(40 nodes) Signaling by SCF-KIT network (Platysternon megacephalum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DR999_PMT10543	Tyrosine-protein kinase. (438 aa)
	DR999_PMT00594	Transmembrane protein 161B. (519 aa)
	DR999_PMT02426	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	DR999_PMT02648	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	DR999_PMT03432	Vitamin K epoxide reductase complex subunit 1-like protein 1. (934 aa)
	DR999_PMT06169	Signal transducer and activator of transcription. (829 aa)
	DR999_PMT02396	DNAation factor subunit beta. (580 aa)
	DR999_PMT01009	Fibronectin type-III domain-containing protein 3a. (999 aa)
	DR999_PMT01562	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (960 aa)
	DR999_PMT05980	A-kinase anchor protein 2. (536 aa)
	DR999_PMT02237	GPN-loop GTPase 3. (679 aa)
	DR999_PMT01959	Zinc finger with UFM1-specific peptidase domain protein. (127 aa)
	DR999_PMT05582	RUN domain-containing protein 3A. (1210 aa)
	DR999_PMT03208	Receptor-type tyrosine-protein phosphatase U. (377 aa)
	DR999_PMT04340	Tyrosine-protein kinase. (541 aa)
	DR999_PMT03925	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	DR999_PMT09858	Cartilage intermediate layer protein 2. (296 aa)
	DR999_PMT05446	Tyrosine-protein kinase. (513 aa)
	DR999_PMT11312	Tyrosine-protein kinase. (533 aa)
	DR999_PMT08094	Growth factor receptor-bound protein 10. (596 aa)
	DR999_PMT12652	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (278 aa)
	DR999_PMT13211	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (876 aa)
	DR999_PMT10758	Putative gastrointestinal growth factor xP4-like. (727 aa)
	DR999_PMT10950	Tumor protein p53-inducible nuclear protein 1. (435 aa)
	DR999_PMT12797	Growth factor receptor-bound protein 2. (217 aa)
	DR999_PMT15938	Reticulocalbin-2. (226 aa)
	DR999_PMT16302	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (611 aa)
	DR999_PMT14120	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B. (341 aa)
	DR999_PMT12589	Tetraspan membrane protein of hair cell stereocilia. (111 aa)
	DR999_PMT16034	Adapter molecule crk. (728 aa)
	DR999_PMT19478	Ribonuclease-like. (860 aa)
	DR999_PMT15894	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	DR999_PMT17807	GTPase HRas. (179 aa)
	DR999_PMT18641	Epididymal sperm-binding protein 1. (309 aa)
	DR999_PMT18649	F-box/WD repeat-containing protein 7-like. (403 aa)
	DR999_PMT19608	Neurosecretory protein VGF; Belongs to the PI3/PI4-kinase family. (571 aa)
	DR999_PMT22614	Whirlin. (319 aa)
	DR999_PMT22085	CTP synthase. (76 aa)
	DR999_PMT22081	GTPase KRas. (266 aa)
	DR999_PMT23102	Protein CapI. (280 aa)

Your Current Organism:

Platysternon megacephalum

NCBI taxonomy Id: 55544
Other names: P. megacephalum, Platysternon macrocephalus, big-headed turtle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR999_PMT00594	DR999_PMT01562	A0A4D9FD08	A0A4D9EU16	Transmembrane protein 161B.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.905
DR999_PMT00594	DR999_PMT01959	A0A4D9FD08	A0A4D9ET69	Transmembrane protein 161B.	Zinc finger with UFM1-specific peptidase domain protein.	0.725
DR999_PMT00594	DR999_PMT02237	A0A4D9FD08	A0A4D9ETJ0	Transmembrane protein 161B.	GPN-loop GTPase 3.	0.896
DR999_PMT00594	DR999_PMT02426	A0A4D9FD08	A0A4D9F3F6	Transmembrane protein 161B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.871
DR999_PMT00594	DR999_PMT02648	A0A4D9FD08	A0A4D9F2U9	Transmembrane protein 161B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.871
DR999_PMT00594	DR999_PMT03208	A0A4D9FD08	A0A4D9ERT2	Transmembrane protein 161B.	Receptor-type tyrosine-protein phosphatase U.	0.430
DR999_PMT00594	DR999_PMT03432	A0A4D9FD08	A0A4D9F2D9	Transmembrane protein 161B.	Vitamin K epoxide reductase complex subunit 1-like protein 1.	0.430
DR999_PMT00594	DR999_PMT04340	A0A4D9FD08	A0A4D9EP42	Transmembrane protein 161B.	Tyrosine-protein kinase.	0.799
DR999_PMT00594	DR999_PMT05446	A0A4D9FD08	A0A4D9EKS3	Transmembrane protein 161B.	Tyrosine-protein kinase.	0.821
DR999_PMT00594	DR999_PMT05980	A0A4D9FD08	A0A4D9ETT5	Transmembrane protein 161B.	A-kinase anchor protein 2.	0.725
DR999_PMT00594	DR999_PMT06169	A0A4D9FD08	A0A4D9EXP6	Transmembrane protein 161B.	Signal transducer and activator of transcription.	0.569
DR999_PMT00594	DR999_PMT08094	A0A4D9FD08	A0A4D9EEZ9	Transmembrane protein 161B.	Growth factor receptor-bound protein 10.	0.725
DR999_PMT00594	DR999_PMT09858	A0A4D9FD08	A0A4D9ELT7	Transmembrane protein 161B.	Cartilage intermediate layer protein 2.	0.790
DR999_PMT00594	DR999_PMT10758	A0A4D9FD08	A0A4D9E920	Transmembrane protein 161B.	Putative gastrointestinal growth factor xP4-like.	0.745
DR999_PMT00594	DR999_PMT11312	A0A4D9FD08	A0A4D9EIB1	Transmembrane protein 161B.	Tyrosine-protein kinase.	0.888
DR999_PMT00594	DR999_PMT12652	A0A4D9FD08	A0A4D9EAK2	Transmembrane protein 161B.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.618
DR999_PMT00594	DR999_PMT12797	A0A4D9FD08	A0A4D9E7T4	Transmembrane protein 161B.	Growth factor receptor-bound protein 2.	0.916
DR999_PMT00594	DR999_PMT15894	A0A4D9FD08	A0A4D9DVA5	Transmembrane protein 161B.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.949
DR999_PMT00594	DR999_PMT15938	A0A4D9FD08	A0A4D9E3V9	Transmembrane protein 161B.	Reticulocalbin-2.	0.794
DR999_PMT00594	DR999_PMT16034	A0A4D9FD08	A0A4D9E085	Transmembrane protein 161B.	Adapter molecule crk.	0.745