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pgi pgi pdhA-2 pdhA-2 SDG33252.1 SDG33252.1 SDG35375.1 SDG35375.1 SDG26278.1 SDG26278.1 SDI18532.1 SDI18532.1 SDG26307.1 SDG26307.1 SDG39335.1 SDG39335.1 pdhA pdhA SDG39430.1 SDG39430.1 SDG39736.1 SDG39736.1 SDG27791.1 SDG27791.1 SDG51281.1 SDG51281.1 SDG55574.1 SDG55574.1 purH purH purD purD purA purA SDG58146.1 SDG58146.1 SDG59000.1 SDG59000.1 purU purU SDG59031.1 SDG59031.1 SDG49517.1 SDG49517.1 gpmI gpmI upp upp SDG49737.1 SDG49737.1 prs prs purC purC SDG75313.1 SDG75313.1 accD accD purF purF SDG69778.1 SDG69778.1 SDG69805.1 SDG69805.1 purN purN purM purM ndk ndk guaA guaA purL purL purT purT adk adk pyrH pyrH accA accA pyrG pyrG eno eno surE surE SDG98216.1 SDG98216.1 cysQ cysQ SDH02509.1 SDH02509.1 SDH07189.1 SDH07189.1 SDH18694.1 SDH18694.1 SDI30023.1 SDI30023.1 pyrD pyrD SDH26888.1 SDH26888.1 amn amn SDH28304.1 SDH28304.1 purU-3 purU-3 SDH29439.1 SDH29439.1 carA carA carB carB tpiA tpiA coaX coaX SDH31520.1 SDH31520.1 atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC SDH38397.1 SDH38397.1 SDH39169.1 SDH39169.1 coaD coaD SDH44780.1 SDH44780.1 pgk pgk pyrB pyrB acsA-2 acsA-2 SDH56200.1 SDH56200.1 pyrF pyrF SDH58192.1 SDH58192.1 purU-2 purU-2 glk glk SDH64463.1 SDH64463.1 SDH63201.1 SDH63201.1 gpmI-2 gpmI-2 eno-2 eno-2 SDH63773.1 SDH63773.1 SDH71051.1 SDH71051.1 SDH71124.1 SDH71124.1 SDI24374.1 SDI24374.1 SDH71145.1 SDH71145.1 SDH71218.1 SDH71218.1 xpt xpt purE purE purK purK SDH69584.1 SDH69584.1 SDH70572.1 SDH70572.1 gmk gmk pyrE pyrE SDH70898.1 SDH70898.1 phnN phnN SDH75810.1 SDH75810.1 SDH87337.1 SDH87337.1 apt apt SDH90104.1 SDH90104.1 ackA ackA SDH91051.1 SDH91051.1 coaE coaE SDI02239.1 SDI02239.1 pyrC pyrC SDI06472.1 SDI06472.1 acsA acsA
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (554 aa)
pdhA-2Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (393 aa)
SDG33252.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (546 aa)
SDG35375.1Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
SDG26278.12-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (407 aa)
SDI18532.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (369 aa)
SDG26307.1Dihydrolipoamide dehydrogenase. (478 aa)
SDG39335.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (391 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa)
SDG39430.1acetyl-CoA synthetase. (587 aa)
SDG39736.1Ribose-phosphate pyrophosphokinase. (325 aa)
SDG27791.1Acyl-CoA thioesterase. (265 aa)
SDG51281.1Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (312 aa)
SDG55574.1Biotin carboxylase /acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
purHIMP cyclohydrolase. (535 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (429 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
SDG58146.1ADP-ribose pyrophosphatase. (199 aa)
SDG59000.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (881 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
SDG59031.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (553 aa)
SDG49517.1Hypoxanthine phosphoribosyltransferase. (185 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa)
SDG49737.1Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (302 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (289 aa)
SDG75313.1Dihydrolipoamide dehydrogenase. (438 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (294 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa)
SDG69778.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (773 aa)
SDG69805.1ATP diphosphatase. (278 aa)
purNPhosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (216 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (352 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (526 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1298 aa)
purTFormate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa)
surE5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa)
SDG98216.1Urea carboxylase. (1229 aa)
cysQ3'(2'), 5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (273 aa)
SDH02509.1ADP-ribose diphosphatase. (188 aa)
SDH07189.1Adenylate cyclase, class 1. (951 aa)
SDH18694.1Adenylate cyclase, class 3. (462 aa)
SDI30023.1Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (340 aa)
SDH26888.1Magnesium and cobalt transporter. (279 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (473 aa)
SDH28304.1acyl-CoA thioesterase-2. (289 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
SDH29439.1Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein. (185 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (382 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1073 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (248 aa)
SDH31520.1glutaryl-CoA dehydrogenase. (392 aa)
atpBF-type H+-transporting ATPase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (289 aa)
atpEATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (85 aa)
atpFATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpHATP synthase F1 subcomplex delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa)
atpAF-type H+-transporting ATPase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (514 aa)
atpGATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa)
atpDF-type H+-transporting ATPase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (458 aa)
atpCATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa)
SDH38397.1Acyl-CoA hydrolase. (160 aa)
SDH39169.1Biotin carboxylase /acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (471 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
SDH44780.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (387 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (336 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SDH56200.1Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (283 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa)
SDH58192.1GMP synthase-Glutamine amidotransferase. (242 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (320 aa)
SDH64463.1Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
SDH63201.1Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
gpmI-2Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (508 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (426 aa)
SDH63773.1Pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
SDH71051.1Catechol 2,3-dioxygenase. (214 aa)
SDH71124.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (234 aa)
SDI24374.1acetoacetyl-CoA synthetase. (651 aa)
SDH71145.12-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (77 aa)
SDH71218.1Pyruvate dehydrogenase E1 component alpha subunit. (329 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (361 aa)
SDH69584.1acyl-CoA thioesterase YciA. (134 aa)
SDH70572.1(p)ppGpp synthetase, RelA/SpoT family; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
SDH70898.1Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa)
phnNRibose 1,5-bisphosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (188 aa)
SDH75810.1Flagellum-specific ATP synthase. (453 aa)
SDH87337.1Pyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
SDH90104.1Malonate decarboxylase beta subunit. (285 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
SDH91051.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (697 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
SDI02239.1Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
SDI06472.1Alpha-ribazole phosphatase. (191 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
Your Current Organism:
Pseudomonas benzenivorans
NCBI taxonomy Id: 556533
Other names: CIP 109857, DSM 8628, P. benzenivorans, Pseudomonas benzenivorans Lang et al. 2012 emend. Hameed et al. 2014, Pseudomonas sp. DSM 8628
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