STRINGSTRING
ARF57313.1 ARF57313.1 ispH-2 ispH-2 ARF57133.1 ARF57133.1 ARF59701.1 ARF59701.1 add add ARF57058.1 ARF57058.1 ARF57047.1 ARF57047.1 folD folD purH purH purN purN guaA guaA purU purU pdxH pdxH ARF59673.1 ARF59673.1 ispF ispF ARF53380.1 ARF53380.1 ARF53366.1 ARF53366.1 ARF53362.1 ARF53362.1 ARF53317.1 ARF53317.1 ARF53260.1 ARF53260.1 ARF53259.1 ARF53259.1 ARF59203.1 ARF59203.1 ispH ispH ispG ispG dxr dxr dxs dxs ARF53191.1 ARF53191.1 nadK nadK ARF52923.1 ARF52923.1 ARF53747.1 ARF53747.1 ARF53754.1 ARF53754.1 ARF53777.1 ARF53777.1 ARF53795.1 ARF53795.1 ARF53385.1 ARF53385.1 pdhA pdhA ARF53396.1 ARF53396.1 ARF53478.1 ARF53478.1 ARF53549.1 ARF53549.1 ARF53677.1 ARF53677.1 ARF53694.1 ARF53694.1 ispD ispD atpB atpB ARF53383.1 ARF53383.1 ARF53382.1 ARF53382.1 ARF59008.1 ARF59008.1 ARF58970.1 ARF58970.1 ARF58798.1 ARF58798.1 ARF58791.1 ARF58791.1 ARF58776.1 ARF58776.1 ARF58701.1 ARF58701.1 dxs-3 dxs-3 ARF58609.1 ARF58609.1 ARF58607.1 ARF58607.1 ARF59876.1 ARF59876.1 ARF58599.1 ARF58599.1 idi idi ARF58473.1 ARF58473.1 fdhD fdhD ARF58303.1 ARF58303.1 psd psd ARF58264.1 ARF58264.1 ARF58234.1 ARF58234.1 ARF58038.1 ARF58038.1 pyrE-2 pyrE-2 ARF57993.1 ARF57993.1 dxs-2 dxs-2 ARF57930.1 ARF57930.1 ARF53800.1 ARF53800.1 dut dut ARF57844.1 ARF57844.1 ARF57843.1 ARF57843.1 tdk tdk ARF57758.1 ARF57758.1 ARF57757.1 ARF57757.1 ARF52917.1 ARF52917.1 ARF53848.1 ARF53848.1 ARF54038.1 ARF54038.1 ARF59287.1 ARF59287.1 ARF54091.1 ARF54091.1 ARF54095.1 ARF54095.1 purA purA ARF54135.1 ARF54135.1 ARF54159.1 ARF54159.1 ARF54194.1 ARF54194.1 ARF54208.1 ARF54208.1 ARF54217.1 ARF54217.1 ARF54263.1 ARF54263.1 ARF59320.1 ARF59320.1 ARF54368.1 ARF54368.1 ARF54379.1 ARF54379.1 gmk gmk pyrF pyrF pyrD pyrD carB carB carA carA ARF54386.1 ARF54386.1 pyrC pyrC pyrB pyrB ARF54394.1 ARF54394.1 ARF54412.1 ARF54412.1 apt apt pdxT pdxT pdxS pdxS ARF54426.1 ARF54426.1 ARF54457.1 ARF54457.1 ARF59341.1 ARF59341.1 ARF54623.1 ARF54623.1 ARF54631.1 ARF54631.1 cmk cmk pyrG pyrG nadK-2 nadK-2 moaA moaA tpiA tpiA ARF54804.1 ARF54804.1 coaE coaE thiE thiE ARF54914.1 ARF54914.1 ARF54915.1 ARF54915.1 thiG thiG ARF54925.1 ARF54925.1 nadA nadA ARF59400.1 ARF59400.1 B1H19_13010 B1H19_13010 nadE nadE ARF55108.1 ARF55108.1 ARF55141.1 ARF55141.1 ARF55297.1 ARF55297.1 nadD nadD ndk ndk ARF55454.1 ARF55454.1 ARF55508.1 ARF55508.1 ARF55509.1 ARF55509.1 ARF55536.1 ARF55536.1 purE purE purK purK glmU glmU prs prs ispE ispE ARF55746.1 ARF55746.1 moaC moaC ARF55748.1 ARF55748.1 ARF59531.1 ARF59531.1 ARF55841.1 ARF55841.1 ARF55862.1 ARF55862.1 guaB guaB coaA coaA adk adk ARF55938.1 ARF55938.1 tmk tmk ARF56119.1 ARF56119.1 purM purM purF purF purL purL purQ purQ purS purS purC purC purD purD purA-2 purA-2 ARF56181.1 ARF56181.1 kynU kynU pyrE pyrE ARF56219.1 ARF56219.1 dcd dcd ARF56321.1 ARF56321.1 ARF59596.1 ARF59596.1 ARF56330.1 ARF56330.1 ARF56333.1 ARF56333.1 ARF56405.1 ARF56405.1 thiC thiC ARF56535.1 ARF56535.1 ARF56541.1 ARF56541.1 upp upp ARF59634.1 ARF59634.1 ARF59637.1 ARF59637.1 ARF56636.1 ARF56636.1 acsA acsA ARF56729.1 ARF56729.1 folE folE ARF56755.1 ARF56755.1 coaX coaX ARF56840.1 ARF56840.1 B1H19_00485 B1H19_00485 ARF52856.1 ARF52856.1 thyX thyX ARF57714.1 ARF57714.1 ispG-2 ispG-2 dxr-2 dxr-2 ARF57673.1 ARF57673.1 pyrH pyrH coaD coaD ARF57609.1 ARF57609.1 thiL thiL gpsA gpsA ARF57603.1 ARF57603.1 ARF57568.1 ARF57568.1 ARF57566.1 ARF57566.1 nadE-2 nadE-2 ARF57480.1 ARF57480.1 ackA ackA atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB-2 atpB-2 ARF57349.1 ARF57349.1 ARF57335.1 ARF57335.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ARF57313.1Molybdopterin biosynthesis protein MoeE; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
ispH-24-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (330 aa)
ARF57133.1Adenylate/guanylate cyclase domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ARF59701.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (386 aa)
ARF57058.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
ARF57047.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (200 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (527 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (297 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (209 aa)
ARF59673.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (170 aa)
ARF53380.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the V-ATPase proteolipid subunit family. (140 aa)
ARF53366.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
ARF53362.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (454 aa)
ARF53317.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
ARF53260.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (422 aa)
ARF53259.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (329 aa)
ARF59203.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (669 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (378 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (449 aa)
dxsHypothetical protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (653 aa)
ARF53191.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
nadKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (354 aa)
ARF52923.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
ARF53747.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ARF53754.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
ARF53777.1Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
ARF53795.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
ARF53385.1V-type ATPase, D subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (341 aa)
ARF53396.1acetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
ARF53478.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
ARF53549.1ATP-grasp domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
ARF53677.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
ARF53694.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (251 aa)
atpBV-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (475 aa)
ARF53383.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (600 aa)
ARF53382.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
ARF59008.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
ARF58970.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
ARF58798.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (399 aa)
ARF58791.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
ARF58776.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
ARF58701.1Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
dxs-31-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
ARF58609.11-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
ARF58607.1Dimethylallyltranstransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (371 aa)
ARF59876.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ARF58599.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (597 aa)
idiIsopentenyl-diphosphate delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (203 aa)
ARF58473.1Peptidase M6; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
fdhDSulfurtransferase FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (284 aa)
ARF58303.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (215 aa)
ARF58264.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (284 aa)
ARF58234.1Dihydropyrimidinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
ARF58038.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (358 aa)
pyrE-2Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (174 aa)
ARF57993.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
dxs-21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (647 aa)
ARF57930.12-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
ARF53800.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (173 aa)
ARF57844.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
ARF57843.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
ARF57758.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (178 aa)
ARF57757.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (220 aa)
ARF52917.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
ARF53848.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
ARF54038.1CDP-alcohol phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (242 aa)
ARF59287.1acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
ARF54091.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (202 aa)
ARF54095.1acetoacetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (677 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (452 aa)
ARF54135.1Oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyridoxamine 5'-phosphate oxidase family. (194 aa)
ARF54159.1Siderophore biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
ARF54194.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
ARF54208.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
ARF54217.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
ARF54263.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
ARF59320.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
ARF54368.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
ARF54379.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (422 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (282 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (370 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1102 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (380 aa)
ARF54386.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (328 aa)
ARF54394.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
ARF54412.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (859 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
pdxTPyridoxal 5'-phosphate synthase glutaminase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (200 aa)
pdxSPyridoxal 5'-phosphate synthase lyase subunit PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa)
ARF54426.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (219 aa)
ARF54457.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
ARF59341.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
ARF54623.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ARF54631.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (557 aa)
nadK-2NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (313 aa)
moaAGTP 3',8-cyclase MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
ARF54804.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa)
ARF54914.1Glycine oxidase ThiO; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
ARF54915.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (278 aa)
ARF54925.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (395 aa)
ARF59400.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
B1H19_13010Hypothetical protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
nadENAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (583 aa)
ARF55108.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (173 aa)
ARF55141.1Nucleoside/nucleotide kinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
ARF55297.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
nadDNicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (203 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
ARF55454.1Peptidase M6; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
ARF55508.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (442 aa)
ARF55509.1Nicotinamidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
ARF55536.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (213 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (180 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (485 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (305 aa)
ARF55746.1Molybdenum cofactor biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
moaCCyclic pyranopterin monophosphate synthase MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa)
ARF55748.1Molybdopterin molybdenumtransferase MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (438 aa)
ARF59531.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
ARF55841.1Oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
ARF55862.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
coaAType I pantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
ARF55938.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa)
ARF56119.1Glycerol acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (519 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (749 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (226 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (87 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (304 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (428 aa)
purA-2Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
ARF56181.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (427 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (180 aa)
ARF56219.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
ARF56321.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
ARF59596.1Molybdopterin molybdenumtransferase MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (461 aa)
ARF56330.1Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (299 aa)
ARF56333.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
ARF56405.1Inositol-3-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
thiCHypothetical protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (602 aa)
ARF56535.1Carboxylate--amine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
ARF56541.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
ARF59634.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
ARF59637.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
ARF56636.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
ARF56729.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
folEGTP cyclohydrolase I FolE; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
ARF56755.1Nicotinate-nucleotide diphosphorylase (carboxylating); Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (265 aa)
ARF56840.1Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (81 aa)
B1H19_00485Integrase; Frameshifted; incomplete; partial on complete genome; missing start and stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
ARF52856.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
thyXThymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (255 aa)
ARF57714.1Riboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (315 aa)
ispG-24-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
dxr-21-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (421 aa)
ARF57673.1Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family. (382 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (256 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (177 aa)
ARF57609.1Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa)
ARF57603.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
ARF57568.1Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
ARF57566.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
nadE-2NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa)
ARF57480.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (698 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (411 aa)
atpCATP synthase F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (127 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (480 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (306 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (530 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (271 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (190 aa)
atpEATP synthase F0 subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpB-2ATP synthase F0 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (265 aa)
ARF57349.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
ARF57335.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (349 aa)
Your Current Organism:
Streptomyces gilvosporeus
NCBI taxonomy Id: 553510
Other names: S. gilvosporeus
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