(78 nodes) Homologous recombination network (Cuculus canorus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N303_03508	Uncharacterized protein. (51 aa)
	N303_04841	Ankyrin repeat domain-containing protein 32. (211 aa)
	N303_04831	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_04540	Multiple coagulation factor deficiency protein 2. (142 aa)
	N303_13323	Spindle assembly abnormal protein 6. (615 aa)
	N303_09682	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (839 aa)
	N303_15686	Crossover junction endonuclease EME1. (490 aa)
	N303_05133	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1000 aa)
	N303_03882	Uncharacterized protein. (710 aa)
	N303_02970	Replication protein A 14 kDa subunit. (116 aa)
	N303_12646	PITH domain-containing protein 1. (146 aa)
	N303_08980	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_04842	Ankyrin repeat domain-containing protein 32. (420 aa)
	N303_01692	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
	N303_15017	Coiled-coil domain-containing protein 94. (181 aa)
	N303_05106	Meiosis-specific with OB domain-containing protein. (469 aa)
	N303_05900	Adenosine monophosphate-protein transferase FICD. (452 aa)
	N303_11676	BRISC complex subunit Abro1. (354 aa)
	N303_09486	Helicase POLQ-like. (992 aa)
	N303_09488	BRCA1-A complex subunit Abraxas. (370 aa)
	N303_12098	PRKR-interacting protein 1. (148 aa)
	N303_07794	Uncharacterized protein. (110 aa)
	N303_15467	DNA repair protein XRCC3. (347 aa)
	N303_05581	Uncharacterized protein. (143 aa)
	N303_02128	Uncharacterized protein. (147 aa)
	N303_03547	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_04715	DNA endonuclease RBBP8. (916 aa)
	N303_08389	NEDD4-binding protein 2. (1324 aa)
	N303_14031	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_08516	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
	N303_13959	26S proteasome complex subunit DSS1. (49 aa)
	N303_12133	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
	N303_15497	RNA-directed DNA polymerase from mobile element jockey. (108 aa)
	N303_07126	DNA repair protein RAD51 2. (253 aa)
	N303_06392	Nibrin. (750 aa)
	N303_10027	Protein CASC5. (471 aa)
	N303_08277	Uncharacterized protein. (1251 aa)
	N303_12457	DNA repair protein RAD51 3. (327 aa)
	N303_03787	DNA repair protein XRCC2. (266 aa)
	N303_01158	Protein unc-93 A. (458 aa)
	N303_04511	UPF0536 protein C12orf66. (446 aa)
	N303_00605	2',3'-cyclic-nucleotide 3'-phosphodiesterase. (426 aa)
	N303_10908	DNA repair protein RAD50. (1318 aa)
	N303_09519	DNA helicase B. (943 aa)
	N303_02127	Breast cancer type 2 susceptibility protein. (3367 aa)
	N303_15377	DNA topoisomerase 2-binding protein 1. (502 aa)
	N303_07839	Transcriptional regulator ATRX. (2401 aa)
	N303_06826	RNA-directed DNA polymerase from mobile element jockey. (103 aa)
	N303_05684	Protein unc-93 B1. (423 aa)
	N303_03564	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_06601	Partner and localizer of BRCA2. (559 aa)
	N303_01984	Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. (683 aa)
	N303_14575	Fanconi anemia group J protein. (1261 aa)
	N303_14594	Putative ATP-dependent RNA helicase DDX52. (616 aa)
	N303_06031	Uncharacterized protein. (51 aa)
	N303_11853	RNA-directed DNA polymerase from mobile element jockey. (103 aa)
	N303_12488	DNA polymerase delta subunit 2. (453 aa)
	N303_15305	BRISC and BRCA1-A complex member 1. (263 aa)
	N303_09911	Meiotic recombination protein DMC1/LIM15; Belongs to the RecA family. (346 aa)
	N303_15315	Transmembrane 6 superfamily member 2. (296 aa)
	N303_04606	BRCA1-associated RING domain protein 1. (726 aa)
	N303_05546	Synaptonemal complex protein 3. (236 aa)
	N303_11980	Regulator of telomere elongation helicase 1. (1131 aa)
	N303_15722	ATP-dependent DNA helicase Q5. (1001 aa)
	N303_04547	BRCA1-A complex subunit BRE. (363 aa)
	N303_05038	Replication protein A 32 kDa subunit. (232 aa)
	N303_02129	NEDD4-binding protein 2-like 2. (625 aa)
	N303_04758	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_04786	Microcephalin. (498 aa)
	N303_04577	General transcription factor 3C polypeptide 6. (198 aa)
	N303_15322	SURP and G-patch domain-containing protein 2. (1039 aa)
	N303_08627	ATP-dependent DNA helicase Q4. (262 aa)
	N303_04551	Kanadaptin. (559 aa)
	N303_08736	M-phase phosphoprotein 9. (1149 aa)
	N303_13273	DNA repair protein RAD52. (420 aa)
	N303_03095	BRCA1-A complex subunit RAP80. (608 aa)
	N303_02005	RNA-directed DNA polymerase from mobile element jockey. (110 aa)
	N303_10028	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)

Your Current Organism:

Cuculus canorus

NCBI taxonomy Id: 55661
Other names: C. canorus, common cuckoo

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N303_00605	N303_05546	A0A091FRA7	A0A091GP68	2',3'-cyclic-nucleotide 3'-phosphodiesterase.	Synaptonemal complex protein 3.	0.460
N303_00605	N303_06601	A0A091FRA7	A0A091GI31	2',3'-cyclic-nucleotide 3'-phosphodiesterase.	Partner and localizer of BRCA2.	0.687
N303_01158	N303_04606	A0A091FTJ8	A0A091GKL5	Protein unc-93 A.	BRCA1-associated RING domain protein 1.	0.498
N303_01158	N303_04786	A0A091FTJ8	A0A091H4Q7	Protein unc-93 A.	Microcephalin.	0.472
N303_01692	N303_01984	A0A091G5Q4	A0A091GCX3	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family.	0.649
N303_01692	N303_02127	A0A091G5Q4	A0A091GDB0	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Breast cancer type 2 susceptibility protein.	0.556
N303_01692	N303_02970	A0A091G5Q4	A0A091G6H1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Replication protein A 14 kDa subunit.	0.954
N303_01692	N303_03882	A0A091G5Q4	A0A091G6J0	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Uncharacterized protein.	0.420
N303_01692	N303_04606	A0A091G5Q4	A0A091GKL5	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	BRCA1-associated RING domain protein 1.	0.668
N303_01692	N303_04715	A0A091G5Q4	A0A091G998	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	DNA endonuclease RBBP8.	0.460
N303_01692	N303_04786	A0A091G5Q4	A0A091H4Q7	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Microcephalin.	0.449
N303_01692	N303_04841	A0A091G5Q4	A0A091G962	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Ankyrin repeat domain-containing protein 32.	0.680
N303_01692	N303_04842	A0A091G5Q4	A0A091G5Q7	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Ankyrin repeat domain-containing protein 32.	0.653
N303_01692	N303_05106	A0A091G5Q4	A0A091G592	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Meiosis-specific with OB domain-containing protein.	0.889
N303_01692	N303_05133	A0A091G5Q4	A0A091G737	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.816
N303_01692	N303_06601	A0A091G5Q4	A0A091GI31	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Partner and localizer of BRCA2.	0.438
N303_01692	N303_07126	A0A091G5Q4	A0A091FI40	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	DNA repair protein RAD51 2.	0.666
N303_01692	N303_08277	A0A091G5Q4	A0A091FVU1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	Uncharacterized protein.	0.746
N303_01692	N303_08627	A0A091G5Q4	A0A091GBP7	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	ATP-dependent DNA helicase Q4.	0.746
N303_01692	N303_08736	A0A091G5Q4	A0A091GBB0	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	M-phase phosphoprotein 9.	0.420