STRINGSTRING
ARF59159.1 ARF59159.1 ARF53966.1 ARF53966.1 soxA soxA ARF53968.1 ARF53968.1 metE metE gcvP gcvP ARF59308.1 ARF59308.1 metK metK ARF54532.1 ARF54532.1 ARF54683.1 ARF54683.1 ARF54910.1 ARF54910.1 ARF55383.1 ARF55383.1 ahcY ahcY ARF59519.1 ARF59519.1 ARF56144.1 ARF56144.1 ARF56432.1 ARF56432.1 ARF56435.1 ARF56435.1 purU purU folD folD glyA glyA ARF57150.1 ARF57150.1 glyA-2 glyA-2 ARF57516.1 ARF57516.1 glyA-3 glyA-3 gcvH gcvH gcvT gcvT ARF57539.1 ARF57539.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARF59159.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ARF53966.12Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
soxAN-methyltryptophan oxidase; Catalyzes the oxidative demethylation of sarcosine. (384 aa)
ARF53968.1Sarcosine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (817 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (774 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
ARF59308.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
ARF54532.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1169 aa)
ARF54683.1Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
ARF54910.1Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (305 aa)
ARF55383.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (123 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)
ARF59519.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ARF56144.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ARF56432.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
ARF56435.1Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (297 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
ARF57150.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (453 aa)
ARF57516.1L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
ARF57539.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
Your Current Organism:
Streptomyces gilvosporeus
NCBI taxonomy Id: 553510
Other names: S. gilvosporeus
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