(45 nodes) Steroid biosynthetic process, and Polyprenyl synthetase network (Blastomyces gilchristii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	BDBG_00070	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating). (425 aa)
	BDBG_00111	Uncharacterized protein. (400 aa)
	BDBG_00254	Sterol desaturase; Belongs to the sterol desaturase family. (334 aa)
	BDBG_00546	C-4 methylsterol oxidase, variant; Belongs to the sterol desaturase family. (255 aa)
	BDBG_00632	Ergosterol biosynthesis protein Erg28. (134 aa)
	BDBG_01260	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (728 aa)
	BDBG_01200	Uncharacterized protein. (101 aa)
	BDBG_01858	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (556 aa)
	BDBG_02187	DUF2236 domain-containing protein. (218 aa)
	BDBG_01678	Cytochrome P450, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family. (525 aa)
	BDBG_02649	C-4 methylsterol oxidase; Belongs to the sterol desaturase family. (239 aa)
	BDBG_01511	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (347 aa)
	BDBG_02700	FAD binding domain-containing protein. (598 aa)
	BDBG_02640	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (404 aa)
	BDBG_03201	C-22 sterol desaturase; Belongs to the cytochrome P450 family. (533 aa)
	BDBG_03695	Uncharacterized protein. (832 aa)
	BDBG_03553	Delta24(24(1))-sterol reductase. (477 aa)
	BDBG_04801	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (433 aa)
	BDBG_03766	Geranylgeranyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (405 aa)
	BDBG_05014	Delta14-sterol reductase. (509 aa)
	BDBG_04705	Geranylgeranyl pyrophosphate synthase. (714 aa)
	BDBG_04749	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1152 aa)
	BDBG_04254	7-dehydrosterol-delta 7-reductase. (465 aa)
	BDBG_04743	Eburicol 14-alpha-demethylase, variant; Belongs to the cytochrome P450 family. (527 aa)
	BDBG_06225	Fatty acid desaturase. (581 aa)
	BDBG_06626	C-8 sterol isomerase. (213 aa)
	BDBG_05713	Zn(2)-C6 fungal-type domain-containing protein. (755 aa)
	BDBG_06527	Isopentenyl-diphosphate delta-isomerase. (270 aa)
	BDBG_07200	Undecaprenyl diphosphate synthase. (412 aa)
	BDBG_06739	26S proteasome regulatory subunit N3. (520 aa)
	BDBG_06077	L-lactate dehydrogenase (Cytochrome), variant 1; Belongs to the cytochrome b5 family. (495 aa)
	BDBG_06069	Uncharacterized protein; Belongs to the cytochrome P450 family. (568 aa)
	BDBG_07225	3-ketosteroid reductase. (476 aa)
	BDBG_06244	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (476 aa)
	BDBG_07522	Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily. (372 aa)
	BDBG_06155	Delta(24(24(1)))-sterol reductase. (548 aa)
	BDBG_08449	Squalene monooxygenase. (484 aa)
	BDBG_07812	Uncharacterized protein. (273 aa)
	BDBG_08700	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (380 aa)
	BDBG_08899	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (528 aa)
	BDBG_09096	Uncharacterized protein; Belongs to the cytochrome P450 family. (580 aa)
	BDBG_09413	C-5 sterol desaturase, variant; Belongs to the sterol desaturase family. (354 aa)
	BDBG_08773	Farnesyl-diphosphate farnesyltransferase. (473 aa)
	BDBG_18119	Uncharacterized protein. (141 aa)
	BDBG_09174	Methylsterol monooxygenase; Belongs to the sterol desaturase family. (299 aa)

Your Current Organism:

Blastomyces gilchristii

NCBI taxonomy Id: 559298
Other names: Ajellomyces dermatitidis SLH#14081, Ajellomyces dermatitidis SLH14081, B. gilchristii SLH14081, Blastomyces dermatitidis SLH14081, Blastomyces gilchristii SLH14081

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDBG_00070	BDBG_00254	A0A179U5P6	A0A179U8B3	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Sterol desaturase; Belongs to the sterol desaturase family.	0.848
BDBG_00070	BDBG_00546	A0A179U5P6	A0A179U9A3	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	C-4 methylsterol oxidase, variant; Belongs to the sterol desaturase family.	0.848
BDBG_00070	BDBG_00632	A0A179U5P6	A0A179U9K9	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Ergosterol biosynthesis protein Erg28.	0.981
BDBG_00070	BDBG_01200	A0A179U5P6	A0A179UBK7	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Uncharacterized protein.	0.504
BDBG_00070	BDBG_01260	A0A179U5P6	A0A179UA82	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.984
BDBG_00070	BDBG_01511	A0A179U5P6	A0A179UEX0	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.637
BDBG_00070	BDBG_01678	A0A179U5P6	A0A179UDM2	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Cytochrome P450, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	0.916
BDBG_00070	BDBG_01858	A0A179U5P6	A0A179UBS2	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.594
BDBG_00070	BDBG_02640	A0A179U5P6	A0A179UFC2	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.633
BDBG_00070	BDBG_02649	A0A179U5P6	A0A179UEQ8	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	C-4 methylsterol oxidase; Belongs to the sterol desaturase family.	0.689
BDBG_00070	BDBG_02700	A0A179U5P6	A0A179UEX3	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	FAD binding domain-containing protein.	0.422
BDBG_00070	BDBG_03201	A0A179U5P6	A0A179UGX1	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	C-22 sterol desaturase; Belongs to the cytochrome P450 family.	0.701
BDBG_00070	BDBG_03553	A0A179U5P6	A0A179UK21	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Delta24(24(1))-sterol reductase.	0.869
BDBG_00070	BDBG_03695	A0A179U5P6	A0A179UHX9	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Uncharacterized protein.	0.504
BDBG_00070	BDBG_04254	A0A179U5P6	A0A179UPF9	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	7-dehydrosterol-delta 7-reductase.	0.883
BDBG_00070	BDBG_04743	A0A179U5P6	A0A179UPS4	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Eburicol 14-alpha-demethylase, variant; Belongs to the cytochrome P450 family.	0.915
BDBG_00070	BDBG_04749	A0A179U5P6	A0A179UM96	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.594
BDBG_00070	BDBG_05014	A0A179U5P6	A0A179ULV0	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Delta14-sterol reductase.	0.883
BDBG_00070	BDBG_05713	A0A179U5P6	A0A179USN2	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Zn(2)-C6 fungal-type domain-containing protein.	0.504
BDBG_00070	BDBG_06069	A0A179U5P6	A0A179UVC3	Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating).	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.504

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