(16 nodes) Thiamin diphosphate-binding fold network (Pectobacterium betavasculorum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

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Your Input:
	dxs	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa)
	menD	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (560 aa)
	KFX06735.1	2-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
	KFX06813.1	3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (643 aa)
	KFX07693.1	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
	KFX07694.1	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
	KFX06001.1	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1177 aa)
	KFX06084.1	Catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (559 aa)
	KFX05158.1	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
	KFX05237.1	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
	KFX05252.1	Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
	aceE	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
	KFX05407.1	Indolepyruvate decarboxylase; Thiamindiphosphate-dependent; catalyzes the formation of indoleacetaldehyde from indolepyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
	KFX01430.1	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
	KFX00585.1	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
	KFX00586.1	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)

Your Current Organism:

Pectobacterium betavasculorum

NCBI taxonomy Id: 55207
Other names: ATCC 43762, CFBP 2122, CIP 105193, DSM 18076, Erwinia carotovora subsp. betavasculorum, ICMP 4226, LMG 2464, LMG 2466, LMG:2464, LMG:2466, NCPPB 2795, P. betavasculorum, Pectobacterium carotovorum subsp. betavasculorum, UCPB 193

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KFX00585.1	KFX00586.1	KP22_19880	KP22_19885	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KFX00585.1	KFX01430.1	KP22_19880	KP22_19360	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.437
KFX00585.1	KFX05158.1	KP22_19880	KP22_10645	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.765
KFX00585.1	KFX05237.1	KP22_19880	KP22_11045	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.437
KFX00585.1	KFX05252.1	KP22_19880	KP22_11125	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.437
KFX00585.1	KFX05407.1	KP22_19880	KP22_11945	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Indolepyruvate decarboxylase; Thiamindiphosphate-dependent; catalyzes the formation of indoleacetaldehyde from indolepyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.760
KFX00585.1	KFX06001.1	KP22_19880	KP22_09090	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.943
KFX00585.1	KFX06084.1	KP22_19880	KP22_09525	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.437
KFX00585.1	KFX06735.1	KP22_19880	KP22_01195	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
KFX00585.1	KFX07693.1	KP22_19880	KP22_06260	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.785
KFX00585.1	KFX07694.1	KP22_19880	KP22_06265	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.772
KFX00585.1	aceE	KP22_19880	KP22_11315	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.748
KFX00586.1	KFX00585.1	KP22_19885	KP22_19880	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KFX00586.1	KFX01430.1	KP22_19885	KP22_19360	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.434
KFX00586.1	KFX05158.1	KP22_19885	KP22_10645	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.757
KFX00586.1	KFX05237.1	KP22_19885	KP22_11045	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.434
KFX00586.1	KFX05252.1	KP22_19885	KP22_11125	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.434
KFX00586.1	KFX05407.1	KP22_19885	KP22_11945	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Indolepyruvate decarboxylase; Thiamindiphosphate-dependent; catalyzes the formation of indoleacetaldehyde from indolepyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.732
KFX00586.1	KFX06001.1	KP22_19885	KP22_09090	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
KFX00586.1	KFX06084.1	KP22_19885	KP22_09525	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.434

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