(26 nodes) DNA replication preinitiation complex, and DNA replication checkpoint signaling network (Lachancea thermotolerans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	C5DCH7_LACTC	KLTH0B03168p. (630 aa)
	C5DCL7_LACTC	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (278 aa)
	C5DCR7_LACTC	KLTH0B05258p. (426 aa)
	C5DDS9_LACTC	DNA helicase; Belongs to the MCM family. (994 aa)
	C5DDT1_LACTC	KLTH0C03564p. (567 aa)
	C5DDY7_LACTC	KLTH0C04862p. (566 aa)
	C5DE91_LACTC	KLTH0C07238p. (632 aa)
	C5DED5_LACTC	KLTH0C08316p. (207 aa)
	C5DEI9_LACTC	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (294 aa)
	C5DFM2_LACTC	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (939 aa)
	C5DG80_LACTC	KLTH0D03080p. (640 aa)
	C5DH35_LACTC	KLTH0E01034p. (583 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (828 aa)
	C5DIX7_LACTC	KLTH0E15972p. (473 aa)
	C5DJ85_LACTC	KLTH0F14322p. (900 aa)
	C5DJR3_LACTC	KLTH0F18480p. (591 aa)
	C5DJX0_LACTC	KLTH0F19756p. (182 aa)
	C5DK73_LACTC	KLTH0F02310p. (1214 aa)
	C5DK89_LACTC	KLTH0F02662p. (471 aa)
	C5DKD6_LACTC	Cell division control protein; Belongs to the CDC6/cdc18 family. (499 aa)
	C5DLN3_LACTC	DNA helicase; Belongs to the MCM family. (1036 aa)
	C5DMZ7_LACTC	KLTH0G12980p. (637 aa)
	C5DN99_LACTC	DNA helicase; Belongs to the MCM family. (764 aa)
	C5E2V9_LACTC	DNA helicase; Belongs to the MCM family. (856 aa)
	C5E2X9_LACTC	DNA helicase; Belongs to the MCM family. (909 aa)
	C5E340_LACTC	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (209 aa)

Your Current Organism:

Lachancea thermotolerans

NCBI taxonomy Id: 559295
Other names: Kluyveromyces thermotolerans CBS 6340, L. thermotolerans CBS 6340, Lachancea thermotolerans CBS 6340

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5DCH7_LACTC	C5DCR7_LACTC	C5DCH7	C5DCR7	KLTH0B03168p.	KLTH0B05258p.	0.999
C5DCH7_LACTC	C5DDS9_LACTC	C5DCH7	C5DDS9	KLTH0B03168p.	DNA helicase; Belongs to the MCM family.	0.969
C5DCH7_LACTC	C5DDT1_LACTC	C5DCH7	C5DDT1	KLTH0B03168p.	KLTH0C03564p.	0.999
C5DCH7_LACTC	C5DDY7_LACTC	C5DCH7	C5DDY7	KLTH0B03168p.	KLTH0C04862p.	0.751
C5DCH7_LACTC	C5DE91_LACTC	C5DCH7	C5DE91	KLTH0B03168p.	KLTH0C07238p.	0.999
C5DCH7_LACTC	C5DFM2_LACTC	C5DCH7	C5DFM2	KLTH0B03168p.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.999
C5DCH7_LACTC	C5DG80_LACTC	C5DCH7	C5DG80	KLTH0B03168p.	KLTH0D03080p.	0.953
C5DCH7_LACTC	C5DH35_LACTC	C5DCH7	C5DH35	KLTH0B03168p.	KLTH0E01034p.	0.900
C5DCH7_LACTC	C5DIX7_LACTC	C5DCH7	C5DIX7	KLTH0B03168p.	KLTH0E15972p.	0.736
C5DCH7_LACTC	C5DJR3_LACTC	C5DCH7	C5DJR3	KLTH0B03168p.	KLTH0F18480p.	0.999
C5DCH7_LACTC	C5DK89_LACTC	C5DCH7	C5DK89	KLTH0B03168p.	KLTH0F02662p.	0.999
C5DCH7_LACTC	C5DKD6_LACTC	C5DCH7	C5DKD6	KLTH0B03168p.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.999
C5DCH7_LACTC	C5DLN3_LACTC	C5DCH7	C5DLN3	KLTH0B03168p.	DNA helicase; Belongs to the MCM family.	0.957
C5DCH7_LACTC	C5DMZ7_LACTC	C5DCH7	C5DMZ7	KLTH0B03168p.	KLTH0G12980p.	0.872
C5DCH7_LACTC	C5DN99_LACTC	C5DCH7	C5DN99	KLTH0B03168p.	DNA helicase; Belongs to the MCM family.	0.985
C5DCH7_LACTC	C5E2V9_LACTC	C5DCH7	C5E2V9	KLTH0B03168p.	DNA helicase; Belongs to the MCM family.	0.998
C5DCH7_LACTC	C5E2X9_LACTC	C5DCH7	C5E2X9	KLTH0B03168p.	DNA helicase; Belongs to the MCM family.	0.980
C5DCH7_LACTC	MCM7	C5DCH7	C5DIG5	KLTH0B03168p.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.972
C5DCL7_LACTC	C5DDS9_LACTC	C5DCL7	C5DDS9	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	DNA helicase; Belongs to the MCM family.	0.963
C5DCL7_LACTC	C5DDT1_LACTC	C5DCL7	C5DDT1	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	KLTH0C03564p.	0.684