(60 nodes) Dicarboxylic acid metabolic process network (Millerozyma farinosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Piso0_004328	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (470 aa)
	Piso0_004162	Piso0_004162 protein. (636 aa)
	Piso0_004096	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (564 aa)
	Piso0_004025	Malate dehydrogenase. (345 aa)
	Piso0_003831	Piso0_003831 protein. (365 aa)
	Piso0_004431	Aspartate aminotransferase. (420 aa)
	Piso0_004484	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (466 aa)
	Piso0_004514	Piso0_004514 protein. (429 aa)
	Piso0_002091	Aspartate aminotransferase. (402 aa)
	Piso0_002094	Piso0_002094 protein. (319 aa)
	Piso0_002387	Piso0_002387 protein. (96 aa)
	Piso0_002431	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
	Piso0_002494	Aspartokinase. (529 aa)
	Piso0_002585	Piso0_002585 protein. (491 aa)
	Piso0_002614	Ornithine aminotransferase. (436 aa)
	Piso0_002699	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (174 aa)
	Piso0_002091-2	Aspartate aminotransferase. (402 aa)
	Piso0_002094-2	Piso0_002094 protein. (321 aa)
	Piso0_002387-2	Piso0_002387 protein. (96 aa)
	Piso0_002431-2	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
	Piso0_002494-2	Aspartokinase. (529 aa)
	Piso0_002585-2	Piso0_002585 protein. (491 aa)
	Piso0_002614-2	Ornithine aminotransferase. (436 aa)
	Piso0_002699-2	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (174 aa)
	Piso0_003194	Piso0_003194 protein. (2152 aa)
	Piso0_003506	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (492 aa)
	Piso0_003626	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (477 aa)
	Piso0_001693	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (456 aa)
	Piso0_001693-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (456 aa)
	Piso0_000617	Piso0_000617 protein. (308 aa)
	Piso0_000744	Phospho-2-dehydro-3-deoxyheptonate aldolase. (366 aa)
	Piso0_000617-2	Piso0_000617 protein. (308 aa)
	Piso0_000744-2	Phospho-2-dehydro-3-deoxyheptonate aldolase. (366 aa)
	Piso0_000563	Chorismate mutase. (259 aa)
	Piso0_000091	Piso0_000091 protein. (270 aa)
	Piso0_000099	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (590 aa)
	Piso0_000091-2	Piso0_000091 protein. (270 aa)
	Piso0_000099-2	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (590 aa)
	Piso0_004695	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (455 aa)
	Piso0_004662	Piso0_004662 protein; Belongs to the dihydrofolate reductase family. (211 aa)
	Piso0_004577	Piso0_004577 protein. (302 aa)
	Piso0_004425	Chorismate synthase. (376 aa)
	Piso0_005419-2	Piso0_005419 protein. (998 aa)
	Piso0_005225-2	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1052 aa)
	Piso0_005165-2	Piso0_005165 protein. (781 aa)
	Piso0_005078-2	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (300 aa)
	Piso0_004903-2	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (449 aa)
	Piso0_005828-2	Malate dehydrogenase. (335 aa)
	Piso0_005807-2	Malate dehydrogenase. (332 aa)
	Piso0_005677-2	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1559 aa)
	Piso0_005510-2	Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family. (804 aa)
	Piso0_005225	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1052 aa)
	Piso0_005165	Piso0_005165 protein. (781 aa)
	Piso0_005078	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (300 aa)
	Piso0_004903	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (449 aa)
	Piso0_005828	Malate dehydrogenase. (335 aa)
	Piso0_005807	Malate dehydrogenase. (332 aa)
	Piso0_005677	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1559 aa)
	Piso0_005510	Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family. (804 aa)
	Piso0_005419	Piso0_005419 protein. (998 aa)

Your Current Organism:

Millerozyma farinosa

NCBI taxonomy Id: 559304
Other names: M. farinosa CBS 7064, Millerozyma farinosa CBS 7064, Pichia farinosa CBS 7064

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Piso0_000091	Piso0_003506	G8YT26	G8YIA3	Piso0_000091 protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.517
Piso0_000091	Piso0_003831	G8YT26	G8Y6R0	Piso0_000091 protein.	Piso0_003831 protein.	0.500
Piso0_000091	Piso0_004162	G8YT26	G8Y7N3	Piso0_000091 protein.	Piso0_004162 protein.	0.510
Piso0_000091	Piso0_004328	G8YT26	G8Y8H8	Piso0_000091 protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.517
Piso0_000091	Piso0_004425	G8YT26	G8Y5F5	Piso0_000091 protein.	Chorismate synthase.	0.533
Piso0_000091	Piso0_004662	G8YT26	G8Y630	Piso0_000091 protein.	Piso0_004662 protein; Belongs to the dihydrofolate reductase family.	0.510
Piso0_000091	Piso0_004903	G8YT26	G8Y0R2	Piso0_000091 protein.	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family.	0.561
Piso0_000091	Piso0_004903-2	G8YT26	G8Y3P8	Piso0_000091 protein.	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family.	0.561
Piso0_000091	Piso0_005165	G8YT26	G8Y1F9	Piso0_000091 protein.	Piso0_005165 protein.	0.412
Piso0_000091	Piso0_005165-2	G8YT26	G8Y4E1	Piso0_000091 protein.	Piso0_005165 protein.	0.412
Piso0_000091	Piso0_005510	G8YT26	G8XZ76	Piso0_000091 protein.	Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family.	0.975
Piso0_000091	Piso0_005510-2	G8YT26	G8Y263	Piso0_000091 protein.	Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family.	0.975
Piso0_000091-2	Piso0_003506	G8YUH8	G8YIA3	Piso0_000091 protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.517
Piso0_000091-2	Piso0_003831	G8YUH8	G8Y6R0	Piso0_000091 protein.	Piso0_003831 protein.	0.500
Piso0_000091-2	Piso0_004162	G8YUH8	G8Y7N3	Piso0_000091 protein.	Piso0_004162 protein.	0.510
Piso0_000091-2	Piso0_004328	G8YUH8	G8Y8H8	Piso0_000091 protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.517
Piso0_000091-2	Piso0_004425	G8YUH8	G8Y5F5	Piso0_000091 protein.	Chorismate synthase.	0.533
Piso0_000091-2	Piso0_004662	G8YUH8	G8Y630	Piso0_000091 protein.	Piso0_004662 protein; Belongs to the dihydrofolate reductase family.	0.510
Piso0_000091-2	Piso0_004903	G8YUH8	G8Y0R2	Piso0_000091 protein.	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family.	0.561
Piso0_000091-2	Piso0_004903-2	G8YUH8	G8Y3P8	Piso0_000091 protein.	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family.	0.561