STRINGSTRING
dsdA dsdA ACT04914.1 ACT04914.1 ACT04928.1 ACT04928.1 ACT04966.1 ACT04966.1 ACT04991.1 ACT04991.1 ACT05013.1 ACT05013.1 ACT05031.1 ACT05031.1 ilvA ilvA wecE wecE ACT05120.1 ACT05120.1 ACT05125.1 ACT05125.1 ACT05164.1 ACT05164.1 argD argD ACT05259.1 ACT05259.1 queG queG ACT05417.1 ACT05417.1 ACT05463.1 ACT05463.1 ACT05466.1 ACT05466.1 ACT05478.1 ACT05478.1 ACT05583.1 ACT05583.1 ACT05589.1 ACT05589.1 lysA lysA ACT05639.1 ACT05639.1 ACT05763.1 ACT05763.1 hemL hemL btuF btuF ACT05928.1 ACT05928.1 glyA glyA iscS iscS ACT06158.1 ACT06158.1 ACT06185.1 ACT06185.1 ACT06253.1 ACT06253.1 ACT06287.1 ACT06287.1 ACT06312.1 ACT06312.1 ACT06479.1 ACT06479.1 ACT06517.1 ACT06517.1 ACT06532.1 ACT06532.1 sufS sufS ACT06716.1 ACT06716.1 ACT06717.1 ACT06717.1 hisC hisC serC serC ACT07338.1 ACT07338.1 bioF bioF bioA bioA ACT07424.1 ACT07424.1 ACT07484.1 ACT07484.1 ACT07504.1 ACT07504.1 ACT07507.1 ACT07507.1 ACT07527.1 ACT07527.1 ACT07736.1 ACT07736.1 menD menD dxs dxs ACT08002.1 ACT08002.1 ACT08160.1 ACT08160.1 ACT08173.1 ACT08173.1 ACT08243.1 ACT08243.1 ACT08251.1 ACT08251.1 ACT08462.1 ACT08462.1 ACT08562.1 ACT08562.1 ACT08676.1 ACT08676.1 kbl kbl ACT08852.1 ACT08852.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dsdATIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bvi:Bcep1808_3327 D-serine dehydratase. (456 aa)
ACT04914.1Aminotransferase class V; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (373 aa)
ACT04928.1PFAM: aminotransferase class I and II; KEGG: eca:ECA4386 valine--pyruvate transaminase. (418 aa)
ACT04966.1TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; Thioesterase; phosphopantetheine-binding; KEGG: plu:plu2186 hypothetical protein. (1439 aa)
ACT04991.1PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: mpo:Mpop_3620 Orn/DAP/Arg decarboxylase 2. (440 aa)
ACT05013.1O-succinylhomoserine (thiol)-lyase; KEGG: eca:ECA4252 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa)
ACT05031.1TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: eca:ECA4229 acetolactate synthase 2 catalytic subunit. (548 aa)
ilvAThreonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa)
wecETDP-4-keto-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
ACT05120.1Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (815 aa)
ACT05125.1Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (805 aa)
ACT05164.1KEGG: vvu:VV2_1425 glutamate decarboxylase. (456 aa)
argDSuccinylornithine transaminase family; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (413 aa)
ACT05259.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa)
queGIron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (379 aa)
ACT05417.1KEGG: eca:ECA3889 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (429 aa)
ACT05463.1TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: eca:ECA3848 acetolactate synthase catalytic subunit. (554 aa)
ACT05466.1TIGRFAM: thiamine ABC transporter, periplasmic binding protein; ABC transporter, periplasmic binding protein, thiB subfamily; PFAM: extracellular solute-binding protein family 1; KEGG: eca:ECA3844 thiamine transporter substrate binding subunit. (327 aa)
ACT05478.1TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: eca:ECA3829 acetolactate synthase 3 catalytic subunit. (573 aa)
ACT05583.1PFAM: aminotransferase class I and II; KEGG: spe:Spro_4445 aromatic amino acid aminotransferase. (397 aa)
ACT05589.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (358 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
ACT05639.1Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (241 aa)
ACT05763.1PFAM: aminotransferase class I and II; KEGG: eca:ECA3488 putative aminotransferase. (385 aa)
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: eum:ECUMN_0151 glutamate-1-semialdehyde aminotransferase (aminomutase). (426 aa)
btuFPeriplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (272 aa)
ACT05928.1KEGG: pfl:PFL_0498 O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; DegT/DnrJ/EryC1/StrS aminotransferase. (422 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa)
ACT06158.1PFAM: aminotransferase class I and II; KEGG: eca:ECA3115 aminotransferase. (407 aa)
ACT06185.1TIGRFAM: amino acid adenylation domain protein; non-ribosomal peptide synthase; PFAM: AMP-dependent synthetase and ligase; Thioesterase; phosphopantetheine-binding; condensation domain protein; KEGG: cvi:CV_2233 synthetase CbsF. (2877 aa)
ACT06253.1PFAM: aminotransferase class I and II; KEGG: eca:ECA3033 aminotransferase AlaT. (404 aa)
ACT06287.1Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; SMART: regulatory protein GntR HTH; KEGG: eca:ECA3004 transcription regulator GntR. (472 aa)
ACT06312.1PFAM: aminotransferase class I and II; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: ent:Ent638_1969 putative aminotransferase. (391 aa)
ACT06479.1TIGRFAM: aminodeoxychorismate lyase; PFAM: aminotransferase class IV; KEGG: eca:ECA1800 4-amino-4-deoxychorismate lyase. (267 aa)
ACT06517.1Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: spe:Spro_1729 aromatic amino acid aminotransferase. (396 aa)
ACT06532.1PFAM: MOSC domain containing protein; MOSC domain protein beta barrel domain protein; ferredoxin; KEGG: spe:Spro_1742 MOSC domain-containing protein. (367 aa)
sufSCysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (417 aa)
ACT06716.1Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; SMART: regulatory protein GntR HTH; KEGG: eca:ECA2052 GntR family transcriptional regulator. (495 aa)
ACT06717.1TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; KEGG: eca:ECA2053 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: eca:ECA2584 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
ACT07338.1PFAM: aminotransferase class-III; KEGG: bpy:Bphyt_0048 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (427 aa)
ACT07424.1PFAM: aminotransferase class I and II; KEGG: eca:ECA4485 aspartate aminotransferase. (400 aa)
ACT07484.1PFAM: 2OG-Fe(II) oxygenase; KEGG: hypothetical protein. (225 aa)
ACT07504.1PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: psb:Psyr_2585 Orn/DAP/Arg decarboxylase 2:Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (418 aa)
ACT07507.1TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; KEGG: psp:PSPPH_2750 diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa)
ACT07527.1KEGG: eca:ECA1543 putrescine--2-oxoglutarate aminotransferase; TIGRFAM: putrescine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (472 aa)
ACT07736.12-oxoglutarate dehydrogenase, E1 subunit; KEGG: kpn:KPN_00732 alpha-ketoglutarate decarboxylase; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component. (935 aa)
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (558 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa)
ACT08002.1PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: eca:ECA1012 cysteine sulfinate desulfinase. (401 aa)
ACT08160.1PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: cko:CKO_03993 hypothetical protein; Belongs to the TPP enzyme family. (643 aa)
ACT08173.1TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: eca:ECA0824 pyruvate-flavodoxin oxidoreductase. (1177 aa)
ACT08243.1Folate-binding protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. (326 aa)
ACT08251.1TIGRFAM: acetolactate synthase, catabolic; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: eca:ECA0741 acetolactate synthase; Belongs to the TPP enzyme family. (559 aa)
ACT08462.1Diaminobutyrate/2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
ACT08562.1TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: eca:ECA0354 cystathionine beta-lyase. (397 aa)
ACT08676.1Transcriptional regulator, GntR family with aminotransferase domain; PFAM: aminotransferase class I and II; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; KEGG: eta:ETA_01690 putative GntR-family transcriptional regulator. (476 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
ACT08852.1Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: eca:ECA4336 putative aminotransferase. (394 aa)
Your Current Organism:
Dickeya chrysanthemi
NCBI taxonomy Id: 561229
Other names: D. chrysanthemi Ech1591, Dickeya chrysanthemi Ech1591, Dickeya dadantii Ech1591, Dickeya zeae Ech1591
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