(54 nodes) Lysine degradation network (Millerozyma farinosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Piso0_002686-2	Piso0_002686 protein; Belongs to the aldehyde dehydrogenase family. (501 aa)
	Piso0_002808-2	Piso0_002808 protein. (506 aa)
	Piso0_002865-2	Dihydrolipoyl dehydrogenase. (495 aa)
	Piso0_003363	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1062 aa)
	Piso0_002889	Piso0_002889 protein. (426 aa)
	Piso0_002969	Succinate-semialdehyde dehydrogenase. (492 aa)
	Piso0_001474	Piso0_001474 protein. (567 aa)
	Piso0_001508	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (551 aa)
	Piso0_001831	Piso0_001831 protein. (344 aa)
	Piso0_001923-2	Piso0_001923 protein. (581 aa)
	Piso0_001419	Piso0_001419 protein. (426 aa)
	Piso0_001474-2	Piso0_001474 protein. (565 aa)
	Piso0_001508-2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (551 aa)
	Piso0_001831-2	Piso0_001831 protein. (344 aa)
	Piso0_001188	Piso0_001188 protein; Belongs to the aldehyde dehydrogenase family. (536 aa)
	Piso0_000604	Piso0_000604 protein. (911 aa)
	Piso0_000628	Piso0_000628 protein. (781 aa)
	Piso0_000660	Piso0_000660 protein. (1158 aa)
	Piso0_000760	Piso0_000760 protein. (404 aa)
	Piso0_002447	Piso0_002447 protein. (405 aa)
	Piso0_002380	Piso0_002380 protein. (603 aa)
	Piso0_002255	Piso0_002255 protein. (445 aa)
	Piso0_002135	Piso0_002135 protein. (406 aa)
	Piso0_002107	Piso0_002107 protein. (842 aa)
	Piso0_002058	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (1076 aa)
	Piso0_001089	Piso0_001089 protein; Belongs to the aldehyde dehydrogenase family. (522 aa)
	Piso0_002447-2	Piso0_002447 protein. (405 aa)
	Piso0_002255-2	Piso0_002255 protein. (445 aa)
	Piso0_002135-2	Piso0_002135 protein. (406 aa)
	Piso0_001923	Piso0_001923 protein. (580 aa)
	Piso0_004012	Piso0_004012 protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	Piso0_003820	Piso0_003820 protein. (379 aa)
	Piso0_004045	Piso0_004045 protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (744 aa)
	Piso0_004655	Piso0_004655 protein. (792 aa)
	Piso0_004421	Piso0_004421 protein. (445 aa)
	Piso0_000660-2	Piso0_000660 protein. (1159 aa)
	Piso0_000760-2	Piso0_000760 protein. (403 aa)
	Piso0_005289-2	Succinate-semialdehyde dehydrogenase. (511 aa)
	Piso0_001058	Piso0_001058 protein. (540 aa)
	Piso0_000280	Piso0_000280 protein. (485 aa)
	Piso0_005898-2	Piso0_005898 protein. (1005 aa)
	Piso0_005588-2	Piso0_005588 protein. (1061 aa)
	Piso0_002107-2	Piso0_002107 protein. (842 aa)
	Piso0_005289	Succinate-semialdehyde dehydrogenase. (511 aa)
	Piso0_005898	Piso0_005898 protein. (1006 aa)
	Piso0_002058-2	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (1076 aa)
	Piso0_002865	Dihydrolipoyl dehydrogenase. (495 aa)
	Piso0_002808	Piso0_002808 protein. (506 aa)
	Piso0_000280-2	Piso0_000280 protein. (484 aa)
	Piso0_002686	Piso0_002686 protein; Belongs to the aldehyde dehydrogenase family. (501 aa)
	Piso0_000471	Piso0_000471 protein. (436 aa)
	Piso0_002506	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family. (369 aa)
	Piso0_005588	Piso0_005588 protein. (1057 aa)
	Piso0_002506-2	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family. (369 aa)

Your Current Organism:

Millerozyma farinosa

NCBI taxonomy Id: 559304
Other names: M. farinosa CBS 7064, Millerozyma farinosa CBS 7064, Pichia farinosa CBS 7064

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Piso0_000280	Piso0_000604	G8YTJ9	G8YPJ5	Piso0_000280 protein.	Piso0_000604 protein.	0.444
Piso0_000280	Piso0_000628	G8YTJ9	G8YPL9	Piso0_000280 protein.	Piso0_000628 protein.	0.452
Piso0_000280	Piso0_000760	G8YTJ9	G8YPZ6	Piso0_000280 protein.	Piso0_000760 protein.	0.510
Piso0_000280	Piso0_000760-2	G8YTJ9	G8YRF7	Piso0_000280 protein.	Piso0_000760 protein.	0.510
Piso0_000280	Piso0_001058	G8YTJ9	G8YS98	Piso0_000280 protein.	Piso0_001058 protein.	0.582
Piso0_000280	Piso0_001831	G8YTJ9	G8YLU9	Piso0_000280 protein.	Piso0_001831 protein.	0.436
Piso0_000280	Piso0_001831-2	G8YTJ9	G8YP76	Piso0_000280 protein.	Piso0_001831 protein.	0.422
Piso0_000280	Piso0_002058	G8YTJ9	G8YBK6	Piso0_000280 protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.678
Piso0_000280	Piso0_002058-2	G8YTJ9	G8YE04	Piso0_000280 protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.678
Piso0_000280	Piso0_002380	G8YTJ9	G8YCG5	Piso0_000280 protein.	Piso0_002380 protein.	0.444
Piso0_000280	Piso0_003363	G8YTJ9	G8YIW4	Piso0_000280 protein.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.832
Piso0_000280	Piso0_003820	G8YTJ9	G8Y8E2	Piso0_000280 protein.	Piso0_003820 protein.	0.566
Piso0_000280	Piso0_004045	G8YTJ9	G8Y7C0	Piso0_000280 protein.	Piso0_004045 protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.752
Piso0_000280	Piso0_005588	G8YTJ9	G8XZE2	Piso0_000280 protein.	Piso0_005588 protein.	0.444
Piso0_000280	Piso0_005588-2	G8YTJ9	G8Y2D5	Piso0_000280 protein.	Piso0_005588 protein.	0.444
Piso0_000280	Piso0_005898	G8YTJ9	G8Y089	Piso0_000280 protein.	Piso0_005898 protein.	0.707
Piso0_000280	Piso0_005898-2	G8YTJ9	G8Y378	Piso0_000280 protein.	Piso0_005898 protein.	0.707
Piso0_000280-2	Piso0_000604	G8YV06	G8YPJ5	Piso0_000280 protein.	Piso0_000604 protein.	0.444
Piso0_000280-2	Piso0_000628	G8YV06	G8YPL9	Piso0_000280 protein.	Piso0_000628 protein.	0.452
Piso0_000280-2	Piso0_000760	G8YV06	G8YPZ6	Piso0_000280 protein.	Piso0_000760 protein.	0.510