(60 nodes) Biosynthesis of unsaturated fatty acids network (Millerozyma farinosa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Piso0_004735	Piso0_004735 protein. (521 aa)
	Piso0_002029	Piso0_002029 protein. (566 aa)
	Piso0_002682	Piso0_002682 protein. (394 aa)
	Piso0_002791	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (485 aa)
	Piso0_001290	Piso0_001290 protein. (548 aa)
	Piso0_002682-2	Piso0_002682 protein. (394 aa)
	Piso0_002791-2	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (485 aa)
	Piso0_002879	Piso0_002879 protein. (524 aa)
	Piso0_003640	Piso0_003640 protein; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	Piso0_002896	Piso0_002896 protein. (522 aa)
	Piso0_002891	Piso0_002891 protein. (578 aa)
	Piso0_002894	Piso0_002894 protein. (521 aa)
	Piso0_002934	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (258 aa)
	Piso0_003085	Piso0_003085 protein. (605 aa)
	Piso0_001438	Piso0_001438 protein. (129 aa)
	Piso0_001536	Elongation of fatty acids protein. (344 aa)
	Piso0_001563	Piso0_001563 protein. (682 aa)
	Piso0_001570	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (390 aa)
	Piso0_001847	Piso0_001847 protein. (327 aa)
	Piso0_002029-2	Piso0_002029 protein. (567 aa)
	Piso0_001303	Piso0_001303 protein. (682 aa)
	Piso0_001218	Piso0_001218 protein. (322 aa)
	Piso0_001290-2	Piso0_001290 protein. (554 aa)
	Piso0_001303-2	Piso0_001303 protein. (682 aa)
	Piso0_001438-2	Piso0_001438 protein. (129 aa)
	Piso0_001536-2	Elongation of fatty acids protein. (344 aa)
	Piso0_001563-2	Piso0_001563 protein. (682 aa)
	Piso0_001570-2	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (343 aa)
	Piso0_001847-2	Piso0_001847 protein. (327 aa)
	Piso0_000662	Piso0_000662 protein. (629 aa)
	Piso0_000662-2	Piso0_000662 protein. (630 aa)
	Piso0_001012	Elongation of fatty acids protein. (324 aa)
	Piso0_001018	Piso0_001018 protein. (425 aa)
	Piso0_001190	Piso0_001190 protein. (567 aa)
	Piso0_000011	Piso0_000011 protein. (595 aa)
	Piso0_000217	Piso0_000217 protein. (664 aa)
	Piso0_000011-2	Piso0_000011 protein. (595 aa)
	Piso0_000217-2	Piso0_000217 protein. (661 aa)
	Piso0_000422	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (704 aa)
	Piso0_000444	Piso0_000444 protein. (478 aa)
	Piso0_000538	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (528 aa)
	Piso0_005507	Piso0_005507 protein. (342 aa)
	Piso0_005773	Piso0_005773 protein. (304 aa)
	Piso0_005882	Piso0_005882 protein. (315 aa)
	Piso0_005907	Piso0_005907 protein. (527 aa)
	Piso0_004830	Piso0_004830 protein. (580 aa)
	Piso0_005096	Piso0_005096 protein. (716 aa)
	Piso0_005183	Piso0_005183 protein. (516 aa)
	Piso0_005507-2	Piso0_005507 protein. (312 aa)
	Piso0_005773-2	Piso0_005773 protein. (304 aa)
	Piso0_005882-2	Piso0_005882 protein. (315 aa)
	Piso0_005907-2	Piso0_005907 protein. (527 aa)
	Piso0_004830-2	Piso0_004830 protein. (581 aa)
	Piso0_005183-2	Piso0_005183 protein. (516 aa)
	Piso0_004706	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (236 aa)
	Piso0_004721	Piso0_004721 protein. (486 aa)
	Piso0_003679	Piso0_003679 protein. (544 aa)
	Piso0_003810	Elongation of fatty acids protein. (334 aa)
	Piso0_004348	Piso0_004348 protein. (582 aa)
	Piso0_003792	Piso0_003792 protein. (481 aa)

Your Current Organism:

Millerozyma farinosa

NCBI taxonomy Id: 559304
Other names: M. farinosa CBS 7064, Millerozyma farinosa CBS 7064, Pichia farinosa CBS 7064

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Piso0_000011	Piso0_000538	G8YSV1	G8YVP9	Piso0_000011 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.852
Piso0_000011	Piso0_002791	G8YSV1	G8YDI6	Piso0_000011 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000011	Piso0_002791-2	G8YSV1	G8YFZ5	Piso0_000011 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000011-2	Piso0_000538	G8YUB0	G8YVP9	Piso0_000011 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.852
Piso0_000011-2	Piso0_002791	G8YUB0	G8YDI6	Piso0_000011 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000011-2	Piso0_002791-2	G8YUB0	G8YFZ5	Piso0_000011 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000217	Piso0_000538	G8YTE2	G8YVP9	Piso0_000217 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.852
Piso0_000217	Piso0_002791	G8YTE2	G8YDI6	Piso0_000217 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000217	Piso0_002791-2	G8YTE2	G8YFZ5	Piso0_000217 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000217-2	Piso0_000538	G8YUU6	G8YVP9	Piso0_000217 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.852
Piso0_000217-2	Piso0_002791	G8YUU6	G8YDI6	Piso0_000217 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000217-2	Piso0_002791-2	G8YUU6	G8YFZ5	Piso0_000217 protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.613
Piso0_000422	Piso0_000538	G8YVE3	G8YVP9	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.595
Piso0_000422	Piso0_001012	G8YVE3	G8YS53	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Elongation of fatty acids protein.	0.464
Piso0_000422	Piso0_001438	G8YVE3	G8YKS8	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Piso0_001438 protein.	0.981
Piso0_000422	Piso0_001438-2	G8YVE3	G8YN61	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Piso0_001438 protein.	0.981
Piso0_000422	Piso0_001536	G8YVE3	G8YL23	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Elongation of fatty acids protein.	0.464
Piso0_000422	Piso0_001536-2	G8YVE3	G8YNF3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Elongation of fatty acids protein.	0.464
Piso0_000422	Piso0_001570	G8YVE3	G8YL54	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	0.779
Piso0_000422	Piso0_001570-2	G8YVE3	G8YNI4	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	0.779