(102 nodes) Central carbon metabolism in cancer network (Neotoma lepida)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A6R68_18086	Ldh_1_C domain-containing protein. (174 aa)
	A6R68_01126	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (318 aa)
	A6R68_11899	Protein kinase domain-containing protein. (128 aa)
	A6R68_11880	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (402 aa)
	A6R68_11434	Phosphotransferase. (218 aa)
	A6R68_11288	Mitogen-activated protein kinase. (325 aa)
	A6R68_09346	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (357 aa)
	A6R68_09414	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1033 aa)
	A6R68_09368	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (318 aa)
	A6R68_08540	Protein kinase domain-containing protein. (254 aa)
	A6R68_08866	Fibroblast growth factor receptor. (784 aa)
	A6R68_08175	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (400 aa)
	A6R68_07585	Protein kinase domain-containing protein. (108 aa)
	A6R68_07751	Uncharacterized protein. (394 aa)
	A6R68_07606	Protein kinase domain-containing protein. (109 aa)
	A6R68_07391	Uncharacterized protein. (454 aa)
	A6R68_07118	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (320 aa)
	A6R68_06583	Uncharacterized protein. (490 aa)
	A6R68_06373	Uncharacterized protein. (113 aa)
	A6R68_06284	Tyrosine-protein kinase receptor. (793 aa)
	A6R68_05987	Uncharacterized protein. (892 aa)
	A6R68_05642	Uncharacterized protein. (108 aa)
	A6R68_05524	Uncharacterized protein. (161 aa)
	A6R68_05136	Uncharacterized protein. (98 aa)
	A6R68_05386	I-set domain-containing protein. (272 aa)
	A6R68_05161	Uncharacterized protein. (497 aa)
	A6R68_04385	Fibroblast growth factor receptor. (847 aa)
	A6R68_05137	Uncharacterized protein. (119 aa)
	A6R68_03991	Uncharacterized protein. (165 aa)
	A6R68_04917	Uncharacterized protein. (86 aa)
	A6R68_04482	Protein kinase domain-containing protein. (368 aa)
	A6R68_04305	Uncharacterized protein. (841 aa)
	A6R68_04024	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (53 aa)
	A6R68_03309	Protein kinase domain-containing protein. (221 aa)
	A6R68_03604	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (368 aa)
	A6R68_03777	Pyruvate kinase; Belongs to the pyruvate kinase family. (347 aa)
	A6R68_03399	Mitogen-activated protein kinase. (244 aa)
	A6R68_03308	Uncharacterized protein. (259 aa)
	A6R68_02975	Uncharacterized protein. (878 aa)
	A6R68_02230	Protein kinase domain-containing protein. (96 aa)
	A6R68_01456	Uncharacterized protein. (270 aa)
	A6R68_01078	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (275 aa)
	A6R68_00841	Protein-serine/threonine kinase. (882 aa)
	A6R68_00557	Deacetylase sirtuin-type domain-containing protein. (174 aa)
	A6R68_01459	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (378 aa)
	A6R68_22344	PK domain-containing protein. (100 aa)
	A6R68_23464	Phosphotransferase. (298 aa)
	A6R68_23994	Pyruvate kinase; Belongs to the pyruvate kinase family. (144 aa)
	A6R68_23457	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
	A6R68_23993	Uncharacterized protein. (257 aa)
	A6R68_24320	Uncharacterized protein. (72 aa)
	A6R68_24131	Uncharacterized protein. (306 aa)
	A6R68_21039	PK domain-containing protein. (116 aa)
	A6R68_20365	Protein kinase domain-containing protein. (57 aa)
	A6R68_20675	Uncharacterized protein. (180 aa)
	A6R68_20927	Uncharacterized protein. (242 aa)
	A6R68_21257	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	A6R68_21033	PARP catalytic domain-containing protein. (595 aa)
	A6R68_21315	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1033 aa)
	A6R68_21419	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (531 aa)
	A6R68_18653	Phosphotransferase. (376 aa)
	A6R68_18114	6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (731 aa)
	A6R68_18805	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (498 aa)
	A6R68_18606	Uncharacterized protein. (49 aa)
	A6R68_18657	Phosphotransferase; Belongs to the hexokinase family. (113 aa)
	A6R68_18647	Uncharacterized protein. (917 aa)
	A6R68_18691	Uncharacterized protein. (189 aa)
	A6R68_18875	Uncharacterized protein. (680 aa)
	A6R68_18698	Uncharacterized protein. (782 aa)
	A6R68_19337	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (410 aa)
	A6R68_19339	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (229 aa)
	A6R68_20108	Uncharacterized protein. (107 aa)
	A6R68_17376	Deacetylase sirtuin-type domain-containing protein. (317 aa)
	A6R68_16954	Uncharacterized protein. (723 aa)
	A6R68_14014	Uncharacterized protein. (119 aa)
	A6R68_17903	Uncharacterized protein. (766 aa)
	A6R68_17578	Uncharacterized protein. (211 aa)
	A6R68_17303	ANK_REP_REGION domain-containing protein. (337 aa)
	A6R68_17312	Amino acid transporter. (561 aa)
	A6R68_14170	Protein kinase domain-containing protein. (61 aa)
	A6R68_17988	Uncharacterized protein. (151 aa)
	A6R68_17659	Pyruvate kinase; Belongs to the pyruvate kinase family. (496 aa)
	A6R68_14416	Uncharacterized protein. (182 aa)
	A6R68_14016	Serine/threonine-protein kinase mTOR. (1425 aa)
	A6R68_17790	Uncharacterized protein. (148 aa)
	A6R68_13996	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1012 aa)
	A6R68_14404	Uncharacterized protein. (380 aa)
	A6R68_14095	Protein kinase domain-containing protein. (685 aa)
	A6R68_14297	Uncharacterized protein. (854 aa)
	A6R68_15875	CNH domain-containing protein. (311 aa)
	A6R68_15471	EF-hand_14 domain-containing protein. (156 aa)
	A6R68_08192	Sema domain-containing protein. (307 aa)
	A6R68_13338	PK_C domain-containing protein. (129 aa)
	A6R68_13427	Uncharacterized protein. (105 aa)
	A6R68_13428	Ig-like domain-containing protein. (101 aa)
	A6R68_00429	ANK_REP_REGION domain-containing protein. (488 aa)
	A6R68_13710	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (533 aa)
	A6R68_00554	Uncharacterized protein. (170 aa)
	A6R68_00645	Uncharacterized protein. (1022 aa)
	A6R68_00260	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	A6R68_00486	MFS domain-containing protein. (469 aa)
	A6R68_00936	SH2 domain-containing protein. (283 aa)

Your Current Organism:

Neotoma lepida

NCBI taxonomy Id: 56216
Other names: N. lepida, desert woodrat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A6R68_00260	A6R68_00557	A0A1A6GYY5	A0A1A6GX33	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Deacetylase sirtuin-type domain-containing protein.	0.605
A6R68_00260	A6R68_00841	A0A1A6GYY5	A0A1A6GWT0	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Protein-serine/threonine kinase.	0.948
A6R68_00260	A6R68_01126	A0A1A6GYY5	A0A1A6GXK9	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.848
A6R68_00260	A6R68_01459	A0A1A6GYY5	A0A1A6GXC8	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.999
A6R68_00260	A6R68_03604	A0A1A6GYY5	A0A1A6GQ92	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.786
A6R68_00260	A6R68_03777	A0A1A6GYY5	A0A1A6GQP4	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.815
A6R68_00260	A6R68_04917	A0A1A6GYY5	A0A1A6GMH6	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein.	0.815
A6R68_00260	A6R68_05161	A0A1A6GYY5	A0A1A6GKA5	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein.	0.601
A6R68_00260	A6R68_07118	A0A1A6GYY5	A0A1A6GF02	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.868
A6R68_00260	A6R68_09346	A0A1A6GYY5	A0A1A6G040	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.866
A6R68_00260	A6R68_09368	A0A1A6GYY5	A0A1A6G117	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	0.786
A6R68_00260	A6R68_13338	A0A1A6GYY5	A0A1A6H3A0	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	PK_C domain-containing protein.	0.815
A6R68_00260	A6R68_17376	A0A1A6GYY5	A0A1A6HE24	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Deacetylase sirtuin-type domain-containing protein.	0.605
A6R68_00260	A6R68_17578	A0A1A6GYY5	A0A1A6HCH6	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein.	0.815
A6R68_00260	A6R68_17659	A0A1A6GYY5	A0A1A6HC81	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.815
A6R68_00260	A6R68_17790	A0A1A6GYY5	A0A1A6HB09	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein.	0.786
A6R68_00260	A6R68_18086	A0A1A6GYY5	A0A1A6HMG4	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Ldh_1_C domain-containing protein.	0.848
A6R68_00260	A6R68_18114	A0A1A6GYY5	A0A1A6HML9	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.	0.601
A6R68_00260	A6R68_20108	A0A1A6GYY5	A0A1A6HFY5	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein.	0.786
A6R68_00260	A6R68_21033	A0A1A6GYY5	A0A1A6HR84	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	PARP catalytic domain-containing protein.	0.815