(107 nodes) Positive regulation of dendritic spine development network (Neotoma lepida)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A6R68_12113	Kinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
	A6R68_11651	Uncharacterized protein. (128 aa)
	A6R68_11360	Uncharacterized protein. (316 aa)
	A6R68_11275	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	A6R68_11652	Uncharacterized protein. (218 aa)
	A6R68_11368	Uncharacterized protein. (405 aa)
	A6R68_11627	Helicase ATP-binding domain-containing protein. (384 aa)
	A6R68_10800	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (208 aa)
	A6R68_11370	Uncharacterized protein. (594 aa)
	A6R68_11337	Uncharacterized protein. (517 aa)
	A6R68_09947	COesterase domain-containing protein. (533 aa)
	A6R68_09946	Uncharacterized protein. (213 aa)
	A6R68_09561	Uncharacterized protein. (152 aa)
	A6R68_09517	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (200 aa)
	A6R68_10272	Uncharacterized protein. (552 aa)
	A6R68_10044	Protein kinase domain-containing protein. (440 aa)
	A6R68_10059	Homeobox protein cut-like. (1451 aa)
	A6R68_09356	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (86 aa)
	A6R68_08957	Uncharacterized protein. (1138 aa)
	A6R68_09114	Uncharacterized protein; Belongs to the actin family. (284 aa)
	A6R68_08783	Fork-head domain-containing protein. (435 aa)
	A6R68_08323	Eph LBD domain-containing protein. (244 aa)
	A6R68_08316	Uncharacterized protein. (338 aa)
	A6R68_08375	Takusan domain-containing protein. (161 aa)
	A6R68_08317	Fibronectin type-III domain-containing protein. (143 aa)
	A6R68_07499	SAM domain-containing protein. (99 aa)
	A6R68_06865	Uncharacterized protein. (181 aa)
	A6R68_07714	G_PROTEIN_RECEP_F1_2 domain-containing protein. (96 aa)
	A6R68_06608	ROKNT domain-containing protein. (109 aa)
	A6R68_06526	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (236 aa)
	A6R68_05939	Takusan domain-containing protein. (100 aa)
	A6R68_05572	Uncharacterized protein. (68 aa)
	A6R68_05257	ADF-H domain-containing protein. (86 aa)
	A6R68_05466	Takusan domain-containing protein. (110 aa)
	A6R68_05991	ADF-H domain-containing protein. (689 aa)
	A6R68_05004	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (482 aa)
	A6R68_04016	Uncharacterized protein. (366 aa)
	A6R68_04770	Uncharacterized protein. (90 aa)
	A6R68_03306	Takusan domain-containing protein. (128 aa)
	A6R68_03287	Uncharacterized protein. (190 aa)
	A6R68_03754	EGF_2 domain-containing protein. (177 aa)
	A6R68_03624	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (195 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (97 aa)
	A6R68_03304	Takusan domain-containing protein. (98 aa)
	A6R68_03236	Uncharacterized protein. (382 aa)
	A6R68_03062	Uncharacterized protein. (302 aa)
	A6R68_03146	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (112 aa)
	A6R68_03447	Uncharacterized protein. (101 aa)
	A6R68_02776	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
	A6R68_01910	Takusan domain-containing protein. (161 aa)
	A6R68_01804	Takusan domain-containing protein. (263 aa)
	A6R68_01463	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (284 aa)
	A6R68_01662	Takusan domain-containing protein. (161 aa)
	A6R68_01570	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (107 aa)
	A6R68_01077	COesterase domain-containing protein. (787 aa)
	A6R68_01914	Uncharacterized protein. (378 aa)
	A6R68_01974	NHR domain-containing protein. (250 aa)
	A6R68_00746	Uncharacterized protein. (1848 aa)
	A6R68_01329	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
	A6R68_01243	Takusan domain-containing protein. (221 aa)
	A6R68_00264	Uncharacterized protein. (634 aa)
	A6R68_00262	Protein kinase domain-containing protein. (146 aa)
	A6R68_00765	Uncharacterized protein. (463 aa)
	A6R68_00682	Eukaryotic elongation factor 2 kinase. (768 aa)
	A6R68_13444	Uncharacterized protein; Belongs to the MAGUK family. (1679 aa)
	A6R68_13544	Ras-associating domain-containing protein. (734 aa)
	A6R68_13445	Takusan domain-containing protein. (121 aa)
	A6R68_12385	Uncharacterized protein. (379 aa)
	A6R68_12357	ANK_REP_REGION domain-containing protein. (308 aa)
	A6R68_12362	SAM domain-containing protein. (1106 aa)
	A6R68_12138	Uncharacterized protein; Belongs to the MAGUK family. (346 aa)
	A6R68_15961	Uncharacterized protein. (188 aa)
	A6R68_15827	Uncharacterized protein. (99 aa)
	A6R68_15826	G_PROTEIN_RECEP_F1_2 domain-containing protein. (144 aa)
	A6R68_14692	Uncharacterized protein. (315 aa)
	A6R68_13967	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (631 aa)
	A6R68_16253	ANK_REP_REGION domain-containing protein. (340 aa)
	A6R68_20065	Uncharacterized protein. (237 aa)
	A6R68_20086	Uncharacterized protein. (305 aa)
	A6R68_19405	Uncharacterized protein. (444 aa)
	A6R68_19406	Uncharacterized protein. (117 aa)
	A6R68_19237	Uncharacterized protein. (475 aa)
	A6R68_19174	C1q domain-containing protein. (484 aa)
	A6R68_19238	Uncharacterized protein. (454 aa)
	A6R68_18253	Protein kinase domain-containing protein. (433 aa)
	A6R68_18352	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (426 aa)
	A6R68_22094	EGF-like domain-containing protein. (517 aa)
	A6R68_22042	Uncharacterized protein. (553 aa)
	A6R68_21748	Uncharacterized protein. (598 aa)
	A6R68_21316	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (636 aa)
	A6R68_21164	Rap-GAP domain-containing protein. (1758 aa)
	A6R68_21029	SH3 domain-containing protein. (124 aa)
	A6R68_21022	Uncharacterized protein. (501 aa)
	A6R68_20431	Uncharacterized protein. (1169 aa)
	A6R68_20545	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (228 aa)
	A6R68_23826	Uncharacterized protein. (102 aa)
	A6R68_23596	Uncharacterized protein. (468 aa)
	A6R68_23542	Uncharacterized protein. (133 aa)
	A6R68_23459	Uncharacterized protein. (401 aa)
	A6R68_23002	IMD domain-containing protein. (292 aa)
	A6R68_22985	Uncharacterized protein. (369 aa)
	A6R68_23456	Protein kinase domain-containing protein. (531 aa)
	A6R68_22955	Uncharacterized protein. (2130 aa)
	A6R68_22888	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (125 aa)
	A6R68_22579	Uncharacterized protein. (190 aa)
	A6R68_22311	COesterase domain-containing protein. (828 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (375 aa)

Your Current Organism:

Neotoma lepida

NCBI taxonomy Id: 56216
Other names: N. lepida, desert woodrat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A6R68_00262	A6R68_00264	A0A1A6GYG5	A0A1A6GXZ4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.899
A6R68_00262	A6R68_05004	A0A1A6GYG5	A0A1A6GJS2	Protein kinase domain-containing protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.590
A6R68_00262	A6R68_11337	A0A1A6GYG5	A0A1A6FWG7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.493
A6R68_00264	A6R68_00262	A0A1A6GXZ4	A0A1A6GYG5	Uncharacterized protein.	Protein kinase domain-containing protein.	0.899
A6R68_00264	A6R68_05004	A0A1A6GXZ4	A0A1A6GJS2	Uncharacterized protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.590
A6R68_00264	A6R68_11337	A0A1A6GXZ4	A0A1A6FWG7	Uncharacterized protein.	Uncharacterized protein.	0.493
A6R68_00682	A6R68_05572	A0A1A6GZI1	A0A1A6GHY6	Eukaryotic elongation factor 2 kinase.	Uncharacterized protein.	0.463
A6R68_00682	A6R68_06865	A0A1A6GZI1	A0A1A6GEC7	Eukaryotic elongation factor 2 kinase.	Uncharacterized protein.	0.463
A6R68_00682	A6R68_10800	A0A1A6GZI1	A0A1A6FVW0	Eukaryotic elongation factor 2 kinase.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.471
A6R68_00746	A6R68_03236	A0A1A6GWJ2	A0A1A6GQS0	Uncharacterized protein.	Uncharacterized protein.	0.558
A6R68_00746	A6R68_05004	A0A1A6GWJ2	A0A1A6GJS2	Uncharacterized protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.610
A6R68_00746	A6R68_08783	A0A1A6GWJ2	A0A1A6G2M3	Uncharacterized protein.	Fork-head domain-containing protein.	0.892
A6R68_00746	A6R68_10059	A0A1A6GWJ2	A0A1A6G0D3	Uncharacterized protein.	Homeobox protein cut-like.	0.777
A6R68_00746	A6R68_18253	A0A1A6GWJ2	A0A1A6HLQ2	Uncharacterized protein.	Protein kinase domain-containing protein.	0.684
A6R68_00746	A6R68_21022	A0A1A6GWJ2	A0A1A6HRB8	Uncharacterized protein.	Uncharacterized protein.	0.584
A6R68_00746	A6R68_21029	A0A1A6GWJ2	A0A1A6HR99	Uncharacterized protein.	SH3 domain-containing protein.	0.584
A6R68_01077	A6R68_03236	A0A1A6GVJ2	A0A1A6GQS0	COesterase domain-containing protein.	Uncharacterized protein.	0.410
A6R68_01077	A6R68_09947	A0A1A6GVJ2	A0A1A6FYC2	COesterase domain-containing protein.	COesterase domain-containing protein.	0.843
A6R68_01077	A6R68_12138	A0A1A6GVJ2	A0A1A6H4P2	COesterase domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.739
A6R68_01077	A6R68_12357	A0A1A6GVJ2	A0A1A6H418	COesterase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.756