31 items (Neotoma lepida) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A6R68_05099	Uncharacterized protein. (96 aa)
	A6R68_05032	Replication factor C subunit 1. (963 aa)
	A6R68_06975	DNA_pol_E_B domain-containing protein. (276 aa)
	A6R68_09134	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (254 aa)
	A6R68_22295	Uncharacterized protein. (361 aa)
	A6R68_22420	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (597 aa)
	A6R68_23433	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2166 aa)
	A6R68_23461	Uncharacterized protein. (497 aa)
	A6R68_22957	DNA_pol_B_exo1 domain-containing protein. (592 aa)
	A6R68_23263	Uncharacterized protein. (182 aa)
	A6R68_23262	Uncharacterized protein. (158 aa)
	A6R68_23640	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (517 aa)
	A6R68_23815	BTB domain-containing protein. (768 aa)
	A6R68_20472	AAA domain-containing protein. (346 aa)
	A6R68_20828	Uncharacterized protein. (462 aa)
	A6R68_22182	Uncharacterized protein. (167 aa)
	A6R68_16708	Uncharacterized protein. (90 aa)
	A6R68_17762	Uncharacterized protein. (288 aa)
	A6R68_17798	DNA_LIGASE_A3 domain-containing protein. (270 aa)
	A6R68_12928	PCNA_C domain-containing protein. (242 aa)
	A6R68_12527	Uncharacterized protein. (107 aa)
	A6R68_00249	PCNA_C domain-containing protein. (96 aa)
	A6R68_00915	BTB domain-containing protein. (479 aa)
	A6R68_02319	ATPase_AAA_core domain-containing protein. (1581 aa)
	A6R68_02801	Uncharacterized protein. (191 aa)
	A6R68_01992	ATPase_AAA_core domain-containing protein. (116 aa)
	A6R68_09992	RPA_C domain-containing protein. (174 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (390 aa)
	A6R68_10640	RPA_C domain-containing protein. (315 aa)
	A6R68_11703	Uncharacterized protein. (470 aa)
	A6R68_04835	Uncharacterized protein. (137 aa)

Your Current Organism:

Neotoma lepida

NCBI taxonomy Id: 56216
Other names: N. lepida, desert woodrat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A6R68_00249	A6R68_01992	A0A1A6H043	A0A1A6GTG5	PCNA_C domain-containing protein.	ATPase_AAA_core domain-containing protein.	0.988
A6R68_00249	A6R68_02319	A0A1A6H043	A0A1A6GTZ6	PCNA_C domain-containing protein.	ATPase_AAA_core domain-containing protein.	0.970
A6R68_00249	A6R68_02801	A0A1A6H043	A0A1A6GRZ2	PCNA_C domain-containing protein.	Uncharacterized protein.	0.931
A6R68_00249	A6R68_04835	A0A1A6H043	A0A1A6GMQ0	PCNA_C domain-containing protein.	Uncharacterized protein.	0.996
A6R68_00249	A6R68_05032	A0A1A6H043	A0A1A6GJI3	PCNA_C domain-containing protein.	Replication factor C subunit 1.	0.977
A6R68_00249	A6R68_05099	A0A1A6H043	A0A1A6GKW7	PCNA_C domain-containing protein.	Uncharacterized protein.	0.783
A6R68_00249	A6R68_06975	A0A1A6H043	A0A1A6GFE5	PCNA_C domain-containing protein.	DNA_pol_E_B domain-containing protein.	0.865
A6R68_00249	A6R68_09134	A0A1A6H043	A0A1A6G2Z6	PCNA_C domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.931
A6R68_00249	A6R68_09992	A0A1A6H043	A0A1A6FY96	PCNA_C domain-containing protein.	RPA_C domain-containing protein.	0.889
A6R68_00249	A6R68_10640	A0A1A6H043	A0A1A6FXB5	PCNA_C domain-containing protein.	RPA_C domain-containing protein.	0.889
A6R68_00249	A6R68_11703	A0A1A6H043	A0A1A6FT93	PCNA_C domain-containing protein.	Uncharacterized protein.	0.975
A6R68_00249	A6R68_12527	A0A1A6H043	A0A1A6H3H3	PCNA_C domain-containing protein.	Uncharacterized protein.	0.541
A6R68_00249	A6R68_16708	A0A1A6H043	A0A1A6HE47	PCNA_C domain-containing protein.	Uncharacterized protein.	0.750
A6R68_00249	A6R68_17762	A0A1A6H043	A0A1A6HBY5	PCNA_C domain-containing protein.	Uncharacterized protein.	0.947
A6R68_00249	A6R68_17798	A0A1A6H043	A0A1A6HBV0	PCNA_C domain-containing protein.	DNA_LIGASE_A3 domain-containing protein.	0.975
A6R68_00249	A6R68_20472	A0A1A6H043	A0A1A6HTH6	PCNA_C domain-containing protein.	AAA domain-containing protein.	0.985
A6R68_00249	A6R68_20828	A0A1A6H043	A0A1A6HRX5	PCNA_C domain-containing protein.	Uncharacterized protein.	0.956
A6R68_00249	A6R68_22182	A0A1A6H043	A0A1A6HMW6	PCNA_C domain-containing protein.	Uncharacterized protein.	0.991
A6R68_00249	A6R68_22420	A0A1A6H043	A0A1A6HZH2	PCNA_C domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.968
A6R68_00249	A6R68_22957	A0A1A6H043	A0A1A6HXU5	PCNA_C domain-containing protein.	DNA_pol_B_exo1 domain-containing protein.	0.986