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| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa) |
| | Fbal_0091 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146: IPR008147: IPR001637: IPR004809; KEGG: vha:VIBHAR_00588 glutamine synthetase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: A0XX56 Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (469 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | Fbal_0312 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518: IPR018223; KEGG: amc:MADE_00529 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: A0XXT0 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | argH | N-acetylglutamate synthase; COGs: COG0165 Argininosuccinate lyase; InterPro IPR000362: IPR000182: IPR020557: IPR009049; KEGG: cps:CPS_0464 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; PFAM: fumarate lyase; GCN5-related N-acetyltransferase; SPTR: P59620 Bifunctional protein argH; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; Acetyltransferase (GNAT) family; TIGRFAM: argininosuccinate lyase; In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (643 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa) |
| | Fbal_0328 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: shm:Shewmr7_0253 ribulose-5-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: A2V3E8 Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (224 aa) |
| | Fbal_0376 | Aconitase; COGs: COG1049 Aconitase B; InterPro IPR015929: IPR001030: IPR018136: IPR004406; KEGG: vpa:VP2495 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal; aconitate hydratase domain protein; SPTR: A3H377 Aconitate hydratase 2; TIGRFAM: aconitate hydratase 2; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (864 aa) |
| | Fbal_0390 | COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: shw:Sputw3181_2923 glyceraldehyde-3-phosphate dehydrogenase; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UV92 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate [...] (335 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa) |
| | Fbal_0616 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | mtnN | Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa) |
| | Fbal_0656 | Glutamate synthase (NADPH) small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR000759: IPR013027: IPR000103: IPR001327: IPR 006006; KEGG: saz:Sama_0856 glutamate synthase subunit beta; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: A2V2C4 Glutamate synthase, small subunit; TIGRFAM: glutamate synthase, small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase small subunit family protein, proteobacterial. (472 aa) |
| | Fbal_0657 | Glutamate synthase (NADPH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002489: IPR002932: IPR006982: IPR000583; KEGG: slo:Shew_1032 glutamate synthase subunit alpha; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; PRIAM: Glutamate synthase (ferredoxin); SPTR: A2V2C5 Ferredoxin-dependent glutamate synthase; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1483 aa) |
| | Fbal_0663 | COGs: COG0527 Aspartokinase; InterPro IPR001048: IPR018042: IPR005260: IPR001341; KEGG: sse:Ssed_0817 aspartate kinase III; PFAM: aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase; SPTR: P08660 Lysine-sensitive aspartokinase 3; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (460 aa) |
| | Fbal_0667 | Aspartate-ammonia ligase; COGs: COG2502 Asparagine synthetase A; InterPro IPR004618: IPR006195; KEGG: sfv:SFV_3770 asparagine synthetase AsnA; PFAM: aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Q83PJ4 Aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type. (325 aa) |
| | Fbal_0688 | COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR002912: IPR006140; KEGG: vpa:VP2593 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: A3ELN9 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (409 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | Fbal_0743 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa) |
| | Fbal_0744 | Chorismate mutase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002701: IPR011277; KEGG: saz:Sama_0894 bifunctional chorismate mutase/prephenate dehydrogenase; PFAM: Chorismate mutase; Prephenate dehydrogenase; SPTR: A2UV38 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydrogenase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of T-protein. (378 aa) |
| | Fbal_0753 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR006218: IPR002912: IPR002701: IPR 018528: IPR006268: IPR010952; KEGG: swd:Swoo_1263 chorismate mutase; PFAM: prephenate dehydratase; DAHP synthetase I/KDSA; amino acid-binding ACT domain protein; Chorismate mutase; SPTR: A2UV42 Chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase domain of p [...] (672 aa) |
| | Fbal_0766 | COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR002912: IPR005106: IPR001048: IPR 019811: IPR018042: IPR001341; KEGG: saz:Sama_0905 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2V048 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase; [...] (818 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | Fbal_0768 | COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR000634: IPR004450; KEGG: shn:Shewana3_1141 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: A2V050 Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | Fbal_0858 | COGs: COG0527 Aspartokinase; InterPro IPR001057: IPR002912: IPR001048: IPR018042: IPR 005260: IPR001341; KEGG: pin:Ping_3379 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: A0Z876 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (406 aa) |
| | Fbal_0880 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa) |
| | luxS | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (169 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | dapD | COGs: COG2171 Tetrahydrodipicolinate N-succinyltransferase; InterPro IPR001451: IPR018357: IPR005664; KEGG: shl:Shal_2984 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; PRIAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; SPTR: B0TP86 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; TIGRFAM:2,3,4,5-tetrahydropyridine-2,6-dicarboxylat eN-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (311 aa) |
| | Fbal_1136 | Glutamate--putrescine ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: cps:CPS_4677 glutamine synthetase family protein; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A3LHA3 Putative uncharacterized protein; PFAM: Glutamine synthetase, catalytic domain. (459 aa) |
| | Fbal_1137 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: asa:ASA_0172 glutamine synthetase; PFAM: glutamine synthetase catalytic region; PRIAM: Glutamate--putrescine ligase; SPTR: A2VUT5 Glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain. (443 aa) |
| | Fbal_1219 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426: IPR017535; KEGG: pla:Plav_0816 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: A0P460 Putative asparagine synthetase (Glutamine amidotransferase) protein; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrol [...] (588 aa) |
| | Fbal_1244 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962: IPR000583: IPR006426; KEGG: sbn:Sbal195_1769 asparagine synthetase B; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: A2V529 Asparagine synthase (Glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (554 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | Fbal_1443 | COGs: COG1045 Serine acetyltransferase; InterPro IPR001451: IPR010493: IPR018357: IPR005881; KEGG: amc:MADE_00201 serine acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein; PRIAM: Serine O-acetyltransferase; SPTR: A0XYV3 Serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase. (267 aa) |
| | Fbal_1622 | Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: azo:azo3380 putative transaminase; PFAM: aminotransferase class I and II; SPTR: A3J880 Aminotransferase, class I and II; PFAM: Aminotransferase class I and II. (379 aa) |
| | hisI | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR002496: IPR008179; KEGG: swp:swp_3009 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: A2V1X4 Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (202 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: kpu:KP1_3685 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase; PFAM: histidine biosynthesis protein; SPTR: B8CR53 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM [...] (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR013954: IPR020565: IPR006543: IPR 005954: IPR006549; KEGG: ppr:PBPRA1089 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; PRIAM: Histidinol-phosphatase; SPTR: P62455 Histidine biosynthesis bifunctional protein hisB; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase; Imidazoleglyce [...] (355 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR001917: IPR005861; KEGG: slo:Shew_2199 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q8EFB2 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (307 aa) |
| | Fbal_1917 | COGs: COG1448 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR000796: IPR004839: IPR004838; KEGG: esa:ESA_02414 aromatic amino acid aminotransferase; PFAM: aminotransferase class I and II; PRIAM: Aspartate transaminase; SPTR: P00509 Aspartate aminotransferase; PFAM: Aminotransferase class I and II. (396 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | hisC-2 | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR001176: IPR004839: IPR001917: IPR005861; KEGG: pin:Ping_1116 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q5QZ49 Histidinol-phosphate aminotransferase 1; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa) |
| | Fbal_1956 | COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: saz:Sama_1806 glyceraldehyde-3-phosphate dehydrogenase; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UZG1 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehyd [...] (474 aa) |
| | Fbal_1958 | COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173: IPR006424; KEGG: slo:Shew_2002 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: A2UZF9 Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phospha [...] (338 aa) |
| | Fbal_1967 | COGs: COG0469 Pyruvate kinase; InterPro IPR015793: IPR015794: IPR001697; KEGG: sbm:Shew185_2128 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: A2V5D4 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | Fbal_1990 | Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804: IPR019818: IPR004439; KEGG: pmr:PMI0891 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: P08200 Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (417 aa) |
| | Fbal_1991 | Isocitrate dehydrogenase, NADP-dependent; COGs: COG2838 Monomeric isocitrate dehydrogenase; InterPro IPR004436; KEGG: pin:Ping_0983 isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: A0Y1L4 Isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Monomeric isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (752 aa) |
| | Fbal_2203 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | Fbal_2228 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: sdn:Sden_2013 pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: A2PU42 Cysteine synthase/cystathionine beta-synthase family protein; PFAM: Pyridoxal-phosphate dependent enzyme. (354 aa) |
| | Fbal_2265 | Transferase hexapeptide repeat containing protein; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: tgr:Tgr7_2377 transferase hexapeptide repeat containing protein; PFAM: transferase hexapeptide repeat containing protein; SPTR: Q46F84 Serine O-acetyltransferase. (196 aa) |
| | Fbal_2373 | Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176: IPR004839: IPR001412; KEGG: sfr:Sfri_1907 aminotransferase AlaT; PFAM: aminotransferase class I and II; SPTR: A2V5E2 Aminotransferase, class I and II; PFAM: Aminotransferase class I and II. (404 aa) |
| | Fbal_2424 | COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR001216: IPR005856: IPR005859; KEGG: yen:YE1208 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: P0A1E3 Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa) |
| | Fbal_2492 | COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR019810: IPR010953; KEGG: shl:Shal_2494 type II citrate synthase; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: A2V1H7 Citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family. (428 aa) |
| | Fbal_2517 | COGs: COG1760 L-serine deaminase; InterPro IPR005130: IPR005131: IPR004644; KEGG: swp:swp_1748 L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A2V1Y8 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (457 aa) |
| | Fbal_2535 | COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218: IPR006268; KEGG: ppr:PBPRA2485 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Q9WYH8 Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa) |
| | Fbal_2536 | COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999: IPR006805: IPR015890: IPR005257; KEGG: slo:Shew_2251 anthranilate synthase component I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: A3H2Y5 Anthranilate synthase aminase component; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: anthranilate synthase component I, proteobacterial subset. (518 aa) |
| | Fbal_2537 | COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterPro IPR006220: IPR011702: IPR001317: IPR000991: IPR 006221; KEGG: sbp:Sbal223_1663 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: A2V452 Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (198 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001240: IPR013798: IPR001468; KEGG: saz:Sama_2132 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase; SPTR: A2V450 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (458 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | Fbal_2580 | COGs: COG3186 Phenylalanine-4-hydroxylase; InterPro IPR019774: IPR018301: IPR005960; KEGG: ilo:IL0725 phenylalanine 4-monooxygenase; PFAM: Aromatic amino acid hydroxylase-like; SPTR: A3WM90 Phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: Biopterin-dependent aromatic amino acid hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase, monomeric form. (263 aa) |
| | asd-2 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | Fbal_2814 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR019818; KEGG: swp:swp_3606 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: A2UVF1 Isocitrate/isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (335 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | Fbal_2851 | COGs: COG0560 Phosphoserine phosphatase; InterPro IPR005834: IPR004469: IPR006383; KEGG: asa:ASA_3650 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Phosphoserine phosphatase; SPTR: A2UZE1 Phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (304 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | Fbal_2935 | COGs: COG2008 Threonine aldolase; InterPro IPR001597: IPR000277; KEGG: son:SO_3338 L-allo-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Threonine aldolase; SPTR: A2V0A9 Aromatic amino acid beta-eliminating lyase/threonine aldolase; PFAM: Beta-eliminating lyase. (336 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | Fbal_3020 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa) |
| | Fbal_3078 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa) |
| | pgk | COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576: IPR015911; KEGG: saz:Sama_2757 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: A8H0N0 Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | Fbal_3324 | COGs: COG1760 L-serine deaminase; InterPro IPR005130: IPR005131: IPR004644; KEGG: sse:Ssed_0859 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A3H312 L-serine dehydratase; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (454 aa) |
| | argD | COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814: IPR004636: IPR017652; KEGG: son:SO_0617 bifunctional N-succinyldiaminopimelate-aminotransferase/ acetylornithine transaminase protein; PFAM: aminotransferase class-III; PRIAM: Succinyldiaminopimelate transaminase; SPTR: P59320 Acetylornithine aminotransferase; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferases; Belongs to [...] (405 aa) |
| | Fbal_3512 | COGs: COG0527 Aspartokinase; InterPro IPR001342: IPR005106: IPR001048: IPR019811: IPR 018042: IPR001341; KEGG: saz:Sama_3170 bifunctional aspartate kinase II/homoserine dehydrogenase II; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: A2UWJ9 Aspartate kinase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine deh [...] (786 aa) |
| | Fbal_3513 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277: IPR011821; KEGG: slo:Shew_0520 O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-synthase; SPTR: A2UWJ8 O-succinylhomoserine (Thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. (381 aa) |
| | Fbal_3558 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839: IPR019546: IPR006311; KEGG: shl:Shal_3744 aminotransferase class I and II; PFAM: aminotransferase class I and II; Twin-arginine translocation pathway, signal sequence, subgroup; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; PFAM: TAT (twin-arginine translocation) pathway signal sequence; Aminotransferase class I and II; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; histidinol-phosphate aminotransferase. (380 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (508 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR020558: IPR004404; KEGG: slo:Shew_0292 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: A3Q9L6 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (323 aa) |
| | Fbal_3649 | COGs: COG3978 Acetolactate synthase (isozyme II) small (regulatory) subunit; KEGG: sdn:Sden_3413 acetolactate synthase 2 regulatory subunit; SPTR: A2UYR6 Amino acid-binding ACT. (87 aa) |
| | Fbal_3650 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012000: IPR011766: IPR012001: IPR000399: IPR 012846; KEGG: shw:Sputw3181_3754 acetolactate synthase 2 catalytic subunit; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; SPTR: A2UYR7 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-termin [...] (548 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (269 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
