(28 nodes) tRNA methylation network (Trichophyton rubrum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TERG_12051	Uncharacterized protein. (99 aa)
	TERG_04147	Uncharacterized protein. (300 aa)
	TERG_04418	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6. (262 aa)
	TRM8	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (322 aa)
	TERG_01679	Uncharacterized protein. (64 aa)
	TERG_02131	Uncharacterized protein. (323 aa)
	TRM5	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (349 aa)
	TERG_01268	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (580 aa)
	TERG_00071	Uncharacterized protein. (326 aa)
	TERG_01299	Uncharacterized protein. (694 aa)
	TERG_12053	Uncharacterized protein. (247 aa)
	TERG_12052	Uncharacterized protein. (449 aa)
	TERG_12054	Uncharacterized protein. (652 aa)
	TERG_11925	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (308 aa)
	TERG_08590	Uncharacterized protein. (502 aa)
	TERG_08526	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (782 aa)
	TERG_08017	Uncharacterized protein. (200 aa)
	TERG_07540	Uncharacterized protein. (433 aa)
	TERG_07441	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (852 aa)
	TERG_07333	UPF0020 domain-containing protein. (276 aa)
	TERG_06618	Uncharacterized protein. (594 aa)
	TERG_06597	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA. (605 aa)
	TRM82	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (510 aa)
	TERG_06482	Methyltransf_11 domain-containing protein. (261 aa)
	TERG_05829	WD_REPEATS_REGION domain-containing protein. (1118 aa)
	TERG_05150	tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. (461 aa)
	TERG_05114	TRAM domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (593 aa)
	TERG_04826	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (381 aa)

Your Current Organism:

Trichophyton rubrum

NCBI taxonomy Id: 559305
Other names: T. rubrum CBS 118892, Trichophyton rubrum CBS 118892

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TERG_01299	TERG_04418	F2SBR5	F2SNA7	Uncharacterized protein.	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6.	0.602
TERG_01299	TERG_05829	F2SBR5	F2STN1	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.463
TERG_01299	TERG_08590	F2SBR5	F2T1A3	Uncharacterized protein.	Uncharacterized protein.	0.540
TERG_01299	TERG_11925	F2SBR5	A0A080WI04	Uncharacterized protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.513
TERG_01299	TRM8	F2SBR5	F2SLK1	Uncharacterized protein.	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.	0.588
TERG_01299	TRM82	F2SBR5	F2SUF3	Uncharacterized protein.	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.	0.466
TERG_01679	TERG_04418	F2SHE8	F2SNA7	Uncharacterized protein.	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6.	0.489
TERG_01679	TERG_05114	F2SHE8	F2SR97	Uncharacterized protein.	TRAM domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	0.404
TERG_01679	TERG_05150	F2SHE8	F2SRD1	Uncharacterized protein.	tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.	0.966
TERG_01679	TERG_06482	F2SHE8	F2SU16	Uncharacterized protein.	Methyltransf_11 domain-containing protein.	0.971
TERG_01679	TERG_07333	F2SHE8	F2SXP1	Uncharacterized protein.	UPF0020 domain-containing protein.	0.983
TERG_01679	TERG_08526	F2SHE8	F2T139	Uncharacterized protein.	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	0.402
TERG_01679	TERG_08590	F2SHE8	F2T1A3	Uncharacterized protein.	Uncharacterized protein.	0.517
TERG_01679	TERG_11925	F2SHE8	A0A080WI04	Uncharacterized protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.519
TERG_01679	TRM8	F2SHE8	F2SLK1	Uncharacterized protein.	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.	0.647
TERG_01679	TRM82	F2SHE8	F2SUF3	Uncharacterized protein.	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.	0.501
TERG_04418	TERG_01299	F2SNA7	F2SBR5	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6.	Uncharacterized protein.	0.602
TERG_04418	TERG_01679	F2SNA7	F2SHE8	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6.	Uncharacterized protein.	0.489
TERG_04418	TERG_05114	F2SNA7	F2SR97	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6.	TRAM domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	0.508
TERG_04418	TERG_05150	F2SNA7	F2SRD1	tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit trm6.	tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.	0.522