STRINGSTRING
Btus_0317 Btus_0317 hisC hisC Btus_0594 Btus_0594 Btus_0632 Btus_0632 aroK aroK Btus_0704 Btus_0704 thrB thrB Btus_0713 Btus_0713 Btus_0927 Btus_0927 Btus_0940 Btus_0940 pheA pheA serC serC Btus_1115 Btus_1115 Btus_1166 Btus_1166 aroE aroE dapF dapF asd asd Btus_1568 Btus_1568 dapA dapA dapA-2 dapA-2 dapB dapB aroA aroA Btus_1716 Btus_1716 trpA trpA trpB trpB trpF trpF trpC trpC trpD trpD aroB aroB aroC aroC Btus_1805 Btus_1805 lysA lysA Btus_1914 Btus_1914 Btus_1915 Btus_1915 hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisD hisD hisG hisG hisZ hisZ hisD-2 hisD-2 Btus_3284 Btus_3284
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Your Input:
Btus_0317PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: cno:NT01CX_2116 diaminopimelate decarboxylase. (477 aa)
hisCKEGG: mta:Moth_0515 histidinol phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa)
Btus_0594KEGG: bbe:BBR47_41660 phospho-2-dehydro-3- deoxyheptonate aldolase/chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II. (365 aa)
Btus_0632KEGG: gym:GYMC10_2089 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (415 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa)
Btus_0704Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (357 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa)
Btus_0713PFAM: Phosphoglycerate mutase; KEGG: phosphoglycerate mutase gpmB; Belongs to the phosphoglycerate mutase family. (213 aa)
Btus_0927PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: mka:MK0297 D-3-phosphoglycerate dehydrogenase. (328 aa)
Btus_0940KEGG: pth:PTH_1601 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (431 aa)
pheAKEGG: adg:Adeg_1153 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (270 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (364 aa)
Btus_1115KEGG: hau:Haur_2989 para-aminobenzoate synthase, subunit I; TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding-like; aminotransferase class IV. (618 aa)
Btus_1166KEGG: pjd:Pjdr2_5919 anthranilate phosphoribosyltransferase; PFAM: Glycosyl transferase, family 3-like. (349 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
Btus_1568KEGG: bcb:BCB4264_A3898 aspartate kinase I; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (407 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
dapA-22,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa)
Btus_1716PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; KEGG: afl:Aflv_1108 prephenate dehydrogenase. (372 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (273 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa)
trpFKEGG: gym:GYMC10_2212 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (213 aa)
trpCKEGG: pzu:PHZ_c1761 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (265 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (377 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (388 aa)
Btus_1805TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: bbe:BBR47_24220 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (527 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (444 aa)
Btus_1914KEGG: aac:Aaci_1220 anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein. (485 aa)
Btus_1915KEGG: gem:GM21_2261 glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (202 aa)
hisIKEGG: gyc:GYMC61_3151 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (230 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cyh:Cyan8802_0338 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. (281 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa)
hisBKEGG: hha:Hhal_1094 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (194 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (211 aa)
hisZhistidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (417 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa)
Btus_3284PFAM: aminotransferase class I and II; KEGG: aac:Aaci_2798 aminotransferase class I and II. (396 aa)
Your Current Organism:
Kyrpidia tusciae
NCBI taxonomy Id: 562970
Other names: Bacillus tusciae DSM 2912, K. tusciae DSM 2912, Kyrpidia tusciae DSM 2912, Kyrpidia tusciae NBRC 15312, Kyrpidia tusciae str. DSM 2912, Kyrpidia tusciae strain DSM 2912
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