(24 nodes) FRS-mediated FGFR3 signaling network (Platysternon megacephalum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	DR999_PMT05275	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	DR999_PMT21393	Perforin-1-like; Belongs to the heparin-binding growth factors family. (363 aa)
	DR999_PMT22274	Receptor protein-tyrosine kinase. (472 aa)
	DR999_PMT17807	GTPase HRas. (179 aa)
	DR999_PMT19478	Ribonuclease-like. (860 aa)
	DR999_PMT16832	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	DR999_PMT14778	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (258 aa)
	DR999_PMT15938	Reticulocalbin-2. (226 aa)
	DR999_PMT22081	GTPase KRas. (266 aa)
	DR999_PMT22085	CTP synthase. (76 aa)
	DR999_PMT01555	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	DR999_PMT01733	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
	DR999_PMT02426	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	DR999_PMT02648	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	DR999_PMT00234	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	DR999_PMT06927	Fibroblast growth factor receptor. (830 aa)
	DR999_PMT00994	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (181 aa)
	DR999_PMT06994	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	DR999_PMT05529	Male-specific lethal 1-like protein. (508 aa)
	DR999_PMT05773	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	DR999_PMT08955	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (175 aa)
	DR999_PMT10231	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	DR999_PMT12797	Growth factor receptor-bound protein 2. (217 aa)
	DR999_PMT13769	RWD domain-containing protein 2B. (515 aa)

Your Current Organism:

Platysternon megacephalum

NCBI taxonomy Id: 55544
Other names: P. megacephalum, Platysternon macrocephalus, big-headed turtle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR999_PMT00234	DR999_PMT01733	A0A4D9F0C2	A0A4D9F5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.460
DR999_PMT00234	DR999_PMT05275	A0A4D9F0C2	A0A4D9ET73	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.500
DR999_PMT00234	DR999_PMT05529	A0A4D9F0C2	A0A4D9ESX2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Male-specific lethal 1-like protein.	0.425
DR999_PMT00234	DR999_PMT06927	A0A4D9F0C2	A0A4D9EW72	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.934
DR999_PMT00234	DR999_PMT10231	A0A4D9F0C2	A0A4D9E964	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.426
DR999_PMT00234	DR999_PMT12797	A0A4D9F0C2	A0A4D9E7T4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2.	0.560
DR999_PMT00234	DR999_PMT13769	A0A4D9F0C2	A0A4D9E723	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	RWD domain-containing protein 2B.	0.414
DR999_PMT00234	DR999_PMT16832	A0A4D9F0C2	A0A4D9DXF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
DR999_PMT00234	DR999_PMT21393	A0A4D9F0C2	A0A4D9DHP0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Perforin-1-like; Belongs to the heparin-binding growth factors family.	0.460
DR999_PMT00234	DR999_PMT22274	A0A4D9F0C2	A0A4D9DLU7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Receptor protein-tyrosine kinase.	0.934
DR999_PMT00994	DR999_PMT01733	A0A4D9EV35	A0A4D9F5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.559
DR999_PMT00994	DR999_PMT02426	A0A4D9EV35	A0A4D9F3F6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.518
DR999_PMT00994	DR999_PMT02648	A0A4D9EV35	A0A4D9F2U9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.518
DR999_PMT00994	DR999_PMT05275	A0A4D9EV35	A0A4D9ET73	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.544
DR999_PMT00994	DR999_PMT05529	A0A4D9EV35	A0A4D9ESX2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Male-specific lethal 1-like protein.	0.542
DR999_PMT00994	DR999_PMT05773	A0A4D9EV35	A0A4D9EL40	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.500
DR999_PMT00994	DR999_PMT06927	A0A4D9EV35	A0A4D9EW72	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.894
DR999_PMT00994	DR999_PMT08955	A0A4D9EV35	A0A4D9EJP1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.493
DR999_PMT00994	DR999_PMT10231	A0A4D9EV35	A0A4D9E964	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508
DR999_PMT00994	DR999_PMT12797	A0A4D9EV35	A0A4D9E7T4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2.	0.684