(133 nodes) C2 domain superfamily network (Cuculus canorus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N303_08198	Phospholipase A2. (774 aa)
	N303_09609	annotation not available (381 aa)
	N303_14067	Copine-1. (527 aa)
	N303_02287	Phosphoinositide phospholipase C. (1013 aa)
	N303_11910	Tandem C2 domains nuclear protein. (488 aa)
	N303_11274	Regulator of G-protein signaling 3. (137 aa)
	N303_05895	Rabphilin-3A. (701 aa)
	N303_12093	Ras GTPase-activating protein 4. (479 aa)
	N303_08202	Phospholipase A2. (779 aa)
	N303_08196	Phospholipase A2. (798 aa)
	N303_08116	Synaptotagmin-13. (429 aa)
	N303_06098	Serine/threonine-protein kinase N2. (757 aa)
	N303_11580	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (1197 aa)
	N303_12454	Rabphilin-3A. (643 aa)
	N303_03126	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1069 aa)
	N303_06711	Protein kinase C epsilon type. (116 aa)
	N303_12845	Phosphoinositide phospholipase C. (733 aa)
	N303_09329	RasGAP-activating-like 1. (484 aa)
	N303_08909	E3 ubiquitin-protein ligase HECW1. (1529 aa)
	N303_05859	Copine-8. (532 aa)
	N303_06224	Disabled 2-interacting protein. (1121 aa)
	N303_05702	Phosphoinositide phospholipase C. (777 aa)
	N303_02060	Calpain-5; Belongs to the peptidase C2 family. (641 aa)
	N303_01210	Phosphoinositide phospholipase C. (1064 aa)
	N303_14105	Regulating synaptic membrane exocytosis protein 4. (237 aa)
	N303_11083	Synaptotagmin-6. (441 aa)
	N303_03578	Protein piccolo. (3389 aa)
	N303_08199	Phospholipase A2. (770 aa)
	N303_09428	Dedicator of cytokinesis protein 7; Belongs to the DOCK family. (2089 aa)
	N303_09441	Putative tyrosine-protein phosphatase auxilin. (928 aa)
	N303_07595	Synaptotagmin-14. (300 aa)
	N303_08643	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	N303_12497	U5 small nuclear ribonucleoprotein 200 kDa helicase. (1629 aa)
	N303_13794	Axin interactor, dorsalization-associated protein. (306 aa)
	N303_08197	Phospholipase A2. (753 aa)
	N303_08203	Phospholipase A2. (828 aa)
	N303_08201	Cytosolic phospholipase A2 epsilon. (138 aa)
	N303_03487	Intersectin-2. (1634 aa)
	N303_10109	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	N303_03368	E3 ubiquitin-protein ligase NEDD4-like. (938 aa)
	N303_08859	E3 ubiquitin-protein ligase NEDD4. (888 aa)
	N303_15617	Protein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (606 aa)
	N303_12938	Copine-5. (494 aa)
	N303_05964	Multiple C2 and transmembrane domain-containing protein 2. (204 aa)
	N303_02433	Ras GTPase-activating protein 2. (773 aa)
	N303_02053	UV radiation resistance-associated gene protein. (688 aa)
	N303_05663	Synaptotagmin-7. (612 aa)
	N303_11699	Synaptotagmin-15. (350 aa)
	N303_14065	Fer-1-like 4. (182 aa)
	N303_09960	Coiled-coil and C2 domain-containing protein 2A. (1544 aa)
	N303_02563	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1037 aa)
	N303_03690	Phosphoinositide phospholipase C. (620 aa)
	N303_12704	Regulating synaptic membrane exocytosis protein 3. (309 aa)
	N303_11472	Synaptotagmin-like 5. (700 aa)
	N303_14388	Synaptotagmin-1. (425 aa)
	N303_06526	Synaptotagmin-like 2. (350 aa)
	N303_13225	Synaptotagmin-like 3. (440 aa)
	N303_12576	Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (188 aa)
	N303_08253	Protein kinase C theta type. (457 aa)
	N303_04821	Ras GTPase-activating protein 1. (829 aa)
	N303_04843	Multiple C2 and transmembrane domain-containing protein 1. (787 aa)
	N303_00764	Protein kinase C eta type. (82 aa)
	N303_00771	Synaptotagmin-16. (401 aa)
	N303_15629	E3 ubiquitin-protein ligase SMURF2. (738 aa)
	N303_01011	Dedicator of cytokinesis protein 4; Belongs to the DOCK family. (1704 aa)
	N303_07027	Protein unc-13 A. (110 aa)
	N303_02299	Regulating synaptic membrane exocytosis protein 1. (1597 aa)
	N303_00446	Ras/Rap GTPase-activating protein SynGAP. (218 aa)
	N303_10130	Otoferlin. (974 aa)
	N303_15731	Protein unc-13 D. (1037 aa)
	N303_05634	Synaptotagmin-9. (442 aa)
	N303_11720	Synaptotagmin-like 2. (946 aa)
	N303_07028	Protein unc-13 A. (463 aa)
	N303_06575	Type II inositol 3,4-bisphosphate 4-phosphatase. (920 aa)
	N303_14532	Copine-9. (487 aa)
	N303_01441	E3 ubiquitin-protein ligase Itchy. (853 aa)
	N303_11295	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1791 aa)
	N303_12521	Dysferlin. (1849 aa)
	N303_01070	Protein WWC2. (1167 aa)
	N303_13514	Translocation protein SEC63. (722 aa)
	N303_02414	Dedicator of cytokinesis protein 10; Belongs to the DOCK family. (1608 aa)
	N303_13712	Intersectin-1. (1711 aa)
	N303_13128	Synaptotagmin-17. (464 aa)
	N303_10215	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2. (493 aa)
	N303_10054	E3 ubiquitin-protein ligase HECW2. (1568 aa)
	N303_08191	Phospholipase A2. (979 aa)
	N303_13165	Phosphoinositide phospholipase C. (1208 aa)
	N303_01376	C2 calcium-dependent domain-containing protein 4C. (450 aa)
	N303_07438	Ras GTPase-activating protein 3. (827 aa)
	N303_11206	Protein unc-13 B. (110 aa)
	N303_15416	Protein unc-13 A. (110 aa)
	N303_11523	Synaptotagmin-11. (418 aa)
	N303_06962	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1624 aa)
	N303_07510	Type I inositol 3,4-bisphosphate 4-phosphatase. (938 aa)
	N303_01211	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
	N303_09782	Synaptotagmin-10. (522 aa)
	N303_00251	Synaptotagmin-like 1. (312 aa)
	N303_05880	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1106 aa)
	N303_00187	Toll-interacting protein. (263 aa)
	N303_05482	Protein WWC3. (1086 aa)
	N303_10356	Copine-2. (484 aa)
	N303_05471	Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (188 aa)
	N303_15415	Protein unc-13 C. (2160 aa)
	N303_07876	Extended synaptotagmin-3. (747 aa)
	N303_05155	Rab11 family-interacting protein 2. (510 aa)
	N303_06642	Protein KIBRA. (1124 aa)
	N303_15390	Copine-4. (556 aa)
	N303_08763	Breakpoint cluster region protein. (1310 aa)
	N303_07531	Synaptotagmin-4. (414 aa)
	N303_09174	Phosphoinositide phospholipase C. (613 aa)
	N303_04879	C2 calcium-dependent domain-containing protein 4C. (366 aa)
	N303_07533	Phosphatidylinositol 3-kinase catalytic subunit type 3; Belongs to the PI3/PI4-kinase family. (859 aa)
	N303_07849	Calpain-5; Belongs to the peptidase C2 family. (644 aa)
	N303_09166	Myoferlin. (2050 aa)
	N303_01171	C2 domain-containing protein 5. (1020 aa)
	N303_14042	Dedicator of cytokinesis protein 11; Belongs to the DOCK family. (2008 aa)
	N303_11623	Serine/threonine-protein kinase N2. (776 aa)
	N303_11207	Protein unc-13 B. (464 aa)
	N303_12422	Active breakpoint cluster region-related protein. (833 aa)
	N303_01419	Protein fantom. (1220 aa)
	N303_06398	Copine-3. (532 aa)
	N303_06400	NEDD4-like E3 ubiquitin-protein ligase WWP1. (906 aa)
	N303_03756	Phosphoinositide phospholipase C. (565 aa)
	N303_03809	Extended synaptotagmin-2. (829 aa)
	N303_12560	Phosphoinositide phospholipase C. (308 aa)
	N303_00971	Phosphoinositide phospholipase C. (1017 aa)
	N303_02883	Dedicator of cytokinesis protein 9; Belongs to the DOCK family. (2105 aa)
	N303_06460	Synaptotagmin-2. (404 aa)
	N303_14066	Fer-1-like 4. (1018 aa)
	N303_10324	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	N303_05604	Phosphoinositide phospholipase C. (1410 aa)
	N303_14954	C2 domain-containing protein 2. (606 aa)
	N303_10516	Synaptotagmin-like 4. (657 aa)

Your Current Organism:

Cuculus canorus

NCBI taxonomy Id: 55661
Other names: C. canorus, common cuckoo

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N303_00251	N303_03487	A0A091FT24	A0A091GP19	Synaptotagmin-like 1.	Intersectin-2.	0.688
N303_00251	N303_13712	A0A091FT24	A0A091GEJ6	Synaptotagmin-like 1.	Intersectin-1.	0.571
N303_00446	N303_00764	A0A091GAN1	A0A091G8R7	Ras/Rap GTPase-activating protein SynGAP.	Protein kinase C eta type.	0.449
N303_00446	N303_02433	A0A091GAN1	A0A091H0N9	Ras/Rap GTPase-activating protein SynGAP.	Ras GTPase-activating protein 2.	0.680
N303_00446	N303_04821	A0A091GAN1	A0A091G8N1	Ras/Rap GTPase-activating protein SynGAP.	Ras GTPase-activating protein 1.	0.782
N303_00446	N303_06711	A0A091GAN1	A0A091GIX4	Ras/Rap GTPase-activating protein SynGAP.	Protein kinase C epsilon type.	0.449
N303_00446	N303_07438	A0A091GAN1	A0A091FWI8	Ras/Rap GTPase-activating protein SynGAP.	Ras GTPase-activating protein 3.	0.680
N303_00446	N303_08253	A0A091GAN1	A0A091G8K0	Ras/Rap GTPase-activating protein SynGAP.	Protein kinase C theta type.	0.406
N303_00446	N303_08643	A0A091GAN1	A0A091GM45	Ras/Rap GTPase-activating protein SynGAP.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.406
N303_00446	N303_09329	A0A091GAN1	A0A091GHD2	Ras/Rap GTPase-activating protein SynGAP.	RasGAP-activating-like 1.	0.558
N303_00446	N303_12093	A0A091GAN1	A0A091G3B6	Ras/Rap GTPase-activating protein SynGAP.	Ras GTPase-activating protein 4.	0.558
N303_00446	N303_15617	A0A091GAN1	A0A091GWC8	Ras/Rap GTPase-activating protein SynGAP.	Protein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.604
N303_00764	N303_00446	A0A091G8R7	A0A091GAN1	Protein kinase C eta type.	Ras/Rap GTPase-activating protein SynGAP.	0.449
N303_00764	N303_01210	A0A091G8R7	A0A091GFM3	Protein kinase C eta type.	Phosphoinositide phospholipase C.	0.418
N303_00764	N303_01211	A0A091G8R7	A0A091FTH5	Protein kinase C eta type.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.418
N303_00764	N303_02563	A0A091G8R7	A0A091G5P1	Protein kinase C eta type.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family.	0.439
N303_00764	N303_03126	A0A091G8R7	A0A091GJF2	Protein kinase C eta type.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.445
N303_00764	N303_04821	A0A091G8R7	A0A091G8N1	Protein kinase C eta type.	Ras GTPase-activating protein 1.	0.545
N303_00764	N303_05702	A0A091G8R7	A0A091GH66	Protein kinase C eta type.	Phosphoinositide phospholipase C.	0.418
N303_00764	N303_05880	A0A091G8R7	A0A091FSN3	Protein kinase C eta type.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family.	0.431