STRINGSTRING
ghrB ghrB mtlD mtlD ACT05014.1 ACT05014.1 ilvC ilvC wecC wecC aroE aroE ACT05402.1 ACT05402.1 ACT05415.1 ACT05415.1 pdxA pdxA leuB leuB garR garR guaB guaB ACT06130.1 ACT06130.1 ACT06135.1 ACT06135.1 ACT06203.1 ACT06203.1 pdxB pdxB ACT06630.1 ACT06630.1 ACT06708.1 ACT06708.1 ACT06794.1 ACT06794.1 ACT06820.1 ACT06820.1 ACT06864.1 ACT06864.1 ACT06943.1 ACT06943.1 ACT07040.1 ACT07040.1 zwf zwf hisD hisD ACT07252.1 ACT07252.1 ACT07255.1 ACT07255.1 maeA maeA ACT07432.1 ACT07432.1 ACT07565.1 ACT07565.1 ACT07669.1 ACT07669.1 ACT07671.1 ACT07671.1 ACT07678.1 ACT07678.1 ACT07902.1 ACT07902.1 ACT07912.1 ACT07912.1 ACT07958.1 ACT07958.1 dxr dxr ACT08006.1 ACT08006.1 ACT08057.1 ACT08057.1 ACT08111.1 ACT08111.1 ACT08157.1 ACT08157.1 ACT08221.1 ACT08221.1 ACT08250.1 ACT08250.1 mdh mdh uxaB uxaB ACT08565.1 ACT08565.1 ACT08566.1 ACT08566.1 ACT08648.1 ACT08648.1 murB murB ACT08701.1 ACT08701.1 gpsA gpsA tdh tdh arnA arnA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ghrBD-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (320 aa)
mtlDPFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: eca:ECA0088 mannitol-1-phosphate 5-dehydrogenase. (383 aa)
ACT05014.1Aspartate kinase; KEGG: eca:ECA4251 bifunctional aspartate kinase II/homoserine dehydrogenase II; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa)
wecCNucleotide sugar dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (275 aa)
ACT05402.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; KEGG: eca:ECA3905 D-3-phosphoglycerate dehydrogenase. (410 aa)
ACT05415.1Aspartate kinase; KEGG: eca:ECA3891 bifunctional aspartokinase I/homeserine dehydrogenase I; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (818 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (333 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
garR2-hydroxy-3-oxopropionate reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (294 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
ACT06130.1Fructuronate reductase; PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: eca:ECA0920 carbohydrate oxidoreductase. (490 aa)
ACT06135.1Hypothetical protein; KEGG: sme:SMc02038 glycerol dehydrogenase. (122 aa)
ACT06203.1Fatty acid oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (732 aa)
pdxBD-isomer specific 2-hydroxyacid dehydrogenase catalytic region; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (377 aa)
ACT06630.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: eca:ECA2000 D-lactate dehydrogenase. (330 aa)
ACT06708.1PFAM: iron-containing alcohol dehydrogenase; KEGG: ilo:IL0796 alcohol dehydrogenase. (382 aa)
ACT06794.1TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: eca:ECA2439 isocitrate dehydrogenase. (417 aa)
ACT06820.1TIGRFAM: 2-deoxy-D-gluconate 3-dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; KEGG: eca:ECA2401 2-deoxy-D-gluconate 3-dehydrogenase. (253 aa)
ACT06864.1PFAM: short-chain dehydrogenase/reductase SDR; KEGG: yen:YE3176 short chain dehydrogenase. (224 aa)
ACT06943.1KEGG: ret:RHE_PF00443 putative dehydrogenase large subunit protein. (612 aa)
ACT07040.1PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: eca:ECA2326 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (900 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)
ACT07252.1TIGRFAM: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: spe:Spro_1557 S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (373 aa)
ACT07255.1PFAM: iron-containing alcohol dehydrogenase; 3-dehydroquinate synthase; KEGG: eca:ECA2718 hypothetical protein. (361 aa)
maeAPFAM: malic protein NAD-binding; malic protein domain protein; KEGG: eca:ECA2831 malate dehydrogenase. (565 aa)
ACT07432.1PFAM: iron-containing alcohol dehydrogenase; KEGG: abu:Abu_0784 iron-containing NADP-dependent alcohol dehydrogenase. (382 aa)
ACT07565.1PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: abu:Abu_0783 zinc-containing NADP-dependent alcohol dehydrogenase. (390 aa)
ACT07669.16-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
ACT07671.1Nucleotide sugar dehydrogenase; KEGG: aha:AHA_2880 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein. (388 aa)
ACT07678.1KEGG: eca:ECA1440 dTDP-4-dehydrorhamnose reductase; TIGRFAM: dTDP-4-dehydrorhamnose reductase; PFAM: dTDP-4-dehydrorhamnose reductase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; polysaccharide biosynthesis protein CapD; NAD-dependent epimerase/dehydratase. (285 aa)
ACT07902.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa)
ACT07912.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (370 aa)
ACT07958.12-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE domain protein; KEGG: eca:ECA1579 2-dehydropantoate 2-reductase. (296 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (397 aa)
ACT08006.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: asa:ASA_0954 D-3-phosphoglycerate dehydrogenase. (337 aa)
ACT08057.1Tartrate dehydrogenase; KEGG: reh:H16_A0477 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (361 aa)
ACT08111.1Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; KEGG: eca:ECA0871 malic enzyme. (759 aa)
ACT08157.1PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: eca:ECA1458 putative myo-inositol 2-dehydrogenase. (328 aa)
ACT08221.1KEGG: pin:Ping_0453 hypothetical protein. (255 aa)
ACT08250.1TIGRFAM: lactaldehyde reductase; PFAM: iron-containing alcohol dehydrogenase; KEGG: eca:ECA0742 L-1,2-propanediol oxidoreductase. (383 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (313 aa)
uxaBPFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: eca:ECA0646 altronate oxidoreductase; Belongs to the mannitol dehydrogenase family. UxaB subfamily. (483 aa)
ACT08565.1PFAM: iron-containing alcohol dehydrogenase; KEGG: spe:Spro_4215 iron-containing alcohol dehydrogenase. (387 aa)
ACT08566.1PFAM: aldo/keto reductase; KEGG: eca:ECA0349 2,5-diketo-D-gluconate reductase A. (281 aa)
ACT08648.1PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: yen:YE3722 NADP-dependent alcohol dehydrogenase. (350 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (345 aa)
ACT08701.1Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: eca:ECA0173 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase. (339 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
arnANAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (663 aa)
Your Current Organism:
Dickeya chrysanthemi
NCBI taxonomy Id: 561229
Other names: D. chrysanthemi Ech1591, Dickeya chrysanthemi Ech1591, Dickeya dadantii Ech1591, Dickeya zeae Ech1591
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