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| | C5DBA4_LACTC | KLTH0A00924p. (696 aa) |
| | C5DBD0_LACTC | KLTH0A01540p. (328 aa) |
| | C5DBH6_LACTC | Structural maintenance of chromosomes protein. (1228 aa) |
| | C5DBL4_LACTC | KLTH0A03564p. (389 aa) |
| | C5DBS4_LACTC | KLTH0A04972p. (604 aa) |
| | C5DBZ3_LACTC | KLTH0A06556p. (460 aa) |
| | C5DC35_LACTC | KLTH0A07480p. (1035 aa) |
| | C5DC47_LACTC | KLTH0A07744p. (253 aa) |
| | C5DCE8_LACTC | KLTH0B02464p. (486 aa) |
| | C5DCF6_LACTC | KLTH0B02662p. (289 aa) |
| | C5DCH7_LACTC | KLTH0B03168p. (630 aa) |
| | C5DCL7_LACTC | Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (278 aa) |
| | C5DCR7_LACTC | KLTH0B05258p. (426 aa) |
| | C5DCR9_LACTC | KLTH0B05302p. (982 aa) |
| | C5DD12_LACTC | KLTH0B07436p. (927 aa) |
| | C5DD26_LACTC | KLTH0B07766p. (333 aa) |
| | C5DD39_LACTC | KLTH0B08052p. (536 aa) |
| | C5DDD3_LACTC | KLTH0B10318p. (1548 aa) |
| | C5DDD6_LACTC | KLTH0B10428p. (1258 aa) |
| | C5DDE8_LACTC | KLTH0C00440p. (2515 aa) |
| | C5DDI3_LACTC | KLTH0C01210p. (111 aa) |
| | C5DDJ9_LACTC | KLTH0C01584p. (913 aa) |
| | C5DDN5_LACTC | KLTH0C02442p. (356 aa) |
| | C5DDS9_LACTC | DNA helicase; Belongs to the MCM family. (994 aa) |
| | C5DDT1_LACTC | KLTH0C03564p. (567 aa) |
| | C5DDT2_LACTC | KLTH0C03586p. (578 aa) |
| | C5DDV3_LACTC | KLTH0C04048p. (935 aa) |
| | C5DDY7_LACTC | KLTH0C04862p. (566 aa) |
| | C5DDZ5_LACTC | KLTH0C05038p. (894 aa) |
| | C5DE26_LACTC | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (792 aa) |
| | C5DE39_LACTC | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2814 aa) |
| | C5DE73_LACTC | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (381 aa) |
| | C5DE91_LACTC | KLTH0C07238p. (632 aa) |
| | C5DED4_LACTC | KLTH0C08294p. (581 aa) |
| | C5DED5_LACTC | KLTH0C08316p. (207 aa) |
| | C5DEI9_LACTC | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (294 aa) |
| | C5DEJ8_LACTC | KLTH0C09856p. (713 aa) |
| | C5DEK0_LACTC | KLTH0C09900p. (322 aa) |
| | C5DEK4_LACTC | KLTH0C09988p; Component of the post-replicative DNA mismatch repair system (MMR). (955 aa) |
| | C5DEL9_LACTC | KLTH0C10318p. (773 aa) |
| | C5DEQ7_LACTC | DNA ligase. (951 aa) |
| | C5DEW4_LACTC | Replication factor C subunit 1. (864 aa) |
| | C5DF05_LACTC | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (795 aa) |
| | C5DF19_LACTC | KLTH0D11550p. (697 aa) |
| | C5DF25_LACTC | DNA polymerase. (1500 aa) |
| | C5DF38_LACTC | KLTH0D11968p. (213 aa) |
| | C5DF75_LACTC | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (664 aa) |
| | C5DFC8_LACTC | KLTH0D14080p. (1102 aa) |
| | C5DFD0_LACTC | KLTH0D14124p. (213 aa) |
| | C5DFL6_LACTC | KLTH0D16126p. (386 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (899 aa) |
| | C5DFM2_LACTC | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (939 aa) |
| | C5DFM6_LACTC | KLTH0D16346p. (175 aa) |
| | C5DFQ3_LACTC | KLTH0D17006p. (2892 aa) |
| | AIM18 | Altered inheritance of mitochondria protein 18, mitochondrial. (305 aa) |
| | C5DFT9_LACTC | KLTH0D17886p. (129 aa) |
| | C5DFV4_LACTC | KLTH0D00132p. (1258 aa) |
| | C5DFX9_LACTC | DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (393 aa) |
| | C5DG04_LACTC | KLTH0D01386p; Belongs to the protein kinase superfamily. (482 aa) |
| | C5DG10_LACTC | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (994 aa) |
| | C5DG30_LACTC | KLTH0D01980p. (1223 aa) |
| | NTG1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (383 aa) |
| | C5DG68_LACTC | KLTH0D02816p. (1094 aa) |
| | C5DG80_LACTC | KLTH0D03080p. (640 aa) |
| | C5DG97_LACTC | KLTH0D03498p. (1090 aa) |
| | C5DG99_LACTC | KLTH0D03542p. (707 aa) |
| | C5DGE9_LACTC | KLTH0D04774p. (602 aa) |
| | C5DGG3_LACTC | KLTH0D05104p. (405 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (385 aa) |
| | C5DGJ7_LACTC | KLTH0D05852p. (702 aa) |
| | C5DGP0_LACTC | KLTH0D06864p. (167 aa) |
| | C5DGP1_LACTC | KLTH0D06886p. (664 aa) |
| | C5DGP8_LACTC | KLTH0D07062p. (1292 aa) |
| | RGT1 | Glucose transport transcription regulator RGT1; Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription (By similarity); Belongs to the EDS1/RGT1 family. (979 aa) |
| | C5DGS7_LACTC | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (506 aa) |
| | C5DGX5_LACTC | DNA polymerase. (1453 aa) |
| | C5DH35_LACTC | KLTH0E01034p. (583 aa) |
| | C5DH93_LACTC | KLTH0E02398p. (665 aa) |
| | C5DHF1_LACTC | KLTH0E03850p. (1021 aa) |
| | C5DHG7_LACTC | KLTH0E04202p. (381 aa) |
| | C5DHH8_LACTC | KLTH0E04444p. (1107 aa) |
| | C5DHJ3_LACTC | Structural maintenance of chromosomes protein. (1170 aa) |
| | C5DHS3_LACTC | Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (229 aa) |
| | C5DHY3_LACTC | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa) |
| | C5DHZ6_LACTC | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (854 aa) |
| | C5DHZ8_LACTC | KLTH0E08514p. (1448 aa) |
| | C5DI15_LACTC | KLTH0E08888p. (191 aa) |
| | C5DI26_LACTC | KLTH0E09174p. (1148 aa) |
| | C5DI37_LACTC | KLTH0E09438p. (449 aa) |
| | C5DI43_LACTC | KLTH0E09570p. (595 aa) |
| | C5DI60_LACTC | KLTH0E09944p. (1133 aa) |
| | C5DIA6_LACTC | KLTH0E11000p. (1019 aa) |
| | C5DIA8_LACTC | KLTH0E11044p. (275 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (828 aa) |
| | C5DIR6_LACTC | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (653 aa) |
| | C5DIS0_LACTC | KLTH0E14696p. (384 aa) |
| | C5DIS6_LACTC | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (258 aa) |
| | C5DIX7_LACTC | KLTH0E15972p. (473 aa) |
| | C5DIZ5_LACTC | KLTH0E16390p. (204 aa) |
| | C5DJ41_LACTC | KLTH0F13310p. (1028 aa) |
| | C5DJ43_LACTC | KLTH0F13354p. (125 aa) |
| | C5DJ58_LACTC | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (417 aa) |
| | C5DJ85_LACTC | KLTH0F14322p. (900 aa) |
| | C5DJB9_LACTC | KLTH0F15158p. (616 aa) |
| | SLD7 | Mitochondrial morphogenesis protein SLD7; Required for the proper initiation of DNA replication. Required for mitochondrial morphology (By similarity); Belongs to the SLD7 family. (241 aa) |
| | C5DJR3_LACTC | KLTH0F18480p. (591 aa) |
| | C5DJR7_LACTC | KLTH0F18568p. (1167 aa) |
| | C5DJU1_LACTC | KLTH0F19118p. (278 aa) |
| | C5DJX0_LACTC | KLTH0F19756p. (182 aa) |
| | C5DJX6_LACTC | KLTH0F19888p. (1406 aa) |
| | C5DJZ1_LACTC | KLTH0F00484p. (993 aa) |
| | C5DK56_LACTC | KLTH0F01936p. (713 aa) |
| | C5DK73_LACTC | KLTH0F02310p. (1214 aa) |
| | C5DK88_LACTC | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2200 aa) |
| | C5DK89_LACTC | KLTH0F02662p. (471 aa) |
| | C5DKA6_LACTC | KLTH0F03058p. (1298 aa) |
| | C5DKD6_LACTC | Cell division control protein; Belongs to the CDC6/cdc18 family. (499 aa) |
| | C5DKF0_LACTC | KLTH0F04136p. (124 aa) |
| | C5DKG1_LACTC | KLTH0F04400p. (116 aa) |
| | C5DKQ2_LACTC | KLTH0F06578p. (596 aa) |
| | C5DKW6_LACTC | KLTH0F08096p. (796 aa) |
| | C5DKW7_LACTC | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (627 aa) |
| | C5DL00_LACTC | Sister chromatid cohesion protein. (1464 aa) |
| | C5DL39_LACTC | KLTH0F09724p. (729 aa) |
| | C5DL40_LACTC | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (383 aa) |
| | C5DL49_LACTC | DNA polymerase. (1095 aa) |
| | C5DL97_LACTC | KLTH0F11198p; Belongs to the PI3/PI4-kinase family. (2360 aa) |
| | C5DLE2_LACTC | KLTH0F12320p. (382 aa) |
| | C5DLF3_LACTC | KLTH0F12606p. (96 aa) |
| | C5DLJ9_LACTC | KLTH0G01298p. (675 aa) |
| | C5DLK2_LACTC | KLTH0G01364p. (421 aa) |
| | C5DLN3_LACTC | DNA helicase; Belongs to the MCM family. (1036 aa) |
| | C5DLQ1_LACTC | KLTH0G02552p. (797 aa) |
| | C5DLU3_LACTC | KLTH0G03586p. (621 aa) |
| | UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (341 aa) |
| | C5DLY3_LACTC | KLTH0G04466p. (541 aa) |
| | C5DLY7_LACTC | KLTH0G04554p. (285 aa) |
| | C5DM01_LACTC | KLTH0G04862p. (479 aa) |
| | C5DM68_LACTC | KLTH0G06402p. (1072 aa) |
| | C5DM75_LACTC | KLTH0G06578p. (308 aa) |
| | C5DM79_LACTC | KLTH0G06666p. (329 aa) |
| | RRM3 | ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (693 aa) |
| | C5DMF0_LACTC | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1436 aa) |
| | C5DMG0_LACTC | KLTH0G08602p. (243 aa) |
| | C5DMG1_LACTC | KLTH0G08624p. (906 aa) |
| | C5DMH4_LACTC | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (342 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (658 aa) |
| | C5DMZ7_LACTC | KLTH0G12980p. (637 aa) |
| | C5DN16_LACTC | KLTH0G13398p. (198 aa) |
| | C5DN32_LACTC | Structural maintenance of chromosomes protein. (1399 aa) |
| | C5DN43_LACTC | KLTH0G14014p; Belongs to the RecA family. (333 aa) |
| | C5DN53_LACTC | KLTH0G14256p. (638 aa) |
| | C5DN63_LACTC | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1276 aa) |
| | C5DN85_LACTC | KLTH0G14960p. (417 aa) |
| | C5DN99_LACTC | DNA helicase; Belongs to the MCM family. (764 aa) |
| | C5DNA3_LACTC | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1148 aa) |
| | C5DND8_LACTC | KLTH0G16148p. (478 aa) |
| | C5DNF8_LACTC | KLTH0G16610p. (571 aa) |
| | C5DNG7_LACTC | KLTH0G16852p. (658 aa) |
| | C5DNH3_LACTC | KLTH0G17028p. (1000 aa) |
| | C5E1Z0_LACTC | KLTH0H00770p. (1539 aa) |
| | C5E216_LACTC | DNA ligase. (723 aa) |
| | C5E275_LACTC | KLTH0H02706p. (1403 aa) |
| | C5E2F7_LACTC | KLTH0H04576p. (544 aa) |
| | C5E2H2_LACTC | KLTH0H04928p. (438 aa) |
| | C5E2L9_LACTC | KLTH0H06028p. (738 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (314 aa) |
| | C5E2N7_LACTC | KLTH0H06468p. (570 aa) |
| | C5E2R6_LACTC | KLTH0H07128p. (464 aa) |
| | C5E2S8_LACTC | KLTH0H07414p. (402 aa) |
| | C5E2S9_LACTC | KLTH0H07436p. (400 aa) |
| | C5E2T3_LACTC | KLTH0H07524p. (614 aa) |
| | C5E2U4_LACTC | KLTH0H07766p. (274 aa) |
| | C5E2V9_LACTC | DNA helicase; Belongs to the MCM family. (856 aa) |
| | C5E2W5_LACTC | KLTH0H08250p. (512 aa) |
| | C5E2X9_LACTC | DNA helicase; Belongs to the MCM family. (909 aa) |
| | C5E303_LACTC | KLTH0H09240p. (214 aa) |
| | C5E335_LACTC | Structural maintenance of chromosomes protein. (1224 aa) |
| | C5E340_LACTC | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (209 aa) |
| | C5E346_LACTC | KLTH0H10318p. (518 aa) |
| | C5E372_LACTC | KLTH0H10890p. (201 aa) |
| | C5E3C7_LACTC | KLTH0H12254p. (375 aa) |
| | C5E3E1_LACTC | KLTH0H12650p. (543 aa) |
| | C5E3F6_LACTC | KLTH0H13024p. (554 aa) |
| | C5E3G0_LACTC | KLTH0H13134p. (286 aa) |
| | C5E3H7_LACTC | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (558 aa) |
| | C5E3J4_LACTC | KLTH0H14058p. (286 aa) |
| | C5E3L4_LACTC | KLTH0H14520p. (379 aa) |
