(17 nodes) Fibroblast growth factor receptor signaling pathway network (Platysternon megacephalum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	DR999_PMT22274	Receptor protein-tyrosine kinase. (472 aa)
	DR999_PMT17322	Neural proliferation differentiation and control protein 1. (929 aa)
	DR999_PMT16832	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	DR999_PMT14778	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (258 aa)
	DR999_PMT10231	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	DR999_PMT08938	Fibroblast growth factor receptor. (845 aa)
	DR999_PMT07038	Fibroblast growth factor receptor. (878 aa)
	DR999_PMT10815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
	DR999_PMT08955	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (175 aa)
	DR999_PMT05773	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	DR999_PMT03545	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	DR999_PMT06845	Voltage-dependent anion-selective channel protein 2. (1633 aa)
	DR999_PMT05529	Male-specific lethal 1-like protein. (508 aa)
	DR999_PMT05275	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	DR999_PMT06927	Fibroblast growth factor receptor. (830 aa)
	DR999_PMT05321	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	DR999_PMT05369	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)

Your Current Organism:

Platysternon megacephalum

NCBI taxonomy Id: 55544
Other names: P. megacephalum, Platysternon macrocephalus, big-headed turtle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR999_PMT03545	DR999_PMT05275	A0A4D9ENX9	A0A4D9ET73	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.662
DR999_PMT03545	DR999_PMT05321	A0A4D9ENX9	A0A4D9EWE4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.658
DR999_PMT03545	DR999_PMT05369	A0A4D9ENX9	A0A4D9EWJ0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.661
DR999_PMT03545	DR999_PMT05529	A0A4D9ENX9	A0A4D9ESX2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Male-specific lethal 1-like protein.	0.712
DR999_PMT03545	DR999_PMT05773	A0A4D9ENX9	A0A4D9EL40	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.683
DR999_PMT03545	DR999_PMT06845	A0A4D9ENX9	A0A4D9ES12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Voltage-dependent anion-selective channel protein 2.	0.680
DR999_PMT03545	DR999_PMT06927	A0A4D9ENX9	A0A4D9EW72	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.954
DR999_PMT03545	DR999_PMT07038	A0A4D9ENX9	A0A4D9EEK3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.952
DR999_PMT03545	DR999_PMT08938	A0A4D9ENX9	A0A4D9EDX6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.952
DR999_PMT03545	DR999_PMT08955	A0A4D9ENX9	A0A4D9EJP1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.539
DR999_PMT03545	DR999_PMT10231	A0A4D9ENX9	A0A4D9E964	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.628
DR999_PMT03545	DR999_PMT10815	A0A4D9ENX9	A0A4D9EGI3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
DR999_PMT03545	DR999_PMT14778	A0A4D9ENX9	A0A4D9E331	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.562
DR999_PMT03545	DR999_PMT16832	A0A4D9ENX9	A0A4D9DXF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.776
DR999_PMT03545	DR999_PMT17322	A0A4D9ENX9	A0A4D9DW21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Neural proliferation differentiation and control protein 1.	0.964
DR999_PMT03545	DR999_PMT22274	A0A4D9ENX9	A0A4D9DLU7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Receptor protein-tyrosine kinase.	0.954
DR999_PMT05275	DR999_PMT03545	A0A4D9ET73	A0A4D9ENX9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.662
DR999_PMT05275	DR999_PMT05321	A0A4D9ET73	A0A4D9EWE4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.827
DR999_PMT05275	DR999_PMT05369	A0A4D9ET73	A0A4D9EWJ0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.692
DR999_PMT05275	DR999_PMT05529	A0A4D9ET73	A0A4D9ESX2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Male-specific lethal 1-like protein.	0.755