STRINGSTRING
Toce_0060 Toce_0060 Toce_0155 Toce_0155 lipB lipB lipA lipA Toce_0808 Toce_0808 gcvH gcvH Toce_1134 Toce_1134 Toce_1201 Toce_1201 Toce_1429 Toce_1429 Toce_1430 Toce_1430 Toce_1431 Toce_1431 pdhA pdhA Toce_1494 Toce_1494 Toce_1548 Toce_1548 Toce_1549 Toce_1549 Toce_1550 Toce_1550 Toce_1625 Toce_1625 Toce_1626 Toce_1626 hcp hcp Toce_1699 Toce_1699 Toce_1931 Toce_1931 Toce_1932 Toce_1932 Toce_1977 Toce_1977 Toce_2027 Toce_2027 Toce_2028 Toce_2028 Toce_2029 Toce_2029 Toce_2030 Toce_2030 pdhA-2 pdhA-2 Toce_2032 Toce_2032 Toce_2033 Toce_2033 Toce_2208 Toce_2208 Toce_2209 Toce_2209
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Toce_0060Thioredoxin; COGs: COG3118 Thioredoxin domain-containing protein; InterProIPR005746:IPR013766:IPR006662:IPR017937:IPR 017936; KEGG: rmr:Rmar_0180 thioredoxin; PFAM: Thioredoxin domain; SPTR: Thioredoxin; TIGRFAM: thioredoxin; PFAM: Thioredoxin; TIGRFAM: thioredoxin; Belongs to the thioredoxin family. (104 aa)
Toce_0155COGs: COG0492 Thioredoxin reductase; InterPro IPR005982:IPR013027:IPR000103:IPR008255; KEGG: pth:PTH_1417 thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: thioredoxin-disulfide reductase. (306 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (226 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (287 aa)
Toce_0808COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR006258:IPR012999:IPR013027:IPR000815:IPR 004099; KEGG: amt:Amet_2023 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. (474 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
Toce_1134NADH:flavin oxidoreductase/NADH oxidase; COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR013027:IPR000103:IPR001155; KEGG: tte:TTE2131 NADH:flavin oxidoreductase; PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: NADH:flavin oxidoreductases, Old Yellow Enzyme family; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family. (646 aa)
Toce_1201COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095:IPR006097:IPR006096:IPR014362; KEGG: tte:TTE1205 glutamate dehydrogenase/leucine dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: Glu/Leu/Phe/Val dehydrogenase; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (415 aa)
Toce_1429COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR006258:IPR013027:IPR004099:IPR012999:IPR 000815; KEGG: tit:Thit_1504 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. (460 aa)
Toce_1430Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: tte:TTE0188 dihydrolipoamide acyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: 2-oxo acid dehydrogenases acyltransferase (Catalytic domain) protein; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...] (432 aa)
Toce_1431Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: tte:TTE0187 thiamine pyrophosphate-dependent dehydrogenase, E1 component beta subunit; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (325 aa)
pdhADehydrogenase E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (319 aa)
Toce_1494KEGG: amt:Amet_4522 hypothetical protein; SPTR: Putative uncharacterized protein. (177 aa)
Toce_1548COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: tex:Teth514_0145 iron-containing alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; SPTR: Iron-containing alcohol dehydrogenase; PFAM: Iron-containing alcohol dehydrogenase. (383 aa)
Toce_1549NADH:flavin oxidoreductase/NADH oxidase; COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR001155:IPR013027:IPR000103; KEGG: tex:Teth514_0146 NADH:flavin oxidoreductase/NADH oxidase; PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: NADH:flavin oxidoreductase/NADH oxidase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family. (654 aa)
Toce_1550Transcriptional regulator, LysR family; COGs: COG0583 Transcriptional regulator; InterPro IPR000847:IPR005119; KEGG: tex:Teth514_0147 LysR family transcriptional regulator; PFAM: regulatory protein LysR; LysR substrate-binding; SPTR: Transcriptional regulator, LysR family; PFAM: LysR substrate binding domain; Bacterial regulatory helix-turn-helix protein, lysR family. (298 aa)
Toce_1625COGs: COG0450 Peroxiredoxin; InterPro IPR000866; KEGG: drt:Dret_1862 peroxiredoxin-like protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Peroxiredoxin-like protein; PFAM: AhpC/TSA family. (46 aa)
Toce_1626Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COGs: COG0450 Peroxiredoxin; InterPro IPR000866:IPR017936; KEGG: dal:Dalk_1204 alkyl hydroperoxide reductase; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Alkyl hydroperoxide reductase; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family. (131 aa)
hcpHybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (437 aa)
Toce_1699Transcriptional regulator, MerR family; COGs: COG0789 transcriptional regulator protein; InterPro IPR000551:IPR015358:IPR012925; KEGG: bcy:Bcer98_3564 MerR family transcriptional regulator; PFAM: TipAS antibiotic-recognition domain protein; regulatory protein MerR; Transcription regulator MerR DNA binding; SMART: regulatory protein MerR; SPTR: Transcriptional regulator, MerR family; PFAM: MerR, DNA binding; MerR family regulatory protein; TipAS antibiotic-recognition domain. (248 aa)
Toce_1931Acetyltransferase, GNAT family; InterPro IPR000182; KEGG: bwe:BcerKBAB4_3495 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Acetyltransferase; PFAM: Acetyltransferase (GNAT) family. (154 aa)
Toce_1932InterPro IPR001387:IPR013096; KEGG: drm:Dred_1558 cupin 2 domain-containing protein; PFAM: Cupin 2 conserved barrel domain protein; helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: Cupin 2, conserved barrel domain protein; PFAM: Cupin domain; Helix-turn-helix. (181 aa)
Toce_1977InterPro IPR005243; KEGG: fno:Fnod_1484 redox-active disulfide protein 2; SPTR: Redox-active disulfide protein 2; TIGRFAM: redox-active disulfide protein 2; TIGRFAM: small redox-active disulfide protein 2. (79 aa)
Toce_2027COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR013027:IPR000815:IPR006258:IPR 004099; KEGG: tex:Teth514_2038 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. (454 aa)
Toce_2028Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR003016:IPR000089:IPR004167:IPR001078; KEGG: tex:Teth514_2030 dehydrogenase catalytic domain-containing protein; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 [...] (404 aa)
Toce_2029ATP-NAD/AcoX kinase; COGs: COG3199 conserved hypothetical protein; InterPro IPR011391:IPR002504; KEGG: tpd:Teth39_0792 ATP-NAD/AcoX kinase; PFAM: ATP-NAD/AcoX kinase; SPTR: ATP-NAD/AcoX kinase; PFAM: ATP-NAD kinase. (332 aa)
Toce_2030Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: tex:Teth514_2032 transketolase, central region; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Transketolase, pyridine binding domain protein; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (323 aa)
pdhA-2Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (328 aa)
Toce_2032Conserved hypothetical protein; InterPro IPR011719; KEGG: tpd:Teth39_0789 hypothetical protein; PFAM: conserved hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Conserved hypothetical protein (Lin0512_fam); TIGRFAM: conserved hypothetical protein. (129 aa)
Toce_2033GAF modulated sigma54 specific transcriptional regulator, Fis family; COGs: COG3284 Transcriptional activator of acetoin/glycerol metabolism; InterProIPR000014:IPR003593:IPR002078:IPR020441:IPR 003018:IPR013767:IPR002197; KEGG: tex:Teth514_2035 fis family GAF modulated sigma54 specific transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; GAF domain protein; PAS fold domain protein; helix-turn-helix Fis-type; SMART: AAA ATPase; PAS domain containing protein; SPTR: GAF modulated sigma54 specific transcriptional regulator, Fis family; PFAM: Bacterial reg [...] (654 aa)
Toce_2208COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: hor:Hore_21290 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (444 aa)
Toce_2209Transcriptional regulator, MerR family; COGs: COG0789 transcriptional regulator protein; InterPro IPR000551; KEGG: hor:Hore_21300 putative transcriptional regulator, MerR family; PFAM: regulatory protein MerR; SMART: regulatory protein MerR; SPTR: Putative transcriptional regulator, MerR family; PFAM: MerR family regulatory protein. (115 aa)
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: medium (44%) [HD]