shn:Shewana3_2938 iron-containing alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; SPTR: A2UVB2 Iron-containing alcohol dehydrogenase; PFAM: Iron-containing alcohol dehydrogenase. (383 aa)
Fbal_2925Tryptophan halogenase; InterPro IPR006905; KEGG: sbl:Sbal_1078 tryptophan halogenase; PFAM: tryptophan halogenase; SPTR: A0Y3N6 Putative tryptophan halogenase; PFAM: Tryptophan halogenase. (515 aa)
Fbal_2935COGs: COG2008 Threonine aldolase; InterPro IPR001597: IPR000277; KEGG: son:SO_3338 L-allo-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Threonine aldolase; SPTR: A2V0A9 Aromatic amino acid beta-eliminating lyase/threonine aldolase; PFAM: Beta-eliminating lyase. (336 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa)
Fbal_3020Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa)
Fbal_3078Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa)
pgkCOGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576: IPR015911; KEGG: saz:Sama_2757 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: A8H0N0 Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa)
hemLCOGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: saz:Sama_0839 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: A1S3U0 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (429 aa)
Fbal_31276-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (506 aa)
Fbal_3171COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR006090: IPR006092: IPR006091: IPR013107; KEGG: sfr:Sfri_2214 acyl-CoA dehydrogenase domain-containing protein; PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase type 2 domain; SPTR: A0Y2R9 Acyl-CoA dehydrogenase; PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain. (408 aa)
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa)
Fbal_3231Aminotransferase class V; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192: IPR006311; KEGG: vha:VIBHAR_04996 cysteine desulfurase; PFAM: aminotransferase class V; SPTR: A3I0R9 L-cysteine/cystine lyase; PFAM: Aminotransferase class-V. (461 aa)
plsYAcyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (200 aa)
Fbal_3278COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123: IPR004552; KEGG: sfr:Sfri_3514 1-acyl-sn-glycerol-3-phosphate acyltransferases; PFAM: phospholipid/glycerol acyltransferase; PRIAM: 1-acylglycerol-3-phosphate O-acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: A2UUS7 1-acyl-sn-glycerol-3-phosphate acyltransferases; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (244 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636: IPR014106; KEGG: ppr:PBPRA1469 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Q480B3 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type. (367 aa)
Fbal_3324COGs: COG1760 L-serine deaminase; InterPro IPR005130: IPR005131: IPR004644; KEGG: sse:Ssed_0859 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A3H312 L-serine dehydratase; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (454 aa)
Fbal_3352D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR006140; KEGG: slo:Shew_0887 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: A2V4Y7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (317 aa)
Fbal_3373Trans-hexaprenyltranstransferase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: swd:Swoo_1003 polyprenyl synthetase; PFAM: Polyprenyl synthetase; PRIAM: Trans-hexaprenyltranstransferase; SPTR: A0Y6E6 Octaprenyl-diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (322 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
argDCOGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814: IPR004636: IPR017652; KEGG: son:SO_0617 bifunctional N-succinyldiaminopimelate-aminotransferase/ acetylornithine transaminase protein; PFAM: aminotransferase class-III; PRIAM: Succinyldiaminopimelate transaminase; SPTR: P59320 Acetylornithine aminotransferase; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferases; Belongs to [...] (405 aa)
Fbal_3512COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR005106: IPR001048: IPR019811: IPR 018042: IPR001341; KEGG: saz:Sama_3170 bifunctional aspartate kinase II/homoserine dehydrogenase II; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2UWJ9 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine deh [...] (786 aa)
Fbal_3513COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277: IPR011821; KEGG: slo:Shew_0520 O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-synthase; SPTR: A2UWJ8 O-succinylhomoserine (Thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. (381 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
Fbal_3555Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: slo:Shew_3382 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: A2V4N4 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa)
Fbal_3558Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR019546: IPR006311; KEGG: shl:Shal_3744 aminotransferase class I and II; PFAM: aminotransferase class I and II; Twin-arginine translocation pathway, signal sequence, subgroup; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; PFAM: TAT (twin-arginine translocation) pathway signal sequence; Aminotransferase class I and II; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; histidinol-phosphate aminotransferase. (380 aa)
ubiD3-octaprenyl-4hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (492 aa)
ubiA4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (289 aa)
Fbal_3643Alanine-glyoxylate aminotransferase apoenzyme; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192: IPR020578; KEGG: saz:Sama_3277 serine--pyruvate transaminase; PFAM: aminotransferase class V; PRIAM: Serine--pyruvate transaminase; SPTR: A3UZX5 Aminotransferase, class V; PFAM: Aminotransferase class-V. (376 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (508 aa)
ilvDCOGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR020558: IPR004404; KEGG: slo:Shew_0292 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: A3Q9L6 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (323 aa)
Fbal_3649COGs: COG3978 Acetolactate synthase (isozyme II) small (regulatory) subunit; KEGG: sdn:Sden_3413 acetolactate synthase 2 regulatory subunit; SPTR: A2UYR6 Amino acid-binding ACT. (87 aa)
Fbal_3650Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012000: IPR011766: IPR012001: IPR000399: IPR 012846; KEGG: shw:Sputw3181_3754 acetolactate synthase 2 catalytic subunit; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; SPTR: A2UYR7 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-termin [...] (548 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
Fbal_3689Uroporphyrinogen-III C-methyltransferase; COGs: COG2959 Uncharacterized protein of heme biosynthesis; InterPro IPR007470; KEGG: asa:ASA_3877 uroporphyrin-III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: A3EML4 Uroporphyrin-III C-methyltransferase, putative; PFAM: HemX. (338 aa)
Fbal_3690Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (269 aa)
Fbal_3713HAD-superfamily hydrolase, subfamily IA, variant 1; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005834: IPR006439; KEGG: vcj:VCD_001589 2-haloalkanoic acid dehalogenase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: A3GZK5 2-haloalkanoic acid dehalogenase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (235 aa)
Fbal_3746COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR010723: IPR007197: IPR006638: IPR004558; KEGG: son:SO_4730 coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; PRIAM: Coproporphyrinogen dehydrogenase; SMART: Elongator protein 3/MiaB/NifB; SPTR: A2V5C7 Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyri [...] (456 aa)
gpsACOGs: COG0240 Glycerol-3-phosphate dehydrogenase; InterPro IPR006168: IPR011128: IPR013332: IPR006109; KEGG: kpu:KP1_5301 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; PRIAM: Glycerol-3-phosphate dehydrogenase (NAD(P)(+)); SPTR: A6TFK3 Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus. (334 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
Your Current Organism:
Ferrimonas balearica
NCBI taxonomy Id: 550540
Other names: F. balearica DSM 9799, Ferrimonas balearica DSM 9799, Ferrimonas balearica PAT, Ferrimonas balearica str. DSM 9799, Ferrimonas balearica strain DSM 9799
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.