(15 nodes) Ribosome assembly network (Streptomyces toyocaensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rplT	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa)
	rimP	Ribosome maturation protein RimP; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (173 aa)
	era	GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (317 aa)
	rsfS	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (148 aa)
	BU52_24755	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (634 aa)
	BU52_26955	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
	BU52_30220	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (731 aa)
	rplV	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (115 aa)
	rpsK	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
	rpsS	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
	rpsG	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
	BU52_04820	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
	BU52_03565	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
	BU52_01325	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
	der	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (496 aa)

Your Current Organism:

Streptomyces toyocaensis

NCBI taxonomy Id: 55952
Other names: S. toyocaensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BU52_01325	BU52_26955	BU52_01325	BU52_26955	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.532
BU52_01325	rplT	BU52_01325	BU52_12260	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.538
BU52_01325	rplV	BU52_01325	BU52_06710	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.762
BU52_01325	rpsG	BU52_01325	BU52_06580	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.	0.555
BU52_01325	rpsK	BU52_01325	BU52_06815	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.911
BU52_01325	rpsS	BU52_01325	BU52_06705	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.562
BU52_01325	rsfS	BU52_01325	BU52_19215	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.784
BU52_03565	BU52_26955	BU52_03565	BU52_26955	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.537
BU52_03565	rplT	BU52_03565	BU52_12260	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.538
BU52_03565	rplV	BU52_03565	BU52_06710	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.762
BU52_03565	rpsG	BU52_03565	BU52_06580	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.	0.555
BU52_03565	rpsK	BU52_03565	BU52_06815	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.911
BU52_03565	rpsS	BU52_03565	BU52_06705	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.562
BU52_03565	rsfS	BU52_03565	BU52_19215	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.784
BU52_04820	BU52_26955	BU52_04820	BU52_26955	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.527
BU52_04820	rplT	BU52_04820	BU52_12260	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.538
BU52_04820	rplV	BU52_04820	BU52_06710	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.762
BU52_04820	rpsG	BU52_04820	BU52_06580	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.	0.555
BU52_04820	rpsK	BU52_04820	BU52_06815	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.911
BU52_04820	rpsS	BU52_04820	BU52_06705	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.562